Article ; Online: Resting-state functional MRI demonstrates brain network reorganization in neuromyelitis optica spectrum disorder (NMOSD).
PloS one
2019 Volume 14, Issue 1, Page(s) e0211465
Abstract: Background: The relation between brain functional connectivity of patients with neuromyelitis optica spectrum disorder (NMOSD) and the degree of disability remains unclear.: Objective: Compare brain functional connectivity of patients with NMOSD to ... ...
| Abstract | Background: The relation between brain functional connectivity of patients with neuromyelitis optica spectrum disorder (NMOSD) and the degree of disability remains unclear. Objective: Compare brain functional connectivity of patients with NMOSD to healthy subjects in resting-state functional MRI (rs-fMRI). Methods: We compared the rs-fMRI connectivity in 12 NMOSD patients with 20 healthy subjects matched for age and sex. Graph theory analysis was used to quantify the role of each node using a set of metrics: degree, global efficiency, clustering and modularity. To summarize the abnormal connectivity profile of brain regions in patients compared to healthy subjects, we defined a hub disruption index κ. Results: Concerning the global organization of networks in NMOSD, a small-world topology was preserved without significant modification concerning all average metrics. However, visual networks and the sensorimotor network showed decreased connectivity with high interindividual variability. The hub disruption index κ was correlated to the Expanded Disability Status Scale (EDSS). Conclusion: These results demonstrate a correlation between disability according to the EDSS and neuronal reorganization using the rs-fMRI graph methodology. The conservation of a normal global topological structure despite local modifications in functional connectivity seems to show brain plasticity in response to the disability. |
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| MeSH term(s) | Adult ; Aged ; Brain/physiology ; Brain Mapping/methods ; Case-Control Studies ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Neuromyelitis Optica/physiopathology ; Rest/physiology |
| Language | English |
| Publishing date | 2019-01-29 |
| Publishing country | United States |
| Document type | Journal Article |
| ISSN | 1932-6203 |
| ISSN (online) | 1932-6203 |
| DOI | 10.1371/journal.pone.0211465 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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