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  1. Article ; Online: The experiences of COVID-19 preprint authors: a survey of researchers about publishing and receiving feedback on their work during the pandemic.

    Rzayeva, Narmin / Henriques, Susana Oliveira / Pinfield, Stephen / Waltman, Ludo

    PeerJ

    2023  Volume 11, Page(s) e15864

    Abstract: The COVID-19 pandemic caused a rise in preprinting, triggered by the need for open and rapid dissemination of research outputs. We surveyed authors of COVID-19 preprints to learn about their experiences with preprinting their work and also with ... ...

    Abstract The COVID-19 pandemic caused a rise in preprinting, triggered by the need for open and rapid dissemination of research outputs. We surveyed authors of COVID-19 preprints to learn about their experiences with preprinting their work and also with publishing their work in a peer-reviewed journal. Our research had the following objectives: 1. to learn about authors' experiences with preprinting, their motivations, and future intentions; 2. to consider preprints in terms of their effectiveness in enabling authors to receive feedback on their work; 3. to compare the impact of feedback on preprints with the impact of comments of editors and reviewers on papers submitted to journals. In our survey, 78% of the new adopters of preprinting reported the intention to also preprint their future work. The boost in preprinting may therefore have a structural effect that will last after the pandemic, although future developments will also depend on other factors, including the broader growth in the adoption of open science practices. A total of 53% of the respondents reported that they had received feedback on their preprints. However, more than half of the feedback was received through "closed" channels-privately to the authors. This means that preprinting was a useful way to receive feedback on research, but the value of feedback could be increased further by facilitating and promoting "open" channels for preprint feedback. Almost a quarter of the feedback received by respondents consisted of detailed comments, showing the potential of preprint feedback to provide valuable comments on research. Respondents also reported that, compared to preprint feedback, journal peer review was more likely to lead to major changes to their work, suggesting that journal peer review provides significant added value compared to feedback received on preprints.
    MeSH term(s) Humans ; Feedback ; Pandemics ; COVID-19/epidemiology ; Learning ; Publishing
    Language English
    Publishing date 2023-08-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2703241-3
    ISSN 2167-8359 ; 2167-8359
    ISSN (online) 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.15864
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Compilation of Evidence Supporting the Role of a T Helper 2 Reaction in the Pathogenesis of Acute Appendicitis.

    Carvalho, Nuno / Barreira, Ana Lúcia / Henriques, Susana / Ferreira, Margarida / Cardoso, Carlos / Luz, Carlos / Costa, Paulo Matos

    International journal of molecular sciences

    2024  Volume 25, Issue 8

    Abstract: Despite being the most common abdominal surgical emergency, the cause of acute appendicitis (AA) remains unclear, since in recent decades little progress has been made regarding its etiology. Obstruction of the appendicular lumen has been traditionally ... ...

    Abstract Despite being the most common abdominal surgical emergency, the cause of acute appendicitis (AA) remains unclear, since in recent decades little progress has been made regarding its etiology. Obstruction of the appendicular lumen has been traditionally presented as the initial event of AA; however, this is often the exception rather than the rule, as experimental data suggest that obstruction is not an important causal factor in AA, despite possibly occurring as a consequence of the inflammatory process. Type I hypersensitivity reaction has been extensively studied, involving Th2 lymphocytes, and cytokines such as IL-4, IL-5, IL-9 and IL-13, which have well-defined functions, such as a positive-feedback effect on Th0 for differentiating into Th2 cells, recruitment of eosinophils and the release of eosinophilic proteins and the production of IgE with the activation of mast cells, with the release of proteins from their granules. Cytotoxic activity and tissue damage will be responsible for the clinical manifestation of the allergy. AA histological features are similar to those found in allergic reactions like asthma. The intestine has all the components for an allergic immune response. It has contact with hundreds of antigens daily, most of them harmless, but some can potentially induce an allergic response. In recent years, researchers have been trying to assess if allergy is a component of AA, with their latest advances in the understanding of AA as a Th2 reaction shown by the authors of this article.
    MeSH term(s) Humans ; Th2 Cells/immunology ; Appendicitis/immunology ; Appendicitis/pathology ; Appendicitis/etiology ; Animals ; Cytokines/metabolism ; Acute Disease
    Chemical Substances Cytokines
    Language English
    Publishing date 2024-04-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25084216
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Multicenter randomized controlled trial of the effects of individual reminiscence therapy on cognition, depression and quality of life: Analysis of a sample of older adults with Alzheimer's disease and vascular dementia.

    Pérez-Sáez, Enrique / Justo-Henriques, Susana I / Alves Apóstolo, João L

    The Clinical neuropsychologist

    2021  Volume 36, Issue 7, Page(s) 1975–1996

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Aged ; Alzheimer Disease/complications ; Alzheimer Disease/therapy ; Cognition ; Dementia ; Dementia, Vascular/complications ; Dementia, Vascular/therapy ; Depression/therapy ; Humans ; Neuropsychological Tests ; Quality of Life/psychology ; Single-Blind Method
    Language English
    Publishing date 2021-01-19
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 639080-8
    ISSN 1744-4144 ; 0920-1637 ; 1385-4046
    ISSN (online) 1744-4144
    ISSN 0920-1637 ; 1385-4046
    DOI 10.1080/13854046.2021.1871962
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Home-Based Individualized Cognitive Stimulation (iCS) Therapy in Portuguese Psychiatric Patients: A Randomized Controlled Trial.

    Justo-Henriques, Susana I / Pérez-Sáez, Enrique / Carvalho, Janessa O / Cavallo, Marco / Sargaço, Paula

    Brain sciences

    2022  Volume 12, Issue 12

    Abstract: Cognitive difficulties are common in people with mental health issues, including psychotic disorders, although this population may have difficulty accessing treatments due to various challenges, including transportation, remembering appointments, or ... ...

    Abstract Cognitive difficulties are common in people with mental health issues, including psychotic disorders, although this population may have difficulty accessing treatments due to various challenges, including transportation, remembering appointments, or discomfort in crowded or unfamiliar places. Home-based services can be crucial and effective for reaching populations with accessibility issues; one home-based intervention technique is individual cognitive stimulation (iCS), which has been shown to be an effective strategy to target and improve cognitive functioning in various samples. Using a previously established Portuguese iCS protocol, based on an initial brief cognitive assessment and the subsequent administration of cognitive stimulation materials and reflection exercises, the current randomized controlled trial explored the effectiveness of the iCS intervention on participants in Portugal with psychotic disorders. Outcome tools included measures of cognition, depression, quality of life, and functional abilities at baseline, the completion of the intervention, and post-intervention follow-up. With two well-matched groups at baseline, the results revealed significant improvements in the intervention group on cognitive functioning, depression, quality of life, and, more modestly, functional activities. These results offer an important contribution to the field of iCS protocols, in an effort to enhance the lives and well-being of various clinical populations, including those with psychotic disorders.
    Language English
    Publishing date 2022-12-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci12121655
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Effectiveness of a year-long individual cognitive stimulation program in Portuguese older adults with cognitive impairment.

    Justo-Henriques, Susana I / Pérez-Sáez, Enrique / Marques-Castro, Ana E / Carvalho, Janessa O

    Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition

    2022  Volume 30, Issue 3, Page(s) 321–335

    Abstract: Cognitive stimulation is a recommended therapy with positive effects on the cognitive performance of older adults with neurocognitive disorders. However, there are few one-on-one, long-term interventions applied by professionals. The aim of the present ... ...

    Abstract Cognitive stimulation is a recommended therapy with positive effects on the cognitive performance of older adults with neurocognitive disorders. However, there are few one-on-one, long-term interventions applied by professionals. The aim of the present study was to determine the effectiveness of 47-week individual cognitive stimulation (iCS) interventions on cognition, mood, instrumental activities of daily living, and quality of life in older adults, with neurocognitive disorders using a single-blind, randomized, parallel two-arm RCT. A sample of 59 older adults with neurocognitive disorders (predominantly Alzheimer's disease), who were non-institutionalized but socially vulnerable, was selected. The intervention group (n = 30) received 47 iCS weekly sessions. The control group (n = 29) maintained their baseline treatments. Outcomes were global cognitive function, cognitive impairment, mood, instrumental activities of daily living, and self-reported quality of life. All participants were assessed at baseline, 25 weeks, and 50 weeks. The results showed a significant effect of the intervention on MMSE, MoCA, GDS-15. Individual cognitive stimulation may have beneficial effects on the cognitive function and mood of older adults with cognitive impairment.
    MeSH term(s) Aged ; Humans ; Activities of Daily Living ; Cognition ; Cognitive Dysfunction ; Portugal ; Quality of Life/psychology ; Single-Blind Method
    Language English
    Publishing date 2022-01-11
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1482447-4
    ISSN 1744-4128 ; 1382-5585
    ISSN (online) 1744-4128
    ISSN 1382-5585
    DOI 10.1080/13825585.2021.2023458
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Clinical Outcomes of Micropulse Transscleral Cyclophotocoagulation: 2 Years of Experience in Portuguese Eyes.

    Basto, Rita C / Almeida, Júlio / Roque, Joana N / Henriques, Susana P / Gonçalves, Ana S / Vaz, Fernando T / Carvalho, Helena / Prieto, Isabel

    Journal of current glaucoma practice

    2023  Volume 17, Issue 1, Page(s) 30–36

    Abstract: Aim: This study evaluates the safety and efficacy of micropulse transscleral cyclophotocoagulation (MPTSCPC) in glaucoma patients, with standard parameters, over a 24-month period.: Methods: Retrospective analysis of 61 eyes undergoing MPTSCPC from ... ...

    Abstract Aim: This study evaluates the safety and efficacy of micropulse transscleral cyclophotocoagulation (MPTSCPC) in glaucoma patients, with standard parameters, over a 24-month period.
    Methods: Retrospective analysis of 61 eyes undergoing MPTSCPC from January 2018 to December 2020 was carried out. Patients received 160 seconds of laser, with settings of 2000 mW/cm
    Results: A total of 61 eyes were included, arranged in an age distribution of 73.9 ± 10.8 years. The most frequent diagnosis was primary open-angle glaucoma (POAG), with a mean best-corrected visual acuity (BCVA) of 5/10 in the Snellen Visual chart. Around 37.7% of the eyes had undergone at least one glaucoma filtration surgery prior to MPTSCPC. The mean pretreatment intraocular pressure (IOP) was 24.9 ± 8.6 mm Hg. Except for the contrast at 24 months, at every other follow-up visit, there was a significant reduction (
    Conclusions: Micropulse transscleral cyclophotocoagulation (MPTSCPC) is an effective and safe procedure for reducing IOP within a broad spectrum of glaucoma patients. Additional studies are needed to confirm the current indications, widen their scope, and determine the optimal treatment settings on an individual basis.
    How to cite this article: Basto RC, Almeida J, Roque JN,
    Language English
    Publishing date 2023-05-25
    Publishing country India
    Document type Journal Article
    ISSN 0974-0333
    ISSN 0974-0333
    DOI 10.5005/jp-journals-10078-1395
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Reliability and Validity of the Geriatric Depression Scale in a Sample of Portuguese Older Adults with Mild-to-Moderate Cognitive Impairment.

    Justo-Henriques, Susana I / Pérez-Sáez, Enrique / Carvalho, Janessa O / Bobrowicz-Campos, Elzbieta / Apóstolo, João L Alves / Otero, Patricia / Vázquez, Fernando L

    Brain sciences

    2023  Volume 13, Issue 8

    Abstract: Although the Geriatric Depression Scale (GDS) is a well-established instrument for the assessment of depressive symptoms in older adults, this has not been validated specifically for Portuguese older adults with cognitive impairment. The objective of ... ...

    Abstract Although the Geriatric Depression Scale (GDS) is a well-established instrument for the assessment of depressive symptoms in older adults, this has not been validated specifically for Portuguese older adults with cognitive impairment. The objective of this study was to analyze the psychometric properties of two Portuguese versions of the GDS (GDS-27 and GDS-15) in a sample of Portuguese older adults with mild-to-moderate cognitive impairment. Clinicians assessed for major depressive disorder and cognitive functioning in 117 participants with mild-to-moderate cognitive decline (76.9% female, M
    Language English
    Publishing date 2023-08-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci13081160
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  8. Article ; Online: Tryptase in Acute Appendicitis: Unveiling Allergic Connections through Compelling Evidence.

    Carvalho, Nuno / Carolino, Elisabete / Ferreira, Margarida / Coelho, Hélder / Santos, Catarina Rolo / Barreira, Ana Lúcia / Henriques, Susana / Cardoso, Carlos / Moita, Luís / Costa, Paulo Matos

    International journal of molecular sciences

    2024  Volume 25, Issue 3

    Abstract: The aetiology of acute appendicitis (AA), the most frequent abdominal surgical emergency, is still unclarified. Recent epidemiologic, clinical and laboratorial data point to an allergic component in the pathophysiology of AA. Mastocytes participate in ... ...

    Abstract The aetiology of acute appendicitis (AA), the most frequent abdominal surgical emergency, is still unclarified. Recent epidemiologic, clinical and laboratorial data point to an allergic component in the pathophysiology of AA. Mastocytes participate in the Th2 immune response, releasing inflammatory mediators from their granules upon stimulation by IgE-specific antigens. Among the well-known mediators are histamine, serotonin and tryptase, which are responsible for the clinical manifestations of allergies. We conducted a prospective single-centre study to measure histamine and serotonin (commercial ELISA kit) and tryptase (ImmunoCAP System) concentrations in appendicular lavage fluid (ALF) and serum. Consecutive patients presenting to the emergency department with a clinical diagnosis of AA were enrolled: 22 patients with phlegmonous AA and 24 with gangrenous AA The control group was composed of 14 patients referred for colectomy for colon malignancy. Appendectomy was performed during colectomy. Tryptase levels were strikingly different between histological groups, both in ALF and serum (
    MeSH term(s) Humans ; Appendicitis/diagnosis ; Appendicitis/surgery ; Appendicitis/etiology ; Tryptases ; Histamine ; Prospective Studies ; Serotonin ; Hypersensitivity/complications
    Chemical Substances Tryptases (EC 3.4.21.59) ; Histamine (820484N8I3) ; Serotonin (333DO1RDJY)
    Language English
    Publishing date 2024-01-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25031645
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  9. Article ; Online: "Slam Sex" - Sexualized Injecting Drug Use ("SIDU") Amongst Men Who Have Sex with Men (MSM)-A Scoping Review.

    Scheibein, Florian / Wells, John / Henriques, Susana / Van Hout, Marie Claire

    Journal of homosexuality

    2020  Volume 68, Issue 14, Page(s) 2344–2358

    Abstract: Sexualized injecting drug use ("SIDU") is a phenomenon associated with a wide array of high-risk injecting and sex-related practices. This scoping review establishes what is known about MSM and SIDU to assess implications for health care and policy. ... ...

    Abstract Sexualized injecting drug use ("SIDU") is a phenomenon associated with a wide array of high-risk injecting and sex-related practices. This scoping review establishes what is known about MSM and SIDU to assess implications for health care and policy.  Characteristics of MSM for "SIDU" may include being on anti-retroviral treatment and urban residency with drivers being challenging social taboos; a search for intimacy; convenience of administration; relationship breakdown and increased restrictions in clubs and saunas. Attraction for use appears to be enhancement or prolongation of sexual experiences/pleasure; intimacy and the facilitation of a range of potentially "unsafe" sexual activity. Traditional services are ill-equipped to address "SIDU" because of a lack of knowledge of practices, lack of associated vocabulary, and a failure to integrate sexual health with drug services. For effective responses, these issues need to be addressed.
    MeSH term(s) HIV Infections/drug therapy ; Homosexuality, Male ; Humans ; Male ; Pharmaceutical Preparations ; Risk-Taking ; Sexual Behavior ; Sexual and Gender Minorities ; Unsafe Sex
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2020-09-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 193138-6
    ISSN 1540-3602 ; 0091-8369
    ISSN (online) 1540-3602
    ISSN 0091-8369
    DOI 10.1080/00918369.2020.1804258
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  10. Article ; Online: Multicentre randomised controlled trial about the effect of individual reminiscence therapy in older adults with neurocognitive disorders.

    Justo-Henriques, Susana I / Pérez-Sáez, Enrique / Alves Apóstolo, João L

    International journal of geriatric psychiatry

    2020  Volume 36, Issue 5, Page(s) 704–712

    Abstract: Objectives: To evaluate the effectiveness of a 13-week individual reminiscence therapy (RT) intervention to improve the overall cognitive function, memory, executive function, mood and quality of life (QoL) of people with neurocognitive disorders.: ... ...

    Abstract Objectives: To evaluate the effectiveness of a 13-week individual reminiscence therapy (RT) intervention to improve the overall cognitive function, memory, executive function, mood and quality of life (QoL) of people with neurocognitive disorders.
    Methods: A single-blind, multicentre, randomised parallel two-arm controlled trial recruited 251 people with neurocognitive disorders attending 24 institutions providing care and support services for older adults in Portugal. The primary outcome measure was cognitive function (Mini-Mental State Examination [MMSE]). Secondary outcomes were memory (Memory Alteration Test [MAT]), executive function (Frontal Assessment Battery [FAB]), mood (Geriatric Depression Scale-15 [GDS-15]) and self-reported QoL-Alzheimer's disease AD). Participants in the intervention group (n = 131) received 26 individual RT sessions, twice a week, over the course of 13 weeks. Participants in the control group (n = 120) maintained their treatment as usual.
    Results: Intention-to-treat analysis showed that, at endpoint assessment, the intervention group had significantly improved in relation to the control group in MMSE (mean difference 1.84, 95% CI [0.80, 2.89], p = .001, d = .44), MAT (mean difference 2.82, 95% CI [0.72, 4.91], p = .009, d = .34) and QoL-AD (mean difference 1.78, 95% CI [0.17, 3.39], p = .031, d = .28). Non-significant improvements were found on FAB (mean difference 0.74, 95% CI [-0.04, 1.52], p = .062, d = .24) and GDS-15 (mean difference -0.63, 95% CI [-1.45, 0.19], p = .130, d = .19).
    Conclusions: For people with neurocognitive disorders attending social care and support services, the individual RT designed for this trial should be considered an intervention with the potential to improve cognition, memory and QoL.
    MeSH term(s) Aged ; Dementia ; Humans ; Portugal ; Psychotherapy ; Quality of Life ; Single-Blind Method
    Language English
    Publishing date 2020-11-17
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 806736-3
    ISSN 1099-1166 ; 0885-6230
    ISSN (online) 1099-1166
    ISSN 0885-6230
    DOI 10.1002/gps.5469
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