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  1. Article ; Online: Evaluation of a Microsurgery Training Curriculum.

    Cuteanu, Anita / Hellich, Agathe / Cardinal, Alba Le / Thomas, Maeve / Valchanova, Anna / Vara, Sital / Horbury, Gwynn / Boal, Matt / Ghamrawi, Walaa / Slim, Naim / Francis, Nader

    Journal of reconstructive microsurgery

    2022  Volume 39, Issue 8, Page(s) 589–600

    Abstract: Background:  Microsurgery is one of the most challenging areas of surgery with a steep learning curve. To address this educational need, microsurgery curricula have been developed and validated, with the majority focus on technical skills only. The aim ... ...

    Abstract Background:  Microsurgery is one of the most challenging areas of surgery with a steep learning curve. To address this educational need, microsurgery curricula have been developed and validated, with the majority focus on technical skills only. The aim of this study was to report on the evaluation of a well-established curriculum using the Kirkpatrick model.
    Methods:  A training curriculum was delivered over 5 days between 2017 and 2020 focusing on (1) microscopic field manipulation, (2) knot tying, nondominant hand usage, (3) 3-D models/anastomosis, and (4) tissue experience. The Kirkpatrick model was applied to evaluate the curriculum at four levels: (1) participants' feedback (2) skills development using a validated, objective assessment tool (Global Assessment Score form) and CUSUM charts were constructed to model proficiency gain (3) and (4) assessing skill retention/long-term impact.
    Results:  In total, 155 participants undertook the curriculum, totaling 5,425 hours of training. More than 75% of students reported the course as excellent, with the remaining voting for "good." All participants agreed that the curriculum met expectations and would recommend it. Significant improvement in anastomosis attainment scores between days 1 and 3 (median score 4) and days 4 and 5 (median score 5) (W = 494.5,
    Conclusion:  Robust evaluation of curriculum can be applied to microsurgery training demonstrating its efficacy in reducing surgical errors with an improvement in overall technical skills that can extend to impact clinical practice. It allows the identification of areas of improvement, driving the refinement of training programs.
    MeSH term(s) Humans ; Microsurgery/education ; Clinical Competence ; Curriculum ; Internship and Residency ; Learning Curve
    Language English
    Publishing date 2022-12-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605983-1
    ISSN 1098-8947 ; 0743-684X ; 0743-684X
    ISSN (online) 1098-8947 ; 0743-684X
    ISSN 0743-684X
    DOI 10.1055/a-2003-7689
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Pineal progenitors originate from a non-neural territory limited by FGF signalling.

    Staudt, Nicole / Giger, Florence A / Fielding, Triona / Hutt, James A / Foucher, Isabelle / Snowden, Vicky / Hellich, Agathe / Kiecker, Clemens / Houart, Corinne

    Development (Cambridge, England)

    2019  Volume 146, Issue 22

    Abstract: The embryonic development of the pineal organ, a neuroendocrine gland on top of the diencephalon, remains enigmatic. Classic fate-mapping studies suggested that pineal progenitors originate from the lateral border of the anterior neural plate. We show ... ...

    Abstract The embryonic development of the pineal organ, a neuroendocrine gland on top of the diencephalon, remains enigmatic. Classic fate-mapping studies suggested that pineal progenitors originate from the lateral border of the anterior neural plate. We show here, using gene expression and fate mapping/lineage tracing in zebrafish, that pineal progenitors originate, at least in part, from the non-neural ectoderm. Gene expression in chick indicates that this non-neural origin of pineal progenitors is conserved in amniotes. Genetic repression of placodal, but not neural crest, cell fate results in pineal hypoplasia in zebrafish, while mis-expression of transcription factors known to specify placodal identity during gastrulation promotes the formation of ectopic pineal progenitors. We also demonstrate that fibroblast growth factors (FGFs) position the pineal progenitor domain within the non-neural border by repressing pineal fate and that the Otx transcription factors promote pinealogenesis by inhibiting this FGF activity. The non-neural origin of the pineal organ reveals an underlying similarity in the formation of the pineal and pituitary glands, and suggests that all CNS neuroendocrine organs may require a non-neural contribution to form neurosecretory cells.
    MeSH term(s) Animals ; Animals, Genetically Modified ; Cell Lineage ; Chick Embryo ; Ectoderm/cytology ; Fibroblast Growth Factors/metabolism ; Gastrulation ; Gene Expression Regulation, Developmental ; Green Fluorescent Proteins/metabolism ; Neural Crest/cytology ; Neural Plate/cytology ; Neuroglia/cytology ; Neurons/cytology ; Neurosecretory Systems/metabolism ; Pineal Gland/cytology ; Pineal Gland/embryology ; Signal Transduction ; Transcription Factors/metabolism ; Zebrafish/embryology ; Zebrafish Proteins/metabolism
    Chemical Substances Transcription Factors ; Zebrafish Proteins ; Green Fluorescent Proteins (147336-22-9) ; Fibroblast Growth Factors (62031-54-3)
    Language English
    Publishing date 2019-11-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 90607-4
    ISSN 1477-9129 ; 0950-1991
    ISSN (online) 1477-9129
    ISSN 0950-1991
    DOI 10.1242/dev.171405
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Evaluation of a Microsurgery Training Curriculum

    Cuteanu, Anita / Hellich, Agathe / Cardinal, Alba Le / Thomas, Maeve / Valchanova, Anna / Vara, Sital / Horbury, Gwynn / Boal, Matt / Ghamrawi, Walaa / Slim, Naim / Francis, Nader

    Journal of Reconstructive Microsurgery

    2022  Volume 39, Issue 08, Page(s) 589–600

    Abstract: Background: Microsurgery is one of the most challenging areas of surgery with a steep learning curve. To address this educational need, microsurgery curricula have been developed and validated, with the majority focus on technical skills only. The aim ... ...

    Abstract Background: Microsurgery is one of the most challenging areas of surgery with a steep learning curve. To address this educational need, microsurgery curricula have been developed and validated, with the majority focus on technical skills only. The aim of this study was to report on the evaluation of a well-established curriculum using the Kirkpatrick model.
    Methods: A training curriculum was delivered over 5 days between 2017 and 2020 focusing on (1) microscopic field manipulation, (2) knot tying, nondominant hand usage, (3) 3-D models/anastomosis, and (4) tissue experience. The Kirkpatrick model was applied to evaluate the curriculum at four levels: (1) participants' feedback (2) skills development using a validated, objective assessment tool (Global Assessment Score form) and CUSUM charts were constructed to model proficiency gain (3) and (4) assessing skill retention/long-term impact.
    Results: In total, 155 participants undertook the curriculum, totaling 5,425 hours of training. More than 75% of students reported the course as excellent, with the remaining voting for “good.” All participants agreed that the curriculum met expectations and would recommend it. Significant improvement in anastomosis attainment scores between days 1 and 3 (median score 4) and days 4 and 5 (median score 5) (W = 494.5, p  = 0.00170). The frequency of errors reduced with successive attempts (chi square = 9.81, p  = 0.00174). The steepest learning curve was in anastomosis and patency domains, requiring 11 attempts on average to reach proficiency. In total, 88.5% survey respondents could apply the skills learnt and 76.9% applied the skills learnt within 6 months. Key areas of improvement were identified from this evaluation, and actions to address them were implemented in the following programs.
    Conclusion: Robust evaluation of curriculum can be applied to microsurgery training demonstrating its efficacy in reducing surgical errors with an improvement in overall technical skills that can extend to impact clinical practice. It allows the identification of areas of improvement, driving the refinement of training programs.
    Keywords microsurgery ; curriculum ; evaluation
    Language English
    Publishing date 2022-12-23
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 605983-1
    ISSN 1098-8947 ; 0743-684X ; 0743-684X
    ISSN (online) 1098-8947 ; 0743-684X
    ISSN 0743-684X
    DOI 10.1055/a-2003-7689
    Database Thieme publisher's database

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