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  1. Article ; Online: The juxtamembrane region of MuSK has a critical role in agrin-mediated signaling.

    Herbst, R / Burden, S J

    The EMBO journal

    2022  Volume 19, Issue 5, Page(s) 1167

    Language English
    Publishing date 2022-11-29
    Publishing country England
    Document type Published Erratum
    ZDB-ID 586044-1
    ISSN 1460-2075 ; 0261-4189
    ISSN (online) 1460-2075
    ISSN 0261-4189
    DOI 10.1038/sj.emboj.7592228b
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  2. Article: Aminosäuren: Einfluss auf mentales und physisches Wohlbefinden bei Freizeitsportlern

    Herbst, Rabea

    Erfahrungsheilkunde

    2022  Volume 71, Issue 01, Page(s) 12–20

    Abstract: Eine randomisierte Doppelblindstudie mit Aminosäuren an insgesamt 38 Freizeitsportlern zeigt spannende Ergebnisse mit praktischer Relevanz im wissenschaftlichen Kontext: Entscheidend ist nicht die Menge, sondern die Qualität und Zusammensetzung der ... ...

    Abstract Eine randomisierte Doppelblindstudie mit Aminosäuren an insgesamt 38 Freizeitsportlern zeigt spannende Ergebnisse mit praktischer Relevanz im wissenschaftlichen Kontext: Entscheidend ist nicht die Menge, sondern die Qualität und Zusammensetzung der zugeführten Aminosäuren. Mit nur 8 Gramm essenziellen Aminosäuren in hydrolisierter Form konnte eine Linderung des Schmerzempfindens innerhalb von 8 Wochen Intervention erzielt werden. Damit stehen die Ergebnisse im Kontrast zu vielen Vorgängerstudien.
    Keywords Aminosäuren ; proteinogene Aminosäuren ; L-Tryptophan ; Freizeitsport ; Amino acids ; proteinogenic amino acids ; L-tryptophan ; recreational sport
    Language German
    Publishing date 2022-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 500791-4
    ISSN 1439-4294 ; 0014-0082
    ISSN (online) 1439-4294
    ISSN 0014-0082
    DOI 10.1055/a-1690-5713
    Database Thieme publisher's database

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  3. Book ; Thesis: Vergleich durchflusszytometrischer und zytologischer Befunde zur Remissionsbeurteilung bei akuten Leukämien mit dem Krankheitsverlauf

    Herbst, Regina

    2002  

    Author's details vorgelegt von Regina Herbst
    Language German
    Size 59 Bl., XXII : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dresden, Univ., Diss., 2003
    HBZ-ID HT013814206
    Database Catalogue ZB MED Medicine, Health

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    2003 E 3076 order for loan Magazin

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  4. Article ; Online: MuSk function during health and disease.

    Herbst, Ruth

    Neuroscience letters

    2019  Volume 716, Page(s) 134676

    Abstract: The receptor tyrosine kinase MuSK (muscle-specific kinase) is the key signaling molecule during the formation of a mature and functional neuromuscular junction (NMJ). Signal transduction events downstream of MuSK activation induce both pre- and ... ...

    Abstract The receptor tyrosine kinase MuSK (muscle-specific kinase) is the key signaling molecule during the formation of a mature and functional neuromuscular junction (NMJ). Signal transduction events downstream of MuSK activation induce both pre- and postsynaptic differentiation, which, most prominently, includes the clustering of acetylcholine receptors (AChRs) at synaptic sites. MuSK activation requires a complex interplay between its co-receptor Lrp4 (low-density lipoprotein receptor-related protein-4), the motor neuron-derived heparan-sulfate proteoglycan Agrin and the intracellular adaptor protein Dok-7. A tight regulation of MuSK kinase activity is crucial for proper NMJ development. Defects in MuSK signaling are the cause of muscle weakness as reported in congenital myasthenic syndromes and myasthenia gravis. This review focuses on recent structure-based analyses of MuSK, Agrin, Lrp4 and Dok-7 interactions and their function during MuSK activation. Conclusions about the regulation of the MuSK kinase that were derived from molecular structures will be highlighted. In addition, the role of MuSK during development and disease will be discussed.
    MeSH term(s) Agrin/metabolism ; Animals ; Humans ; LDL-Receptor Related Proteins/metabolism ; Muscle Proteins/metabolism ; Neuromuscular Junction/metabolism ; Neuromuscular Junction Diseases/metabolism ; Receptor Protein-Tyrosine Kinases/metabolism ; Receptors, Cholinergic/metabolism
    Chemical Substances Agrin ; DOK7 protein, human ; LDL-Receptor Related Proteins ; LRP4 protein, human ; Muscle Proteins ; Receptors, Cholinergic ; MUSK protein, human (EC 2.7.10.1) ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1)
    Language English
    Publishing date 2019-12-04
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 194929-9
    ISSN 1872-7972 ; 0304-3940
    ISSN (online) 1872-7972
    ISSN 0304-3940
    DOI 10.1016/j.neulet.2019.134676
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  5. Article ; Online: Building, Breaking, and Repairing Neuromuscular Synapses.

    Herbst, Ruth / Huijbers, Maartje G / Oury, Julien / Burden, Steven J

    Cold Spring Harbor perspectives in biology

    2024  Volume 16, Issue 5

    Abstract: A coordinated and complex interplay of signals between motor neurons, skeletal muscle cells, and Schwann cells controls the formation and maintenance of neuromuscular synapses. Deficits in the signaling pathway for building synapses, caused by mutations ... ...

    Abstract A coordinated and complex interplay of signals between motor neurons, skeletal muscle cells, and Schwann cells controls the formation and maintenance of neuromuscular synapses. Deficits in the signaling pathway for building synapses, caused by mutations in critical genes or autoantibodies against key proteins, are responsible for several neuromuscular diseases, which cause muscle weakness and fatigue. Here, we describe the role that four key genes,
    MeSH term(s) Humans ; Neuromuscular Junction ; Signal Transduction ; Animals ; Agrin/metabolism ; LDL-Receptor Related Proteins/metabolism ; Receptor Protein-Tyrosine Kinases/metabolism ; Muscle Proteins/metabolism ; Neuromuscular Diseases ; Receptors, Cholinergic/metabolism ; Synapses/physiology ; Synapses/metabolism ; Motor Neurons/physiology ; Motor Neurons/metabolism
    Chemical Substances Agrin ; LDL-Receptor Related Proteins ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; Muscle Proteins ; LRP4 protein, human ; Receptors, Cholinergic ; DOK7 protein, human
    Language English
    Publishing date 2024-05-02
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 1943-0264
    ISSN (online) 1943-0264
    DOI 10.1101/cshperspect.a041490
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  6. Article ; Online: Clinical Framework for Dismantling Antiblack Racism in the Clinic Room.

    Herbst, Rachel / Corley, Alexandra M S / McTate, Emily

    Clinical pediatrics

    2023  Volume 62, Issue 10, Page(s) 1129–1136

    Abstract: Children who identify as Black or multiracial report significantly higher exposure to adverse childhood experiences, which places them at greater risk for poor mental and physical health outcomes. These disparities and increasing awareness of racism as ... ...

    Abstract Children who identify as Black or multiracial report significantly higher exposure to adverse childhood experiences, which places them at greater risk for poor mental and physical health outcomes. These disparities and increasing awareness of racism as an adverse childhood experience has resulted in the American Academy of Pediatrics, American Psychological Association, and other groups declaring racism a public health crisis. To provide high-quality care, providers who engage with patients and families impacted by systemic racism must be aware of its role in health disparities. This requires clinicians to have the knowledge and skills to discuss racism with colleagues, patients, and families. To promote clinicians' competence to engage in these discussions, this article 1) sensitizes providers to historical and contextual factors that inform experiences with anti-Black racism and health disparities and 2) offers strategies to address anti-Black racism in clinical care.Embracing the process of brave, informed conversations about race represents a pathway for building trust between providers and patients, a key component of various health outcomes. Additionally, these foundational skills of reflection, cultural humility, and bias recognition will be needed to engage in allyship and advocacy both within and beyond the exam room.
    MeSH term(s) Humans ; United States ; Child ; Racism ; Trust
    Language English
    Publishing date 2023-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207678-0
    ISSN 1938-2707 ; 0009-9228
    ISSN (online) 1938-2707
    ISSN 0009-9228
    DOI 10.1177/00099228231156009
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  7. Article ; Online: Learnings from the implementation of standardized content and processes for integrated behavioral health prevention visits.

    Meister, Kate / Ryan, Paige / Austin, Jillian / Herbst, Rachel

    Families, systems & health : the journal of collaborative family healthcare

    2023  Volume 41, Issue 3, Page(s) 358–365

    Abstract: Introduction: Integrated behavioral health (IBH) in pediatric primary care has spread significantly over the past two decades. However, a crucial component of advancing the state of science is articulating specific intervention models and their ... ...

    Abstract Introduction: Integrated behavioral health (IBH) in pediatric primary care has spread significantly over the past two decades. However, a crucial component of advancing the state of science is articulating specific intervention models and their associated outcomes. Foundational to this research is the standardization of IBH interventions; however, limited scholarship exists. This is particularly true for IBH prevention (IBH-P) interventions, which pose unique challenges to standardization. The present study presents the development of a standardized IBH-P model, processes to ensure fidelity, and fidelity outcomes.
    Method: The IBH-P model was delivered by psychologists in two large, diverse pediatric primary care clinics. Extant research and quality improvement processes supported the development of standardized criteria. Fidelity procedures were developed through an iterative process, resulting in two measures: provider self-rated fidelity and independent rater fidelity. These tools assessed fidelity to IBH-P visits and comparison of self and independently rated fidelity.
    Results: Data from both self and independent ratings indicated 90.5% of items were completed across all visits. The agreement between independent rater coding and provider self-coding was high (87.5%).
    Discussion: Results indicated a high level of concordance between provider self-ratings and independent coder ratings of fidelity. Findings suggest that a prevention-based, universal, standardized model of care with a psychosocially complex population was feasible to develop and adhere to. Learnings generated from this study may guide other programs seeking to develop standardization interventions and fidelity processes that can ensure high-quality, evidence-based care. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
    MeSH term(s) Humans ; Child ; Behavior Therapy ; Psychiatry ; Marriage ; Quality of Health Care
    Language English
    Publishing date 2023-04-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1326859-4
    ISSN 1939-0602 ; 1091-7527 ; 0736-1718
    ISSN (online) 1939-0602
    ISSN 1091-7527 ; 0736-1718
    DOI 10.1037/fsh0000790
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  8. Article ; Online: From phosphorylation to phenotype - Recent key findings on kinase regulation, downstream signaling and disease surrounding the receptor tyrosine kinase MuSK.

    Prömer, Jakob / Barresi, Cinzia / Herbst, Ruth

    Cellular signalling

    2023  Volume 104, Page(s) 110584

    Abstract: Muscle-specific kinase (MuSK) is the key regulator of neuromuscular junction development. MuSK acts via several distinct pathways and is responsible for pre- and postsynaptic differentiation. MuSK is unique among receptor tyrosine kinases as activation ... ...

    Abstract Muscle-specific kinase (MuSK) is the key regulator of neuromuscular junction development. MuSK acts via several distinct pathways and is responsible for pre- and postsynaptic differentiation. MuSK is unique among receptor tyrosine kinases as activation and signaling are particularly tightly regulated. Initiation of kinase activity requires Agrin, a heparan sulphate proteoglycan derived from motor neurons, the low-density lipoprotein receptor-related protein-4 (Lrp4) and the intracellular adaptor protein Dok-7. There is a great knowledge gap between MuSK activation and downstream signaling. Recent studies using omics techniques have addressed this knowledge gap, thereby greatly contributing to a better understanding of MuSK signaling. Impaired MuSK signaling causes severe muscle weakness as described in congenital myasthenic syndromes or myasthenia gravis but the underlying pathophysiology is often unclear. This review focuses on recent advances in deciphering MuSK activation and downstream signaling. We further highlight latest break-throughs in understanding and treatment of MuSK-related disorders and discuss the role of MuSK in non-muscle tissue.
    MeSH term(s) Phosphorylation ; Neuromuscular Junction/genetics ; Neuromuscular Junction/metabolism ; Receptors, Cholinergic/genetics ; Receptors, Cholinergic/metabolism ; LDL-Receptor Related Proteins/genetics ; Muscle Proteins/metabolism ; Receptor Protein-Tyrosine Kinases/metabolism
    Chemical Substances Receptors, Cholinergic ; LDL-Receptor Related Proteins ; Muscle Proteins ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1)
    Language English
    Publishing date 2023-01-03
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1002702-6
    ISSN 1873-3913 ; 0898-6568
    ISSN (online) 1873-3913
    ISSN 0898-6568
    DOI 10.1016/j.cellsig.2022.110584
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  9. Article ; Online: Staying in bounds: A framework for setting workplace boundaries to promote physician wellness.

    Herbst, Rachel / Sump, Courtney / Riddle, Sarah

    Journal of hospital medicine

    2023  Volume 18, Issue 12, Page(s) 1139–1143

    MeSH term(s) Humans ; Workplace ; Physicians ; Working Conditions
    Language English
    Publishing date 2023-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2233783-0
    ISSN 1553-5606 ; 1553-5592
    ISSN (online) 1553-5606
    ISSN 1553-5592
    DOI 10.1002/jhm.13102
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  10. Article ; Online: Strengthening Preparedness Against Terror: A Bystander Training Concept by Israel's Emergency Medical Services.

    Nerlander, Maximilian P / Klein, Abigail / Herbst, Raphael / Jaffe, Eli

    The American surgeon

    2023  Volume 90, Issue 4, Page(s) 489–493

    MeSH term(s) Humans ; Israel ; Terrorism ; Disaster Planning ; Emergency Medical Services
    Language English
    Publishing date 2023-11-30
    Publishing country United States
    Document type Editorial
    ZDB-ID 202465-2
    ISSN 1555-9823 ; 0003-1348
    ISSN (online) 1555-9823
    ISSN 0003-1348
    DOI 10.1177/00031348231219257
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