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  1. Article ; Online: Ischemic Heart Disease and Chronic Obstructive Pulmonary Disease Hospitalizations in Japan Before and After the Introduction of a Heated Tobacco Product.

    van der Plas, Angela / Antunes, Meagan / Romero-Kauss, Alba / Hankins, Matthew / Heremans, Annie

    Frontiers in public health

    2022  Volume 10, Page(s) 909459

    Abstract: To substantiate the beneficial effects of switching from cigarette smoking to heated tobacco products (HTP), this study conducted a time-trend analysis using data from the Japanese Medical Data Center (JMDC) database. Specifically, we assessed ... ...

    Abstract To substantiate the beneficial effects of switching from cigarette smoking to heated tobacco products (HTP), this study conducted a time-trend analysis using data from the Japanese Medical Data Center (JMDC) database. Specifically, we assessed hospitalization numbers for chronic obstructive pulmonary disease (COPD) exacerbations and acute ischemic heart disease (IHD) before and after the introduction of HTPs in the Japanese market. This study replicated a previous study using a different Japanese real-world data source (Medical Data Vision). We retrieved the number of hospitalizations associated with the International Classification of Diseases-10 codes for COPD and IHD from 2010 to 2019-5 years before to 4 years after introducing HTPs in the Japanese market-from the JMDC database. Then, we used interrupted time-series analyses to test the hypothesis that the introduction of HTPs is associated with a reduction in hospitalizations for COPD (all codes), COPD exacerbation, COPD exacerbation plus lower respiratory tract infections (LRTI), and IHD, adjusting for age, sex, seasonality, and flu vaccination rates. Analysis of all available data from the JMDC database revealed a significant reduction in the number of hospitalizations for COPD (all codes;
    MeSH term(s) Hospitalization ; Humans ; Japan/epidemiology ; Myocardial Ischemia/complications ; Myocardial Ischemia/diagnosis ; Myocardial Ischemia/epidemiology ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Tobacco Products
    Language English
    Publishing date 2022-06-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2022.909459
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Meta-analysis of the effects of smoking and smoking cessation on triglyceride levels.

    van der Plas, Angela / Antunes, Meagan / Pouly, Sandrine / de La Bourdonnaye, Guillaume / Hankins, Matthew / Heremans, Annie

    Toxicology reports

    2023  Volume 10, Page(s) 367–375

    Abstract: Smoking increases lipid levels, including triglycerides, leading to increased cardiovascular disease risk. We performed a meta-analysis to quantify the effects of smoking and smoking cessation on triglyceride levels. The PubMed and Scopus databases were ... ...

    Abstract Smoking increases lipid levels, including triglycerides, leading to increased cardiovascular disease risk. We performed a meta-analysis to quantify the effects of smoking and smoking cessation on triglyceride levels. The PubMed and Scopus databases were searched to identify studies reporting either triglyceride levels in smokers and non-smokers or the effects of smoking cessation on triglyceride levels. Fixed- and random-effects models were used to perform the analyses when three or more studies/comparisons were available. We identified 169 and 21 studies evaluating the effects of smoking and smoking cessation, respectively, on triglyceride levels. Triglyceride levels were 0.50 mmol/L (95% confidence interval: 0.49-0.50 mmol/L) higher in smokers than non-smokers, but the effect differed widely across studies. No statistically significant effect was observed on triglyceride levels between baseline and 6 weeks (mean difference [MD] = 0.02 [-0.09, 0.12] mmol/L), 2 months (MD = 0.03 [-0.21, 0.27] mmol/L), 3 months (MD = 0.08 [-0.03, 0.21] mmol/L), or 1 year (MD = 0.04 [-0.06, 0.14] mmol/L) after quitting. However, a slightly significant decrease in triglyceride levels was observed at 1 month after cessation (MD = -0.15 [-0.15, -0.01] mmol/L). The results of this meta-analysis provide a basis for understanding the effects of smoking and smoking cessation on triglyceride levels, which could have important implications for public health.
    Language English
    Publishing date 2023-03-04
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 2805786-7
    ISSN 2214-7500 ; 2214-7500
    ISSN (online) 2214-7500
    ISSN 2214-7500
    DOI 10.1016/j.toxrep.2023.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Impact of gender on extent of lung injury in COVID-19.

    Dangis, A / De Brucker, N / Heremans, A / Gillis, M / Frans, J / Demeyere, A / Symons, R

    Clinical radiology

    2020  Volume 75, Issue 7, Page(s) 554–556

    MeSH term(s) Aged ; Belgium ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/diagnostic imaging ; Female ; Humans ; Lung/diagnostic imaging ; Lung Injury/complications ; Lung Injury/diagnostic imaging ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnostic imaging ; SARS-CoV-2 ; Sex Factors ; Tomography, X-Ray Computed/methods
    Keywords covid19
    Language English
    Publishing date 2020-04-23
    Publishing country England
    Document type Letter
    ZDB-ID 391227-9
    ISSN 1365-229X ; 0009-9260
    ISSN (online) 1365-229X
    ISSN 0009-9260
    DOI 10.1016/j.crad.2020.04.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.201: Show issues Location:
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  4. Article ; Online: Influence of tobacco smoking on the development of halitosis.

    Kauss, Alba Romero / Antunes, Meagan / Zanetti, Filippo / Hankins, Matthew / Hoeng, Julia / Heremans, Annie / van der Plas, Angela

    Toxicology reports

    2022  Volume 9, Page(s) 316–322

    Abstract: Background: Halitosis is the general term used to describe any disagreeable odor in exhaled air, regardless of whether the odorous substances originate from oral or non-oral sources. Previous research has strongly associated tobacco smoking in the ... ...

    Abstract Background: Halitosis is the general term used to describe any disagreeable odor in exhaled air, regardless of whether the odorous substances originate from oral or non-oral sources. Previous research has strongly associated tobacco smoking in the development of halitosis, as it increases the synthesis of toxic volatile sulfur compounds in diseased periodontal pockets. In this review, we summarize the etiopathology and epidemiology of halitosis as well as the current evidence on the impact of smoking by means of a meta-analysis.
    Methods: PubMed and Embase were searched to identify publications that reported halitosis in smokers and nonsmokers. Meta-analyses were performed if a sufficient number (n ≥ 3) of articles were available that evaluated the same outcome.
    Results: The meta-analyses showed that there was an increased risk of halitosis in current smokers versus nonsmokers (odds ratios). These results were consistent both in fixed and random effects models. Even though the interstudy heterogeneity was high (I
    Conclusions: Halitosis is a common condition which can affect the quality of life of those affected. The results from this literature review and meta-analysis show that current smokers are more likely to suffer from halitosis, even if they are less likely to report it.
    Language English
    Publishing date 2022-03-06
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 2805786-7
    ISSN 2214-7500 ; 2214-7500
    ISSN (online) 2214-7500
    ISSN 2214-7500
    DOI 10.1016/j.toxrep.2022.02.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Smoking and apolipoprotein levels: A meta-analysis of published data.

    Kauss, Alba Romero / Antunes, Meagan / de La Bourdonnaye, Guillaume / Pouly, Sandrine / Hankins, Matthew / Heremans, Annie / van der Plas, Angela

    Toxicology reports

    2022  Volume 9, Page(s) 1150–1171

    Abstract: Background: Apolipoproteins are major components of lipoproteins such as high-density lipoprotein (HDL) and very-low-density lipoprotein and are considered nontraditional markers in the risk assessment for cardiovascular disease. The goal of this review ...

    Abstract Background: Apolipoproteins are major components of lipoproteins such as high-density lipoprotein (HDL) and very-low-density lipoprotein and are considered nontraditional markers in the risk assessment for cardiovascular disease. The goal of this review was to quantify the effects of smoking and smoking cessation on serum levels of apolipoproteins AI, AII, and B and the ratio of apolipoproteins B and AI.
    Methods: PubMed and Scopus were searched up to June 2021 to identify publications that reported the levels of apolipoproteins AI, AII, and B and the apolipoprotein B/AI ratio in smokers and nonsmokers as well as articles reporting the effect of smoking cessation on the same endpoints. Meta-analyses were performed when a sufficient number (n ≥ 3) of articles evaluating the same outcome were available.
    Results: Forty-nine studies had assessed apolipoprotein levels in smokers and nonsmokers. The meta-analyses comparing the levels of apolipoproteins AI and AII showed decreased levels in smokers relative to nonsmokers. On the other hand, the apolipoprotein B levels and apolipoprotein B/AI ratio were increased in smokers relative to nonsmokers. Insufficient publications were available on which to perform meta-analyses on the effects of smoking cessation on apolipoprotein levels.
    Conclusions: Smoking is associated with reduced levels of apolipoproteins AI and AII (in line with reduced levels of HLD-cholesterol) and increased apolipoprotein B levels and apolipoprotein B/AI ratio, thereby confirming the negative impact of smoking on lipid metabolism, which contributes to increased cardiovascular risk. More data are needed to elucidate the effects of smoking cessation on these cardiovascular risk endpoints.
    Language English
    Publishing date 2022-05-17
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 2805786-7
    ISSN 2214-7500 ; 2214-7500
    ISSN (online) 2214-7500
    ISSN 2214-7500
    DOI 10.1016/j.toxrep.2022.05.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Impact of gender on extent of lung injury in COVID-19

    Dangis, A. / De Brucker, N. / Heremans, A. / Gillis, M. / Frans, J. / Demeyere, A. / Symons, R.

    Clinical Radiology

    2020  Volume 75, Issue 7, Page(s) 554–556

    Keywords Radiology Nuclear Medicine and imaging ; General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 391227-9
    ISSN 1365-229X ; 0009-9260
    ISSN (online) 1365-229X
    ISSN 0009-9260
    DOI 10.1016/j.crad.2020.04.005
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.201: Show issues Location:
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  8. Article ; Online: Impact of switching to a heat-not-burn tobacco product on CYP1A2 activity.

    van der Plas, Angela / Pouly, Sandrine / Blanc, Nicolas / Haziza, Christelle / de La Bourdonnaye, Guillaume / Titz, Bjorn / Hoeng, Julia / Ivanov, Nikolai V / Taranu, Brindusa / Heremans, Annie

    Toxicology reports

    2020  Volume 7, Page(s) 1480–1486

    Abstract: Background: Cigarette smoking induces cytochrome P450 1A2 (CYP1A2) expression and activity, while smoking cessation normalizes the levels of this enzyme. The aim of this publication is to summarize the data on CYP1A2 gene expression and activity in ... ...

    Abstract Background: Cigarette smoking induces cytochrome P450 1A2 (CYP1A2) expression and activity, while smoking cessation normalizes the levels of this enzyme. The aim of this publication is to summarize the data on CYP1A2 gene expression and activity in preclinical and clinical studies on the Tobacco Heating System (THS), currently marketed as
    Methods: We summarized PMI's preclinical and clinical data on the effects of switching from cigarette smoking to THS.
    Results: Data from four preclinical mouse and rat studies showed that, upon either cessation of cigarette smoke exposure or switching to THS exposure, the upregulation of CYP1A2 observed with exposure to cigarette smoke reverted close to fresh-air levels. Data from four clinical studies yielded similar results on CYP1A2 activity within a time frame of five days. Furthermore, the effects of switching to THS were similar to those seen after smoking cessation.
    Conclusions: Because smoking cessation and switching to either electronic cigarettes or THS seem to have similar effects on CYP1A2 activity, the same measures taken for patients treated with narrow therapeutic index drugs that are metabolized by CYP1A2 and who quit smoking should be recommended for those switching to RRPs.
    Language English
    Publishing date 2020-10-29
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 2805786-7
    ISSN 2214-7500 ; 2214-7500
    ISSN (online) 2214-7500
    ISSN 2214-7500
    DOI 10.1016/j.toxrep.2020.10.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Tretinoin: an established long-term safety profile.

    Powers, William / Shapiro, Stanley S / Heremans, Annie

    Archives of dermatology

    2009  Volume 145, Issue 9, Page(s) 1063–4; author reply 1064–5

    MeSH term(s) Administration, Topical ; Antineoplastic Agents/administration & dosage ; Follow-Up Studies ; Humans ; Skin Neoplasms/prevention & control ; Time Factors ; Treatment Outcome ; Tretinoin/administration & dosage
    Chemical Substances Antineoplastic Agents ; Tretinoin (5688UTC01R)
    Language English
    Publishing date 2009-09
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 212139-6
    ISSN 1538-3652 ; 0003-987X
    ISSN (online) 1538-3652
    ISSN 0003-987X
    DOI 10.1001/archdermatol.2009.206
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    Ui VI Zs.32: Show issues Location:
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  10. Article ; Online: Prognostic Value and Reproducibility of AI-assisted Analysis of Lung Involvement in COVID-19 on Low-Dose Submillisievert Chest CT: Sample Size Implications for Clinical Trials.

    Gieraerts, Christopher / Dangis, Anthony / Janssen, Lode / Demeyere, Annick / De Bruecker, Yves / De Brucker, Nele / van Den Bergh, Annelies / Lauwerier, Tine / Heremans, André / Frans, Eric / Laurent, Michaël / Ector, Bavo / Roosen, John / Smismans, Annick / Frans, Johan / Gillis, Marc / Symons, Rolf

    Radiology. Cardiothoracic imaging

    2020  Volume 2, Issue 5, Page(s) e200441

    Abstract: Purpose: To compare the prognostic value and reproducibility of visual versus AI-assisted analysis of lung involvement on submillisievert low-dose chest CT in COVID-19 patients.: Materials and methods: This was a HIPAA-compliant, institutional review ...

    Abstract Purpose: To compare the prognostic value and reproducibility of visual versus AI-assisted analysis of lung involvement on submillisievert low-dose chest CT in COVID-19 patients.
    Materials and methods: This was a HIPAA-compliant, institutional review board-approved retrospective study. From March 15 to June 1, 2020, 250 RT-PCR confirmed COVID-19 patients were studied with low-dose chest CT at admission. Visual and AI-assisted analysis of lung involvement was performed by using a semi-quantitative CT score and a quantitative percentage of lung involvement. Adverse outcome was defined as intensive care unit (ICU) admission or death. Cox regression analysis, Kaplan-Meier curves, and cross-validated receiver operating characteristic curve with area under the curve (AUROC) analysis was performed to compare model performance. Intraclass correlation coefficients (ICCs) and Bland- Altman analysis was used to assess intra- and interreader reproducibility.
    Results: Adverse outcome occurred in 39 patients (11 deaths, 28 ICU admissions). AUC values from AI-assisted analysis were significantly higher than those from visual analysis for both semi-quantitative CT scores and percentages of lung involvement (all P<0.001). Intrareader and interreader agreement rates were significantly higher for AI-assisted analysis than visual analysis (all ICC ≥0.960 versus ≥0.885). AI-assisted variability for quantitative percentage of lung involvement was 17.2% (coefficient of variation) versus 34.7% for visual analysis. The sample size to detect a 5% change in lung involvement with 90% power and an α error of 0.05 was 250 patients with AI-assisted analysis and 1014 patients with visual analysis.
    Conclusion: AI-assisted analysis of lung involvement on submillisievert low-dose chest CT outperformed conventional visual analysis in predicting outcome in COVID-19 patients while reducing CT variability. Lung involvement on chest CT could be used as a reliable metric in future clinical trials.
    Language English
    Publishing date 2020-10-22
    Publishing country United States
    Document type Journal Article
    ISSN 2638-6135
    ISSN (online) 2638-6135
    DOI 10.1148/ryct.2020200441
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