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  1. Article ; Online: An interesting case of a unilaterally dilated pupil.

    Gala, Payal Kadia / Henretig, Frederick M / Alpern, Elizabeth R / Sampayo, Esther M

    Pediatric emergency care

    2013  Volume 29, Issue 5, Page(s) 648–649

    Abstract: Facial lacerations from minor trauma are a common presenting complaint to the emergency department. With the increasing availability of topical anesthetics, there is a decrease in the need for injectable local anesthetic and sedation services, ... ...

    Abstract Facial lacerations from minor trauma are a common presenting complaint to the emergency department. With the increasing availability of topical anesthetics, there is a decrease in the need for injectable local anesthetic and sedation services, facilitating the ease of facial laceration repairs for young children. One such topical anesthetic is a widely used pharmacy preparation of lidocaine 4%-epinephrine 0.1%-tetracaine 0.5% gel (LET). Although the use of LET has decreased the need for injectable lidocaine and sedation for facial lacerations, both of which can be unpleasant for children with potentially life-threatening adverse events, it may still lead to unexpected and untoward adverse events. We explore here a little-known adverse effect of LET in a child who presented to a pediatric emergency department with an eyelid laceration after minor head trauma.
    MeSH term(s) Anesthetics, Local/adverse effects ; Anisocoria/chemically induced ; Anisocoria/diagnosis ; Brain Injuries/diagnosis ; Child, Preschool ; Diagnosis, Differential ; Epinephrine/administration & dosage ; Epinephrine/adverse effects ; Eye Foreign Bodies/complications ; Eye Foreign Bodies/diagnosis ; Eyelids/injuries ; Eyelids/surgery ; Facial Injuries/diagnosis ; Facial Injuries/therapy ; Gels ; Humans ; Hypnotics and Sedatives/therapeutic use ; Lidocaine/administration & dosage ; Lidocaine/adverse effects ; Male ; Orbital Fractures/complications ; Orbital Fractures/diagnostic imaging ; Oxycodone/therapeutic use ; Pneumocephalus/etiology ; Radiography ; Suture Techniques ; Tetracaine/administration & dosage ; Tetracaine/adverse effects ; Tonic Pupil/diagnosis
    Chemical Substances Anesthetics, Local ; Gels ; Hypnotics and Sedatives ; LET, anesthetic ; Tetracaine (0619F35CGV) ; Lidocaine (98PI200987) ; Oxycodone (CD35PMG570) ; Epinephrine (YKH834O4BH)
    Language English
    Publishing date 2013-05
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 632588-9
    ISSN 1535-1815 ; 0749-5161
    ISSN (online) 1535-1815
    ISSN 0749-5161
    DOI 10.1097/PEC.0b013e31828e9f39
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2083: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Childhood exposures to environmental chemicals and neurodevelopmental outcomes in congenital heart disease.

    Gaynor, J William / Burnham, Nancy B / Ittenbach, Richard F / Gerdes, Marsha / Bernbaum, Judy C / Zackai, Elaine / Licht, Daniel J / Russell, William W / Zullo, Erin E / Miller, Thomas / Hakonarson, Hakon / Clarke, Kayan A / Jarvik, Gail P / Calafat, Antonia M / Bradman, Asa / Bellinger, David C / Henretig, Frederick M / Coker, Eric S

    PloS one

    2022  Volume 17, Issue 11, Page(s) e0277611

    Abstract: Background: Children with congenital heart defects have an increased risk of neurodevelopmental disability. The impact of environmental chemical exposures during daily life on neurodevelopmental outcomes in toddlers with congenital heart defects is ... ...

    Abstract Background: Children with congenital heart defects have an increased risk of neurodevelopmental disability. The impact of environmental chemical exposures during daily life on neurodevelopmental outcomes in toddlers with congenital heart defects is unknown.
    Methods: This prospective study investigated the impacts of early childhood exposure to mixtures of environmental chemicals on neurodevelopmental outcomes after cardiac surgery. Outcomes were assessed at 18 months of age using The Bayley Scales of Infant and Toddler Development-III. Urinary concentrations of exposure biomarkers of pesticides, phenols, parabens, and phthalates, and blood levels of lead, mercury, and nicotine were measured at the same time point. Bayesian profile regression and weighted quantile sum regression were utilized to assess associations between mixtures of biomarkers and neurodevelopmental scores.
    Results: One-hundred and forty infants were enrolled, and 110 (79%) returned at 18 months of age. Six biomarker exposure clusters were identified from the Bayesian profile regression analysis; and the pattern was driven by 15 of the 30 biomarkers, most notably 13 phthalate biomarkers. Children in the highest exposure cluster had significantly lower adjusted language scores by -9.41 points (95%CI: -17.2, -1.7) and adjusted motor scores by -4.9 points (-9.5, -0.4) compared to the lowest exposure. Weighted quantile sum regression modeling for the overall exposure-response relationship showed a significantly lower adjusted motor score (β = -2.8 points [2.5th and 97.5th percentile: -6.0, -0.6]). The weighted quantile sum regression index weights for several phthalates, one paraben, and one phenol suggest their relevance for poorer neurodevelopmental outcomes.
    Conclusions: Like other children, infants with congenital heart defects are exposed to complex mixtures of environmental chemicals in daily life. Higher exposure biomarker concentrations were associated with significantly worse performance for language and motor skills in this population.
    MeSH term(s) Infant ; Humans ; Child, Preschool ; Prospective Studies ; Bayes Theorem ; Heart Defects, Congenital/chemically induced ; Heart Defects, Congenital/surgery ; Parabens ; Phenols ; Biomarkers
    Chemical Substances phthalic acid (6O7F7IX66E) ; Parabens ; Phenols ; Biomarkers
    Language English
    Publishing date 2022-11-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0277611
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Perioperative Exposure to Suspect Neurotoxicants From Medical Devices in Newborns With Congenital Heart Defects.

    Gaynor, J William / Ittenbach, Richard F / Calafat, Antonia M / Burnham, Nancy B / Bradman, Asa / Bellinger, David C / Henretig, Frederick M / Wehrung, Erin E / Ward, J Laurenson / Russell, William W / Spray, Thomas L

    The Annals of thoracic surgery

    2018  Volume 107, Issue 2, Page(s) 567–572

    Abstract: Background: Industrial chemicals are increasingly recognized as potential developmental neurotoxicants. Di(2-ethylhexyl) phthalate (DEHP), used to impart flexibility and temperature tolerance to polyvinylchloride, and bisphenol A (BPA), used to ... ...

    Abstract Background: Industrial chemicals are increasingly recognized as potential developmental neurotoxicants. Di(2-ethylhexyl) phthalate (DEHP), used to impart flexibility and temperature tolerance to polyvinylchloride, and bisphenol A (BPA), used to manufacture polycarbonate, are commonly present in medical devices. The magnitude of exposure in neonates during hospitalization for cardiac operations is unknown.
    Methods: We quantified urinary concentrations of DEHP metabolites and BPA preoperatively and postoperatively in neonates undergoing cardiac operations and their mothers. Urinary concentrations of these biomarkers reflect recent exposures (half-lives are approximately 6 to 24 hours). Biomarker concentrations in mothers' and infants' preoperative and postoperative samples were compared.
    Results: Operations were performed in 18 infants (mean age, 5 ± 4 [SD] days). The maternal sample was obtained on postpartum day 4 ± 4. The preoperative urine sample was obtained on day-of-life 4 ± 2 and the postoperative sample on day-of-life 6 ± 4. Mean maternal concentrations for DEHP metabolites and BPA were at the 50th percentile for females in the United States general population. Infant preoperative concentrations of 1 DEHP metabolite and BPA were significantly higher than maternal concentrations. Postoperative concentrations for all DEHP metabolites were significantly greater than preoperative concentrations.
    Conclusions: There is considerable perioperative exposure to DEHP and BPA for neonates undergoing cardiac operations. Infant concentrations for both BPA and DEHP metabolites were significantly higher than maternal concentrations, consistent with the infant's exposure to medical devices. Further study is needed to determine the potential role of these suspect neurotoxicants in the etiology of neurodevelopmental disability after cardiac operations.
    MeSH term(s) Benzhydryl Compounds/adverse effects ; Benzhydryl Compounds/urine ; Biomarkers/urine ; Diethylhexyl Phthalate/adverse effects ; Diethylhexyl Phthalate/urine ; Environmental Exposure/adverse effects ; Equipment and Supplies/adverse effects ; Female ; Follow-Up Studies ; Heart Defects, Congenital/surgery ; Heart Defects, Congenital/urine ; Humans ; Infant, Newborn ; Male ; Neurotoxins/adverse effects ; Neurotoxins/urine ; Phenols/adverse effects ; Phenols/urine ; Postoperative Period ; Preoperative Period ; Prospective Studies ; Risk Factors
    Chemical Substances Benzhydryl Compounds ; Biomarkers ; Neurotoxins ; Phenols ; Diethylhexyl Phthalate (C42K0PH13C) ; bisphenol A (MLT3645I99)
    Language English
    Publishing date 2018-07-30
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2018.06.035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 252: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Potential applications of proton nuclear magnetic resonance spectroscopy in the diagnosis and management of methanol intoxication in the pediatric population.

    Carpentieri, David F / Wherli, Suzanne / Pawel, Barbara / Henretig, Frederick M / Drott, Henry R

    Pediatric emergency care

    2003  Volume 19, Issue 3, Page(s) 178–180

    MeSH term(s) Accidents, Home ; Acidosis/chemically induced ; Blood Chemical Analysis/instrumentation ; Blood Chemical Analysis/methods ; Dyspnea/chemically induced ; Emergencies ; Formates/blood ; Formates/urine ; Humans ; Infant ; Magnetic Resonance Spectroscopy/instrumentation ; Male ; Methanol/blood ; Methanol/poisoning ; Methanol/urine ; Poisoning/blood ; Poisoning/urine ; Protons ; Sleep Stages ; Urinalysis/instrumentation ; Urinalysis/methods
    Chemical Substances Formates ; Protons ; formic acid (0YIW783RG1) ; Methanol (Y4S76JWI15)
    Language English
    Publishing date 2003-06
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 632588-9
    ISSN 1535-1815 ; 0749-5161
    ISSN (online) 1535-1815
    ISSN 0749-5161
    DOI 10.1097/01.pec.0000081237.98249.a4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2083: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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