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Article ; Online: Electrodeposited polyaniline based carbon nanotubes fiber as efficient counter electrode in wire-shaped dye sensitized solar cells.

Hendi, Awatif A / Awad, Manal A / Ortashi, Khalid M

2023 Volume 35, Issue 8

Abstract: Electrodeposited polyaniline over the carbon nanotubes fiber (CNTF) has been investigated as potential candidate to substitutes the Pt based auxiliary electrodes in unidimensional fibrous solar cells. CNTF, with excellent electrical and mechanical ... ...

Abstract	Electrodeposited polyaniline over the carbon nanotubes fiber (CNTF) has been investigated as potential candidate to substitutes the Pt based auxiliary electrodes in unidimensional fibrous solar cells. CNTF, with excellent electrical and mechanical properties, modified with conducting polymer (polyaniline) via facile electrodeposition process which employed as cathodic materials showed efficient electrochemical reduction of triiodide ions in the fiber shaped dye-sensitized solar cells. Scanning electron microscopic analysis showed the efficacious integration of conducting polymer over the CNTF surface. The admirable electrocatalytic behavior of the fabricated electrode has investigated by electrochemical impedance spectroscopy and cyclic voltammetry. Current density and voltage (
Language	English
Publishing date	2023-12-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1362365-5
ISSN	1361-6528 ; 0957-4484
ISSN (online)	1361-6528
ISSN	0957-4484
DOI	10.1088/1361-6528/ad01c3
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Article ; Online: Utilizing

Awad, Manal A / Hendi, Awatif A / Ortashi, Khalid M O / Alnamlah, Reema A / Alangery, Asma / Ali Alshaya, Eman / Alshammari, Saad G

Molecules (Basel, Switzerland)

2024 Volume 29, Issue 2

Abstract: This study successfully synthesized zinc oxide nanorod needles (ZnO-NRNs) using an environmentally friendly method ... ...

Abstract	This study successfully synthesized zinc oxide nanorod needles (ZnO-NRNs) using an environmentally friendly method employing
Language	English
Publishing date	2024-01-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules29020355
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Article ; Online: Putative anti-proliferative effect of Indian mustard (Brassica juncea) seed and its nano-formulation

Virk Promy / Awad Manal A. / Alanazi Meznah M. / Hendi Awatif A. / Elobeid Mai / Ortashi Khalid M. / Alrowaily Albandari W. / Bahlool Taghreed / Aouaini Fatma

Green Processing and Synthesis, Vol 12, Iss 1, Pp 685-

2023 Volume 850

Abstract: Over the past few decades, nanotechnology has shown promising prospects in biomedicine and has a proven impact on enhancing therapeutics by facilitating drug delivery. The present study brings an amalgamation of nanoscience and “clean technology” by ... ...

Abstract	Over the past few decades, nanotechnology has shown promising prospects in biomedicine and has a proven impact on enhancing therapeutics by facilitating drug delivery. The present study brings an amalgamation of nanoscience and “clean technology” by fabricating nature-friendly nanoparticles (NPs) sans the use of chemical surfactants using Indian mustard seed, Brassica juncea L. The as-synthesized NPs were characterized to assess their average size, crystallinity, morphology, and constituent functional groups through conventional techniques: dynamic light scattering (DLS), X-ray diffraction (XRD), scanning electron microscopy (SEM), and Fourier-transform infrared spectroscopy (FTIR). The NPs were crystalline in nature and exhibited a mean size of 205.5 nm (PDI of 0.437) being primarily polygonal in shape. Additionally, the therapeutic efficacy of the green NPs was evaluated based on their cytotoxic effect against two human cancer lines, MCF-7 and HepG-2. Both the NPs and the bulk seeds showed a dose-dependent cytotoxic effect. However, an assessment of the antiproliferative/cytotoxic potential of the green NPs versus the bulk seeds showed that the NPs were relatively more efficacious on both cell lines. Taken together, the mustard seed NPs could be potential nutraceuticals considering the green credential in their mode of biosynthesis.
Keywords	green synthesis ; nanoformulation ; indian mustard seed ; brassica juncea l ; anti-proliferative effect ; Chemistry ; QD1-999
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	De Gruyter
Document type	Article ; Online
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Article ; Online: Reducing the Threshold of Primary Prevention of Cardiovascular Disease to 10% Over 10 Years: The Implications of Altered Intensity "Statin" Therapy Guidance.

Sultan, Salma / Khan, Shahid Ullah / Holden, Keith / Hendi, Awatif A / Saeed, Sumbul / Abbas, Ali / Zaman, Umber / Naeem, Sobia / Rehman, Khalil Ur

Current problems in cardiology

2022 Volume 48, Issue 2, Page(s) 101486

Abstract: Cardiovascular disease (CVD) is a significant noncommunicable disease associated with high long-term mortality. In addition to more effective secondary therapies, the primary prevention of CVD has developed markedly in the past several years. This study ... ...

Abstract	Cardiovascular disease (CVD) is a significant noncommunicable disease associated with high long-term mortality. In addition to more effective secondary therapies, the primary prevention of CVD has developed markedly in the past several years. This study aims to investigate the evidence and impact of reducing the threshold for primary CVD risk management to 10% over 10 years with "statin" therapy. To conduct research a systematic review utilizing 5 electronic database searches was completed for studies, analyzing the clinical effect of reducing the threshold of CVD risk to 10% over 10 years for primary prevention with statin therapy. The study included six (6) trials. Statin therapy was allocated to 31,018 participants. The mean age was 61 years and the mean follow-up was 4.6 years. The mean relative reduction in total cholesterol was 19% (from an average of), low-density lipoprotein cholesterol was 28.3% (from mmol/L to mmol/L) and triglycerides were 14.8% (from mmol/L to mmol/L). High-density lipoprotein cholesterol was observed to increase by a mean of 3.3% (from mmol/L to mmol/L). When examining all-cause mortality, statin therapy was associated with a 12% relative risk reduction compared with control, where overall rates were reduced from 1.4% to 1. % There is a 30% risk reduction in general major coronary events (from to %). There is a 19% risk reduction in general major cerebrovascular events with the statin group. While there is undoubtedly statistical evidence that supports the observation of the effectiveness of statin therapy for primary prevention, there is a risk that many hundreds of patients need to be treated to avoid a single adverse clinical outcome.
Language	English
Publishing date	2022-11-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	441230-8
ISSN	1535-6280 ; 0146-2806
ISSN (online)	1535-6280
ISSN	0146-2806
DOI	10.1016/j.cpcardiol.2022.101486
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Article: Zinc and Potassium Fertilizer Synergizes Plant Nutrient Availability and Affects Growth, Yield, and Quality of Wheat Genotypes.

Bashir, Aneela / Khan, Qudrat Ullah / Alem, Ahmad / Hendi, Awatif A / Zaman, Umber / Khan, Shahid Ullah / Rehman, Khalil Ur / Khan, Asghar Ali / Ullah, Ihsan / Anwar, Yasir / Abdelrahman, Ehab A

Plants (Basel, Switzerland)

2023 Volume 12, Issue 12

Abstract: The growth and productivity of wheat crops depend on the availability of essential nutrients such as zinc (Zn) and potassium ( ... ...

Abstract	The growth and productivity of wheat crops depend on the availability of essential nutrients such as zinc (Zn) and potassium (K
Language	English
Publishing date	2023-06-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants12122241
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Article ; Online: A Comprehensive Review: Epidemiological Strategies, Catheterization and Biomarkers used as a Bioweapon in Diagnosis and Management of Cardio Vascular Diseases.

Abbas, Ali / Raza, Ali / Ullah, Muneeb / Hendi, Awatif A / Akbar, Fazal / Khan, Shahid Ullah / Zaman, Umber / Saeed, Sumbul / Ur Rehman, Khalil / Sultan, Salma / Hosny, Khaled M / Alissa, Mohammed / Rizg, Waleed Y

Current problems in cardiology

2023 Volume 48, Issue 7, Page(s) 101661

Abstract: Coronary artery disease (CAD) is a serious health problem that causes a considerable number of mortality in a number of affluent nations throughout the world. The estimated death encountered in many developed countries includes including Pakistan, ... ...

Abstract	Coronary artery disease (CAD) is a serious health problem that causes a considerable number of mortality in a number of affluent nations throughout the world. The estimated death encountered in many developed countries includes including Pakistan, reached 111,367 and accounted for 9.87% of all deaths, despite the mortality rate being around 7.2 million deaths per year, or 12% of all estimated deaths accounted annually around the globe, with improved health systems. Atherosclerosis progressing causes the coronary arteries to become partially or completely blocked, which results in CAD. Additionally, smoking, diabetes mellitus, homocystinuria, hypertension, obesity, hyperlipidemia, and psychological stress are risk factors for CAD. The symptoms of CAD include angina which is described as a burning, pain or discomfort in the chest, nausea, weakness, shortness of breath, lightheadedness, and pain or discomfort in the arms or shoulders. Atherosclerosis and thrombosis are the 2 pathophysiological pathways most frequently involved in acute coronary syndrome (ACS). Asymptomatic plaque disruption, plaque bleeding, symptomatic coronary blockage, and myocardial infarction are the prognoses for CAD. In this review, we will focus on medicated therapy which is being employed for the relief of angina linked with CAD including antiplatelet medicines, nitrates, calcium antagonists, blockers, catheterization, and the frequency of recanalized infarct-related arteries in patients with acute anterior wall myocardial infarction (AWMI). Furthermore, we have also enlightened the importance of biomarkers that are helpful in the diagnosis and management of CAD.
MeSH term(s)	Humans ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/epidemiology ; Coronary Artery Disease/therapy ; Angina Pectoris ; Risk Factors ; Biomarkers ; Catheterization ; Atherosclerosis
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-02-22
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	441230-8
ISSN	1535-6280 ; 0146-2806
ISSN (online)	1535-6280
ISSN	0146-2806
DOI	10.1016/j.cpcardiol.2023.101661
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Article: The possible counteractive effect of gold nanoparticles against streptozotocin-induced type 1 diabetes in young male albino rats.

Selim, Manar E / Hendi, Awatif A / Alfallaj, Ebtesam

Pakistan journal of pharmaceutical sciences

2016 Volume 29, Issue 3, Page(s) 823–836

Abstract: The current study was performed to study the effect of biologically synthesised gold nanoparticles (AuNPs) to control hyperglycaemic conditions in streptozotocin (STZ)-induced diabetic mice. In this study, the rats were divided into four groups: Group I ... ...

Abstract	The current study was performed to study the effect of biologically synthesised gold nanoparticles (AuNPs) to control hyperglycaemic conditions in streptozotocin (STZ)-induced diabetic mice. In this study, the rats were divided into four groups: Group I normal control rats (non-diabetic, untreated); Group II diabetes-induced rats used as diabetic controls DC (diabetic, untreated). Group III diabetes-induced rats treated with AuNPs DT; Group IV normal rats treated with AuNPs NT. Diabetes was induced by administering an intraperitoneal injection of a freshly prepared solution of STZ (50mg/kg body weight (bw)). The glucose level was significantly increased in the diabetic control rats compared with the controls (P<0.001). Decreased liver function and kidney function were detected in the diabetic treated rats and normal treated rats after AuNP administration compared with the controls. The present study is the first to demonstrate that AuNPs significantly enhance antioxidant production in STZ-induced diabetic rats, a recognised model of type 1 diabetes mellitus (T1DM).
MeSH term(s)	Age Factors ; Animals ; Antioxidants/metabolism ; Biomarkers/blood ; Blood Glucose/drug effects ; Blood Glucose/metabolism ; Blood Urea Nitrogen ; Creatinine/blood ; Diabetes Mellitus, Experimental/blood ; Diabetes Mellitus, Experimental/chemically induced ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Type 1/blood ; Diabetes Mellitus, Type 1/chemically induced ; Diabetes Mellitus, Type 1/drug therapy ; Enzymes/blood ; Glucose Tolerance Test ; Gold Compounds/pharmacology ; Hypoglycemic Agents/pharmacology ; Male ; Metal Nanoparticles ; Rats ; Streptozocin ; Time Factors ; Uric Acid/blood
Chemical Substances	Antioxidants ; Biomarkers ; Blood Glucose ; Enzymes ; Gold Compounds ; Hypoglycemic Agents ; Uric Acid (268B43MJ25) ; Streptozocin (5W494URQ81) ; Creatinine (AYI8EX34EU)
Language	English
Publishing date	2016-05
Publishing country	Pakistan
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	885131-1
ISSN	1011-601X
ISSN	1011-601X
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Article ; Online: Gold nanoparticles induce apoptosis in MCF-7 human breast cancer cells.

Selim, Manar E / Hendi, Awatif A

Asian Pacific journal of cancer prevention : APJCP

2012 Volume 13, Issue 4, Page(s) 1617–1620

Abstract: Background: Gold nanoparticles have recently been investigated with respect to biocompatibility according to their interactions with cells. The purpose of this study was to examine cytotoxicity and apoptosis induction by well-characterized gold ... ...

Abstract	Background: Gold nanoparticles have recently been investigated with respect to biocompatibility according to their interactions with cells. The purpose of this study was to examine cytotoxicity and apoptosis induction by well-characterized gold nanoparticles in human breast epithelial MCF-7 cells. Methods: Apoptosis was assessed by TUNEL, cytotoxicity by MTT assay and caspase 3, 9, p53, Bax and Bcl expression by real-time PCR assays. Results: Gold nanoparticles at up to 200 μg/mL for 24 hours exerted concentration-dependent cytotoxicity and significant upregulation of mRNA expression of p53, bax, caspase-3 and caspase-9, whereas expression of anti- apoptotic bcl-2 was down-regulated. Conclusion: To the best of our knowledge this is the first report showing that gold nanoparticles induce apoptosis in MCF-7 cells via p53, bax/bcl-2 and caspase pathways.
MeSH term(s)	Apoptosis/drug effects ; Caspase 3/drug effects ; Caspase 3/genetics ; Caspase 9/drug effects ; Caspase 9/genetics ; Cell Survival/drug effects ; Gene Expression/drug effects ; Gold/pharmacology ; Humans ; MCF-7 Cells ; Nanoparticles ; Proto-Oncogene Proteins c-bcl-2/drug effects ; Proto-Oncogene Proteins c-bcl-2/genetics ; Tumor Suppressor Protein p53/drug effects ; Tumor Suppressor Protein p53/genetics ; bcl-2-Associated X Protein/genetics
Chemical Substances	Proto-Oncogene Proteins c-bcl-2 ; Tumor Suppressor Protein p53 ; bcl-2-Associated X Protein ; Gold (7440-57-5) ; Caspase 3 (EC 3.4.22.-) ; Caspase 9 (EC 3.4.22.-)
Language	English
Publishing date	2012-07-06
Publishing country	Thailand
Document type	Journal Article
ZDB-ID	2218955-5
ISSN	2476-762X ; 1513-7368
ISSN (online)	2476-762X
ISSN	1513-7368
DOI	10.7314/apjcp.2012.13.4.1617
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Article ; Online: In Silico Studies on Zinc Oxide Based Nanostructured Oil Carriers with Seed Extracts of

Hendi, Awatif A / Virk, Promy / Awad, Manal A / Elobeid, Mai / Ortashi, Khalid M O / Alanazi, Meznah M / Alkallas, Fatemah H / Almoneef, Maha Mohammad / Abdou, Mohammed Aly

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 13

Abstract: Coming into the second year of the pandemic, the acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants continue to be a serious health hazard globally. A surge in the omicron wave, despite the discovery of the vaccines, has shifted the ... ...

Abstract	Coming into the second year of the pandemic, the acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants continue to be a serious health hazard globally. A surge in the omicron wave, despite the discovery of the vaccines, has shifted the attention of research towards the discovery and use of bioactive compounds, being potential inhibitors of the viral structural proteins. The present study aimed at the green synthesis of zinc oxide (ZnO) nanoparticles with seed extracts of
MeSH term(s)	COVID-19/drug therapy ; Cysteine Endopeptidases/chemistry ; Humans ; Ligands ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Nanostructures ; Nigella sativa/metabolism ; Peptide Hydrolases/metabolism ; Pimpinella ; Plant Extracts/pharmacology ; Protease Inhibitors/chemistry ; SARS-CoV-2 ; Seeds/metabolism ; Viral Nonstructural Proteins/metabolism ; Zinc Oxide/pharmacology
Chemical Substances	Ligands ; Plant Extracts ; Protease Inhibitors ; Viral Nonstructural Proteins ; Peptide Hydrolases (EC 3.4.-) ; Cysteine Endopeptidases (EC 3.4.22.-) ; Zinc Oxide (SOI2LOH54Z)
Language	English
Publishing date	2022-07-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27134301
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Article ; Online: Kinetic and thermodynamic studies of novel acid phosphatase isolated and purified from Carthamus oxyacantha seedlings.

Zaman, Umber / Khan, Shahid Ullah / Hendi, Awatif A / Rehman, Khalil Ur / Badshah, Syed / Refat, Moamen S / Alsuhaibani, Amnah Mohammed / Ullah, Kalim / Wahab, Abdul

International journal of biological macromolecules

2022 Volume 224, Page(s) 20–31

Abstract: Acid phosphatase (ACP) is a key enzyme in the regulation of phosphate feeding in plants. In this study, a new ACP from C. oxyacantha was isolated to homogeneity and biochemically described for the first time. Specific activity (283 nkat/mg) was found ... ...

Abstract	Acid phosphatase (ACP) is a key enzyme in the regulation of phosphate feeding in plants. In this study, a new ACP from C. oxyacantha was isolated to homogeneity and biochemically described for the first time. Specific activity (283 nkat/mg) was found after 2573 times purification fold and (17 %) yield. Using SDS-PAGE under denaturing and nondenaturing conditions, ACP was isolated as a monomer with a molecular weight of 36 kDa. LC-MS/MS confirmed the presence of this band, suggesting that C. oxycantha ACP is a monomer. The enzyme could also hydrolyze orthophosphate monoester with an optimal pH of 5.0 and a temperature of 50 °C. Thermodynamic parameters were also determined (Ea, ΔH°, ΔG°, and ΔS°). ACP activity was further studied in the presence of cysteine, DTT, SDS, EDTA, β-ME, Triton-X-100 H
Language	English
Publishing date	2022-12-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2022.12.025
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