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  1. Article ; Online: Cerebral and cerebellar pseudoatrophy associated with valproic acid. Report of three pediatric cases.

    Ordoño-Saiz, M V / Púa-Torrejón, R C / Justel-Rodríguez, M / Arias-Vivas, E / Heppe-Montero, M / González-Alguacil, E / Duat-Rodríguez, A / Ruiz-Falcó-Rojas, M L / García-Peñas, J J / Gutiérrez-Delicado, E / Soto-Insuga, V

    Revista de neurologia

    2023  Volume 77, Issue 8, Page(s) 197–201

    Abstract: Introduction: Cerebral and cerebellar pseudoatrophy is a rare adverse effect of valproic acid (VPA) that we need to be aware of, due to its diagnostic and therapeutic implications.: Case report: We report three cases of children between 5 and 9 years ...

    Title translation Pseudoatrofia cerebral y cerebelosa asociada a ácido valproico. Descripción de tres casos pediátricos.
    Abstract Introduction: Cerebral and cerebellar pseudoatrophy is a rare adverse effect of valproic acid (VPA) that we need to be aware of, due to its diagnostic and therapeutic implications.
    Case report: We report three cases of children between 5 and 9 years old, with epilepsy and previous normal brain magnetic resonance imaging, who were taking the drug at correct doses. Pseudoatrophy manifests subacutely with symptoms and images of cerebral and/or cerebellar atrophy, reversible after drug withdrawal.
    Discussion and conclusions: This is a type of VPA-related encephalopathy, different from dose-dependent toxic encephalopathy, hyperammonaemic encephalopathy or encephalopathy related to liver failure. In children, it causes cognitive, motor, mood and behavioral deterioration, and may be accompanied by epileptic decompensation. Withdrawing the drug leads to complete clinical-radiological recovery, and reducing the dose leads to improvement.
    MeSH term(s) Humans ; Child ; Child, Preschool ; Valproic Acid/adverse effects ; Epilepsy/drug therapy ; Brain Diseases/chemically induced ; Brain Diseases/diagnosis ; Brain/pathology ; Cerebellum/diagnostic imaging ; Neurotoxicity Syndromes/etiology ; Anticonvulsants/therapeutic use
    Chemical Substances Valproic Acid (614OI1Z5WI) ; Anticonvulsants
    Language Spanish
    Publishing date 2023-10-07
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 1468278-3
    ISSN 1576-6578 ; 0210-0010
    ISSN (online) 1576-6578
    ISSN 0210-0010
    DOI 10.33588/rn.7708.2023186
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5003: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Burden of respiratory syncytial virus-associated lower respiratory infections in children in Spain from 2012 to 2018.

    Heppe-Montero, Marco / Walter, Stefan / Hernández-Barrera, Valentín / Gil-Prieto, Ruth / Gil-de-Miguel, Ángel

    BMC infectious diseases

    2022  Volume 22, Issue 1, Page(s) 315

    Abstract: Background: Respiratory syncytial virus (RSV) is a major cause of acute lower respiratory tract infection (ALRI) leading to infant hospitalization, morbidity and postnatal mortality in children younger than 5 years of age worldwide. The aim of this ... ...

    Abstract Background: Respiratory syncytial virus (RSV) is a major cause of acute lower respiratory tract infection (ALRI) leading to infant hospitalization, morbidity and postnatal mortality in children younger than 5 years of age worldwide. The aim of this study was to collect data on hospitalizations for RSV-related ALRI in children in Spain from 2012 to 2018.
    Methods: We used the discharge reports from the Minimum Basic Data Set (MBDS) to retrospectively analyze hospital discharge data in children ≤ 14 years of age with a diagnosis of acute lower respiratory tract infection, based on the ICD-9-CM and ICD-10-CM diagnosis codes, from 2012 to 2018.
    Results: A total of 190,474 children, 58.1% boys and 41.9% girls, were admitted for lower respiratory tract infections in Spain, including 118,731 cases of bronchiolitis, 53,972 cases of bronchitis, 3710 cases of RSV-positive pneumonia, and 14,061 cases of RSV infections. Of these, 92,426 children (48.5%) had laboratory-confirmed RSV infection. The mean case fatality rate was almost 6 times higher for pneumonia (0.6%) than for bronchiolitis (0.1%) or bronchitis (0.1%). A significant linear increase in the mean annual hospitalization rate for pneumonia of almost 15% per year was found, with no changes in the trend over the study period.
    Conclusions: RSV-related respiratory infections remain a leading cause of infant hospitalization in Spain. Effective antiviral treatments and preventive vaccines are urgently needed for the management of RSV infection in children, especially for those aged 6 to 12 months.
    MeSH term(s) Child ; Female ; Humans ; Infant ; Male ; Pneumonia, Viral ; Respiratory Syncytial Virus, Human ; Respiratory Tract Infections/epidemiology ; Retrospective Studies ; Spain/epidemiology
    Language English
    Publishing date 2022-03-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041550-3
    ISSN 1471-2334 ; 1471-2334
    ISSN (online) 1471-2334
    ISSN 1471-2334
    DOI 10.1186/s12879-022-07261-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Impact of Respiratory Syncytial Virus and Influenza Virus Infection in the Adult Population in Spain between 2012 and 2020.

    Heppe-Montero, Marco / Gil-Prieto, Ruth / Del Diego Salas, Jorge / Hernández-Barrera, Valentín / Gil-de-Miguel, Ángel

    International journal of environmental research and public health

    2022  Volume 19, Issue 22

    Abstract: Respiratory syncytial virus (RSV) infection is increasingly recognized as a cause of significant morbidity and mortality in adults. We aimed to estimate the rates of age-specific hospitalization and in-hospital mortality caused by acute lower respiratory ...

    Abstract Respiratory syncytial virus (RSV) infection is increasingly recognized as a cause of significant morbidity and mortality in adults. We aimed to estimate the rates of age-specific hospitalization and in-hospital mortality caused by acute lower respiratory tract infections (ALRTIs) in Spain between 2012 and 2020 and to compare the relative impact of RSV and influenza virus infection in adults. We used the discharge reports from the Minimum Basic Data Set to retrospectively analyze hospital discharge data on the basis of the ICD-9-CM and ICD-10-CM diagnosis codes. A total of 1,518,244 patients were hospitalized for ALRTIs, of whom 137,794 (9.1%) were admitted for RSV-related infections and 46,288 (3.0%) for influenza-related infections. In patients aged 60 years or older, the hospitalization rates (per 100,000 population) were estimated at 1.69 (95% CI 1.68-1.70) and 2.72 (95% CI 2.71-2.73) for RSV and influenza patients, respectively. However, in-hospital mortality rates were significantly higher among RSV patients than among influenza patients, 7.91% (95% CI 7.89-7.93) (83.0% of all RSV-related deaths) versus 6.91% (95% CI 6.89-6.93) (85.6% of all influenza-related deaths), respectively (
    MeSH term(s) Humans ; Aged ; Respiratory Syncytial Viruses ; Influenza, Human/epidemiology ; Retrospective Studies ; Spain/epidemiology ; Respiratory Syncytial Virus Infections/epidemiology ; Communicable Diseases
    Language English
    Publishing date 2022-11-09
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph192214680
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Burden of severe bronchiolitis in children up to 2 years of age in Spain from 2012 to 2017.

    Heppe Montero, Marco / Gil-Prieto, Ruth / Walter, Stefan / Aleixandre Blanquer, Fernando / Gil De Miguel, Ángel

    Human vaccines & immunotherapeutics

    2021  Volume 18, Issue 1, Page(s) 1883379

    Abstract: Bronchiolitis represents a heavy burden of disease in children under 2 years of age in our society due to the high infectivity of the Respiratory Syncytial Virus [RSV] and the vulnerability of the youngest children.The objective of this retrospective ... ...

    Abstract Bronchiolitis represents a heavy burden of disease in children under 2 years of age in our society due to the high infectivity of the Respiratory Syncytial Virus [RSV] and the vulnerability of the youngest children.The objective of this retrospective epidemiological study was to show the burden of severe bronchiolitis in Spain through population-based estimates of hospitalizations due to bronchiolitis in children up to 24 months old during a 6-year period (2012-2017).A total of 100,115 cases of bronchiolitis required hospitalization in Spain from 2012 to 2017. Most cases of bronchiolitis that required hospitalization were in infants under 3 months of age. The hospitalization rate for bronchiolitis for children under 1 year of age was 3,838.27 per 100,000 healthy children. During the 6-year study period, a total of 82 deaths due to bronchiolitis were reported among hospitalized infants. Among these deaths, more than 50% were in patients younger than 3 months of age. The annual average cost to the National Health Care System was €58 M, with a mean hospitalization cost of €3,512 per case.
    MeSH term(s) Bronchiolitis/epidemiology ; Child ; Child, Preschool ; Hospitalization ; Humans ; Infant ; Respiratory Syncytial Virus Infections/epidemiology ; Respiratory Syncytial Virus, Human ; Retrospective Studies ; Spain/epidemiology
    Language English
    Publishing date 2021-03-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2021.1883379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6967: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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