LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 30

Search options

  1. Book ; Thesis: Die Rolle der miRNA 132 für die Proliferation pankreatischer beta-Zellen

    Hempel, Sebastian

    2013  

    Author's details von Sebastian Hempel
    Language German
    Size 100 Bl. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dresden, Univ., Diss., 2014
    HBZ-ID HT018399405
    Database Catalogue ZB MED Medicine, Health

    Kategorien

  2. Article ; Online: Reply to: Letter to the Editor: More is More? Total Pancreatectomy for Periampullary Cancer as an Alternative in Patients with High-Risk Pancreatic Anastomosis: A Propensity Score-Matched Analysis, by Marchegiani, Giovanni et al.

    Hempel, Sebastian / Oehme, Florian / Weitz, Jürgen / Distler, Marius

    Annals of surgical oncology

    2022  Volume 29, Issue 6, Page(s) 3519–3520

    MeSH term(s) Anastomosis, Surgical ; Duodenal Neoplasms/surgery ; Humans ; Pancreas/surgery ; Pancreatectomy ; Pancreatic Neoplasms/surgery ; Propensity Score
    Language English
    Publishing date 2022-02-25
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-022-11468-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Preoperative IL-8 levels as prognostic indicators of overall survival: an extended follow-up in a prospective cohort with colorectal liver metastases.

    Pecqueux, Mathieu / Brückner, Frederik / Oehme, Florian / Hempel, Sebastian / Baenke, Franziska / Riediger, Carina / Distler, Marius / Weitz, Jürgen / Kahlert, Christoph

    BMC cancer

    2024  Volume 24, Issue 1, Page(s) 90

    Abstract: Introduction: CRC with liver metastases is a major contributor to cancer-related mortality. Despite advancements in liver resection techniques, patient survival remains a concern due to high recurrence rates. This study seeks to uncover prognostic ... ...

    Abstract Introduction: CRC with liver metastases is a major contributor to cancer-related mortality. Despite advancements in liver resection techniques, patient survival remains a concern due to high recurrence rates. This study seeks to uncover prognostic biomarkers that predict overall survival in patients undergoing curative hepatic resection for CRC liver metastases.
    Methods: Prospectively collected serum samples from a cohort of 49 patients who received curative hepatic resection for CRC liver metastases were studied. The patients are part of a cohort, previously analyzed for perioperative complications (see methods). Various preoperative serum markers, clinical characteristics, and factors were analyzed. Univariate and multivariate Cox regression analyses were conducted to determine associations between these variables and disease-free survival as well as overall survival.
    Results: For disease-free survival, univariate analysis highlighted the correlation between poor outcomes and advanced primary tumor stage, high ASA score, and synchronous liver metastases. Multivariate analysis identified nodal-positive primary tumors and synchronous metastases as independent risk factors for disease-free survival. Regarding overall survival, univariate analysis demonstrated significant links between poor survival and high preoperative IL-8 levels, elevated neutrophil-lymphocyte ratio (NLR), and presence of metastases in other organs. Multivariate analysis confirmed preoperative IL-8 and having three or more liver metastases as independent risk factors for overall survival. The impact of IL-8 on survival was particularly noteworthy, surpassing the influence of established clinical factors.
    Conclusion: This study establishes preoperative IL-8 levels as a potential prognostic biomarker for overall survival in patients undergoing curative liver resection for CRC liver metastases. This study underscores the importance of incorporating IL-8 and other biomarkers into clinical decision-making, facilitating improved patient stratification and tailored treatment approaches. Further research and validation studies are needed to solidify the clinical utility of IL-8 as a prognostic marker.
    MeSH term(s) Humans ; Biomarkers ; Colorectal Neoplasms/pathology ; Follow-Up Studies ; Hepatectomy ; Interleukin-8 ; Liver Neoplasms/secondary ; Prognosis ; Prospective Studies ; Retrospective Studies
    Chemical Substances Biomarkers ; Interleukin-8 ; CXCL8 protein, human
    Language English
    Publishing date 2024-01-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041352-X
    ISSN 1471-2407 ; 1471-2407
    ISSN (online) 1471-2407
    ISSN 1471-2407
    DOI 10.1186/s12885-023-11787-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Textbook outcome after pancreatoduodenectomy and distal pancreatectomy with postoperative hyperamylasemia-a propensity score matching analysis.

    Radulova-Mauersberger, Olga / Mibelli, Nicolas / von Bechtolsheim, Felix / Kroesen, Louisa / Hempel, Sebastian / Weitz, Jürgen / Distler, Marius / Oehme, Florian

    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

    2024  Volume 28, Issue 4, Page(s) 451–457

    Abstract: Purpose: Postoperative serum hyperamylasemia (POH) is a part of the new, increasingly highlighted, definition for postpancreatectomy pancreatitis (PPAP). This study aimed to analyze whether the biochemical changes of PPAP are differently associated with ...

    Abstract Purpose: Postoperative serum hyperamylasemia (POH) is a part of the new, increasingly highlighted, definition for postpancreatectomy pancreatitis (PPAP). This study aimed to analyze whether the biochemical changes of PPAP are differently associated with postoperative complications after distal pancreatectomy (DP) compared with pancreatoduodenectomy (PD). The textbook outcome (TO) was used as a summary measure to capture real-world data.
    Methods: The data were retrospectively extracted from a prospective clinical database. Patients with POH, defined as levels above our institution's upper limit of normal on postoperative day 1, after DP and the corresponding propensity score-matched cohort after PD were evaluated on postoperative complications by using logistic regression analyses.
    Results: We analyzed 723 patients who underwent PD and DP over a period of 9 years. After propensity score matching, 384 patients (192 patients in each group) remained. POH was observed in 78 (41.1%) and 74 (39.4%) after PD and DP correspondingly. There was a significant increase of postoperative complications in the PD group: Clavien-Dindo classification system ≥3 (P < .01 vs P = .71), clinically relevant postoperative pancreatic fistula (P < .001 vs P = .2), postpancreatectomy hemorrhage (P < .001 vs P = .11), and length of hospital stay (P < .001 vs P = .69) if POH occurred compared with in the DP group. TO was significantly unlikely in cases with POH after PD compared with DP (P > .001 vs P = .41). Furthermore, POH was found to be an independent predictor for missing TO after PD (odds ratio [OR], 0.29; 95% CI, 0.14-0.60; P < .001), whereas this was not observed in patients after DP (OR, 0.53; 95% CI, 0.21-1.33; P = .18).
    Conclusion: As a part of the definition for PPAP, POH is a predictive indicator associated with postoperative complications after PD but not after DP.
    MeSH term(s) Humans ; Pancreatectomy/adverse effects ; Pancreaticoduodenectomy/adverse effects ; Hyperamylasemia/complications ; Propensity Score ; Retrospective Studies ; Prospective Studies ; Pancreatic Fistula/epidemiology ; Pancreatic Fistula/etiology ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Pancreatitis/complications ; Propylamines
    Chemical Substances N-(3-phenyl-n-propyl)-1-phenyl-2-aminopropane (131903-56-5) ; Propylamines
    Language English
    Publishing date 2024-02-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2012365-6
    ISSN 1873-4626 ; 1934-3213 ; 1091-255X
    ISSN (online) 1873-4626 ; 1934-3213
    ISSN 1091-255X
    DOI 10.1016/j.gassur.2024.02.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: RAB27B expression in pancreatic cancer is predictive of poor survival but good response to chemotherapy.

    Pecqueux, Mathieu / Wende, Beate / Sommer, Ulrich / Baenke, Franziska / Oehme, Florian / Hempel, Sebastian / Aust, Daniela / Distler, Marius / Weitz, Jürgen / Kahlert, Christoph

    Cancer biomarkers : section A of Disease markers

    2023  Volume 37, Issue 4, Page(s) 207–215

    Abstract: Background: Pancreatic cancer is the 4th leading cause of cancer-related death with poor survival even after curative resection. RAB27A and RAB27B are key players in the exosome pathway where they play important roles in exosome secretion. Evidence ... ...

    Abstract Background: Pancreatic cancer is the 4th leading cause of cancer-related death with poor survival even after curative resection. RAB27A and RAB27B are key players in the exosome pathway where they play important roles in exosome secretion. Evidence suggests that RAB27A and RAB27B expression not only leads to tumor proliferation and invasion, but also plays an important role in antigen transfer necessary for anticancer immunity.
    Objective: In this study, we analyze the expression of RAB27A and RAB27B in patients after pancreatic cancer surgery with or without adjuvant chemotherapy and its influence on overall survival.
    Methods: We analyzed a total of 167 patients with pancreatic cancer for their RAB27A and RAB27B expression. We dichotomized the patients along the median and compared survival in patients with high and low RAB27A and RAB27B expression with or without adjuvant chemotherapy treatment.
    Results: We found a significant improvement in overall survival in patients with a negative resection margin (p= 0.037) and in patients who received adjuvant chemotherapy (p= 0.039). The survival benefit after chemotherapy was dependent on RAB27B expression status: only the subgroup of patients with high RAB27B expression benefited from adjuvant chemotherapy (p= 0.006), but not the subgroup with low RAB27B expression (p= 0.59). Patients with high RAB27B expression who did not receive adjuvant chemotherapy showed a trend towards worse survival compared to the other subgroups. This difference was abolished after treatment with adjuvant chemotherapy.
    Conclusion: These results suggest that RAB27B expression in pancreatic cancer might identify a subgroup of patients with poor survival who might respond well to adjuvant chemotherapy. If resectable, these patients could be considered for neoadjuvant chemotherapy to minimize the risk of not receiving adjuvant chemotherapy. Further prospective studies are needed to confirm these findings.
    MeSH term(s) Humans ; rab GTP-Binding Proteins/genetics ; rab GTP-Binding Proteins/metabolism ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/metabolism ; Chemotherapy, Adjuvant ; Pancreas/pathology ; Pancreatic Neoplasms
    Chemical Substances rab GTP-Binding Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2023-05-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2203517-5
    ISSN 1875-8592 ; 1574-0153 ; 1875-8592
    ISSN (online) 1875-8592 ; 1574-0153
    ISSN 1875-8592
    DOI 10.3233/CBM-220460
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Preoperative anaemia in distal pancreatectomy: a propensity-score matched analysis.

    Radulova-Mauersberger, Olga / von Bechtolsheim, Felix / Teske, Christian / Hempel, Sebastian / Kroesen, Louisa / Pecqueux, Mathieu / Kahlert, Christoph / Weitz, Jürgen / Distler, Marius / Oehme, Florian

    Langenbeck's archives of surgery

    2024  Volume 409, Issue 1, Page(s) 119

    Abstract: Background: Preoperative anaemia is a prevalent morbidity predictor that adversely affects short- and long-term outcomes of patients undergoing surgery. This analysis aimed to investigate preoperative anaemia and its detrimental effects on patients ... ...

    Abstract Background: Preoperative anaemia is a prevalent morbidity predictor that adversely affects short- and long-term outcomes of patients undergoing surgery. This analysis aimed to investigate preoperative anaemia and its detrimental effects on patients after distal pancreatectomy.
    Material and methods: The present study was a propensity-score match analysis of 286 consecutive patients undergoing distal pancreatectomy. Patients were screened for preoperative anaemia and classified according to WHO recommendations. The primary outcome measure was overall morbidity. The secondary endpoints were in-hospital mortality and rehospitalization.
    Results: The preoperative anaemia rate before matching was 34.3% (98 patients), and after matching a total of 127 patients (non-anaemic 42 vs. anaemic 85) were included. Anaemic patients had significantly more postoperative major complications (54.1% vs. 23.8%; p < 0.01), a higher comprehensive complication index (26.2 vs. 4.3; p < 0.01), and higher in-hospital mortality rate (14.1% vs. 2.4%; p = 0.04). Multivariate regression analysis confirmed these findings and identified preoperative anaemia as a strong independent risk factor for postoperative major morbidity (OR 4.047; 95% CI: 1.587-10.320; p < 0.01).
    Conclusion: The current propensity-score matched analysis strongly considered preoperative anaemia as a risk factor for major complications following distal pancreatectomy. Therefore, an intense preoperative anaemia workup should be increasingly prioritised.
    MeSH term(s) Humans ; Pancreatectomy/adverse effects ; Anemia/complications ; Anemia/epidemiology ; Hospital Mortality ; Multivariate Analysis ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology
    Language English
    Publishing date 2024-04-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1423681-3
    ISSN 1435-2451 ; 1435-2443
    ISSN (online) 1435-2451
    ISSN 1435-2443
    DOI 10.1007/s00423-024-03300-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Book ; Online ; Thesis: Konfessionszugehörigkeit als Einstellungsvoraussetzung in Organisationen der sozialen Arbeit

    Hempel, Sebastian

    eine Analyse von Stellenausschreibungen der Caritas

    2012  

    Author's details vorgelegt von: Sebastian Hempel
    Language German
    Size Online-Ressource
    Edition [Online-Ausg.]
    Publishing place Köln
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Fachhochsch., Bachelorarbeit--Köln, 2012
    Database Former special subject collection: coastal and deep sea fishing

    More links

    Kategorien

  8. Article ; Online: Wound complications after primary and repeated midline, transverse and modified Makuuchi incision: A single-center experience in 696 patients.

    Hempel, Sebastian / Kalauch, Anne / Oehme, Florian / Wolk, Steffen / Welsch, Thilo / Weitz, Jürgen / Distler, Marius

    Medicine

    2021  Volume 100, Issue 20, Page(s) e25989

    Abstract: Abstract: There are 3 main types of incisions in major open, elective abdominal surgery: the midline incision (MI), the transverse incision (TI) and the modified Makuuchi incision (MMI). This study aimed to compare these approaches regarding wound ... ...

    Abstract Abstract: There are 3 main types of incisions in major open, elective abdominal surgery: the midline incision (MI), the transverse incision (TI) and the modified Makuuchi incision (MMI). This study aimed to compare these approaches regarding wound complications and hernias, with a special focus on suture material and previous laparotomies.Patients who underwent elective abdominal surgery between 2015 and 2016 were retrospectively analyzed. Uni- and multivariate analyses were computed using stepwise binary and multifactorial regression models.In total, 696 patients (406 MI, 137 TI and 153 MMI) were included. No relevant differences were observed for patient characteristics (e.g., sex, age, body mass index [BMI], American Society of Anesthesiologists [ASA] score). Fewer wound complications (TI 22.6% vs MI 33.5% vs MMI 32.7%, P = .04) occurred in the TI group. However, regarding the endpoints surgical site infection (SSI), fascial dehiscence and incisional hernia, no risk factor after MI, TI, and MMI could be detected in statistical analysis. There was no difference regarding the occurrence of fascial dehiscence (P = .58) or incisional hernia (P = .97) between MI, TI, and MMI. In cases of relaparotomies, the incidence of fascial dehiscence (P = .2) or incisional hernia (P = .58) did not significantly differ between the MI, TI, or MMI as well as between primary and reincision of each type. On the other hand, the time to first appearance of a hernia after MMI is significantly shorter (P = .03) than after MI or TI, even after previous laparotomy (P = .003).In comparing the 3 most common types of abdominal incisions and ignoring the type of operative procedure performed, TI seems to be the least complicated approach. However, because the incidence of fascial dehiscence and incisional hernia is not relevantly increased, the stability of the abdominal wall is apparently not affected by relaparotomy, even by repeated MIs, TIs, and MMIs. Therefore, the type of laparotomy, especially a relaparotomy, can be chosen based on the surgeon's preference and planned procedure without worrying about increased wound complications.
    MeSH term(s) Abdominal Wall/surgery ; Aged ; Elective Surgical Procedures/adverse effects ; Elective Surgical Procedures/methods ; Female ; Follow-Up Studies ; Humans ; Incidence ; Incisional Hernia/epidemiology ; Incisional Hernia/etiology ; Incisional Hernia/surgery ; Male ; Middle Aged ; Prospective Studies ; Reoperation/adverse effects ; Retrospective Studies ; Risk Factors ; Surgical Wound Dehiscence/epidemiology ; Surgical Wound Dehiscence/etiology ; Surgical Wound Dehiscence/surgery ; Surgical Wound Infection/epidemiology ; Surgical Wound Infection/etiology ; Surgical Wound Infection/surgery ; Suture Techniques/adverse effects ; Suture Techniques/instrumentation ; Sutures/adverse effects
    Language English
    Publishing date 2021-06-08
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Observational Study
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000025989
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article: The Impact of Pancreatic Head Resection on Blood Glucose Homeostasis in Patients with Chronic Pancreatitis.

    Hempel, Sebastian / Oehme, Florian / Ehehalt, Florian / Solimena, Michele / Kolbinger, Fiona R / Bogner, Andreas / Welsch, Thilo / Weitz, Jürgen / Distler, Marius

    Journal of clinical medicine

    2022  Volume 11, Issue 3

    Abstract: Background: Chronic pancreatitis (CP) often leads to recurrent pain as well as exocrine and/or endocrine pancreatic insufficiency. This study aimed to investigate the effect of pancreatic head resections on glucose metabolism in patients with CP.: ... ...

    Abstract Background: Chronic pancreatitis (CP) often leads to recurrent pain as well as exocrine and/or endocrine pancreatic insufficiency. This study aimed to investigate the effect of pancreatic head resections on glucose metabolism in patients with CP.
    Methods: Patients who underwent pylorus-preserving pancreaticoduodenectomy (PPPD), Whipple procedure (cPD), or duodenum-preserving pancreatic head resection (DPPHR) for CP between January 2011 and December 2020 were retrospectively analyzed with regard to markers of pancreatic endocrine function including steady-state beta cell function (%B), insulin resistance (IR), and insulin sensitivity (%S) according to the updated Homeostasis Model Assessment (HOMA2).
    Results: Out of 141 pancreatic resections for CP, 43 cases including 31 PPPD, 2 cPD and 10 DPPHR, met the inclusion criteria. Preoperatively, six patients (14%) were normoglycemic (NG), 10 patients (23.2%) had impaired glucose tolerance (IGT) and 27 patients (62.8%) had diabetes mellitus (DM). In each subgroup, no significant changes were observed for HOMA2-%B (NG:
    Conclusion: Pancreatic head resections for CP, including DPPHR and pancreatoduodenectomies, do not significantly affect glucose metabolism within a follow-up period of 12 months.
    Language English
    Publishing date 2022-01-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11030663
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Systematic Review and Meta-analysis of the Role of Total Pancreatectomy as an Alternative to Pancreatoduodenectomy in Patients at High Risk for Postoperative Pancreatic Fistula: Is it a Justifiable Indication?

    Stoop, Thomas F / Bergquist, Erik / Theijse, Rutger T / Hempel, Sebastian / van Dieren, Susan / Sparrelid, Ernesto / Distler, Marius / Hackert, Thilo / Besselink, Marc G / Del Chiaro, Marco / Ghorbani, Poya

    Annals of surgery

    2023  Volume 278, Issue 4, Page(s) e702–e711

    Abstract: Objective: Examine the potential benefit of total pancreatectomy (TP) as an alternative to pancreatoduodenectomy (PD) in patients at high risk for postoperative pancreatic fistula (POPF).: Summary background data: TP is mentioned as an alternative to ...

    Abstract Objective: Examine the potential benefit of total pancreatectomy (TP) as an alternative to pancreatoduodenectomy (PD) in patients at high risk for postoperative pancreatic fistula (POPF).
    Summary background data: TP is mentioned as an alternative to PD in patients at high risk for POPF, but a systematic review is lacking.
    Methods: Systematic review and meta-analyses using Pubmed, Embase (Ovid), and Cochrane Library to identify studies published up to October 2022, comparing elective single-stage TP for any indication versus PD in patients at high risk for POPF. The primary endpoint was short-term mortality. Secondary endpoints were major morbidity (i.e., Clavien-Dindo grade ≥IIIa) on the short-term and quality of life.
    Results: After screening 1212 unique records, five studies with 707 patients (334 TP and 373 high-risk PD) met the eligibility criteria, comprising one randomized controlled trial and four observational studies. The 90-day mortality after TP and PD did not differ (6.3% vs. 6.2%; RR=1.04 [95%CI 0.56-1.93]). Major morbidity rate was lower after TP compared to PD (26.7% vs. 38.3%; RR=0.65 [95%CI 0.48-0.89]), but no significance was seen in matched/randomized studies (29.0% vs. 36.9%; RR = 0.73 [95%CI 0.48-1.10]). Two studies investigated quality of life (EORTC QLQ-C30) at a median of 30-52 months, demonstrating comparable global health status after TP and PD (77% [±15] vs. 76% [±20]; P =0.857).
    Conclusions: This systematic review and meta-analysis found no reduction in short-term mortality and major morbidity after TP as compared to PD in patients at high risk for POPF. However, if TP is used as a bail-out procedure, the comparable long-term quality of life is reassuring.
    MeSH term(s) Humans ; Pancreatectomy/adverse effects ; Pancreatectomy/methods ; Pancreaticoduodenectomy/adverse effects ; Pancreaticoduodenectomy/methods ; Pancreatic Fistula/epidemiology ; Pancreatic Fistula/etiology ; Quality of Life ; Pancreas/surgery ; Postoperative Complications/prevention & control
    Language English
    Publishing date 2023-05-09
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000005895
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top