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Book: EPIDEMIOLOGY AND CANCER REGISTRIES IN THE PACIFIC BASIN

Henderson, Brian E.

A CONF. HELD IN MAUI, HAWAII, NOV. 11 - 14, 1975

(NATIONAL CANCER INSTITUTE MONOGRAPH ; 47 ; DHEW PUBLICATION : (NIH) ; 77-1223)

1977

Author's details	CHAIRMAN: BRIAN E. HENDERSON
Series title	NATIONAL CANCER INSTITUTE MONOGRAPH ; 47 DHEW PUBLICATION : (NIH) ; 77-1223 DHEW publication National Cancer Institute monograph DHEW PUBLICATION ; (NIH)
Collection	DHEW publication National Cancer Institute monograph DHEW PUBLICATION ; (NIH)
Keywords	NEOPLASMS / EPIDEMIOLOGY
Size	182 S. ; 29 CM
Publisher	U.S. DEP. OF HEALTH, EDUCATION, AND WELFARE
Publishing place	BETHESDA, MD
Document type	Book
Remark	2 EX.
HBZ-ID	HT001075925
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
SE 101 -(NIH) 77-1223-	verfügbar in Königswinter	Königswinter

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Article ; Online: Inverse associations of dietary fiber and menopausal hormone therapy with colorectal cancer risk in the Multiethnic Cohort Study.

Park, Song-Yi / Wilkens, Lynne R / Kolonel, Laurence N / Henderson, Brian E / Le Marchand, Loïc

International journal of cancer

2016 Volume 139, Issue 6, Page(s) 1241–1250

Abstract: In the Multiethnic Cohort Study, we previously reported that dietary fiber intake was inversely associated with colorectal cancer risk in men only. In women, the inverse relationship was weaker and appeared to be confounded by menopausal hormone therapy ( ...

Abstract	In the Multiethnic Cohort Study, we previously reported that dietary fiber intake was inversely associated with colorectal cancer risk in men only. In women, the inverse relationship was weaker and appeared to be confounded by menopausal hormone therapy (MHT). We re-examined this observation with a greatly increased power. Using Cox proportional hazards models, we analyzed data from 187,674 participants with 4,692 cases identified during a mean follow-up period of 16 years. In multivariable-adjusted models, dietary fiber intake was inversely associated with colorectal cancer risk in both sexes: HR = 0.73, 95% CI: 0.61-0.89 for highest vs. lowest quintile, ptrend = 0.0020 in men and HR = 0.76, 95% CI: 0.62-0.91, ptrend = 0.0067 in women. Postmenopausal women who ever used MHT had a 19% lower risk of colorectal cancer (95% CI: 0.74-0.89) compared with MHT never users. In a joint analysis of dietary fiber and MHT, dietary fiber intake was associated with a lower colorectal cancer risk in MHT never users (HR = 0.75, 95% CI: 0.59-0.95, ptrend = 0.045), but did not appear to further decrease the colorectal cancer risk of MHT ever users (ptrend = 0.11). Our results support the overall protective roles of dietary fiber and MHT against colorectal cancer and suggest that dietary fiber may not lower risk further among women who ever used MHT. If confirmed, these results would suggest that MHT and dietary fiber may share overlapping mechanisms in protecting against colorectal cancer.
MeSH term(s)	Aged ; California/epidemiology ; Cohort Studies ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/etiology ; Dietary Fiber ; Ethnic Groups/statistics & numerical data ; Female ; Hawaii/epidemiology ; Hormone Replacement Therapy/adverse effects ; Humans ; Male ; Menopause ; Middle Aged ; Population Surveillance ; Risk Factors ; Surveys and Questionnaires
Chemical Substances	Dietary Fiber
Language	English
Publishing date	2016-05-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	218257-9
ISSN	1097-0215 ; 0020-7136
ISSN (online)	1097-0215
ISSN	0020-7136
DOI	10.1002/ijc.30172
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Article ; Online: The influence of race and ethnicity on the biology of cancer.

Henderson, Brian E / Lee, Norman H / Seewaldt, Victoria / Shen, Hongbing

Nature reviews. Cancer

2012 Volume 12, Issue 9, Page(s) 648–653

Abstract: It is becoming clear that some of the differences in cancer risk, incidence and survival among people of different racial and ethnic backgrounds can be attributed to biological factors. However, identifying these factors and exploiting them to help ... ...

Abstract	It is becoming clear that some of the differences in cancer risk, incidence and survival among people of different racial and ethnic backgrounds can be attributed to biological factors. However, identifying these factors and exploiting them to help eliminate cancer disparities has proved challenging. With this in mind, we asked four scientists for their opinions on the most crucial advances, as well as the challenges and what the future holds for this important emerging area of research.
MeSH term(s)	Genomics/trends ; Humans ; Incidence ; Neoplasms/ethnology ; Neoplasms/genetics ; Risk Factors
Language	English
Publishing date	2012-08-02
Publishing country	England
Document type	Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2062767-1
ISSN	1474-1768 ; 1474-175X
ISSN (online)	1474-1768
ISSN	1474-175X
DOI	10.1038/nrc3341
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Article: Menstrual and reproductive factors and risk of renal cell cancer in the Multiethnic Cohort.

Setiawan, Veronica Wendy / Kolonel, Laurence N / Henderson, Brian E

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

2009 Volume 18, Issue 1, Page(s) 337–340

Abstract: A relationship between female reproductive and menstrual factors, including exogenous hormone use, and renal cell cancer (RCC) has been hypothesized, but supporting epidemiologic evidence is limited and inconsistent. Here, the association of reproductive ...

Abstract	A relationship between female reproductive and menstrual factors, including exogenous hormone use, and renal cell cancer (RCC) has been hypothesized, but supporting epidemiologic evidence is limited and inconsistent. Here, the association of reproductive and menstrual factors with RCC risk was examined among 106,036 Hawaii-Los Angeles Multiethnic Cohort female participants who entered the cohort between 1993 and 1996. During an average 10.6 years of follow-up, 229 RCC cases were identified among these women. Data on known and potential risk factors were obtained from the baseline questionnaire. Relative risks and 95% confidence intervals for RCC associated with each factor were estimated using Cox proportional hazard models stratified by race/ethnicity, study center, and menopausal status and adjusted for age and several confounding factors. We found no evidence of association between RCC and parity, age at first birth, age at menarche, age and type of menopause (hysterectomy or bilateral oophorectomy), use and duration of oral contraceptive, and type and duration of postmenopausal hormone use. Our results do not support the hypothesis that hormone-related factors play an etiologic role in RCC among women.
MeSH term(s)	Age Factors ; Aged ; Body Mass Index ; Carcinoma, Renal Cell/epidemiology ; Carcinoma, Renal Cell/ethnology ; Female ; Hawaii/epidemiology ; Humans ; Incidence ; Kidney Neoplasms/epidemiology ; Kidney Neoplasms/ethnology ; Los Angeles/epidemiology ; Menstruation ; Middle Aged ; Proportional Hazards Models ; Prospective Studies ; Reproductive History ; Risk ; SEER Program
Language	English
Publishing date	2009-01-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1153420-5
ISSN	1055-9965
ISSN	1055-9965
DOI	10.1158/1055-9965.EPI-08-0790
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Article ; Online: Dietary fat and breast cancer in postmenopausal women according to ethnicity and hormone receptor status: the Multiethnic Cohort Study.

Park, Song-Yi / Kolonel, Laurence N / Henderson, Brian E / Wilkens, Lynne R

Cancer prevention research (Philadelphia, Pa.)

2011 Volume 5, Issue 2, Page(s) 216–228

Abstract: Dietary fat has been widely studied as a risk factor for breast cancer, with little consistency in results. The Multiethnic Cohort Study (MEC) provides an opportunity to assess this relationship for possible heterogeneity across different racial/ethnic ... ...

Abstract	Dietary fat has been widely studied as a risk factor for breast cancer, with little consistency in results. The Multiethnic Cohort Study (MEC) provides an opportunity to assess this relationship for possible heterogeneity across different racial/ethnic groups, as well as by stratification on several other variables associated with risk. Therefore, we investigated the associations between dietary fat, overall and by type, and breast cancer risk among 85,089 postmenopausal women who entered the MEC by completing a comprehensive dietary questionnaire in 1993 to 1996. During a mean follow-up of 12 years, 3,885 incident invasive breast cancer cases were identified. The multivariate HR [95% confidence interval (CI)] for the highest versus lowest quintile of intake was 0.94 (95% CI, 0.85-1.05) for total fat and 0.93 (95% CI, 0.83-1.04) for saturated fat. Other specific types of dietary fat, including individual fatty acids, were not related to risk of postmenopausal breast cancer. We found no heterogeneity in these null findings across the five ethnic groups. Furthermore, we found no evidence that the association between dietary fat and postmenopausal breast cancer risk differed by estrogen/progesterone receptor status, tumor stage, body mass index, hormone replacement therapy use, follow-up period, family history of breast cancer, and smoking status at baseline. In conclusion, this comprehensive prospective analysis in the MEC does not support a role of adult intake of dietary fat in the etiology of postmenopausal breast cancer.
MeSH term(s)	Adult ; Aged ; Breast Neoplasms/ethnology ; Breast Neoplasms/etiology ; Breast Neoplasms/metabolism ; Dietary Fats/adverse effects ; Female ; Humans ; Middle Aged ; Postmenopause ; Prognosis ; Prospective Studies ; Receptors, Estrogen/metabolism ; Receptors, Progesterone/metabolism ; Risk Factors ; Surveys and Questionnaires
Chemical Substances	Dietary Fats ; Receptors, Estrogen ; Receptors, Progesterone
Language	English
Publishing date	2011-12-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2434717-6
ISSN	1940-6215 ; 1940-6207
ISSN (online)	1940-6215
ISSN	1940-6207
DOI	10.1158/1940-6207.CAPR-11-0260
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Article ; Online: Linking data from the Multiethnic Cohort Study to Medicare data: linkage results and application to chronic disease research.

Setiawan, Veronica Wendy / Virnig, Beth A / Porcel, Jacqueline / Henderson, Brian E / Le Marchand, Loïc / Wilkens, Lynne R / Monroe, Kristine R

American journal of epidemiology

2015 Volume 181, Issue 11, Page(s) 917–919

MeSH term(s)	Aged ; Centers for Medicare and Medicaid Services (U.S.) ; Chronic Disease ; Cohort Studies ; Data Collection/methods ; Epidemiologic Methods ; Ethnic Groups/statistics & numerical data ; Female ; Heart Failure/epidemiology ; Heart Failure/ethnology ; Humans ; Insurance Claim Review/statistics & numerical data ; Male ; Medicare/statistics & numerical data ; Risk Factors ; United States
Language	English
Publishing date	2015-06-01
Publishing country	United States
Document type	Letter ; Research Support, N.I.H., Extramural
ZDB-ID	2937-3
ISSN	1476-6256 ; 0002-9262
ISSN (online)	1476-6256
ISSN	0002-9262
DOI	10.1093/aje/kwv055
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Article ; Online: Racial/ethnic differences in lifestyle-related factors and prostate cancer risk: the Multiethnic Cohort Study.

Park, Song-Yi / Haiman, Christopher A / Cheng, Iona / Park, Sungshim Lani / Wilkens, Lynne R / Kolonel, Laurence N / Le Marchand, Loïc / Henderson, Brian E

Cancer causes & control : CCC

2015 Volume 26, Issue 10, Page(s) 1507–1515

Abstract: Purpose: Older age, African ancestry, and family history of prostate cancer are well-established risk factors for prostate cancer, and all are non-modifiable. Various lifestyle factors have been examined in relation to prostate cancer risk, including ... ...

Abstract	Purpose: Older age, African ancestry, and family history of prostate cancer are well-established risk factors for prostate cancer, and all are non-modifiable. Various lifestyle factors have been examined in relation to prostate cancer risk, including diet, obesity, and physical activity; however, none of them has been consistently related to risk. In the Multiethnic Cohort Study, we investigated whether lifestyle-related factors are associated with prostate cancer risk and whether such factors explain the racial/ethnic differences in risk. Methods: During a mean follow-up of 13.9 years, 7,115 incident cases were identified among 75,216 white, African-American, Native Hawaiian, Japanese American, and Latino men. Cox proportional hazards models were used to calculate relative risks (RRs) and 95 % confidence intervals (95 % CIs) for prostate cancer. Results: Among selected lifestyle-related factors including body mass index, height, education, physical activity, and intakes of alcohol, calcium, legumes, lycopene, and selenium, only smoking (RR for current (≥20 cigarettes/day) vs. never smoking = 0.72; 95 % CI 0.63-0.83) and history of diabetes (RR for yes vs. no = 0.78; 95 % CI 0.72-0.85) were significantly associated with prostate cancer risk. Compared to whites, the risk of incident prostate cancer was twofold higher in African-Americans and 16 % higher in Latinos. Additional adjustment for a history of PSA testing did not change the results. Conclusions: The findings suggest that racial/ethnic differences in prostate cancer risk are not explained by the lifestyle factors examined and that underlying genetic factors may be involved.
MeSH term(s)	African Americans ; Aged ; Asian Americans ; Cohort Studies ; Diabetes Complications ; European Continental Ancestry Group ; Hispanic Americans ; Humans ; Life Style ; Male ; Middle Aged ; Oceanic Ancestry Group ; Prostatic Neoplasms/ethnology ; Risk Factors ; Smoking/adverse effects
Language	English
Publishing date	2015-10
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1064022-8
ISSN	1573-7225 ; 0957-5243
ISSN (online)	1573-7225
ISSN	0957-5243
DOI	10.1007/s10552-015-0644-y
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Article ; Online: Excess body weight and colorectal cancer survival: the multiethnic cohort.

Maskarinec, Gertraud / Harmon, Brook E / Little, Melissa A / Ollberding, Nicholas J / Kolonel, Laurence N / Henderson, Brian E / Le Marchand, Loic / Wilkens, Lynne R

Cancer causes & control : CCC

2015 Volume 26, Issue 12, Page(s) 1709–1718

Abstract: Purpose: Excess body weight is a risk factor for colorectal cancer (CRC) and may also adversely affect survival in CRC patients.: Methods: This study examined the relation of body mass index (BMI), which was self-reported at cohort entry and after 5 ... ...

Abstract	Purpose: Excess body weight is a risk factor for colorectal cancer (CRC) and may also adversely affect survival in CRC patients. Methods: This study examined the relation of body mass index (BMI), which was self-reported at cohort entry and after 5.7 ± 0.8 years, with CRC-specific and all-cause survival among 4,204 incident cases of invasive CRC in the multiethnic cohort. Cox regression analysis with age as time metric and BMI as time-varying exposure was applied to estimate hazard ratios (HR) and 95% confidence intervals (CIs) while adjusting for relevant covariates. Results: Over 6.0 ± 4.7 years of follow-up, 1,976 all-cause and 1,095 CRC-specific deaths were recorded. The mean time interval between cohort entry and diagnosis was 7.6 ± 4.7 years. No association with CRC-specific survival was detected in men (HR5units = 0.94; 95%CI 0.84-1.04) or women (HR5units = 0.98; 95%CI 0.89-1.08). In men, all-cause survival also showed no relation with BMI (HR5unit = 0.97; 95%CI 0.90-1.06), whereas it was reduced in women (HR5units = 1.10; 95%CI 1.03-1.18). Interactions of BMI with ethnicity were only significant for obesity. Obese Latino and overweight Native Hawaiian men as well as overweight African-American women experienced significantly better CRC-specific survival than whites. Overweight Japanese men and African-American women had better all-cause survival and obese Latino women had the lowest all-cause survival (HRobese = 1.74; 95%CI 1.08-2.80). Conclusions: This analysis detected little evidence for an adverse effect of excess body weight on CRC-specific survival, but all-cause survival was reduced in women. These findings suggest that adiposity may be less important for CRC survival than as an etiologic factor.
MeSH term(s)	Aged ; Body Mass Index ; Body Weight ; Cohort Studies ; Colorectal Neoplasms/ethnology ; Colorectal Neoplasms/etiology ; Colorectal Neoplasms/pathology ; Female ; Humans ; Male ; Middle Aged ; Obesity/complications ; Overweight/complications ; Proportional Hazards Models ; Prospective Studies ; Regression Analysis ; Risk Factors ; Self Report
Language	English
Publishing date	2015-09-10
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1064022-8
ISSN	1573-7225 ; 0957-5243
ISSN (online)	1573-7225
ISSN	0957-5243
DOI	10.1007/s10552-015-0664-7
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Article ; Online: Smoking and Risk of Breast Cancer in a Racially/Ethnically Diverse Population of Mainly Women Who Do Not Drink Alcohol: The MEC Study.

Gram, Inger T / Park, Song-Yi / Kolonel, Laurence N / Maskarinec, Gertraud / Wilkens, Lynne R / Henderson, Brian E / Le Marchand, Loïc

American journal of epidemiology

2015 Volume 182, Issue 11, Page(s) 917–925

Abstract: We prospectively examined the association between smoking and the risk of breast cancer in a racially/ethnically diverse population comprising mainly women who did not drink alcohol. From 1993 to 2010, we followed 83,300 women who were enrolled in the ... ...

Abstract	We prospectively examined the association between smoking and the risk of breast cancer in a racially/ethnically diverse population comprising mainly women who did not drink alcohol. From 1993 to 2010, we followed 83,300 women who were enrolled in the Multiethnic Cohort Study at 45-75 years of age. We identified cancer cases via linkage to the Surveillance, Epidemiology, and End Results Program cancer registries that covered the states of Hawaii and California through December 2010. We used Cox proportional hazards models to estimate hazard ratios and 95% confidence intervals while adjusting for confounders that were decided a priori. During a mean follow-up of 15 years, 4,484 women developed invasive breast cancer. Compared with parous never smokers, women who had smoked for more than 20 pack-years and initiated smoking more than 5 years before their first childbirth had an overall risk of breast cancer that was 35% higher (hazard ratio = 1.35, 95% confidence interval: 1.13, 1.63). Among women who did not drink alcohol, the risk was 40% higher (hazard ratio = 1.40, 95% confidence interval: 1.08, 1.81). This higher risk did not significantly differ among racial/ethnic groups (P(interaction) = 0.82). We found that various measures of smoking exposure were associated with a higher risk of breast cancer, especially smoking initiated many years before first childbirth, and that risk did not differ by alcohol consumption (yes vs. no) or racial/ethnic group.
MeSH term(s)	Aged ; Alcohol Drinking/adverse effects ; Alcohol Drinking/epidemiology ; Breast Neoplasms/epidemiology ; Breast Neoplasms/etiology ; California/epidemiology ; Continental Population Groups/statistics & numerical data ; Ethnic Groups/statistics & numerical data ; Female ; Hawaii/epidemiology ; Humans ; Middle Aged ; Proportional Hazards Models ; Prospective Studies ; Registries ; Risk Factors ; SEER Program ; Smoking/adverse effects ; Smoking/epidemiology
Language	English
Publishing date	2015-12-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2937-3
ISSN	1476-6256 ; 0002-9262
ISSN (online)	1476-6256
ISSN	0002-9262
DOI	10.1093/aje/kwv092
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Article ; Online: Serum zinc and prostate cancer risk in a nested case-control study: The multiethnic cohort.

Park, Song-Yi / Wilkens, Lynne R / Morris, J Steven / Henderson, Brian E / Kolonel, Laurence N

The Prostate

2012 Volume 73, Issue 3, Page(s) 261–266

Abstract: Background: Experimental studies have provided evidence that zinc has a protective effect against development and progression of prostate cancer. However, epidemiological studies have reported inconsistent findings. We evaluated the association between ... ...

Abstract	Background: Experimental studies have provided evidence that zinc has a protective effect against development and progression of prostate cancer. However, epidemiological studies have reported inconsistent findings. We evaluated the association between prediagnostic serum zinc and prostate cancer risk in a cohort of multiethnic population. Methods: This case-control study is nested within the Multiethnic Cohort of African Americans, Native Hawaiians, Japanese Americans, Latinos, and whites in Hawaii and California. The analysis included 392 prostate cancer cases and 783 controls matched on age, race/ethnicity, date/time of blood draw and fasting status. Conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). Results: The mean serum zinc concentrations did not significantly differ between cases (94.9 µg/dl) and controls (93.9 µg/dl). No association was found between serum zinc levels and prostate cancer either overall or by tumor stage/grade. In ethnic-specific analyses, positive associations were found in Japanese Americans (OR for the highest vs. the lowest tertile = 2.59, 95% CI: 1.09-6.17) and Latinos (OR = 2.74, 95% CI: 1.05-7.10), whereas no association was observed in African Americans and whites. Conclusions: We found no evidence to support an inverse relationship between serum zinc and prostate cancer risk, and, to the contrary, found a suggestion in the ethnic-specific results of a possible increase in risk; however, blood concentrations of zinc may not adequately reflect the levels in prostate tissue. Further study with a larger sample size, and if possible, with assessment of zinc tissue levels, is warranted to confirm these findings.
MeSH term(s)	African Americans/ethnology ; Aged ; Asian Americans/ethnology ; Biomarkers/blood ; California ; Case-Control Studies ; Cohort Studies ; European Continental Ancestry Group/ethnology ; Hawaii ; Hispanic Americans/ethnology ; Humans ; Logistic Models ; Male ; Middle Aged ; Oceanic Ancestry Group/ethnology ; Prospective Studies ; Prostatic Neoplasms/blood ; Prostatic Neoplasms/epidemiology ; Prostatic Neoplasms/ethnology ; Risk Factors ; Zinc/blood
Chemical Substances	Biomarkers ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2012-07-31
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	604707-5
ISSN	1097-0045 ; 0270-4137
ISSN (online)	1097-0045
ISSN	0270-4137
DOI	10.1002/pros.22565
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