Article ; Online: Multimodal and spatially resolved profiling identifies distinct patterns of T cell infiltration in nodal B cell lymphoma entities.
2024 Volume 26, Issue 3, Page(s) 478–489
Abstract: The redirection of T cells has emerged as an attractive therapeutic principle in B cell non-Hodgkin lymphoma (B-NHL). However, a detailed characterization of lymphoma-infiltrating T cells across B-NHL entities is missing. Here we present an in-depth T ... ...
| Abstract | The redirection of T cells has emerged as an attractive therapeutic principle in B cell non-Hodgkin lymphoma (B-NHL). However, a detailed characterization of lymphoma-infiltrating T cells across B-NHL entities is missing. Here we present an in-depth T cell reference map of nodal B-NHL, based on cellular indexing of transcriptomes and epitopes, T cell receptor sequencing, flow cytometry and multiplexed immunofluorescence applied to 101 lymph nodes from patients with diffuse large B cell, mantle cell, follicular or marginal zone lymphoma, and from healthy controls. This multimodal resource revealed quantitative and spatial aberrations of the T cell microenvironment across and within B-NHL entities. Quantitative differences in PD1 |
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| MeSH term(s) | Humans ; T-Lymphocytes/pathology ; B-Lymphocytes/pathology ; Lymphoma, B-Cell, Marginal Zone/pathology ; Transforming Growth Factor beta ; Tumor Microenvironment | ||||||||||
| Chemical Substances | Transforming Growth Factor beta | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2024-02-20 | ||||||||||
| Publishing country | England | ||||||||||
| Document type | Journal Article | ||||||||||
| ZDB-ID | 1474722-4 | ||||||||||
| ISSN | 1476-4679 ; 1465-7392 | ||||||||||
| ISSN (online) | 1476-4679 | ||||||||||
| ISSN | 1465-7392 | ||||||||||
| DOI | 10.1038/s41556-024-01358-2 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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