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  1. Book ; Online ; Thesis: Pharmakologische Modulation des CB1-Rezeptors im Abcb4-/- Mausmodell für Cholestase

    Helmrich, Nora [Verfasser]

    2020  

    Author's details Nora Lou Helmrich
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek
    Publishing place Gießen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  2. Article ; Online: Pharmacologic Antagonization of Cannabinoid Receptor 1 Improves Cholestasis in Abcb4

    Helmrich, Nora / Roderfeld, Martin / Baier, Anne / Windhorst, Anita / Herebian, Diran / Mayatepek, Ertan / Dierkes, Christian / Ocker, Matthias / Glebe, Dieter / Christ, Bruno / Churin, Yuri / Irungbam, Karuna / Roeb, Elke

    Cellular and molecular gastroenterology and hepatology

    2021  Volume 13, Issue 4, Page(s) 1041–1055

    Abstract: Background & aims: The endocannabinoid system is involved in the modulation of inflammatory, fibrotic, metabolic, and carcinogenesis-associated signaling pathways via cannabinoid receptor (CB)1 and CB2. We hypothesized that the pharmacologic ... ...

    Abstract Background & aims: The endocannabinoid system is involved in the modulation of inflammatory, fibrotic, metabolic, and carcinogenesis-associated signaling pathways via cannabinoid receptor (CB)1 and CB2. We hypothesized that the pharmacologic antagonization of CB1 receptor improves cholestasis in Abcb4
    Methods: After weaning, male Abcb4
    Results: Cholestasis-induced symptoms such as liver damage, bile duct proliferation, and enhanced circulating bile acids were improved by CB1 antagonization. Rimonabant treatment also improved Phosphoenolpyruvat-Carboxykinase expression and reduced inflammation and the acute-phase response. The carcinogenesis-associated cellular-Jun N-terminal kinase/cellular-JUN and signal transducer and activator of transcription 3 signaling pathways activated in Abcb4
    Conclusions: We showed a protective effect of oral CB1 antagonization in chronic cholestasis using the established Abcb4
    MeSH term(s) Animals ; Carcinogenesis ; Cholestasis/drug therapy ; Inflammation ; Male ; Mice ; Receptor, Cannabinoid, CB1 ; Rimonabant/pharmacology
    Chemical Substances Receptor, Cannabinoid, CB1 ; Rimonabant (RML78EN3XE)
    Language English
    Publishing date 2021-12-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2819778-1
    ISSN 2352-345X ; 2352-345X
    ISSN (online) 2352-345X
    ISSN 2352-345X
    DOI 10.1016/j.jcmgh.2021.12.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: IL-13 as Target to Reduce Cholestasis and Dysbiosis in

    Hahn, Luisa / Helmrich, Nora / Herebian, Diran / Mayatepek, Ertan / Drebber, Uta / Domann, Eugen / Olejniczak, Stefan / Weigel, Markus / Hain, Torsten / Rath, Timo / Wirtz, Stefan / Mollenkopf, Hans-Joachim / Schmidt, Nadine / Ewers, Christa / Baier, Anne / Churin, Yuri / Windhorst, Anita / Weiskirchen, Ralf / Steinhoff, Ulrich /
    Roeb, Elke / Roderfeld, Martin

    Cells

    2020  Volume 9, Issue 9

    Abstract: The Th2 cytokine IL-13 is involved in biliary epithelial injury and liver fibrosis in patients as well as in animal models. The aim of this study was to investigate IL-13 as a therapeutic target during short term and chronic intrahepatic cholestasis in ... ...

    Abstract The Th2 cytokine IL-13 is involved in biliary epithelial injury and liver fibrosis in patients as well as in animal models. The aim of this study was to investigate IL-13 as a therapeutic target during short term and chronic intrahepatic cholestasis in an
    MeSH term(s) Animals ; Cholestasis, Intrahepatic/therapy ; Disease Models, Animal ; Dysbiosis/therapy ; Humans ; Interleukin-13/metabolism ; Mice ; Mice, Knockout
    Chemical Substances Interleukin-13
    Language English
    Publishing date 2020-08-24
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells9091949
    Database MEDical Literature Analysis and Retrieval System OnLINE

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