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  1. Article: Cetyl Alcohol Polyethoxylates Disrupt Metabolic Health in Developmentally Exposed Zebrafish.

    LeFauve, Matthew K / Bérubé, Roxanne / Heldman, Samantha / Chiang, Yu-Ting Tiffany / Kassotis, Christopher D

    Metabolites

    2023  Volume 13, Issue 3

    Abstract: Alcohol polyethoxylates (AEOs), such as cetyl alcohol ethoxylates (CetAEOs), are high-production-volume surfactants used in laundry detergents, hard-surface cleaners, pesticide formulations, textile production, oils, paints, and other products. AEOs have ...

    Abstract Alcohol polyethoxylates (AEOs), such as cetyl alcohol ethoxylates (CetAEOs), are high-production-volume surfactants used in laundry detergents, hard-surface cleaners, pesticide formulations, textile production, oils, paints, and other products. AEOs have been suggested as lower toxicity replacements for alkylphenol polyethoxylates (APEOs), such as the nonylphenol and octylphenol polyethoxylates. We previously demonstrated that nonylphenol polyethoxylates induced triglyceride accumulation in several in vitro adipogenesis models and promoted adiposity and increased body weights in developmentally exposed zebrafish. We also demonstrated that diverse APEOs and AEOs were able to increase triglyceride accumulation and/or pre-adipocyte proliferation in a murine pre-adipocyte model. As such, the goals of this study were to assess the potential of CetAEOs to promote adiposity and alter growth and/or development (toxicity, length, weight, behavior, energy expenditure) of developmentally exposed zebrafish (
    Language English
    Publishing date 2023-02-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo13030359
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Evaluating Phenotypic and Transcriptomic Responses Induced by Low-Level VOCs in Zebrafish: Benzene as an Example.

    Wu, Chia-Chen / Blount, Jessica R / Haimbaugh, Alex / Heldman, Samantha / Shields, Jeremiah N / Baker, Tracie R

    Toxics

    2022  Volume 10, Issue 7

    Abstract: Urban environments are plagued by complex mixtures of anthropogenic volatile organic compounds (VOCs), such as mixtures of benzene, toluene, ethylene, and xylene (BTEX). Sources of BTEX that drive human exposure include vehicle exhaust, industrial ... ...

    Abstract Urban environments are plagued by complex mixtures of anthropogenic volatile organic compounds (VOCs), such as mixtures of benzene, toluene, ethylene, and xylene (BTEX). Sources of BTEX that drive human exposure include vehicle exhaust, industrial emissions, off-gassing of building material, as well as oil spillage and leakage. Among the BTEX mixture, benzene is the most volatile compound and has been linked to numerous adverse health outcomes. However, few studies have focused on the effects of low-level benzene on exposure during early development, which is a susceptible window when hematological, immune, metabolic, and detoxification systems are immature. In this study, we used zebrafish to conduct a VOC exposure model and evaluated phenotypic and transcriptomic responses following 0.1 and 1 ppm benzene exposure during the first five days of embryogenesis (n = 740 per treatment). The benzene body burden was 2 mg/kg in 1 ppm-exposed larval zebrafish pools and under the detection limit in 0.1 ppm-exposed fish. No observable phenotypic changes were found in both larvae except for significant skeletal deformities in 0.1 ppm-exposed fish (
    Language English
    Publishing date 2022-06-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics10070351
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Adipogenic and endocrine disrupting mixture effects of organic and inorganic pollutant mixtures.

    Bérubé, Roxanne / LeFauve, Matthew K / Heldman, Samantha / Chiang, Yu-Ting Tiffany / Birbeck, Johnna / Westrick, Judy / Hoffman, Kate / Kassotis, Christopher D

    The Science of the total environment

    2023  Volume 876, Page(s) 162587

    Abstract: Chronic health conditions are rapidly increasing in prevalence and cost to society worldwide: in the US, >42 % of adults aged 20 and older are currently classified as obese. Exposure to endocrine disrupting chemicals (EDCs) has been implicated as a ... ...

    Abstract Chronic health conditions are rapidly increasing in prevalence and cost to society worldwide: in the US, >42 % of adults aged 20 and older are currently classified as obese. Exposure to endocrine disrupting chemicals (EDCs) has been implicated as a causal factor; some EDCs, termed "obesogens", can increase weight and lipid accumulation and/or perturb metabolic homeostasis. This project aimed to assess the potential combination effects of diverse inorganic and organic contaminant mixtures, which more closely reflect environmentally realistic exposures, on nuclear receptor activation/inhibition and adipocyte differentiation. Herein, we focused on two polychlorinated biphenyls (PCB-77 and 153), two perfluoroalkyl substances (PFOA and PFOS), two brominated flame retardants (PBB-153 and BDE-47), and three inorganic contaminants (lead, arsenic, and cadmium). We examined adipogenesis using human mesenchymal stem cells and receptor bioactivities using luciferase reporter gene assays in human cell lines. We observed significantly greater effects for several receptor bioactivities by various contaminant mixtures relative to individual components. All nine contaminants promoted triglyceride accumulation and/or pre-adipocyte proliferation in human mesenchymal stem cells. Comparing simple component mixtures to individual components at 10 % and 50 % effect levels revealed putative synergistic effects for each of the mixtures for at least one of the concentrations relative to the individual component chemicals, some of which also exhibited significantly greater effects than the component contaminants. Our results support further testing of more realistic and complex contaminant mixtures that better reflect environmental exposures, in order to more conclusively define mixture responses both in vitro and in vivo.
    MeSH term(s) Adult ; Humans ; Environmental Pollutants/toxicity ; Environmental Pollutants/analysis ; Adipogenesis ; Environmental Exposure ; Cell Differentiation ; Triglycerides ; Endocrine Disruptors/toxicity
    Chemical Substances Environmental Pollutants ; Triglycerides ; Endocrine Disruptors
    Language English
    Publishing date 2023-03-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.162587
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Increasing Incidence of Spotted Fever Group Rickettsioses in the United States, 2010–2018

    Bishop, Alexandra / Borski, Jennifer / Wang, Hsiao-Hsuan / Donaldson, Taylor G. / Michalk, Avery / Montgomery, Annie / Heldman, Samantha / Mogg, Michael / Derouen, Zakary / Grant, William E. / Teel, Pete D.

    Vector borne and zoonotic diseases. 2022 Aug. 26,

    2022  

    Abstract: Spotted fever group Rickettsia species are intracellular bacteria transmitted by tick or mite vectors and that cause human diseases referred to as spotted fever group rickettsioses, or spotted fevers. In the United States, the most recognized and ... ...

    Abstract Spotted fever group Rickettsia species are intracellular bacteria transmitted by tick or mite vectors and that cause human diseases referred to as spotted fever group rickettsioses, or spotted fevers. In the United States, the most recognized and commonly reported spotted fevers are Rocky Mountain spotted fever (RMSF) (Rickettsia rickettsii), Rickettsia parkeri rickettsiosis, Pacific Coast tick fever (Rickettsia species 364D), and rickettsialpox (Rickettsia akari). In this study, we summarize and evaluate surveillance data on spotted fever cases reported to the Centers for Disease Control and Prevention (CDC) through the National Notifiable Diseases Surveillance System from 2010 to 2018. During this period, there were 36,632 reported cases of spotted fevers with 95.83% (N = 35,104) reported as meeting the case definition as probable and 4.17% (N = 1528) reported as meeting the case definition as confirmed. The average national incidence of total cases, both probable and confirmed, was 12.77 cases per million persons per year. The highest statewide incidence was in Arkansas, with 256.84 per million per year, whereas the lowest incidence occurred in California, with 0.32 per million per year (note that spotted fevers were not notifiable in Hawaii and Alaska). Cases of spotted fevers were reported more frequently among males by gender, White by race, and non-Hispanic by ethnicity. The incidence of spotted fevers increased significantly from 2010 to 2018, but it is uncertain how many of the reported cases were RMSF and how many developed from more moderate spotted fevers. Improvement of the ability to differentiate between spotted fever group Rickettsia species is needed.
    Keywords Dermacentor occidentalis ; Hawaii ; Rickettsia akari ; Rickettsia parkeri ; Rickettsia rickettsii ; fever ; gender ; humans ; mites ; monitoring ; nationalities and ethnic groups ; rickettsial diseases ; ticks ; Alaska ; Arkansas ; California
    Language English
    Dates of publication 2022-0826
    Publishing place Mary Ann Liebert, Inc.
    Document type Article
    ZDB-ID 2047199-3
    ISSN 1557-7759 ; 1530-3667
    ISSN (online) 1557-7759
    ISSN 1530-3667
    DOI 10.1089/vbz.2022.0021
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6137: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Increasing Incidence of Spotted Fever Group Rickettsioses in the United States, 2010-2018.

    Bishop, Alexandra / Borski, Jennifer / Wang, Hsiao-Hsuan / Donaldson, Taylor G / Michalk, Avery / Montgomery, Annie / Heldman, Samantha / Mogg, Michael / Derouen, Zakary / Grant, William E / Teel, Pete D

    Vector borne and zoonotic diseases (Larchmont, N.Y.)

    2022  Volume 22, Issue 9, Page(s) 491–497

    Abstract: Spotted fever ... ...

    Abstract Spotted fever group
    MeSH term(s) Animals ; Humans ; Incidence ; Male ; Rickettsia ; Rickettsia Infections/epidemiology ; Rickettsia Infections/microbiology ; Rickettsia Infections/veterinary ; Rickettsia rickettsii ; Rocky Mountain Spotted Fever/epidemiology ; Rocky Mountain Spotted Fever/microbiology ; Rocky Mountain Spotted Fever/veterinary ; Spotted Fever Group Rickettsiosis/epidemiology ; Spotted Fever Group Rickettsiosis/veterinary ; United States/epidemiology
    Language English
    Publishing date 2022-08-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2047199-3
    ISSN 1557-7759 ; 1530-3667
    ISSN (online) 1557-7759
    ISSN 1530-3667
    DOI 10.1089/vbz.2022.0021
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6137: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: A Review of Volatile Organic Compound Contamination in Post-Industrial Urban Centers: Reproductive Health Implications Using a Detroit Lens.

    Miller, Carol J / Runge-Morris, Melissa / Cassidy-Bushrow, Andrea E / Straughen, Jennifer K / Dittrich, Timothy M / Baker, Tracie R / Petriello, Michael C / Mor, Gil / Ruden, Douglas M / O'Leary, Brendan F / Teimoori, Sadaf / Tummala, Chandra M / Heldman, Samantha / Agarwal, Manisha / Roth, Katherine / Yang, Zhao / Baker, Bridget B

    International journal of environmental research and public health

    2020  Volume 17, Issue 23

    Abstract: Volatile organic compounds (VOCs) are a group of aromatic or chlorinated organic chemicals commonly found in manufactured products that have high vapor pressure, and thus vaporize readily at room temperature. While airshed VOCs are well studied and have ... ...

    Abstract Volatile organic compounds (VOCs) are a group of aromatic or chlorinated organic chemicals commonly found in manufactured products that have high vapor pressure, and thus vaporize readily at room temperature. While airshed VOCs are well studied and have provided insights into public health issues, we suggest that belowground VOCs and the related vapor intrusion process could be equally or even more relevant to public health. The persistence, movement, remediation, and human health implications of subsurface VOCs in urban landscapes remain relatively understudied despite evidence of widespread contamination. This review explores the state of the science of subsurface movement and remediation of VOCs through groundwater and soils, the linkages between these poorly understood contaminant exposure pathways and health outcomes based on research in various animal models, and describes the role of these contaminants in human health, focusing on birth outcomes, notably low birth weight and preterm birth. Finally, this review provides recommendations for future research to address knowledge gaps that are essential for not only tackling health disparities and environmental injustice in post-industrial cities, but also protecting and preserving critical freshwater resources.
    MeSH term(s) Animals ; Cities ; Environmental Exposure/statistics & numerical data ; Female ; Groundwater/chemistry ; Humans ; Infant, Low Birth Weight ; Infant, Newborn ; Michigan ; Pregnancy ; Premature Birth ; Reproductive Health/statistics & numerical data ; Soil Pollutants/analysis ; Volatile Organic Compounds/adverse effects
    Chemical Substances Soil Pollutants ; Volatile Organic Compounds
    Language English
    Publishing date 2020-11-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph17238755
    Database MEDical Literature Analysis and Retrieval System OnLINE

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