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  1. Book: Immigration and health

    Hemminki, Kari

    North Africans in Europe

    (European journal of public health ; 24, Suppl. 1)

    2014  

    Author's details guest ed.: Kari Hemminki
    Series title European journal of public health ; 24, Suppl. 1
    Collection
    Language English
    Size 95 S. : Ill., graph. Darst., Kt.
    Publisher Oxford Univ. Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT018434691
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    Zs A 3499 -24,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  2. Article ; Online: Response to letter entitled: Re: Survival trends in solid cancers in the Nordic countries through 50 years.

    Hemminki, Kari

    European journal of cancer (Oxford, England : 1990)

    2023  Volume 183, Page(s) 190

    MeSH term(s) Humans ; Scandinavian and Nordic Countries/epidemiology ; Survival Rate ; Neoplasms/epidemiology ; Neoplasms/therapy
    Language English
    Publishing date 2023-02-13
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 82061-1
    ISSN 1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
    ISSN (online) 1879-0852
    ISSN 0277-5379 ; 0959-8049 ; 0964-1947
    DOI 10.1016/j.ejca.2023.01.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 456: Show issues Location:
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    Zs.MO 583: Show issues

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  3. Article ; Online: A metric for comparison and visualization of age disparities in cancer survival.

    Zitricky, Frantisek / Hemminki, Kari

    Cancer epidemiology

    2024  Volume 91, Page(s) 102586

    Abstract: Aims: Diagnostic age is an important determinant of cancer survival but the methods generally used to analyze age-group-specific survival are not developed for ready visualization of survival differences. We aim at developing a novel metric for ... ...

    Abstract Aims: Diagnostic age is an important determinant of cancer survival but the methods generally used to analyze age-group-specific survival are not developed for ready visualization of survival differences. We aim at developing a novel metric for comparing and visualizing age-group-specific survival data over different cancers, sexes, periods and countries.
    Methods: The metric describes the mean absolute deviation between age-groups. The metric can be used in two variations, one showing the mean variation and its 95% confidence intervals and the other highlighting individually each age-groups distinguishing positive or negative deviations. We demonstrate the applications with age-group- specific 5-year relative survival data from the NORDCAN database RESULTS: The mean absolute deviation between age-groups for Swedish colon cancer survival declined from about 5% in 1972-1981-1% in 1992-2001 and to 1.3% in 2012-2021. Patients diagnosed before age 50 years accounted for the largest positive deviation. For acute myeloid leukemia (AML) the mean deviation increased from 4% (female) to 17% and 23%. Patients diagnosed at age below 50 years showed the largest deviations. Comparing colon cancer mean deviations between the Nordic countries, a time-related decline was observed for all, those in Sweden ending at the lowest and in Finland the highest level.
    Conclusions: We demonstrated the usefulness of the devised metric for summarizing age-specific survival data between cancers, sexes, periods and countries. The two variations of the metric allow a simple visual presentation of the survival experience as to deviation of the survival data, its 95%CIs and its highlighted individual age-group components.
    Language English
    Publishing date 2024-05-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2508729-0
    ISSN 1877-783X ; 1877-7821
    ISSN (online) 1877-783X
    ISSN 1877-7821
    DOI 10.1016/j.canep.2024.102586
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1427: Show issues Location:
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  4. Article ; Online: Determining the Appropriate Risk-Adapted Screening Age for Familial Breast Cancer.

    Hemminki, Kari

    JAMA oncology

    2020  Volume 6, Issue 6, Page(s) 933–934

    MeSH term(s) Breast Neoplasms/diagnosis ; Breast Neoplasms/epidemiology ; Breast Neoplasms/genetics ; Early Detection of Cancer ; Humans ; Mammography ; Mass Screening
    Language English
    Publishing date 2020-05-06
    Publishing country United States
    Document type Letter ; Comment
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2020.0286
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: Occupational cancer and carcinogenesis

    Hemminki, Kari

    (Scandinavian journal of work, environment & health ; 18, Suppl. 1)

    1992  

    Author's details guest ed. Kari Hemminki
    Series title Scandinavian journal of work, environment & health ; 18, Suppl. 1
    Collection
    Keywords Neoplasms / chemically induced ; Occupational Diseases ; Krebs ; Berufskrankheit ; Carcinogenese
    Subject Krebs ; Krebsentstehung ; Karzinogenese ; Kanzerogenese ; Onkogenese ; Arbeitsbedingte Krankheit ; Berufskrankheiten ; Carcinom ; Malignom ; Maligner Tumor ; Neoplasma ; Karzinom ; Bösartiger Tumor ; Krebserkrankung
    Size 117 S. : Ill., graph. Darst.
    Publisher Institute of Occupational Health u.a.
    Publishing place Helsinki
    Publishing country Finland
    Document type Book
    HBZ-ID HT004254197
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    Zs A 1153 -18,Suppl.1- verfügbar in Königswinter Königswinter

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  6. Article: Incidence, Mortality and Survival Trends in Breast Cancers Coincident with Introduction of Mammography in the Nordic Countries.

    Hemminki, Kari / Försti, Asta

    Cancers

    2022  Volume 14, Issue 23

    Abstract: Survival in female breast cancers has generally improved but the relative contribution of early detection or treatment in this positive development is not known. Our aim was to assess the possible role of national mammography screening programs in ... ...

    Abstract Survival in female breast cancers has generally improved but the relative contribution of early detection or treatment in this positive development is not known. Our aim was to assess the possible role of national mammography screening programs in survival improvement. Such screening has been offered to women, usually at 50-69 years of age, in Finland and Sweden since the 1980s and in Denmark and Norway since the 1990s. Participation rates have been high, ranging from 60% to 90%. We analyzed incidence and mortality changes and relative 5- and 10-year survival trends in breast cancer as novel measures in these countries using the NORDCAN database. Survival trends were compared in age groups of women who were screened to those who were not screened. We observed a relative survival advantage in 5-year and 10-year survival in the screened age groups after the period of national mammography screening was in place and this was consistent in each country. Timing and age-specific targeting of the improvements suggest that mammography may have contributed to the survival benefits. However, as we had no individual data on women who used the service, more detailed studies are needed to confirm the suggested survival advantage, particularly concerning mortality in stage-specific breast cancer.
    Language English
    Publishing date 2022-11-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14235907
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Genetic And Environmental Associations Of Nonspecific Chromosomal Aberrations.

    Hemminki, Kari / Niazi, Yasmeen / Vodickova, Ludmila / Vodicka, Pavel / Försti, Asta

    Mutagenesis

    2024  

    Abstract: Nonspecific structural chromosomal aberrations (CAs) are found in around 1% of circulating lymphocytes from healthy individuals but the frequency may be higher after exposure to carcinogenic chemicals or radiation. CAs have been used in the monitoring of ...

    Abstract Nonspecific structural chromosomal aberrations (CAs) are found in around 1% of circulating lymphocytes from healthy individuals but the frequency may be higher after exposure to carcinogenic chemicals or radiation. CAs have been used in the monitoring of persons exposed to genotoxic agents and radiation. Previous studies on occupationally exposed individuals have shown associations between the frequency of CAs in peripheral blood lymphocytes and subsequent cancer risk. The cause for CA formation are believed to be unrepaired or insufficiently repaired DNA double-strand breaks or other DNA damage, and additionally telomere shortening. CAs include chromosome (CSAs) and chromatid type aberrations (CTAs). In the present review, we first describe the types of CAs, the conventional techniques used for their detection and some aspects of interpreting the results. We then focus on germline genetic variation in the frequency and type of CAs measured in a genome-wide association study (GWAS) in healthy individuals in relation to occupational and smoking-related exposure compared to non-exposed referents. The associations (at p<10-5) on 1473 healthy individuals were broadly classified in candidate genes from functional pathways related to DNA damage response/repair, including PSMA1, UBR5, RRM2B, PMS2P4, STAG3L4, BOD1, COPRS and FTO; another group included genes related to apoptosis, cell proliferation, angiogenesis and tumorigenesis, COPB1, NR2C1, COPRS, RHOT1, ITGB3, SYK, and SEMA6A; a third small group mapped to genes KLF7, SEMA5A and ITGB3 which were related to autistic traits, known to manifest frequent CAs. Dedicated studies on 153 DNA repair genes showed associations for some 30 genes, expression of which could be modified by the implicated variants. We finally point out that monitoring of CAs is so far the only method of assessing cancer risk in healthy human populations, and the use of the technology should be made more attractive by developing automated performance steps and incorporating artificial intelligence methods into the scoring.
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 632903-2
    ISSN 1464-3804 ; 0267-8357
    ISSN (online) 1464-3804
    ISSN 0267-8357
    DOI 10.1093/mutage/geae006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2189: Show issues Location:
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  8. Article ; Online: Conditional survival in breast cancer up to 10 years in the Nordic countries.

    Zitricky, Frantisek / Försti, Asta / Hemminki, Akseli / Hemminki, Kari

    Cancer medicine

    2023  Volume 12, Issue 17, Page(s) 17945–17951

    Abstract: Background: Survival in breast cancer (BC) has developed favorably but late recurrences are still a problem.: Methods: We model survival data from the NORDCAN database and analyze 1-, 5-, and 10-year relative survival and 5/1- and 10/5-year ... ...

    Abstract Background: Survival in breast cancer (BC) has developed favorably but late recurrences are still a problem.
    Methods: We model survival data from the NORDCAN database and analyze 1-, 5-, and 10-year relative survival and 5/1- and 10/5-year conditional survival in BC from Denmark (DK), Finland (FI), Norway (NO), and Sweden (SE) between 1971 and 2020. Conditional survival measures survival in those who had survived year 1 to reach year 5 (5/1), or in those who had survived year 5 to reach year 10 (10/5).
    Results: Almost all survival metrics were best for SE but survival in all countries improved in the course of time approaching the SE levels which were 98.3% for 1-year, 92.3% for 5-year, and 87.8% for 10-year survival. Conditional 10/5-year survival, covering 5 years, was better than 5/1-year survival, covering 4 years. A contributing factor is most likely the high rate of recurrence in period 2-5 years. The difference was observed for all countries but for DK 10/5-year survival approached 1-year survival and for NO and SE 10/5-year survival was only barely better than 5/1-year survival. The explanation to this was the excellent 10/5-year survival in DK compared to SE and particularly to NO. Literature search suggested that the reason for the relatively low 10/5-year survival in NO might be stagnant survival development in old patients.
    Conclusions: We assume that late mortality is critically limiting survival in BC and either interference with the late metastatic process or effective treatment will be key to future improvements in BC survival.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/epidemiology ; Breast Neoplasms/therapy ; Survival Rate ; Risk Factors ; Registries ; Scandinavian and Nordic Countries/epidemiology ; Finland/epidemiology ; Norway ; Sweden/epidemiology ; Denmark/epidemiology
    Language English
    Publishing date 2023-08-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2659751-2
    ISSN 2045-7634 ; 2045-7634
    ISSN (online) 2045-7634
    ISSN 2045-7634
    DOI 10.1002/cam4.6436
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Are population level familial risks and germline genetics meeting each other?

    Hemminki, Kari / Li, Xinjun / Försti, Asta / Eng, Charis

    Hereditary cancer in clinical practice

    2023  Volume 21, Issue 1, Page(s) 3

    Abstract: Large amounts of germline sequencing data have recently become available and we sought to compare these results with population-based family history data. Family studies are able to describe aggregation of any defined cancers in families. The Swedish ... ...

    Abstract Large amounts of germline sequencing data have recently become available and we sought to compare these results with population-based family history data. Family studies are able to describe aggregation of any defined cancers in families. The Swedish Family-Cancer Database is the largest of its kind in the world, covering the Swedish families through nearly a century with all cancers in family members since the start of national cancer registration in 1958. The database allows estimation of familial risks, ages of cancer onset and the proportion of familial cancer in different family constellations. Here, we review the proportion of familial cancer for all common cancers and specify them based on the number of affected individuals. With the exception of a few cancers, age of onset of familial cancer is not different from all cancers combined. The highest proportions of familial cancer were found for prostate (26.4%), breast (17.5%) and colorectal (15.7%) cancers, but the proportions of high-risk families with multiple affected individuals were only 2.8%, 1% and 0.9%, respectively. A large sequencing study on female breast cancer found that BRCA1 and BRCA2 mutations could account for 2% of the cases (subtracting the proportions in healthy individuals) and that all germline mutations accounted for 5.6% of the cases. Early age of onset was a distinct feature of only BRCA mutations. In heritable colorectal cancer, Lynch syndrome genes dominate. Large studies on penetrance in Lynch syndrome have shown an approximately linear increase in risk from 40-50 years up to age 80 years. Interesting novel data revealed a strong modification of familial risk by unknown factors. High-risk germline genetics of prostate cancer is characterized by BRCA and other DNA repair genes. HOXB13 encodes a transcription factor which contributes to germline risk of prostate cancer. A strong interaction was shown with a polymorphism in the CIP2A gene. The emerging germline landscape of common cancers can be reasonably accommodated by family data on these cancers as to high-risk proportions and age of onset.
    Language English
    Publishing date 2023-03-08
    Publishing country Poland
    Document type Journal Article ; Review
    ZDB-ID 2252512-9
    ISSN 1897-4287 ; 1731-2302
    ISSN (online) 1897-4287
    ISSN 1731-2302
    DOI 10.1186/s13053-023-00247-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6407: Show issues Location:
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  10. Article ; Online: Re: Mark N. Brook, Holly Ní Raghallaigh, Koveela Govindasami, et al. Family History of Prostate Cancer and Survival Outcomes in the UK Genetic Prostate Cancer Study. Eur Urol 2023;83:257-66.

    Hemminki, Kari / Ji, Jianguang / Sundquist, Jan

    European urology

    2023  Volume 84, Issue 1, Page(s) e13–e14

    MeSH term(s) Male ; Humans ; Ilex ; Prostatic Neoplasms/genetics ; Medical History Taking ; United Kingdom/epidemiology
    Language English
    Publishing date 2023-04-13
    Publishing country Switzerland
    Document type Letter ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2023.03.039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 294: Show issues

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