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Article ; Online: Authors' Reply: Risk Factors for Mortality and Morbidity in Elderly Patients Presenting with Digestive Surgical Emergencies.

Hentati, Hassen / Lim, Chetana / Salloum, Chady / Azoulay, Daniel

2018 Volume 42, Issue 12, Page(s) 4129

MeSH term(s)	Aged ; Digestive System Surgical Procedures ; Emergencies ; Humans ; Morbidity ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2018-06-26
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	224043-9
ISSN	1432-2323 ; 0364-2313
ISSN (online)	1432-2323
ISSN	0364-2313
DOI	10.1007/s00268-018-4701-z
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Article ; Online: Extensive lethal gas diffusion complicating a 'benign' disease.

Hentati, Hassen / Petrucciani, Niccolò / Urciuoli, Irene / de'Angelis, Nicola / Naanaa, Tarek / Najah, Haythem

ANZ journal of surgery

2019 Volume 90, Issue 3, Page(s) 391–392

MeSH term(s)	Aged, 80 and over ; Diverticulosis, Colonic/complications ; Diverticulosis, Colonic/diagnostic imaging ; Diverticulosis, Colonic/surgery ; Fatal Outcome ; Humans ; Intestinal Perforation/complications ; Intestinal Perforation/diagnostic imaging ; Intestinal Perforation/surgery ; Male ; Mediastinal Emphysema/diagnostic imaging ; Mediastinal Emphysema/etiology ; Mediastinal Emphysema/surgery ; Pneumoperitoneum/diagnostic imaging ; Pneumoperitoneum/etiology ; Pneumoperitoneum/surgery ; Subcutaneous Emphysema/diagnostic imaging ; Subcutaneous Emphysema/etiology ; Subcutaneous Emphysema/surgery ; Tomography, X-Ray Computed
Language	English
Publishing date	2019-05-08
Publishing country	Australia
Document type	Case Reports ; Journal Article
ZDB-ID	2050749-5
ISSN	1445-2197 ; 1445-1433 ; 0004-8682
ISSN (online)	1445-2197
ISSN	1445-1433 ; 0004-8682
DOI	10.1111/ans.15172
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Article ; Online: Short-term outcomes of da Vinci Xi versus Si robotic systems for minor hepatectomies.

Bianchi, Giorgio / De'Angelis, Nicola / Musa, Nicola / Beghdadi, Nassiba / Hentati, Hassen / Ammendola, Michele / Inchingolo, Riccardo / Laurent, Alexis / Sommacale, Daniele / Memeo, Riccardo

Acta bio-medica : Atenei Parmensis

2022 Volume 93, Issue 5, Page(s) e2022223

Abstract: Background: In the recent years, robotic technology has been drastically improved and the last generation of robotic platforms is hardly comparable with the earlier ones. The present study aims to investigate the short-term outcomes of minor ... ...

Abstract	Background: In the recent years, robotic technology has been drastically improved and the last generation of robotic platforms is hardly comparable with the earlier ones. The present study aims to investigate the short-term outcomes of minor hepatectomies performed with da Vinci Xi surgical system vs. Si surgical systems. Methods: Consecutive patients operated on between 2013 and 2020 in two referral centers were selected if underwent elective robotic minor hepatectomy (<3 consecutive segments) for primarily resectable benign or malignant lesions. Operative, postoperative, and cost outcomes were compared between the two groups by univariate and multivariate analyses. Results: Eighty-nine patients were selected (64 in the Si system vs. 25 in the Xi system group). Wedge resection was the most commonly performed procedure (49.4%). The Si system group showed a significantly greater total incisional length (+8.99 mm; p<0.0001) related to the use of a higher number of robotic/laparoscopic ports. Pedicle clamping was more frequent in patients operated on by the Xi system (80% vs. 21.9%; p<0.0001) but without group differences in ischemia duration when clamping. A significantly shorter time to flatus (-0.75 days; p=0.015) was observed for patients operated on by the Xi system, whereas no group differences were found for operative time, conversion rate, estimated blood loss, postoperative complications, mortality, use of analgesics, and costs. Conclusion: The da Vinci Xi system represents a technological advancement with a potential clinical relevance, although further studies are needed to clearly detect the clinical impact of the use of this robotic platform in liver surgery.
MeSH term(s)	Humans ; Robotic Surgical Procedures/methods ; Hepatectomy ; Treatment Outcome ; Operative Time ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Retrospective Studies
Language	English
Publishing date	2022-10-26
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2114240-3
ISSN	2531-6745 ; 0392-4203
ISSN (online)	2531-6745
ISSN	0392-4203
DOI	10.23750/abm.v93i5.12851
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Article ; Online: Mesh repair versus non-mesh repair for strangulated inguinal hernia: systematic review with meta-analysis.

Hentati, Hassen / Dougaz, Wajih / Dziri, Chadli

World journal of surgery

2014 Volume 38, Issue 11, Page(s) 2784–2790

Abstract: Background: The optimal technique to cure strangulated inguinal hernia remains controversial. The use of mesh in cases of strangulated hernia is still debated due to the potential risk of infection.: Objective: This systematic review aimed to ... ...

Abstract	Background: The optimal technique to cure strangulated inguinal hernia remains controversial. The use of mesh in cases of strangulated hernia is still debated due to the potential risk of infection. Objective: This systematic review aimed to determine whether or not the mesh repair technique is associated with a higher risk of surgical site infection than non-mesh techniques for strangulated inguinal hernias in adults. Methods: An electronic search of the relevant literature was performed on 15 December 2012 using the following databases: MEDLINE, the Cochrane Library, Scopus, Embase, and the Web of Science. Articles reporting a comparison between the mesh repair technique and a non-mesh technique to treat strangulated inguinal hernias in adults, and published in the English or French language in a peer-reviewed journal, were considered for analysis. The quality of randomized controlled trials (RCTs) was assessed using the Jadad scoring system. To assess the quality of non-randomized trials, we used the Methodological Index for Non-Randomized Studies (MINORS). Results: A total of 232 papers was found in the initial search; nine were included in the meta-analysis. The wound infection rate in the mesh repair technique group was lower than in the control group, with a trend towards significance (odds ratio [OR] 0.46, 95 % confidence interval [CI] 0.20-1.07; p = 0.07). The hernia recurrence rate was lower in the mesh repair group (OR 0.2, 95 % CI 0.05-0.78; p = 0.02). Conclusion: The mesh repair technique is a good option for the treatment of strangulated inguinal hernias in adults, giving an acceptable wound infection rate and fewer recurrences than non-mesh repair. Our study does not allow us to recommend the use of mesh in cases of bowel resection. We emphasize that, except the two RCTs, the results are predicated on patient selection bias by careful surgeons. Further RCTs are required to obtain more powerful evidence-based data.
MeSH term(s)	Adult ; Female ; Hernia, Inguinal/complications ; Hernia, Inguinal/surgery ; Humans ; Recurrence ; Surgical Mesh ; Surgical Wound Infection/epidemiology
Language	English
Publishing date	2014-08-20
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	224043-9
ISSN	1432-2323 ; 0364-2313
ISSN (online)	1432-2323
ISSN	0364-2313
DOI	10.1007/s00268-014-2710-0
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Article ; Online: Risk Factors for Mortality and Morbidity in Elderly Patients Presenting with Digestive Surgical Emergencies.

Hentati, Hassen / Salloum, Chady / Caillet, Philippe / Lahat, Eylon / Disabato, Mara / Levesque, Eric / Compagnon, Philippe / Lim, Chetana / Azoulay, Daniel

World journal of surgery

2017 Volume 42, Issue 7, Page(s) 1988–1996

Abstract: Background: Emergency digestive surgery is being increasingly performed in elderly patients. The aim of the present study was to identify the predictors of mortality and morbidity following emergency digestive surgery in patients aged 80 years and older. ...

Abstract	Background: Emergency digestive surgery is being increasingly performed in elderly patients. The aim of the present study was to identify the predictors of mortality and morbidity following emergency digestive surgery in patients aged 80 years and older. Methods: A single-center retrospective review was performed of consecutive patients aged ≥65 years operated for a digestive surgical emergency between January 2011 and December 2013. Two groups were compared: group A (aged 65-79 years) and group B (aged ≥80 years). Results: The study population included 185 patients: 76 patients in group A and 109 in group B. The mean age was 79.9 years (65-104 years). The overall 90-day mortality rate was 23.2 and 31.9% at 1 year, which was similar between groups. The overall morbidity was 28.6%. No differences were noted between the two groups in overall, minor (Dindo I-II) or major (Dindo III-IV) morbidity rates. Multivariate analysis identified pulmonary disease (odds ratio, OR = 6.43, p = 0.02), bowel ischemia (OR = 11.41, p = 0.01), postoperative ICU stay (OR = 7.37, p < 0.0001) and the occurrence of postoperative complications (OR = 2.66, p = 0.03) as predictors of 90-day mortality. Predictors of in-hospital morbidity were preoperative hemoglobin <12 g/dL (OR = 2.49, p = 0.02) and postoperative intensive care unit (ICU) stay (OR = 6.69, p < 0.0001). An age ≥80 year was not associated with mortality or morbidity in this study. Conclusions: The decision to perform abdominal surgery in the emergency setting should be based on physiological status, which accounts for a patient's comorbidities and health status, rather than on chronological age per se.
MeSH term(s)	Aged ; Aged, 80 and over ; Digestive System Surgical Procedures/adverse effects ; Digestive System Surgical Procedures/mortality ; Emergencies ; Female ; Humans ; Intensive Care Units ; Length of Stay ; Male ; Morbidity ; Postoperative Complications/epidemiology ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2017-12-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	224043-9
ISSN	1432-2323 ; 0364-2313
ISSN (online)	1432-2323
ISSN	0364-2313
DOI	10.1007/s00268-017-4419-3
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Article ; Online: Liver Transplantation with "Hors Tour" Allocated Versus Standard MELD Allocated Grafts: Single-Center Audit and Impact on the Liver Pool in France.

Azoulay, Daniel / Disabato, Mara / Gomez-Gavara, Concepcion / Feray, Cyrille / Salloum, Chady / Ngonggang, Norbert / Winter, Audrey / Hentati, Hassen / Levesque, Eric / Lim, Chetana / Compagnon, Philippe

World journal of surgery

2019 Volume 44, Issue 3, Page(s) 912–924

Abstract: Background: The French transplant governing system defined "Rescue" (the so-called "Hors Tour") livers as those livers which were declined for the five top-listed patients. This study compares the outcomes following liver transplantation (LT) in ... ...

Abstract	Background: The French transplant governing system defined "Rescue" (the so-called "Hors Tour") livers as those livers which were declined for the five top-listed patients. This study compares the outcomes following liver transplantation (LT) in patients who received a donor liver through a rescue allocation (RA) procedure or according to MELD score priority (standard allocation, SA) and evaluates the impact on the graft pool of a proactive policy to accept RA grafts. Methods: Data from all consecutive patients who underwent LT with SA or RA grafts from 2011 to 2015 were compared in terms of short- and long-term outcomes. Results: The 249 elective first LTs were performed with 64 (25.7%) RA and 185 (74.3%) SA grafts. RA grafts were obtained from older donors and were associated with a longer cold ischemia time. Recipients of RA livers were older and had lower MELD scores. The rates of delayed graft function, primary nonfunction, retransplantation, complications, and mortality were similar between the RA and SA groups. At 1 and 3 and 5 years, graft and patient survival rates were similar between the groups. These results were maintained after matching on recipient characteristics. Our proactive policy to accept RA grafts increased the liver pool for elective first transplantation by 25%. Conclusions: RA livers can be safely transplanted into selected recipients and significantly expand the liver pool.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Allografts/standards ; Allografts/supply & distribution ; Delayed Graft Function/etiology ; End Stage Liver Disease/surgery ; Female ; France ; Graft Survival ; Humans ; Liver Transplantation/adverse effects ; Male ; Middle Aged ; Postoperative Complications/etiology ; Reoperation ; Resource Allocation/methods ; Severity of Illness Index ; Survival Rate ; Tissue and Organ Procurement ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2019-11-18
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	224043-9
ISSN	1432-2323 ; 0364-2313
ISSN (online)	1432-2323
ISSN	0364-2313
DOI	10.1007/s00268-019-05271-w
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Article ; Online: Annular pancreas intra operatively discovered

Zeineb Mzoughi / Ben Abid Sadri / Miloudi Nizar / Hentati Hassen / Arfa Nafaa / Khalfallah Taher

Clinics and Practice, Vol 1, Iss

a case report

2011 Volume 4

Abstract: Annular pancreas is a rare congenital abnormality. This entity can rarely be symptomatic. Patients can present with gastrointestinal obstruction or acute pancreatitis. We report a case with a rich iconography, of an annular pancreas discovered ... ...

Abstract	Annular pancreas is a rare congenital abnormality. This entity can rarely be symptomatic. Patients can present with gastrointestinal obstruction or acute pancreatitis. We report a case with a rich iconography, of an annular pancreas discovered intraoperatively. A 46- year-old woman was operated with the diagnosis of acute cholecystitis with common bile duct stones. At operation, a strip of pancreatic tissue (2 cm) completely encircled the second duodenum. Open cholecytectomy with choledocotomy and stones extractionwas done. Postoperatively, she developed an acute pancreatitis. The post-operative cholangiography showed the annular duct surrounding the second duodenum. Annular pancreas is rare. Symptoms may occur in newborn children. In adults, annular pancreas discovering is radiological or intra operatively.
Keywords	annular pancreas ; annular duct ; pancreatitis ; Medicine (General) ; R5-920
Language	English
Publishing date	2011-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Thymoquinone protects rat liver after partial hepatectomy under ischaemia/reperfusion through oxidative stress and endoplasmic reticulum stress prevention.

Bouhlel, Ahlem / Bejaoui, Mohamed / Ben Mosbah, Ismail / Hadj Abdallah, Najet / Ribault, Catherine / Viel, Roselyne / Hentati, Hassen / Corlu, Anne / Ben Abdennebi, Hassen

Clinical and experimental pharmacology & physiology

2018

Abstract: Ischaemia reperfusion (I/R) is associated with liver injury and impaired regeneration during partial hepatectomy (PH). The aim of this study was to investigate the effect of thymoquinone (TQ), the active compound of essential oil obtained from Nigella ... ...

Abstract	Ischaemia reperfusion (I/R) is associated with liver injury and impaired regeneration during partial hepatectomy (PH). The aim of this study was to investigate the effect of thymoquinone (TQ), the active compound of essential oil obtained from Nigella sativa seeds, on rat liver after PH. Male Wistar rats were divided equally into four groups (n = 6) receiving an oral administration of either vehicle solution (sham and PH groups) or TQ at 30 mg/kg (TQ and TQ + PH groups) for 10 consecutive days. Then, rats underwent PH (70%) with 60 minutes of ischaemia followed by 24 hours of reperfusion (PH and TQ + PH groups). Alanine aminotransferase (ALT) activity and histopathological damage were determined. Also, antioxidant parameters, liver regeneration index, hepatic adenosine triphosphate (ATP) content, endoplasmic reticulum (ER) stress and apoptosis were assessed. In response to PH under I/R, liver damage was significantly alleviated by TQ treatment as evidenced by the decrease in ALT activity (P < .01) and histological findings (P < .001). In parallel, TQ preconditioning increased hepatic antioxidant capacities. Moreover, TQ improved mitochondrial function (ATP, P < .05), attenuated ER stress parameters and repressed the expression of apoptotic effectors. Taken together, our results suggest that TQ preconditioning could be an effective strategy to reduce liver injury after PH under I/R. The protective effects were mediated by the increase of antioxidant capacities and the decrease of ER stress and apoptosis.
Language	English
Publishing date	2018-05-07
Publishing country	Australia
Document type	Journal Article
ZDB-ID	189277-0
ISSN	1440-1681 ; 0305-1870 ; 0143-9294
ISSN (online)	1440-1681
ISSN	0305-1870 ; 0143-9294
DOI	10.1111/1440-1681.12961
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Zs.A 990: Show issues

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Article ; Online: An Oxygenated and Transportable Machine Perfusion System Fully Rescues Liver Grafts Exposed to Lethal Ischemic Damage in a Pig Model of DCD Liver Transplantation.

Compagnon, Philippe / Levesque, Eric / Hentati, Hassen / Disabato, Mara / Calderaro, Julien / Feray, Cyrille / Corlu, Anne / Cohen, José Laurent / Ben Mosbah, Ismail / Azoulay, Daniel

Transplantation

2017 Volume 101, Issue 7, Page(s) e205–e213

Abstract: Background: Control of warm ischemia (WI) lesions that occur with donation after circulatory death (DCD) would significantly increase the donor pool for liver transplantation. We aimed to determine whether a novel, oxygenated and hypothermic machine ... ...

Abstract	Background: Control of warm ischemia (WI) lesions that occur with donation after circulatory death (DCD) would significantly increase the donor pool for liver transplantation. We aimed to determine whether a novel, oxygenated and hypothermic machine perfusion device (HMP Airdrive system) improves the quality of livers derived from DCDs using a large animal model. Methods: Cardiac arrest was induced in female large white pigs by intravenous injection of potassium chloride. After 60 minutes of WI, livers were flushed in situ with histidine-tryptophan-ketoglutarate and subsequently preserved either by simple cold storage (WI-SCS group) or HMP (WI-HMP group) using Belzer-MPS solution. Liver grafts procured from heart-beating donors and preserved by SCS served as controls. After 4 hours of preservation, all livers were transplanted. Results: All recipients in WI-SCS group died within 6 hours after transplantation. In contrast, the HMP device fully protected the liver against lethal ischemia/reperfusion injury, allowing 100% survival rate. A postreperfusion syndrome was observed in all animals of the WI-SCS group but none of the control or WI-HMP groups. After reperfusion, HMP-preserved livers functioned better and showed less hepatocellular and endothelial cell injury, in agreement with better-preserved liver histology relative to WI-SCS group. In addition to improved energy metabolism, this protective effect was associated with an attenuation of inflammatory response, oxidative load, endoplasmic reticulum stress, mitochondrial damage, and apoptosis. Conclusions: This study demonstrates for the first time the efficacy of the HMP Airdrive system to protect liver grafts from lethal ischemic damage before transplantation in a clinically relevant DCD model.
MeSH term(s)	Allografts ; Animals ; Biomarkers/metabolism ; Disease Models, Animal ; Energy Metabolism ; Equipment Design ; Female ; Glucose/pharmacology ; Graft Survival ; Heart Arrest/chemically induced ; Hepatectomy/adverse effects ; Liver/metabolism ; Liver/pathology ; Liver/surgery ; Liver Function Tests ; Liver Transplantation/adverse effects ; Liver Transplantation/instrumentation ; Liver Transplantation/methods ; Mannitol/pharmacology ; Materials Testing ; Organ Preservation Solutions/pharmacology ; Perfusion/adverse effects ; Perfusion/instrumentation ; Perfusion/methods ; Potassium Chloride/pharmacology ; Procaine/pharmacology ; Reperfusion Injury/etiology ; Reperfusion Injury/metabolism ; Reperfusion Injury/pathology ; Reperfusion Injury/prevention & control ; Sus scrofa ; Time Factors ; Tissue Survival ; Warm Ischemia/adverse effects ; Warm Ischemia/instrumentation ; Warm Ischemia/methods
Chemical Substances	Biomarkers ; Bretschneider cardioplegic solution ; Organ Preservation Solutions ; Mannitol (3OWL53L36A) ; Procaine (4Z8Y51M438) ; Potassium Chloride (660YQ98I10) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2017-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000001764
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Article: Emphysematous pyelitis: epidemiological, therapeutic and evolutive features.

Derouiche, Amine / El Attat, Rabii / Hentati, Hassen / Blah, Mehdi / Slama, Anis / Chebil, Mohamed

La Tunisie medicale

2009 Volume 87, Issue 3, Page(s) 180–183

Abstract: Aim: Emphysematous pyelitis is an uncommon form of acute pyelonephritis. It has been reported sporadically in the literature. Our objective is to study the epidemiological, clinical and therapeutic characteristics of emphysematous pyelitis.: Methods: ...

Abstract	Aim: Emphysematous pyelitis is an uncommon form of acute pyelonephritis. It has been reported sporadically in the literature. Our objective is to study the epidemiological, clinical and therapeutic characteristics of emphysematous pyelitis. Methods: The data of six patients managed for emphysematous pyelitis were collected and analyzed. Results: The mean age was 55 years. Urinary lithiasis and diabetes were the most common co-morbidities. Febrile lumbar pain and general health impairment were the presenting symptoms in five patients; the remaining case presented with septic shock. Urine and blood culture grew E. Coli in 4 and 3 cases respectively. Computed tomography of the abdomen led to diagnosis by showing gas images in the collecting system. Treatment consisted of antibiotics associated with collecting system drainage. It avoided emergent nephrectomy in all cases. The treatment of the calculi was held at distance from the infection. Nephrectomy was done in one patient presenting a thinned -- dedifferentiated -- renal parenchyma. Outcome was good. Conclusion: Emphysematous pyelonephritis is a rare upper urinary tract infection. Risk factors include diabetes and urinary obstruction. The diagnosis is made by computed tomography. Efficient antibiotics administration associated with collecting system drainage allow soon recovery and avoid nephrectomy.
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Drainage ; Emphysema/diagnosis ; Emphysema/therapy ; Female ; Humans ; Low Back Pain/etiology ; Male ; Middle Aged ; Pyelitis/diagnosis ; Pyelitis/therapy ; Retrospective Studies
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2009-03
Publishing country	Tunisia
Document type	Journal Article
ZDB-ID	128627-4
ISSN	0041-4131
ISSN	0041-4131
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