Article: White Matter Hyperintensities and Cerebral Microbleeds in Ataxia-Telangiectasia.
2021 Volume 7, Issue 6, Page(s) e640
Abstract: Background and objectives: To systematically assess the occurrence of cerebral microbleeds (CMBs) and white matter hyperintensities (WMHs) in the largest published cohort of adults with ataxia-telangiectasia (AT).: Methods: We assessed 38 adults with ...
| Abstract | Background and objectives: To systematically assess the occurrence of cerebral microbleeds (CMBs) and white matter hyperintensities (WMHs) in the largest published cohort of adults with ataxia-telangiectasia (AT). Methods: We assessed 38 adults with AT (age range 18-55 years) including 15 classic and 23 variant AT, evaluated by two independent assessors. WMHs were quantified on T2-fluid attenuated inversion recovery images using the semiquantitative modified Scheltens and Fazekas scales and CMB on susceptibility-weighted imaging and T2*-weighted gradient echo sequences using the Brain Observer MicroBleed Scale. Results: CMBs were more frequently found in classic AT compared with variant AT (66.7% vs 5.9%) predominantly in cortical and subcortical regions. WMHs were seen in 25 (73.5%) probands and CMBs in 9 (31.0%). The burden of WMHs increased with age, and WMHs were focused in periventricular and deep white matter regions. WMHs were more frequently seen in variant than classic AT. Discussion: This cohort study confirms that WMHs and CMBs are a frequent finding in AT. Further longitudinal studies are required to understand how WMHs and CMBs relate to the neurodegeneration that occurs in AT and the predisposition to cerebral hemorrhage. |
|---|---|
| Language | English |
| Publishing date | 2021-11-30 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 2818607-2 |
| ISSN | 2376-7839 |
| ISSN | 2376-7839 |
| DOI | 10.1212/NXG.0000000000000640 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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