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Article ; Online: Anticancer Potentials of the Lignan Magnolin

Md. Shimul Bhuia / Polrat Wilairatana / Raihan Chowdhury / Asraful Islam Rakib / Hossam Kamli / Ahmad Shaikh / Henrique D. M. Coutinho / Muhammad Torequl Islam

Molecules, Vol 28, Iss 3671, p

A Systematic Review

2023 Volume 3671

Abstract: Magnolin is a naturally occurring, multi-bioactive lignan molecule with inherent anticancer effects. This study aims to summarize the botanical origins and anticancer properties of magnolin. For this, a recent (as of March 2023) literature review was ... ...

Abstract	Magnolin is a naturally occurring, multi-bioactive lignan molecule with inherent anticancer effects. This study aims to summarize the botanical origins and anticancer properties of magnolin. For this, a recent (as of March 2023) literature review was conducted using various academic search engines, including PubMed, Springer Link, Wiley Online, Web of Science, Science Direct, and Google Scholar. All the currently available information about this phytochemical and its role in various cancer types has been gathered and investigated. Magnolin is a compound found in many different plants. It has been demonstrated to have anticancer activity in numerous experimental models by inhibiting the cell cycle (G1 and G2/M phase); inducing apoptosis; and causing antiinvasion, antimetastasis, and antiproliferative effects via the modulation of several pathways. In conclusion, magnolin showed robust anticancer activity against many cancer cell lines by altering several cancer signaling pathways in various non- and pre-clinical experimental models, making it a promising plant-derived chemotherapeutic option for further clinical research.
Keywords	lignan ; magnolin ; biological sources ; pharmacokinetic profile ; cancer cell lines ; Organic chemistry ; QD241-441
Subject code	610
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Phytochemical Profile of Asplenium aethiopicum (Burm. f.) Becherer Using HPTLC

Marimuthu alias Antonysamy Johnson / Janarthanan Gowtham / Narayanan Janakiraman / Tharmaraj Renisheya Joy Jeba Malar / Janaina E. Rocha / Henrique D. M. Coutinho

Separations, Vol 7, Iss 1, p

2020 Volume 8

Abstract: The present study was aimed to validate the phenolic, flavonoids, alkaloids and tannins profile of Aspleniuma ethiopicum (Burm. f.) Becherer methanolic extracts using HPTLC (High-performance thin-layer chromatography). The chromatographic separation ... ...

Abstract	: The present study was aimed to validate the phenolic, flavonoids, alkaloids and tannins profile of Aspleniuma ethiopicum (Burm. f.) Becherer methanolic extracts using HPTLC (High-performance thin-layer chromatography). The chromatographic separation was performed using the standard method. The separation methodology was optimized and phytoconstituents of A. aethiopicum methanolic extracts were separated. The methanolic extract of A. aethiopicum showed several bands identified as known phenolic compounds. The obtained flavonoids profiles were identified. HPTLC alkaloids profile of A. aethiopicum revealed 11 types of alkaloids. The tannin profile of methanolic extracts of A. aethiopicum demonstrated 11 different types of tannins. The observed profiles will be used as phytomarker to identify the chemical constituents of A. aethiopicum methanolic extracts. These profiles will act as a fingerprint of A. aethiopicum and help us to distinguish from its adulterants. The observed profile will help us to identify the crude drugs and improve the therapeutic potentials of A. aethiopicum .
Keywords	asplenium aethiopicum ; hptlc ; flavonoids ; alkaloids ; tannins ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	500
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Potentiation of the Activity of Antibiotics against ATCC and MDR Bacterial Strains with (+)-α-Pinene and (-)-Borneol

Nadghia F. Leite-Sampaio / Cicera N. F. L. Gondim / Rachel A. A. Martins / Abolghasem Siyadatpanah / Roghayeh Norouzi / Bonglee Kim / Celestina E. Sobral-Souza / Gonçalo E. C. Gondim / Jaime Ribeiro-Filho / Henrique D. M. Coutinho

BioMed Research International, Vol

2022 Volume 2022

Abstract: The increasing rates of antimicrobial resistance have demanded the development of new drugs as conventional antibiotics have become significantly less effective. Evidence has identified a variety of phytocompounds with the potential to be used in the ... ...

Abstract	The increasing rates of antimicrobial resistance have demanded the development of new drugs as conventional antibiotics have become significantly less effective. Evidence has identified a variety of phytocompounds with the potential to be used in the combat of infections caused by multidrug-resistant (MDR) bacteria. Considering the verification that terpenes are promising antibacterial compounds, the present research aimed to evaluate the antibacterial and antibiotic-modulating activity of (+)-α-pinene and (-)-borneol against MDR bacterial strains. The broth microdilution method was used to determine the minimum inhibitory concentration (MIC) of the compounds and antibiotics and further evaluate the intrinsic and associated antibiotic activity. These analyses revealed that (+)-α-pinene showed significant antibacterial activity only against E. coli (MIC=512 μg.mL−1), while no significant inhibition of S. aureus and P. aeruginosa growth was observed (MIC≥1024 μg mL−1). However, when combined with antibiotics, this compound induced a significant improvement in the activity of conventional antibiotics, as observed for ciprofloxacin, amikacin, and gentamicin against Staphylococcus aureus, as well as for amikacin and gentamicin against Escherichia coli, and amikacin against Pseudomonas aeruginosa. On the other hand, (-)-borneol was found to inhibit the growth of E. coli and enhance the antibiotic activity of ciprofloxacin and gentamicin against S. aureus. The present findings indicate that (+)-α-pinene and (-)-borneol are phytocompounds with the potential to be used in the combat of antibacterial resistance.
Keywords	Medicine ; R
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Antiemetic activity of trans-ferulic acid possibly through muscarinic receptors interaction pathway

Md. Shimul Bhuia / Hossam Kamli / Tawhida Islam / Fatema Akter Sonia / Md. Azim Kazi / Md. Sajjad Hossain Siam / Naimur Rahman / Mehedi Hasan Bappi / Md. Nayem Mia / Md. Munnaf Hossen / Daniel Luna Lucetti / Paulo Leonardo Celestino Oliveira / Henrique D.M. Coutinho / Muhammad Torequl Islam

Results in Chemistry, Vol 6, Iss , Pp 101014- (2023)

In vivo and in silico study

2023

Abstract: Current study was conducted to assess the effectiveness of the polyphenol trans-ferulic acid (TFA) as an antiemetic agent using in vivo and in silico methods. To evaluate this, we induced emesis in 3-day-old chicks through the oral administration of ... ...

Abstract	Current study was conducted to assess the effectiveness of the polyphenol trans-ferulic acid (TFA) as an antiemetic agent using in vivo and in silico methods. To evaluate this, we induced emesis in 3-day-old chicks through the oral administration of copper sulfate (CuSO4·5H2O) at a dose of 50 mg/kg. To ascertain the potential antiemetic mechanism of TFA, we employed various reference drugs such as domperidone (6 mg/kg), ondansetron (5 mg/kg), and hyoscine (21 mg/kg) as positive control groups, while the vehicle acted as a negative control group. TFA was administered orally at the doses of 25, 50 and 100 mg/kg body weight. Both the TFA and reference drug provided alone or in combined groups to assess their synergistic or antagonistic activity on the chicks. Molecular docking of TFA and the selected reference drugs was conducted against 5HT3, D2, H1, NK1, and mAChRs (M1-M5) receptors for determining binding affinity to the receptors. Active binding sites and drug-receptor interactions were predicted with the aid of various computational tools. Various pharmacokinetic features and drug-likeness of all the selected ligands were determined through the SwissADME online server. The results suggest that TFA diminishes the mean number of retches and enhances latency in the chicks at lower doses. In the combined drug therapy, TFA exhibited better antiemetic effects with ondansetron and hyoscine. In silico ADME proposed that TFA retains preferable drug-likeness and better pharmacokinetic properties to be a reliable lead. Additionally, TFA revealed the elevated binding affinity against mAChRs and the ligand (TFA) expressed the highest binding affinity (−7 kcal/mol) with the M5 receptor (6OL9). In conclusion, TFA demonstrated mild antiemetic effects in chicks, possibly through the mAChRs interaction pathway.
Keywords	Emesis ; Trans-ferulic acid ; Gallus gallus domesticus ; Molecular docking study ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of gallium and strontium salts on the characteristics and biological applications of Sr and Ga-modified titanate nanotubes

Raimundo L.S. Pereira / Ana C.J. de Araújo / Priscilla R. Freitas / Isaac M. Araújo / Sheila A. Gonçalves / Suziete B.S. Gusmão / Ramón R. Peña-Garcia / Yuset G. Dávila / Bartolomeu C. Viana / João H. da Silva / Irwin R.A. de Menezes / Henrique D.M. Coutinho / Alexandre M.R. Teixeira

Results in Chemistry, Vol 6, Iss , Pp 101162- (2023)

2023

Abstract: In this work, we report the synthesis of Na-TiNTs sodium titanate nanotubes prepared by the hydrothermal method in a highly alkaline subsequently modified by the substitution of Na+ ions present in the walls of the nanotubes by ions of Sr2+ and Ga3+ ... ...

Abstract	In this work, we report the synthesis of Na-TiNTs sodium titanate nanotubes prepared by the hydrothermal method in a highly alkaline subsequently modified by the substitution of Na+ ions present in the walls of the nanotubes by ions of Sr2+ and Ga3+ revealing the presence of phases such as SrOH2 and α-GaOOH through the analysis by X-ray diffraction. Raman spectroscopy showed the characteristic peaks of the vibrational modes of the titanate nanotube structure. UV–Vis analysis revealed a blueshift of absorption edge that leads to an increase in the bandgap with the insertion of Sr and Ga ions. The ion exchange causes a decrease in the Urbach energy, which suggests a certain attenuation in the concentration of structural defects.Through the SEM images it is observed the cluster of interwoven nanotubes it self is characteristic of titanate nanotubes and, the elemental mapping shows the complete efficiency of the reaction process of sodium ion exchange by strontium and gallium in the Sr-TiNT and Ga-TiNT samples respectively, showing the environment of the chemical composition of the surface with the presence of chemical elements such as Sr, Ga. The Na-TiNT, Sr-TiNT, and Ga-TiNT nanotubes did not show direct antibacterial activity against the tested strains. The Na, Ga, and Sr TiNTs of the ampicillin antibiotic exhibited significant values against the microorganism S. aureus 10 compared to the control antibiotic, thereby reducing its inhibitory concentration. The same was observed for gentamicin. The Na-TiNT, in combination with gentamicin, displayed a reduction in inhibitory concentration compared to the control for P. aeruginosa 24. In E. coli 06, the Na, Sr, and Ga TiNTs showed a reduction in concentration when combined with gentamicin, indicating a potential synergistic effect.
Keywords	Titanate nanotubes ; Ion exchange ; Antibacterial ; Potentiating ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Synthesis of Silver Nanoparticles Using Odontosoria chinensis (L.) J. Sm. and Evaluation of their Biological Potentials

Marimuthu Alias Antonysamy Johnson / Thangaiah Shibila / Santhanam Amutha / Irwin R.A. Menezes / José G.M. da Costa / Nadghia F. L. Sampaio / Henrique D.M. Coutinho

Pharmaceuticals, Vol 13, Iss 66, p

2020 Volume 66

Abstract: The present study was aimed to synthesize silver nanoparticles (AgNPs) from the aqueous extracts of Odontosoria chinensis (L.) J. Sm. and the synthesized AgNPs were examined for their biopotentials. The Odontosoria chinensis extracts were added to 1 mM ... ...

Abstract	The present study was aimed to synthesize silver nanoparticles (AgNPs) from the aqueous extracts of Odontosoria chinensis (L.) J. Sm. and the synthesized AgNPs were examined for their biopotentials. The Odontosoria chinensis extracts were added to 1 mM AgNO 3 solution with different ratios viz., 0.5: 9.5, 1:9, 1.5: 8.5 and 2: 8 ratios for the reduction of Ag ions. After reduction, the AgNPs of Odontosoria chinensis were analyzed spectroscopically for further confirmation. The synthesized AgNPs of Odontosoria chinensis were characterized by pH, ultra violet–visible spectroscopy (UV-Vis), Fourier transform–infra red spectroscopy (FT-IR), scanning electron microscopy-energy dispersive X-ray analysis (SEM-EDAX) and X-Ray diffraction (XRD). The time taken for the complete reduction of Silver (Ag) in solution to nanoparticle was 10 min. The O. chinensis aqueous extracts mediated silver nanoparticles showed a broad peak with distinct absorption at around 400–420 nm and confirmed the silver nanoparticle formation. FT-IR results also confirmed the existence of organic materials in the silver nanoparticles of O. chinensis . The EDX spectra of AgNPs of O. chinenesis revealed the occurrence of a strong Ag peak. The synthesis of AgNPs of O. chinenesis was confirmed with the existence of a peak at 46.228°. The toxic potential of AgNPs of O. chinenesis showed varied percentage mortality with the LC 50 values of 134.68 μL/ 50 mL and 76.5 μL/50 mL, respectively. The anti-inflammatory and anti-diabetic activities of aqueous and AgNPs of O. chinenesis were statistically significant at p < 0.05 level. Conclusion: The results demonstrated the toxicity, anti-diabetic and anti-inflammatory potential of the studied AgNPs . The synthesized nanoparticles of Odontosoria chinensis could be tested as an alternative to anticancer, anti-diabetic and anti-inflammatory drugs.
Keywords	anti-diabetic ; anti-inflammatory ; cytotoxic ; silver nanoparticles ; Odontosoria chinenesis ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
Subject code	500
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of hybrid combinations of Erythroxylum revolutum Mart. leaf ethanolic extract or alkaloid-enriched fraction with antibiotic drugs against multidrug-resistant bacteria strains

Maísa F.S. Barbosa / Paulo H.O. Miranda / Carlos A. Souza / Clécio S. Ramos / André L. Melo / Janaína E. Rocha / Camila F. Bezerra / Maria S. Costa / Helenicy N.H. Veras / Henrique D.M. Coutinho / Irwin R.A. Menezes / Rogério A. Saraiva

Phytomedicine Plus, Vol 1, Iss 4, Pp 100105- (2021)

2021

Abstract: Background The combination between antibiotic drugs and extracts derived from medicinal plants is one of the promising strategies against multidrug-resistant (MDR) bacterial strains to overwhelm the antimicrobial resistance.Hypothesis/Purpose We aimed to ...

Abstract	Background The combination between antibiotic drugs and extracts derived from medicinal plants is one of the promising strategies against multidrug-resistant (MDR) bacterial strains to overwhelm the antimicrobial resistance.Hypothesis/Purpose We aimed to evaluate the antibacterial effect of hybrid combinations of ethanolic extract (EREE) or alkaloid-enriched fraction (ERAF) obtained from Erythroxylum revolutum leaves and conventional antibiotic drugs.Methods We tested the antimicrobial activity of EREE and ERAF in vitro against gram-positive (Staphyloccocus aureus) and Gram-negative (Escherichia coli and Pseudomonas aeruginosa) standard and MDR strains. Additionally, we performed phytochemical studies using GC/MS, 1H, 13C NMR spectra, and two-dimensional techniques.Results Although the minimum inhibitory concentration (MIC) values of EREE or ERAF alone against bacterial growth were ≥ 1024 µg/ml, we denoted a total synergism effect in the hybrid combinations ERAF + gentamicin, ERAF + norfloxacin, and ERAF + erythromycin against MDR S. aureus strain, with a significant MIC reduction of 84.7%, 75.0%, and 89.85%, respectively. Although EREE demonstrated a total synergism effect in the hybrid combination gentamicin + EREE (with a significant decrease of MIC of 68.8%), on the contrary, EREE also elicited a strong antagonist effect in some hybrid combinations against the MDR bacteria strains tested. Phytochemical studies revealed in ERAF the presence of two tropane alkaloids described for the first time in the family Erythroxylaceae: 6-(2’-methylbutyryloxy)-3-hydroxytropane (87.07%) and 6-butyryloxy-3-hydroxytropane (12.93%).Conclusion Together, these data can highlight the first evidence of enriched-alkaloid fractions of E. revolutum in hybrid combinations with antibiotics, and propose tropane alkaloids from E. revolutum as new potential candidates in drug combinations for the treatment of infections caused by MDR S. aureus, which is one of the main agents causing infections with death worldwide.
Keywords	Natural products ; Synergism ; Erythroxylaceae ; Medicinal plants ; Microbial resistance ; Other systems of medicine ; RZ201-999
Subject code	630
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Antinociceptive Effect of a p-Cymene/β-Cyclodextrin Inclusion Complex in a Murine Cancer Pain Model

Wagner B. R. Santos / Lícia T. S. Pina / Marlange A. de Oliveira / Lucas A. B. O. Santos / Marcus V. A. Batista / Gabriela G. G. Trindade / Marcelo C. Duarte / Jackson R. G. S. Almeida / Lucindo J. Quintans-Júnior / Jullyana S. S. Quintans / Mairim R. Serafini / Henrique D. M. Coutinho / Grażyna Kowalska / Tomasz Baj / Radosław Kowalski / Adriana G. Guimarães

Molecules, Vol 28, Iss 4465, p

Characterization Aided through a Docking Study

2023 Volume 4465

Abstract: Pain is one of the most prevalent and difficult to manage symptoms in cancer patients, and conventional drugs present a range of adverse reactions. The development of β-cyclodextrins (β-CD) complexes has been used to avoid physicochemical and ... ...

Abstract	Pain is one of the most prevalent and difficult to manage symptoms in cancer patients, and conventional drugs present a range of adverse reactions. The development of β-cyclodextrins (β-CD) complexes has been used to avoid physicochemical and pharmacological limitations due to the lipophilicity of compounds such as p-Cymene (PC), a monoterpene with antinociceptive effects. Our aim was to obtain, characterize, and measure the effect of the complex of p-cymene and β-cyclodextrin (PC/β-CD) in a cancer pain model. Initially, molecular docking was performed to predict the viability of complex formation. Afterward, PC/β-CD was obtained by slurry complexation, characterized by HPLC and NMR. Finally, PC/β-CD was tested in a Sarcoma 180 (S180)-induced pain model. Molecular docking indicated that the occurrence of interaction between PC and β-CD is favorable. PC/β-CD showed complexation efficiency of 82.61%, and NMR demonstrated PC complexation in the β-CD cavity. In the S180 cancer pain model, PC/β-CD significantly reduced the mechanical hyperalgesia, spontaneous nociception, and nociception induced by non-noxious palpation at the doses tested ( p < 0.05) when compared to vehicle differently from free PC ( p > 0.05). Therefore, the complexation of PC in β-CD was shown to improve the pharmacological effect of the drug as well as reducing the required dose.
Keywords	cancer pain ; natural products ; monoterpenes ; inclusion complex ; Organic chemistry ; QD241-441
Subject code	540
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Isolation of phytosterols of Dalbergia ecastophyllum (L.) Taub. (Leguminosae) and modulation of antibiotic resistance by a possible membrane effect

Gláucia M.M. Guedes / Rosimeire S. Albuquerque / Rafela S. Soares-Maciel / Maria A. Freitas / Viviane A. Silva / Edeltrudes O. Lima / Micheline A. Lima / Emidio V.L. Cunha / Henrique D.M. Coutinho

Arabian Journal of Chemistry, Vol 12, Iss 7, Pp 1576-

2019 Volume 1580

Abstract: Globally there are a larger number of strains of microorganisms resistant to multiple drugs mainly due to misuse and indiscriminate, resulting in increased morbidity, costs inherent benefits of health care, as well as mortality rates for infections. As a ...

Abstract	Globally there are a larger number of strains of microorganisms resistant to multiple drugs mainly due to misuse and indiscriminate, resulting in increased morbidity, costs inherent benefits of health care, as well as mortality rates for infections. As a result of this a large number of researches have been conducted emphasizing the antimicrobial properties of plant products. In this study, the ethanol extract and hexane fraction of Dalbergia ecastophyllum (L.) Taub. (Leguminosae) have been used to evaluate the antibacterial and antifungal activity and for modulating the resistance of antimicrobials against bacterial strains of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans and fungal strains of Candida krusei, Candida tropicalis. The antibacterial and modulatory activity was determined by microdilution. Inhibition of the growth of bacteria and fungi tested extract was ⩾1024. The activity was enhanced when aminoglycosides were associated with sub-inhibitory concentrations of the ethanol extract and hexane fraction of Dalbergia ecastophyllum. Therefore, it is suggested that the ethanol extract and hexane fraction of Dalbergia ecastophyllum (L.) Taub. (Leguminosae) can be used as a source of natural products with a view to changing the resistance of these microorganisms to antimicrobials. Keywords: Microbial resistance, Dalbergia ecastophyllum, Antibacterial activity, Antifungal activity, Modulation
Keywords	Chemistry ; QD1-999
Subject code	571
Language	English
Publishing date	2019-11-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: LC-MS characterization and reduction of the phytotoxic effect of aluminium by natural products from Eugenia jambolana Lam

Sousa, Amanda K / Celestina E. Sobral – Souza / Larissa A. Rolim / Ana R.P. Silva / Nadghia F. Leite / Janaina E. Rocha / Henrique D.M. Coutinho

Applied geochemistry. 2018 Nov., v. 98

2018

Abstract: The objective of this study was to quantify the flavonoids present in the Eugenia jambolana Lam extract and fractions, identify their composition by LC-MS, to determine the cytoprotective potential against aluminium Chloride toxicity in a prokaryotic and ...

Abstract	The objective of this study was to quantify the flavonoids present in the Eugenia jambolana Lam extract and fractions, identify their composition by LC-MS, to determine the cytoprotective potential against aluminium Chloride toxicity in a prokaryotic and eukaryotic model, as well as the mechanism of cytoprotection of the extract and fractions. The ethanolic extract from E. jambolana, as well as its tannic and flavonoid fractions, were tested and the minimum bactericidal and fungicidal concentration of the products associated with aluminum chloride in different concentrations were established. These same products were used in the germination of lettuce seeds (Lactuva sativa). The extract and fractions did not show cytoprotective activity in bacterial and fungal models, since it was not able to interfere with the growth profile of these microorganisms. In relation to the vegetal model, it was possible to observe significant effects on caulis and lettuce radicle growth, as well as on the dry weight of radicles, showing a cytoprotective effect capable of inhibiting the aluminum chloride toxicity at different concentrations. In this way, due to the problems faced with aluminum contamination and the characteristics of the soils the E. jambolana extract may show an alternative to the toxicity of this metal.
Keywords	Syzygium cumini ; aluminum ; aluminum chloride ; flavonoids ; fungi ; geochemistry ; germination ; lettuce ; liquid chromatography ; mass spectrometry ; models ; phytotoxicity ; seeds ; soil
Language	English
Dates of publication	2018-11
Size	p. 191-196.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1499242-5
ISSN	0883-2927
ISSN	0883-2927
DOI	10.1016/j.apgeochem.2018.09.010
Database	NAL-Catalogue (AGRICOLA)

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