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  1. Article: Novel use of the double kissing crush technique to stent complex pulmonary artery stenosis in a child with Alagille syndrome.

    Strah, Danielle D / Hellinger, Riley D / Lee, Kwan S / Seckeler, Michael D

    Annals of pediatric cardiology

    2024  Volume 16, Issue 4, Page(s) 290–292

    Abstract: Coronary bifurcation lesions and treatment with two-stent techniques have been developed, including the double kissing (DK) crush technique. The use of this technique in children or noncoronary vessels, including pulmonary arteries, has not been ... ...

    Abstract Coronary bifurcation lesions and treatment with two-stent techniques have been developed, including the double kissing (DK) crush technique. The use of this technique in children or noncoronary vessels, including pulmonary arteries, has not been described. We present a 12-year-old girl with Alagille syndrome, a ventricular septal defect (VSD), and complex bilateral pulmonary artery (PA) stenoses who is status post six catheterizations for PA angioplasty and stenting to improve her marked right ventricular hypertension. With collaboration between the congenital and structural teams, she successfully underwent the DK crush technique for a complex lesion in her PA. This improved pulmonary flow and allowed for successful surgical VSD closure.
    Language English
    Publishing date 2024-01-05
    Publishing country India
    Document type Case Reports
    ZDB-ID 2430956-4
    ISSN 0974-5149 ; 0974-2069
    ISSN (online) 0974-5149
    ISSN 0974-2069
    DOI 10.4103/apc.apc_60_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Incidence of Radiation-Associated Cancer in Patients With Congenital Heart Disease.

    Caryl, Natalie E / June, Ciara / Culbert, M Hunter / Hellinger, Riley D / Hoyer, Andrew W / Klewer, Scott E / Seckeler, Michael D

    The American journal of cardiology

    2023  Volume 210, Page(s) 65–68

    Language English
    Publishing date 2023-10-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2023.10.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs.73: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Acute Hospital Outcomes for Renal Transplantation in Patients With Moderate or Severe Congenital Heart Disease.

    Patel, Surbhi B / Webber, Zak / Strah, Danielle D / Hellinger, Riley D / Yrun-Duffy, Macken / Kowalek, Katie A / Seckeler, Michael D

    The American journal of cardiology

    2022  Volume 186, Page(s) 87–90

    Abstract: Children and adults with congenital heart disease (CHD) are increasingly recognized to be at risk for acute and chronic renal injury. Some of these may progress to the need for renal transplantation. We hypothesized that patients with underlying moderate ...

    Abstract Children and adults with congenital heart disease (CHD) are increasingly recognized to be at risk for acute and chronic renal injury. Some of these may progress to the need for renal transplantation. We hypothesized that patients with underlying moderate or severe CHD who undergo renal transplantation will have worse acute hospital outcomes. Using a national administrative database, we queried for admissions aged 0 to 50 years with moderate or severe CHD and renal transplantation and compared these to admissions without CHD. There were 56 admissions for renal transplantation in the CHD group (0.04%) and 26,285 admissions in the group without CHD (0.21%, p<0.001). The CHD group were younger, had a higher proportion of Whites, longer length of stay, higher complication rates, higher in-hospital mortality, and higher costs. In conclusion, although renal transplantation is still relatively uncommon in the CHD population, there is an increasing recognition of severe chronic renal disease in the setting of CHD, making it important to understand the potential implications of these findings.
    MeSH term(s) Adult ; Child ; Humans ; Kidney Transplantation ; Retrospective Studies ; Heart Defects, Congenital/epidemiology ; Heart Defects, Congenital/surgery ; Heart Defects, Congenital/complications ; Hospital Mortality ; Hospitals ; Heart Transplantation/adverse effects
    Language English
    Publishing date 2022-11-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2022.10.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs.73: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Novel dithiocarbamate derivatives are effective copper-dependent antimicrobials against

    Menghani, Sanjay V / Sanchez-Rosario, Yamil / Pok, Chansorena / Liu, Renshuai / Gao, Feng / O'Brien, Henrik / Neubert, Miranda J / Ochoa, Klariza / Durckel, Meredythe / Hellinger, Riley D / Hackett, Nadia / Wang, Wei / Johnson, Michael D L

    Frontiers in microbiology

    2023  Volume 13, Page(s) 1099330

    Abstract: Despite the availability of several vaccines against multiple disease-causing strains ... ...

    Abstract Despite the availability of several vaccines against multiple disease-causing strains of
    Language English
    Publishing date 2023-01-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.1099330
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Leukemia-intrinsic determinants of CAR-T response revealed by iterative in vivo genome-wide CRISPR screening.

    Ramos, Azucena / Koch, Catherine E / Liu-Lupo, Yunpeng / Hellinger, Riley D / Kyung, Taeyoon / Abbott, Keene L / Fröse, Julia / Goulet, Daniel / Gordon, Khloe S / Eidell, Keith P / Leclerc, Paul / Whittaker, Charles A / Larson, Rebecca C / Muscato, Audrey J / Yates, Kathleen B / Dubrot, Juan / Doench, John G / Regev, Aviv / Vander Heiden, Matthew G /
    Maus, Marcela V / Manguso, Robert T / Birnbaum, Michael E / Hemann, Michael T

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 8048

    Abstract: CAR-T therapy is a promising, novel treatment modality for B-cell malignancies and yet many patients relapse through a variety of means, including loss of CAR-T cells and antigen escape. To investigate leukemia-intrinsic CAR-T resistance mechanisms, we ... ...

    Abstract CAR-T therapy is a promising, novel treatment modality for B-cell malignancies and yet many patients relapse through a variety of means, including loss of CAR-T cells and antigen escape. To investigate leukemia-intrinsic CAR-T resistance mechanisms, we performed genome-wide CRISPR-Cas9 loss-of-function screens in an immunocompetent murine model of B-cell acute lymphoblastic leukemia (B-ALL) utilizing a modular guide RNA library. We identified IFNγR/JAK/STAT signaling and components of antigen processing and presentation pathway as key mediators of resistance to CAR-T therapy in vivo; intriguingly, loss of this pathway yielded the opposite effect in vitro (sensitized leukemia to CAR-T cells). Transcriptional characterization of this model demonstrated upregulation of these pathways in tumors relapsed after CAR-T treatment, and functional studies showed a surprising role for natural killer (NK) cells in engaging this resistance program. Finally, examination of data from B-ALL patients treated with CAR-T revealed an association between poor outcomes and increased expression of JAK/STAT and MHC-I in leukemia cells. Overall, our data identify an unexpected mechanism of resistance to CAR-T therapy in which tumor cell interaction with the in vivo tumor microenvironment, including NK cells, induces expression of an adaptive, therapy-induced, T-cell resistance program in tumor cells.
    MeSH term(s) Humans ; Animals ; Mice ; Receptors, Chimeric Antigen ; RNA, Guide, CRISPR-Cas Systems ; Immunotherapy, Adoptive ; T-Lymphocytes ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Leukemia ; Burkitt Lymphoma ; Tumor Microenvironment
    Chemical Substances Receptors, Chimeric Antigen ; RNA, Guide, CRISPR-Cas Systems
    Language English
    Publishing date 2023-12-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-43790-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Direct capture of neutralized RBD enables rapid point-of-care assessment of SARS-CoV-2 neutralizing antibody titer.

    Connelly, Guinevere G / Kirkland, Orville O / Bohannon, Seven / Lim, Daniel C / Wilson, Robert M / Richards, Edward J / Tay, Dousabel M / Jee, Hyuk / Hellinger, Riley D / Hoang, Ngoc K / Hao, Liang / Chhabra, Arnav / Martin-Alonso, Carmen / Tan, Edward K W / Koehler, Angela N / Yaffe, Michael B / London, Wendy B / Lee, Pui Y / Krammer, Florian /
    Bohannon, Robert C / Bhatia, Sangeeta N / Sikes, Hadley D / Li, Hojun

    Cell reports methods

    2022  Volume 2, Issue 8, Page(s) 100273

    Abstract: Neutralizing antibody (NAb) titer is a key biomarker of protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but point-of-care methods for assessing NAb titer are not widely available. Here, we present a lateral flow ...

    Abstract Neutralizing antibody (NAb) titer is a key biomarker of protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but point-of-care methods for assessing NAb titer are not widely available. Here, we present a lateral flow assay that captures SARS-CoV-2 receptor-binding domain (RBD) that has been neutralized from binding angiotensin-converting enzyme 2 (ACE2). Quantification of neutralized RBD in this assay correlates with NAb titer from vaccinated and convalescent patients. This methodology demonstrated superior performance in assessing NAb titer compared with either measurement of total anti-spike immunoglobulin G titer or quantification of the absolute reduction in binding between ACE2 and RBD. Our testing platform has the potential for mass deployment to aid in determining at population scale the degree of protective immunity individuals may have following SARS-CoV-2 vaccination or infection and can enable simple at-home assessment of NAb titer.
    MeSH term(s) Humans ; Antibodies, Neutralizing ; SARS-CoV-2 ; Angiotensin-Converting Enzyme 2 ; COVID-19 Vaccines ; Point-of-Care Systems ; Antibodies, Viral ; COVID-19/diagnosis
    Chemical Substances Antibodies, Neutralizing ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; COVID-19 Vaccines ; Antibodies, Viral
    Language English
    Publishing date 2022-08-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2667-2375
    ISSN (online) 2667-2375
    DOI 10.1016/j.crmeth.2022.100273
    Database MEDical Literature Analysis and Retrieval System OnLINE

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