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  1. Article: Tumid Lupus Erythematosus Presenting as Patchy Alopecia: A Discussion of Alopecia Associated With Lupus Erythematosus.

    Henehan, Mason R / Stillman, Sydney / Grubbs, Hailey E / Cohen, Carlos

    Cureus

    2023  Volume 15, Issue 3, Page(s) e36956

    Abstract: Tumid lupus erythematosus (TLE), a subtype of chronic cutaneous lupus erythematosus (CCLE), presents with firm erythematous plaques that lack surface changes such as follicular plugging or scale. These lesions most commonly occur on the face and other ... ...

    Abstract Tumid lupus erythematosus (TLE), a subtype of chronic cutaneous lupus erythematosus (CCLE), presents with firm erythematous plaques that lack surface changes such as follicular plugging or scale. These lesions most commonly occur on the face and other photosensitive areas but may also present on the scalp as recurrent circumscribed patches of non-cicatricial alopecia. Including TLE as part of the differential for non-cicatricial alopecia can prove helpful in patients who fail to improve with empiric first-line treatments for more common causes of hair loss. We report a case of TLE that clinically mimicked alopecia areata and seek to highlight the relevant clinical and histological features to promote earlier diagnosis of this entity. A discussion of improved diagnostic and treatment modalities, as well as identifying the uncommon but possible association of TLE with underlying systemic disease, adds to the importance of maintaining clinical suspicion for TLE. Finally, we provide an overview to discriminate TLE from other forms of cutaneous lupus and their unique patterns of alopecia when presenting on the scalp.
    Language English
    Publishing date 2023-03-31
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.36956
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Flagellate erythema with relapsing fevers and arthralgia.

    McNamara, Stephanie A / Henehan, Mason / Zubair, Raheel / Nousari, Carlos

    International journal of dermatology

    2023  Volume 63, Issue 4, Page(s) 464–466

    MeSH term(s) Humans ; Relapsing Fever ; Dermatitis ; Bleomycin ; Arthralgia/diagnosis ; Arthralgia/etiology ; Erythema/diagnosis ; Erythema/etiology
    Chemical Substances Bleomycin (11056-06-7)
    Language English
    Publishing date 2023-09-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.16851
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Update on protease-activated receptor 2 in cutaneous barrier, differentiation, tumorigenesis and pigmentation, and its role in related dermatologic diseases.

    Henehan, Mason / De Benedetto, Anna

    Experimental dermatology

    2019  Volume 28, Issue 8, Page(s) 877–885

    Abstract: Protease-activated receptor 2 (PAR2) is a transmembrane receptor expressed by multiple tissues, including skin, with rapidly expanding knowledge regarding its roles. In the skin, PAR2 has extensively documented effects in promoting Th2 inflammation and ... ...

    Abstract Protease-activated receptor 2 (PAR2) is a transmembrane receptor expressed by multiple tissues, including skin, with rapidly expanding knowledge regarding its roles. In the skin, PAR2 has extensively documented effects in promoting Th2 inflammation and pruritus; and its role in atopic dermatitis continues to be thoroughly studied. Numerous new investigations have shown a more complex range of activities potentially related to dermatologic diseases. Goal of this review is to outline emerging effects of PAR2 activation in the skin other than those related to immunologic and pruritic functions. Specifically, this work seeks to summarize current knowledge (and gaps) of PAR2 as a regulator of epidermal barrier, keratinocyte differentiation, cutaneous tumorigenesis and pigmentation. Additional focus will be placed on possible involvement in dermatologic disease and emergence as a therapeutic target.
    MeSH term(s) Animals ; Carcinogenesis ; Cell Differentiation ; Extracellular Matrix/metabolism ; Humans ; Keratinocytes/physiology ; Paracrine Communication ; Phagocytosis ; Receptor, PAR-2/metabolism ; Skin Diseases/metabolism ; Skin Pigmentation ; Tight Junction Proteins/metabolism
    Chemical Substances Receptor, PAR-2 ; Tight Junction Proteins
    Language English
    Publishing date 2019-05-15
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 1130936-2
    ISSN 1600-0625 ; 0906-6705
    ISSN (online) 1600-0625
    ISSN 0906-6705
    DOI 10.1111/exd.13936
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Activation of protease-activated receptor 2 leads to impairment of keratinocyte tight junction integrity.

    Nadeau, Peter / Henehan, Mason / De Benedetto, Anna

    The Journal of allergy and clinical immunology

    2018  Volume 142, Issue 1, Page(s) 281–284.e7

    MeSH term(s) Dermatitis, Atopic/metabolism ; Dermatitis, Atopic/pathology ; Humans ; Keratinocytes/metabolism ; Keratinocytes/pathology ; Permeability ; Receptor, PAR-2/metabolism ; Tight Junctions/metabolism ; Tight Junctions/pathology
    Chemical Substances Receptor, PAR-2
    Language English
    Publishing date 2018-01-31
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2018.01.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Hypopigmented Macules With Onychodystrophy: Answer.

    Henehan, Mason / Nozile, Wallace / Longo, Maria Isabel / Walker, Addie / Motaparthi, Kiran

    The American Journal of dermatopathology

    2019  Volume 42, Issue 1, Page(s) 66–67

    MeSH term(s) Administration, Topical ; Adrenal Cortex Hormones/administration & dosage ; Adult ; African Americans ; Biopsy, Needle ; Darier Disease/diagnosis ; Darier Disease/drug therapy ; Darier Disease/pathology ; Diagnosis, Differential ; Female ; Humans ; Hypopigmentation/diagnosis ; Hypopigmentation/pathology ; Immunohistochemistry ; Nails, Malformed/diagnosis ; Nails, Malformed/pathology ; Rare Diseases ; Retinoids/therapeutic use
    Chemical Substances Adrenal Cortex Hormones ; Retinoids
    Language English
    Publishing date 2019-12-24
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 448469-1
    ISSN 1533-0311 ; 0193-1091
    ISSN (online) 1533-0311
    ISSN 0193-1091
    DOI 10.1097/DAD.0000000000001308
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Hypopigmented Macules With Onychodystrophy: Challenge.

    Henehan, Mason / Nozile, Wallace / Longo, Maria Isabel / Walker, Addie / Motaparthi, Kiran

    The American Journal of dermatopathology

    2018  Volume 42, Issue 1, Page(s) e5–e6

    MeSH term(s) Administration, Topical ; Adrenal Cortex Hormones/administration & dosage ; Adult ; African Americans ; Biopsy, Needle ; Darier Disease/diagnosis ; Darier Disease/drug therapy ; Darier Disease/pathology ; Female ; Humans ; Hypopigmentation/diagnosis ; Hypopigmentation/drug therapy ; Hypopigmentation/pathology ; Immunohistochemistry ; Nails, Malformed/diagnosis ; Nails, Malformed/drug therapy ; Nails, Malformed/pathology ; Rare Diseases ; Retinoids/administration & dosage
    Chemical Substances Adrenal Cortex Hormones ; Retinoids
    Language English
    Publishing date 2018-11-14
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 448469-1
    ISSN 1533-0311 ; 0193-1091
    ISSN (online) 1533-0311
    ISSN 0193-1091
    DOI 10.1097/DAD.0000000000001309
    Database MEDical Literature Analysis and Retrieval System OnLINE

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