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  1. Book ; Thesis: Molekulargenetische Analyse von bilateralen Keimzelltumoren des Ovars

    Hennes, Elisa

    2013  

    Author's details vorgelegt von Elisa Hennes
    Language German
    Size 59 Bl., Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Düsseldorf, Univ., Diss., 2013
    HBZ-ID HT017654046
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2014 E 196 order for loan Magazin

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  2. Book ; Online: Private Hypothesis Testing for Social Sciences

    Mulay, Ajinkya K / Lane, Sean / Hennes, Erin

    2022  

    Abstract: While running any experiment, we often have to consider the statistical power to ensure an effective study. Statistical power or power ensures that we can observe an effect with high probability if such a true effect exists. However, several studies lack ...

    Abstract While running any experiment, we often have to consider the statistical power to ensure an effective study. Statistical power or power ensures that we can observe an effect with high probability if such a true effect exists. However, several studies lack the appropriate planning for determining the optimal sample size to ensure adequate power. Thus, careful planning ensures that the power remains high even under high measurement errors while keeping the type 1 error constrained. We study the impact of differential privacy on experiments and theoretically analyze the change in sample size required due to the Gaussian mechanisms. Further, we provide an empirical method to improve the accuracy of private statistics with simple bootstrapping.

    Comment: There are no significant alterations from version 1. We mistakenly included metadata from a journal Latex template while using its document class and it's now removed to avoid any confusion. This article has been accepted at the Workshop on Theory and Practice of Differential Privacy at ICML 2022
    Keywords Statistics - Methodology ; Computer Science - Cryptography and Security
    Subject code 005
    Publishing date 2022-05-07
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: An overview of values for the threshold of toxicological concern.

    Hennes, E C

    Toxicology letters

    2012  Volume 211, Issue 3, Page(s) 296–303

    Abstract: An overview of values for the threshold of toxicological concern (TTC) is presented. This comprises the more established TTC values, including those that have been endorsed by regulatory bodies, and those that have more recently been proposed and may ... ...

    Abstract An overview of values for the threshold of toxicological concern (TTC) is presented. This comprises the more established TTC values, including those that have been endorsed by regulatory bodies, and those that have more recently been proposed and may still need further development. The overview is structured by use/exposure scenario and provides, in particular, key information on the underlying databases. It is aimed to support the application of the TTC approach in the risk assessment of chemicals whereby it is important to be aware under which circumstances a certain TTC value can be applied. Some recommendations for potential future developments to further improve the TTC approach are also being made.
    MeSH term(s) Administration, Topical ; Air Pollutants/analysis ; Animals ; Databases, Factual ; Drug Contamination ; Environmental Pollutants/analysis ; Environmental Pollutants/toxicity ; Flavoring Agents/toxicity ; Food Analysis ; Food Contamination/analysis ; Food Packaging ; Humans ; Maximum Allowable Concentration ; Organic Chemicals/adverse effects ; Organic Chemicals/analysis ; Pharmaceutical Preparations/analysis ; Toxicology/legislation & jurisprudence ; Toxicology/standards ; Water Pollutants, Chemical/adverse effects ; Water Pollutants, Chemical/toxicity
    Chemical Substances Air Pollutants ; Environmental Pollutants ; Flavoring Agents ; Organic Chemicals ; Pharmaceutical Preparations ; Water Pollutants, Chemical
    Language English
    Publishing date 2012-06-20
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 433788-8
    ISSN 1879-3169 ; 0378-4274
    ISSN (online) 1879-3169
    ISSN 0378-4274
    DOI 10.1016/j.toxlet.2012.03.795
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Book ; Online: PowerGraph

    Mulay, Ajinkya K / Lane, Sean / Hennes, Erin

    Using neural networks and principal components to determine multivariate statistical power trade-offs

    2021  

    Abstract: Statistical power estimation for studies with multiple model parameters is inherently a multivariate problem. Power for individual parameters of interest cannot be reliably estimated univariately since correlation and variance explained relative to one ... ...

    Abstract Statistical power estimation for studies with multiple model parameters is inherently a multivariate problem. Power for individual parameters of interest cannot be reliably estimated univariately since correlation and variance explained relative to one parameter will impact the power for another parameter, all usual univariate considerations being equal. Explicit solutions in such cases, especially for models with many parameters, are either impractical or impossible to solve, leaving researchers to the prevailing method of simulating power. However, the point estimates for a vector of model parameters are uncertain, and the impact of inaccuracy is unknown. In such cases, sensitivity analysis is recommended such that multiple combinations of possible observable parameter vectors are simulated to understand power trade-offs. A limitation to this approach is that it is computationally expensive to generate sufficient sensitivity combinations to accurately map the power trade-off function in increasingly high-dimensional spaces for the models that social scientists estimate. This paper explores the efficient estimation and graphing of statistical power for a study over varying model parameter combinations. We propose a simple and generalizable machine learning inspired solution to cut the computational cost to less than 10% of the brute force method while providing F1 scores above 90%. We further motivate the impact of transfer learning in learning power manifolds across varying distributions.

    Comment: Submitted to AI4Science (ICML workshop). Not published yet
    Keywords Statistics - Methodology ; Computer Science - Machine Learning
    Subject code 310
    Publishing date 2021-12-29
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Gas Damping in Capacitive MEMS Transducers in the Free Molecular Flow Regime.

    Boom, Boris A / Bertolini, Alessandro / Hennes, Eric / van den Brand, Johannes F J

    Sensors (Basel, Switzerland)

    2021  Volume 21, Issue 7

    Abstract: We present a novel analysis of gas damping in capacitive MEMS transducers that is based on a simple analytical model, assisted by Monte-Carlo simulations performed in Molflow+ to obtain an estimate for the geometry dependent gas diffusion time. This ... ...

    Abstract We present a novel analysis of gas damping in capacitive MEMS transducers that is based on a simple analytical model, assisted by Monte-Carlo simulations performed in Molflow+ to obtain an estimate for the geometry dependent gas diffusion time. This combination provides results with minimal computational expense and through freely available software, as well as insight into how the gas damping depends on the transducer geometry in the molecular flow regime. The results can be used to predict damping for arbitrary gas mixtures. The analysis was verified by experimental results for both air and helium atmospheres and matches these data to within 15% over a wide range of pressures.
    Language English
    Publishing date 2021-04-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s21072566
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Discovery of the sEH Inhibitor Epoxykynin as a Potent Kynurenine Pathway Modulator.

    Dötsch, Lara / Davies, Caitlin / Hennes, Elisabeth / Schönfeld, Julia / Kumar, Adarsh / Guita, Celine Da Cruz Lopes / Ehrler, Johanna H M / Hiesinger, Kerstin / Thavam, Sasikala / Janning, Petra / Sievers, Sonja / Knapp, Stefan / Proschak, Ewgenij / Ziegler, Slava / Waldmann, Herbert

    Journal of medicinal chemistry

    2024  Volume 67, Issue 6, Page(s) 4691–4706

    Abstract: Disease-related phenotypic assays enable unbiased discovery of novel bioactive small molecules and may provide novel insights into physiological systems and unprecedented molecular modes of action (MMOA). Herein, we report the identification and ... ...

    Abstract Disease-related phenotypic assays enable unbiased discovery of novel bioactive small molecules and may provide novel insights into physiological systems and unprecedented molecular modes of action (MMOA). Herein, we report the identification and characterization of epoxykynin, a potent inhibitor of the soluble epoxide hydrolase (sEH). Epoxykynin was discovered by means of a cellular assay monitoring modulation of kynurenine (Kyn) levels in BxPC-3 cells upon stimulation with the cytokine interferon-γ (IFN-γ) and subsequent target identification employing affinity-based chemical proteomics. Increased Kyn levels are associated with immune suppression in the tumor microenvironment and, thus, the Kyn pathway and its key player indoleamine 2,3-dioxygenase 1 (IDO1) are appealing targets in immuno-oncology. However, targeting IDO1 directly has led to limited success in clinical investigations, demonstrating that alternative approaches to reduce Kyn levels are in high demand. We uncover a cross-talk between sEH and the Kyn pathway that may provide new opportunities to revert cancer-induced immune tolerance.
    MeSH term(s) Humans ; Kynurenine/metabolism ; Neoplasms/metabolism ; Indoleamine-Pyrrole 2,3,-Dioxygenase ; Tumor Microenvironment
    Chemical Substances Kynurenine (343-65-7) ; Indoleamine-Pyrrole 2,3,-Dioxygenase
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.3c02245
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: An overview of values for the threshold of toxicological concern

    Hennes, E.C

    Toxicology letters. 2012 June 20, v. 211, no. 3

    2012  

    Abstract: An overview of values for the threshold of toxicological concern (TTC) is presented. This comprises the more established TTC values, including those that have been endorsed by regulatory bodies, and those that have more recently been proposed and may ... ...

    Abstract An overview of values for the threshold of toxicological concern (TTC) is presented. This comprises the more established TTC values, including those that have been endorsed by regulatory bodies, and those that have more recently been proposed and may still need further development. The overview is structured by use/exposure scenario and provides, in particular, key information on the underlying databases. It is aimed to support the application of the TTC approach in the risk assessment of chemicals whereby it is important to be aware under which circumstances a certain TTC value can be applied. Some recommendations for potential future developments to further improve the TTC approach are also being made.
    Keywords chemical compounds ; databases ; exposure scenario ; reference standards
    Language English
    Dates of publication 2012-0620
    Size p. 296-303.
    Publishing place Elsevier Ireland Ltd
    Document type Article
    ZDB-ID 433788-8
    ISSN 1879-3169 ; 0378-4274
    ISSN (online) 1879-3169
    ISSN 0378-4274
    DOI 10.1016/j.toxlet.2012.03.795
    Database NAL-Catalogue (AGRICOLA)

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    Zs.A 1367: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Cell-Based Identification of New IDO1 Modulator Chemotypes.

    Hennes, Elisabeth / Lampe, Philipp / Dötsch, Lara / Bruning, Nora / Pulvermacher, Lisa-Marie / Sievers, Sonja / Ziegler, Slava / Waldmann, Herbert

    Angewandte Chemie (International ed. in English)

    2021  Volume 60, Issue 18, Page(s) 9869–9874

    Abstract: The immunoregulatory enzyme indoleamine-2,3-dioxygenase (IDO1) strengthens cancer immune escape, and inhibition of IDO1 by means of new chemotypes and mechanisms of action is considered a promising opportunity for IDO1 inhibitor discovery. IDO1 is a ... ...

    Abstract The immunoregulatory enzyme indoleamine-2,3-dioxygenase (IDO1) strengthens cancer immune escape, and inhibition of IDO1 by means of new chemotypes and mechanisms of action is considered a promising opportunity for IDO1 inhibitor discovery. IDO1 is a cofactor-binding, redox-sensitive protein, which calls for monitoring of IDO1 activity in its native cellular environment. We developed a new, robust fluorescence-based assay amenable to high throughput, which detects kynurenine in cells. Screening of a ca. 150 000-member compound library discovered unprecedented, potent IDO1 modulators with different mechanisms of action, including direct IDO1 inhibitors, regulators of IDO1 expression, and inhibitors of heme synthesis. Three IDO1-modulator chemotypes were identified that bind to apo-IDO1 and compete with the heme cofactor. Our new cell-based technology opens up novel opportunities for medicinal chemistry programs in immuno-oncology.
    MeSH term(s) Cell Line, Tumor ; Coumarins/chemistry ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Fluorescent Dyes/chemistry ; Humans ; Indoleamine-Pyrrole 2,3,-Dioxygenase/antagonists & inhibitors ; Indoleamine-Pyrrole 2,3,-Dioxygenase/genetics ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Kynurenine/analysis ; Molecular Structure
    Chemical Substances Coumarins ; Enzyme Inhibitors ; Fluorescent Dyes ; IDO1 protein, human ; Indoleamine-Pyrrole 2,3,-Dioxygenase ; Kynurenine (343-65-7) ; coumarin (A4VZ22K1WT)
    Language English
    Publishing date 2021-03-24
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202016004
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  9. Article ; Online: Characterization of Covalent Pyrazolopyrimidine-MKK7 Complexes and a Report on a Unique DFG-in/Leu-in Conformation of Mitogen-Activated Protein Kinase Kinase 7 (MKK7).

    Wolle, Patrik / Engel, Julian / Smith, Steven / Goebel, Lisa / Hennes, Elisabeth / Lategahn, Jonas / Rauh, Daniel

    Journal of medicinal chemistry

    2019  Volume 62, Issue 11, Page(s) 5541–5546

    Abstract: Pyrazolopyrimidines are well-established as covalent inhibitors of protein kinases such as the epidermal growth factor receptor or Bruton's tyrosine kinase, and we recently described their potential in targeting mitogen-activated protein kinase kinase 7 ( ...

    Abstract Pyrazolopyrimidines are well-established as covalent inhibitors of protein kinases such as the epidermal growth factor receptor or Bruton's tyrosine kinase, and we recently described their potential in targeting mitogen-activated protein kinase kinase 7 (MKK7). Herein, we report the structure-activity relationship of pyrazolopyrimidine-based MKK7 inhibitors and solved several complex crystal structures to gain insights into their binding mode. In addition, we present two structures of apo-MKK7, exhibiting a DFG-out and an unprecedented DFG-in/Leu-in conformation.
    MeSH term(s) Amino Acid Motifs ; MAP Kinase Kinase 7/antagonists & inhibitors ; MAP Kinase Kinase 7/chemistry ; MAP Kinase Kinase 7/metabolism ; Models, Molecular ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/metabolism ; Protein Kinase Inhibitors/pharmacology ; Pyrimidines/chemistry ; Pyrimidines/metabolism ; Pyrimidines/pharmacology
    Chemical Substances Protein Kinase Inhibitors ; Pyrimidines ; MAP Kinase Kinase 7 (EC 2.7.12.2) ; pyrimidine (K8CXK5Q32L)
    Language English
    Publishing date 2019-05-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.9b00472
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Identification of a Novel Pseudo-Natural Product Type IV IDO1 Inhibitor Chemotype.

    Davies, Caitlin / Dötsch, Lara / Ciulla, Maria Gessica / Hennes, Elisabeth / Yoshida, Kei / Gasper, Raphael / Scheel, Rebecca / Sievers, Sonja / Strohmann, Carsten / Kumar, Kamal / Ziegler, Slava / Waldmann, Herbert

    Angewandte Chemie (International ed. in English)

    2022  Volume 61, Issue 40, Page(s) e202209374

    Abstract: Natural product (NP)-inspired design principles provide invaluable guidance for bioactive compound discovery. Pseudo-natural products (PNPs) are de novo combinations of NP fragments to target biologically relevant chemical space not covered by NPs. We ... ...

    Abstract Natural product (NP)-inspired design principles provide invaluable guidance for bioactive compound discovery. Pseudo-natural products (PNPs) are de novo combinations of NP fragments to target biologically relevant chemical space not covered by NPs. We describe the design and synthesis of apoxidoles, a novel pseudo-NP class, whereby indole- and tetrahydropyridine fragments are linked in monopodal connectivity not found in nature. Apoxidoles are efficiently accessible by an enantioselective [4+2] annulation reaction. Biological evaluation revealed that apoxidoles define a new potent type IV inhibitor chemotype of indoleamine 2,3-dioxygenase 1 (IDO1), a heme-containing enzyme considered a target for the treatment of neurodegeneration, autoimmunity and cancer. Apoxidoles target apo-IDO1, prevent heme binding and induce unique amino acid positioning as revealed by crystal structure analysis. Novel type IV apo-IDO1 inhibitors are in high demand, and apoxidoles may provide new opportunities for chemical biology and medicinal chemistry research.
    MeSH term(s) Amino Acids ; Biological Products/chemistry ; Biological Products/pharmacology ; Enzyme Inhibitors/chemistry ; Heme ; Indoleamine-Pyrrole 2,3,-Dioxygenase ; Indoles ; Pyrrolidines ; Structure-Activity Relationship
    Chemical Substances Amino Acids ; Biological Products ; Enzyme Inhibitors ; Indoleamine-Pyrrole 2,3,-Dioxygenase ; Indoles ; Pyrrolidines ; Heme (42VZT0U6YR)
    Language English
    Publishing date 2022-08-29
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202209374
    Database MEDical Literature Analysis and Retrieval System OnLINE

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