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Article ; Online: Online Combustion Status Recognition of Municipal Solid Waste Incineration Process Using DFC Based on Convolutional Multi-Layer Feature Fusion

Xiaotong Pan / Jian Tang / Heng Xia / Tianzheng Wang

Sustainability, Vol 15, Iss 23, p

2023 Volume 16473

Abstract: The prevailing method for handling municipal solid waste (MSW) is incineration, a critical process that demands safe, stable, and eco-conscious operation. While grate-typed furnaces offer operational flexibility, they often generate pollution during ... ...

Abstract	The prevailing method for handling municipal solid waste (MSW) is incineration, a critical process that demands safe, stable, and eco-conscious operation. While grate-typed furnaces offer operational flexibility, they often generate pollution during unstable operating conditions. Moreover, fluctuations in the physical and chemical characteristics of MSW contribute to variable combustion statuses, accelerating internal furnace wear and ash accumulation. Tackling the challenges of pollution, wear, and efficiency in the MSW incineration (MSWI) process necessitates the automatic online recognition of combustion status. This article introduces a novel online recognition method using deep forest classification (DFC) based on convolutional multi-layer feature fusion. The method entails several key steps: initial collection and analysis of flame image modeling data and construction of an offline model utilizing LeNet-5 and DFC. Here, LeNet-5 trains to extract deep features from flame images, while an adaptive selection fusion method on multi-layer features selects the most effective fused deep features. Subsequently, these fused deep features feed into DFC, constructing an offline recognition model for identifying combustion status. Finally, embedding this recognition system into an existing MSWI process data monitoring system enables online flame video recognition. Experimental results show remarkable accuracies: 93.80% and 95.08% for left and right grate furnace offline samples, respectively. When implemented in an online flame video recognition platform, it aptly meets recognition demands.
Keywords	municipal solid waste incineration ; combustion status ; LeNet-5 network ; deep forest classification ; online flame video identification ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	004
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Non-Manipulated Variable Analysis of Solid-Phase Combustion in the Furnace of Municipal Solid-Waste Incineration Process Based on the Biorthogonal Numerical-Simulation Experiment

Jiakun Chen / Jian Tang / Heng Xia / Tianzheng Wang / Bingyin Gao

Sustainability, Vol 15, Iss 14159, p

2023 Volume 14159

Abstract: The operating conditions of municipal solid waste incineration (MSWI) are influenced by manipulated variables, such as the feed rate, primary air, and grate speed, as well as non-manipulated variables, such as municipal solid waste (MSW) particle size, ... ...

Abstract	The operating conditions of municipal solid waste incineration (MSWI) are influenced by manipulated variables, such as the feed rate, primary air, and grate speed, as well as non-manipulated variables, such as municipal solid waste (MSW) particle size, mixing coefficient, emissivity, moisture content, and the ratio of C to O. Based on the actual data of an MSWI plant in Beijing, a non-manipulated variable single-factor analysis of solid-phase combustion in the furnace was carried out based on the biorthogonal numerical simulation experiment. First, a solid-phase combustion analysis of the MSWI process was performed for non-manipulated variables, with the main non-manipulated variables determined. Then, based on FLIC 2.3c software, the numerical model was established under benchmark operating conditions. Based on the biorthogonal experiment, several groups of numerical model inputs were designed to generate mechanism data in multi-operating conditions. Finally, a multi-condition numerical simulation experiment was used to study solid-phase combustion under different conditions and analyze non-manipulated variables. The simulation results showed that the maximum solid temperature was 1360 K under the benchmark operating condition and ranged from 1120 to 1470 K under five conditions. Large-size particles and large emissivity were beneficial to solid-phase combustion, while high moisture content and a large mixing coefficient weakened combustion. The results provide support for the subsequent optimal control of the whole MSWI process.
Keywords	municipal solid waste incineration (MSWI) ; numerical simulation ; orthogonal experimental design ; multi-operating conditions ; single-factor analysis ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	660
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Psychrophilic phage VSW-3 RNA polymerase reduces both terminal and full-length dsRNA byproducts in in vitro transcription

Heng Xia / Bingbing Yu / Yixin Jiang / Rui Cheng / Xueling Lu / Hui Wu / Bin Zhu

RNA Biology, Vol 19, Iss 1, Pp 1130-

2022 Volume 1142

Abstract: RNA research and applications are underpinned by in vitro transcription (IVT), but RNA impurities resulting from the enzymatic reagents severely impede downstream applications. To improve the stability and purity of synthesized RNA, we have characterized ...

Abstract	RNA research and applications are underpinned by in vitro transcription (IVT), but RNA impurities resulting from the enzymatic reagents severely impede downstream applications. To improve the stability and purity of synthesized RNA, we have characterized a novel single-subunit RNA polymerase (RNAP) encoded by the psychrophilic phage VSW-3 from a plateau lake. The VSW-3 RNAP is capable of carrying out in vitro RNA synthesis at low temperatures (4–25°C). Compared to routinely used T7 RNAP, VSW-3 RNAP provides a similar yield of transcripts but is insensitive to class II transcription terminators and synthesizes RNA without redundant 3’-cis extensions. More importantly, through dot-blot detection with the J2 monoclonal antibody, we found that the RNA products synthesized by VSW-3 RNAP contained a much lower amount of double-stranded RNA byproducts (dsRNA), which are produced by transcription from both directions and are significant in T7 RNAP IVT products. Taken together, the VSW-3 RNAP almost eliminates both terminal loop-back dsRNA and full-length dsRNA in IVT and thus is especially advantageous for producing RNA for in vivo use.
Keywords	dsrna ; sgrna ; mrna medicine ; t7 rna polymerase ; in vitro transcription ; Genetics ; QH426-470
Subject code	570
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Observation on clinical effect of Huoxue-Jiangtang decoction formula granules in treating prediabetes: a randomized prospective placebo-controlled double-blind trial protocol.

Zhang, Peng-Xiang / Zeng, Lin / Meng, Lu / Li, Hui-Lin / Zhao, Heng-Xia / Liu, De-Liang

BMC complementary medicine and therapies

2022 Volume 22, Issue 1, Page(s) 274

Abstract: Background: Prediabetes is a hypermetabolic syndrome with blood sugar levels falling between the normal and diabetes. People with prediabetes have a significantly increased chances of developing diabetes, cardiovascular and cerebrovascular diseases, ... ...

Abstract	Background: Prediabetes is a hypermetabolic syndrome with blood sugar levels falling between the normal and diabetes. People with prediabetes have a significantly increased chances of developing diabetes, cardiovascular and cerebrovascular diseases, tumors, dementia, and other diseases in the future when compared to the healthy population. However, prediabetes is mainly treated based on lifestyle intervention, currently without targeted drug treatment plan. Traditional Chinese medicine (TCM), which has a longstanding experience, has been shown in clinical studies to be effective for the treatment of diabetes and its related complications. Furthermore, different dosage forms such as decoction and granule have developed gradually in clinical application. Preliminary studies have found that Huoxue-Jangtang Decoction (HJD), with good hypoglycemic and lipid-regulating effects, is potentially one of the complementary and alternative treatments for prediabetes. Therefore, this project intends to perform a prospective clinical study to observe the clinical effectiveness of HJD on prediabetes and the consistency of the efficacy of formula granules and the elixation. Methods: This is a prospective, randomized, double-blind, and placebo-controlled clinical trial. A total of 183 participants are randomly assigned to HJD Formula Granules plus lifestyle intervention, HJD Elixation plus lifestyle intervention, and placebo plus lifestyle intervention. All subjects undergo 1 day of screening before participating in the study, followed by 84 days of drug intervention and observation. During and after treatment, the main outcome measures include fasting blood glucose and 2-hour postprandial blood glucose. Discussion: This research attempts to verify the clinical efficacy and possible mechanism of HJD in the treatment of prediabetes, and prove the consistency of HJD Formula Granules with HJD Elixation. This study also aims to provide a treatment that is both effective and safe for prediabetic patients. Trial registration: ClinicalTrials.gov Identifier: ChiCTR2200060813, Registered 12 June 2022.
MeSH term(s)	Humans ; Prediabetic State/drug therapy ; Blood Glucose ; Prospective Studies ; Hypoglycemic Agents/therapeutic use ; Diabetes Mellitus/drug therapy ; Lipids ; Randomized Controlled Trials as Topic
Chemical Substances	Blood Glucose ; Hypoglycemic Agents ; Lipids
Language	English
Publishing date	2022-10-19
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ISSN	2662-7671
ISSN (online)	2662-7671
DOI	10.1186/s12906-022-03755-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Development and validation of a diabetic retinopathy risk prediction model for middle-aged patients with type 2 diabetes mellitus.

Wang, Gao-Xiang / Hu, Xin-Yu / Zhao, Heng-Xia / Li, Hui-Lin / Chu, Shu-Fang / Liu, De-Liang

Frontiers in endocrinology

2023 Volume 14, Page(s) 1132036

Abstract: Objectives: The study aims to establish a predictive nomogram of diabetic retinopathy(DR) for the middle-aged population with type 2 diabetes mellitus (T2DM).: Methods: This retrospective study screened 931 patients with T2DM between 30 and 59 years ... ...

Abstract	Objectives: The study aims to establish a predictive nomogram of diabetic retinopathy(DR) for the middle-aged population with type 2 diabetes mellitus (T2DM). Methods: This retrospective study screened 931 patients with T2DM between 30 and 59 years of age from the 2011-2018 National Health and Nutrition Examination Survey database. The development group comprised 704 participants from the 2011-2016 survey, and the validation group included 227 participants from the 2017-2018 survey. The least absolute shrinkage and selection operator regression model was used to determine the best predictive variables. The logistic regression analysis built three models: the full model, the multiple fractional polynomial (MFP) model, and the stepwise (stepAIC) selected model. Then we decided optimal model based on the receiver operating characteristic curve (ROC). ROC, calibration curve, Hosmer-Lemeshow test, and decision curve analysis (DCA) were used to validate and assess the model. An online dynamic nomogram prediction tool was also constructed. Results: The MFP model was selected to be the final model, including gender, the use of insulin, duration of diabetes, urinary albumin-to-creatinine ratio, and serum phosphorus. The AUC was 0.709 in the development set and 0.704 in the validation set. According to the ROC, calibration curves, and Hosmer-Lemeshow test, the nomogram demonstrated good coherence. The nomogram was clinically helpful, according to DCA. Conclusion: This study established and validated a predictive model for DR in the mid-life T2DM population, which can assist clinicians quickly determining who is prone to develop DR.
MeSH term(s)	Middle Aged ; Humans ; Diabetes Mellitus, Type 2/complications ; Diabetic Retinopathy/diagnosis ; Diabetic Retinopathy/epidemiology ; Diabetic Retinopathy/etiology ; Nutrition Surveys ; Retrospective Studies ; Insulin
Chemical Substances	Insulin
Language	English
Publishing date	2023-03-15
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1132036
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The correlation between high-density lipoprotein cholesterol and bone mineral density in adolescents: a cross-sectional study.

Wang, Gao-Xiang / Li, Jun-Tong / Liu, De-Liang / Chu, Shu-Fang / Li, Hui-Lin / Zhao, Heng-Xia / Fang, Ze-Bin / Xie, Wei

Scientific reports

2023 Volume 13, Issue 1, Page(s) 5792

Abstract: Recent studies have shown a correlation between high-density lipoprotein cholesterol (HDL-C) and bone mineral density (BMD) in adults, but their relationship is unclear in adolescents. This study aimed to explore whether a correlation existed between ... ...

Abstract	Recent studies have shown a correlation between high-density lipoprotein cholesterol (HDL-C) and bone mineral density (BMD) in adults, but their relationship is unclear in adolescents. This study aimed to explore whether a correlation existed between them among adolescents aged 12-19. Data analyzed in our study was fetched from the National Health and Nutrition Examination Survey (NHANES) database 2011-2018. The relationship between HDL-C level and total BMD value was analyzed by multivariate logistic regression models, fitted smoothing curves, and generalized additive models. 3770 participants participated in this analysis. After adjusting for all relevant covariates involved in this study, we found a negative correlation between HDL-C levels and total bone density in male adolescents.Furthermore, the stratified analysis showed that all covariables-adjusted models retained the negative correlation excepting female, black, or Mexican American subgroups. An inverted U-shaped curve represented the correlation of HDL-C and total BMD among adolescents aged 16 to 19, and the turning point was 1.06 mmol/L. After adjusting for all relevant covariates involved in this study, the study found a negative correlation between HDL-C levels and total BMD in male adolescents aged 12 to 19, particularly among those of races other than Black and Mexican. There was a saturation effect between HDL-C level and total BMD in 16-19-year-old adolescents. The turning point was 1.06 mmol/L. Therefore, HDL-C might be a biomarker to detect bone health and further perform a more detailed examination.
MeSH term(s)	Adult ; Humans ; Male ; Female ; Adolescent ; Young Adult ; Bone Density ; Cholesterol, HDL ; Cross-Sectional Studies ; Nutrition Surveys ; Triglycerides
Chemical Substances	Cholesterol, HDL ; Triglycerides
Language	English
Publishing date	2023-04-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-32885-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: mRNA produced by VSW-3 RNAP has high-level translation efficiency with low inflammatory stimulation

Guoquan Wang / Rui Cheng / Qiubing Chen / Yuandong Xu / Bingbing Yu / Bin Zhu / Hao Yin / Heng Xia

Cell Insight, Vol 1, Iss 5, Pp 100056- (2022)

2022

Abstract: In vitro preparation of mRNA is a key step for mRNA therapeutics. The widely used T7 RNA polymerase (RNAP) was shown to have many by-products during in vitro transcription (IVT) process, among which double-stranded RNA (dsRNA) is the major by-product to ... ...

Abstract	In vitro preparation of mRNA is a key step for mRNA therapeutics. The widely used T7 RNA polymerase (RNAP) was shown to have many by-products during in vitro transcription (IVT) process, among which double-stranded RNA (dsRNA) is the major by-product to activate the intracellular immune response. Here, we describe the use of a new VSW-3 RNAP that reduced dsRNA production during IVT and the resulting mRNA exhibited low inflammatory stimulation in cells. Compared to T7 RNAP transcripts, these mRNA exhibited superior protein expression levels, with an average of 14-fold increase in Hela cells and 5-fold increase in mice. In addition, we found that VSW-3 RNAP did not require modified nucleotides to improve protein production of IVT products. Our data suggest that VSW-3 RNAP could be a useful tool for mRNA therapeutics.
Keywords	Biology (General) ; QH301-705.5 ; Medicine (General) ; R5-920
Language	English
Publishing date	2022-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Observation on clinical effect of Huoxue-Jiangtang decoction formula granules in treating prediabetes: a randomized prospective placebo-controlled double-blind trial protocol

Zhang, Peng-Xiang / Zeng, Lin / Meng, Lu / Li, Hui-Lin / Zhao, Heng-Xia / Liu, De-Liang

BMC Complement Med Ther. 2022 Dec., v. 22, no. 1 p.274-274

2022

Abstract: BACKGROUND: Prediabetes is a hypermetabolic syndrome with blood sugar levels falling between the normal and diabetes. People with prediabetes have a significantly increased chances of developing diabetes, cardiovascular and cerebrovascular diseases, ... ...

Abstract	BACKGROUND: Prediabetes is a hypermetabolic syndrome with blood sugar levels falling between the normal and diabetes. People with prediabetes have a significantly increased chances of developing diabetes, cardiovascular and cerebrovascular diseases, tumors, dementia, and other diseases in the future when compared to the healthy population. However, prediabetes is mainly treated based on lifestyle intervention, currently without targeted drug treatment plan. Traditional Chinese medicine (TCM), which has a longstanding experience, has been shown in clinical studies to be effective for the treatment of diabetes and its related complications. Furthermore, different dosage forms such as decoction and granule have developed gradually in clinical application. Preliminary studies have found that Huoxue-Jangtang Decoction (HJD), with good hypoglycemic and lipid-regulating effects, is potentially one of the complementary and alternative treatments for prediabetes. Therefore, this project intends to perform a prospective clinical study to observe the clinical effectiveness of HJD on prediabetes and the consistency of the efficacy of formula granules and the elixation. METHODS: This is a prospective, randomized, double-blind, and placebo-controlled clinical trial. A total of 183 participants are randomly assigned to HJD Formula Granules plus lifestyle intervention, HJD Elixation plus lifestyle intervention, and placebo plus lifestyle intervention. All subjects undergo 1 day of screening before participating in the study, followed by 84 days of drug intervention and observation. During and after treatment, the main outcome measures include fasting blood glucose and 2-hour postprandial blood glucose. DISCUSSION: This research attempts to verify the clinical efficacy and possible mechanism of HJD in the treatment of prediabetes, and prove the consistency of HJD Formula Granules with HJD Elixation. This study also aims to provide a treatment that is both effective and safe for prediabetic patients. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: ChiCTR2200060813, Registered 12 June 2022.
Keywords	Oriental traditional medicine ; blood glucose ; clinical trials ; complement ; dementia ; diabetes ; drug therapy ; drugs ; lifestyle ; people ; placebos
Language	English
Dates of publication	2022-12
Size	p. 274.
Publishing place	BioMed Central
Document type	Article ; Online
ISSN	2662-7671
DOI	10.1186/s12906-022-03755-2
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The correlation between high-density lipoprotein cholesterol and bone mineral density in adolescents

Gao-Xiang Wang / Jun-Tong Li / De-Liang Liu / Shu-Fang Chu / Hui-Lin Li / Heng-Xia Zhao / Ze-Bin Fang / Wei Xie

Scientific Reports, Vol 13, Iss 1, Pp 1-

a cross-sectional study

2023 Volume 8

Abstract: Abstract Recent studies have shown a correlation between high-density lipoprotein cholesterol (HDL-C) and bone mineral density (BMD) in adults, but their relationship is unclear in adolescents. This study aimed to explore whether a correlation existed ... ...

Abstract	Abstract Recent studies have shown a correlation between high-density lipoprotein cholesterol (HDL-C) and bone mineral density (BMD) in adults, but their relationship is unclear in adolescents. This study aimed to explore whether a correlation existed between them among adolescents aged 12–19. Data analyzed in our study was fetched from the National Health and Nutrition Examination Survey (NHANES) database 2011–2018. The relationship between HDL-C level and total BMD value was analyzed by multivariate logistic regression models, fitted smoothing curves, and generalized additive models. 3770 participants participated in this analysis. After adjusting for all relevant covariates involved in this study, we found a negative correlation between HDL-C levels and total bone density in male adolescents.Furthermore, the stratified analysis showed that all covariables-adjusted models retained the negative correlation excepting female, black, or Mexican American subgroups. An inverted U-shaped curve represented the correlation of HDL-C and total BMD among adolescents aged 16 to 19, and the turning point was 1.06 mmol/L. After adjusting for all relevant covariates involved in this study, the study found a negative correlation between HDL-C levels and total BMD in male adolescents aged 12 to 19, particularly among those of races other than Black and Mexican. There was a saturation effect between HDL-C level and total BMD in 16–19-year-old adolescents. The turning point was 1.06 mmol/L. Therefore, HDL-C might be a biomarker to detect bone health and further perform a more detailed examination.
Keywords	Medicine ; R ; Science ; Q
Subject code	616
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Association between urinary nickel with obesity status in adults

Gao-Xiang Wang / Bao-Li Huang / Jun-Tong Li / Ze-Bin Fang / Le-Yi Feng / Heng-Xia Zhao / Shu-Fang Chu / De-Liang Liu / Hui-Lin Li

Frontiers in Public Health, Vol

A cross-sectional study

2023 Volume 11

Abstract: ObjectivesThe prevalence of obesity is on the rise and is connected to numerous factors. However, the relationship between obesity and nickel has never been investigated. Our study aimed to explore the association between urinary nickel and obesity ... ...

Abstract	ObjectivesThe prevalence of obesity is on the rise and is connected to numerous factors. However, the relationship between obesity and nickel has never been investigated. Our study aimed to explore the association between urinary nickel and obesity Status in adults.MethodsFrom the 2017–2018 National Health and Nutrition Examination Surveys (NHANES), 1,705 participants ≥18 years of age were enrolled. To explore further the relationship among urinary nickel, body mass index (BMI), and waist circumference(WC), Weighted multivariate linear regression analyses and further subgroup analyzes were conducted.ResultsUrinary nickel does not correlate with BMI level but positively correlates with WC. In the subgroup analyzed according to sex, Urinary nickel has a positive correlation with BMI and WC in males but has a negative correlation in females. Secondary stratification analysis according to sex and race, Urinary nickel positively correlates with BMI in White males. It also positively correlates with WC in both White and Black males.ConclusionsA correlation was found between urinary nickel levels and BMI and WC in adult males. Adult men, especially those already obese, may need to reduce nickel exposure.
Keywords	urinary nickel ; obesity ; body mass index ; waist circumference ; NHANES ; Public aspects of medicine ; RA1-1270
Subject code	796
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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