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  1. AU="Herman, Andrew"
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  1. Article ; Online: Leading countries in global science increasingly receive more citations than other countries doing similar research.

    Gomez, Charles J / Herman, Andrew C / Parigi, Paolo

    Nature human behaviour

    2022  Volume 6, Issue 7, Page(s) 919–929

    Abstract: Citations and text analysis are both used to study the distribution and flow of ideas between researchers, fields and countries, but the resulting flows are rarely equal. We argue that the differences in these two flows capture a growing global ... ...

    Abstract Citations and text analysis are both used to study the distribution and flow of ideas between researchers, fields and countries, but the resulting flows are rarely equal. We argue that the differences in these two flows capture a growing global inequality in the production of scientific knowledge. We offer a framework called 'citational lensing' to identify where citations should appear between countries but are absent given that what is embedded in their published abstract texts is highly similar. This framework also identifies where citations are overabundant given lower similarity. Our data come from nearly 20 million papers across nearly 35 years and 150 fields from the Microsoft Academic Graph. We find that scientific communities increasingly centre research from highly active countries while overlooking work from peripheral countries. This inequality is likely to pose substantial challenges to the growth of novel ideas.
    MeSH term(s) Humans ; Knowledge ; Research Personnel
    Language English
    Publishing date 2022-05-30
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 2397-3374
    ISSN (online) 2397-3374
    DOI 10.1038/s41562-022-01351-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Fluorescence-Activated Cell Sorting and Quantitative Real-Time PCR to Reveal VEGF-Expressing Macrophage Populations in the Zebrafish Larvae.

    Herman, Andrew / Greenhough, Alexander / Gurevich, David B

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2475, Page(s) 325–337

    Abstract: The transparent, genetically tractable zebrafish is increasingly recognized as a useful model to both live image and uncover mechanistic insight into cell interactions governing tissue homeostasis, pathology, and regeneration. Here, we describe a ... ...

    Abstract The transparent, genetically tractable zebrafish is increasingly recognized as a useful model to both live image and uncover mechanistic insight into cell interactions governing tissue homeostasis, pathology, and regeneration. Here, we describe a protocol for the isolation of macrophages from zebrafish wounds using fluorescence-activated cell sorting (FACS), and the identification of specific pro-angiogenic macrophage populations that express high levels of vascular endothelial growth factor (vegf) using quantitative real-time PCR (qPCR). The cell dissociation and FACS sorting techniques have been optimized for immune cells and successfully used to isolate other fluorescently marked populations within the wound such as neutrophils and endothelial cells. More broadly, this protocol can be easily adapted to other contexts where identification of pro-angiogenic immune cells is transformative for understanding, from development to pathologies such as infection, cancer, and diabetes.
    MeSH term(s) Animals ; Endothelial Cells ; Flow Cytometry/methods ; Larva/genetics ; Macrophages ; Real-Time Polymerase Chain Reaction ; Vascular Endothelial Growth Factor A/genetics ; Zebrafish/genetics
    Chemical Substances Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2022-04-22
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2217-9_24
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The tyrosine kinase inhibitor Dasatinib reduces cardiac steatosis and fibrosis in obese, type 2 diabetic mice.

    Gu, Yue / Avolio, Elisa / Alvino, Valeria V / Thomas, Anita C / Herman, Andrew / Miller, Poppy J / Sullivan, Niall / Faulkner, Ashton / Madeddu, Paolo

    Cardiovascular diabetology

    2023  Volume 22, Issue 1, Page(s) 214

    Abstract: Background: Cardiac steatosis is an early yet overlooked feature of diabetic cardiomyopathy. There is no available therapy to treat this condition. Tyrosine kinase inhibitors (TKIs) are used as first or second-line therapy in different types of cancer. ... ...

    Abstract Background: Cardiac steatosis is an early yet overlooked feature of diabetic cardiomyopathy. There is no available therapy to treat this condition. Tyrosine kinase inhibitors (TKIs) are used as first or second-line therapy in different types of cancer. In cancer patients with diabetes mellitus, TKIs reportedly improved glycemic control, allowing insulin discontinuation. They also reduced liver steatosis in a murine model of non-alcoholic fatty liver disease. The present study aimed to determine the therapeutic effect of the second-generation TKI Dasatinib on lipid accumulation and cardiac function in obese, type 2 diabetic mice. We also assessed if the drug impacts extra-cardiac fat tissue depots.
    Methods: Two studies on 21-week-old male obese leptin receptor mutant BKS.Cg-+Leprdb/+Leprdb/OlaHsd (db/db) mice compared the effect of Dasatinib (5 mg/kg) and vehicle (10% DMSO + 90% PEG-300) given via gavage once every three days for a week or once every week for four weeks. Functional and volumetric indices were studied using echocardiography. Post-mortem analyses included the assessment of fat deposits and fibrosis using histology, and senescence using immunohistochemistry and flow cytometry. The anti-adipogenic action of Dasatinib was investigated on human bone marrow (BM)-derived mesenchymal stem cells (MSCs). Unpaired parametric or non-parametric tests were used to compare two and multiple groups as appropriate.
    Results: Dasatinib reduced steatosis and fibrosis in the heart of diabetic mice. The drug also reduced BM adiposity but did not affect other fat depots. These structural changes were associated with improved diastolic indexes, specifically the E/A ratio and non-flow time. Moreover, Dasatinib-treated mice had lower levels of p16 in the heart compared with vehicle-treated controls, suggesting an inhibitory impact of the drug on the senescence signalling pathway. In vitro, Dasatinib inhibited human BM-MSC viability and adipogenesis commitment.
    Conclusions: Our findings suggest that Dasatinib opposes heart and BM adiposity and cardiac fibrosis. In the heart, this was associated with favourable functional consequences, namely improvement in an index of diastolic function. Repurposing TKI for cardiac benefit could address the unmet need of diabetic cardiac steatosis.
    MeSH term(s) Humans ; Male ; Animals ; Mice ; Dasatinib/pharmacology ; Tyrosine Kinase Inhibitors ; Diabetes Mellitus, Experimental ; Protein Kinase Inhibitors/pharmacology ; Non-alcoholic Fatty Liver Disease ; Fibrosis ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy
    Chemical Substances Dasatinib (RBZ1571X5H) ; Tyrosine Kinase Inhibitors ; Protein Kinase Inhibitors
    Language English
    Publishing date 2023-08-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2093769-6
    ISSN 1475-2840 ; 1475-2840
    ISSN (online) 1475-2840
    ISSN 1475-2840
    DOI 10.1186/s12933-023-01955-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Pediatric Surgical Reentry Strategy Following the COVID-19 Pandemic: A Tiered and Balanced Approach.

    Pickens, Ryan C / Kao, Angela M / Williams, Mark A / Herman, Andrew C / Kneisl, Jeffrey S

    The American surgeon

    2021  Volume 89, Issue 2, Page(s) 267–276

    Abstract: Background: In response to the COVID-19 pandemic, children's hospitals across the country postponed elective surgery beginning in March 2020. As projective curves flattened, administrators and surgeons sought to develop strategies to safely resume non- ... ...

    Abstract Background: In response to the COVID-19 pandemic, children's hospitals across the country postponed elective surgery beginning in March 2020. As projective curves flattened, administrators and surgeons sought to develop strategies to safely resume non-emergent surgery. This article reviews challenges and solutions specific to a children's hospital related to the resumption of elective pediatric surgeries. We present our tiered reentry approach for pediatric surgery as well as report early data for surgical volume and tracking COVID-19 cases during reentry.
    Methods: The experience of shutdown, protocol development, and early reentry of elective pediatric surgery are reported from Levine's Children's Hospital (LCH), a free-leaning children's hospital in Charlotte, North Carolina. Data reported were obtained from de-identified hospital databases.
    Results: Pediatric surgery experienced a dramatic decrease in case volumes at LCH during the shutdown, variable by specialty. A tiered and balanced reentry strategy was implemented with steady resumption of elective surgery following strict pre-procedural screening and testing. Early outcomes showed a steady thorough fluctuating increase in elective case volumes without evidence of a surgery-associated positive spread through periprocedural tracking.
    Conclusion: Reentry of non-emergent pediatric surgical care requires unique considerations including the impact of COVID-19 on children, each children hospital structure and resources, and preventing undue delay in intervention for age- and disease-specific pediatric conditions. A carefully balanced strategy has been critical for safe reentry following the anticipated surge. Ongoing tracking of resource utilization, operative volumes, and testing results will remain vital as community spread continues to fluctuate across the country.
    MeSH term(s) Humans ; Child ; COVID-19/epidemiology ; Pandemics/prevention & control ; Elective Surgical Procedures ; Hospitals ; Surgeons
    Language English
    Publishing date 2021-05-19
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 202465-2
    ISSN 1555-9823 ; 0003-1348
    ISSN (online) 1555-9823
    ISSN 0003-1348
    DOI 10.1177/00031348211011125
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.106: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  5. Book: Theories of the mobile internet

    Hadlaw, Jan / Herman, Andrew / Swiss, Thomas

    materialities and imaginaries

    (Routledge studies in new media and cyberculture ; 24)

    2015  

    Abstract: This volume proposes the mobile Internet is best understood as a socio-technical "assemblage" of objects, practices, symbolic representations, experiences and affects. Authors from a variety of disciplines discuss practices mediated through mobile ... ...

    Author's details ed. by Andrew Herman; Jan Hadlaw and Thom Swiss
    Series title Routledge studies in new media and cyberculture ; 24
    Abstract This volume proposes the mobile Internet is best understood as a socio-technical "assemblage" of objects, practices, symbolic representations, experiences and affects. Authors from a variety of disciplines discuss practices mediated through mobile communication, including current phone and tablet devices. The converging concepts of Materialities (ranging from the political economy of communication to physical devices) and Imaginaries (including cultural values, desires and perceptions) are touchstones for each of the chapters in the book.
    Keywords Mobile computing/Social aspects ; Wireless Internet/Social aspects
    Language English
    Size VIII, 260 S, Ill
    Publisher Routledge
    Publishing place New York, NY u.a.
    Document type Book
    Note Literaturangaben
    ISBN 9780415731003 ; 9781315849850 ; 0415731003 ; 1315849852
    Database Former special subject collection: coastal and deep sea fishing

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  6. Article ; Online: Design and Selection of Heterodimerizing Helical Hairpins for Synthetic Biology.

    Smith, Abigail J / Naudin, Elise A / Edgell, Caitlin L / Baker, Emily G / Mylemans, Bram / FitzPatrick, Laura / Herman, Andrew / Rice, Helen M / Andrews, David M / Tigue, Natalie / Woolfson, Derek N / Savery, Nigel J

    ACS synthetic biology

    2023  Volume 12, Issue 6, Page(s) 1845–1858

    Abstract: Synthetic biology applications would benefit from protein modules of reduced complexity that function orthogonally to cellular components. As many subcellular processes depend on peptide-protein or protein-protein interactions, ...

    Abstract Synthetic biology applications would benefit from protein modules of reduced complexity that function orthogonally to cellular components. As many subcellular processes depend on peptide-protein or protein-protein interactions,
    MeSH term(s) Animals ; Synthetic Biology ; Escherichia coli/genetics ; Peptides/chemistry ; Proteins/chemistry ; Mammals
    Chemical Substances Peptides ; Proteins
    Language English
    Publishing date 2023-05-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2161-5063
    ISSN (online) 2161-5063
    DOI 10.1021/acssynbio.3c00231
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online: The World Wide Web and Contemporary Cultural Theory

    Herman, Andrew / Swiss, Thomas

    Magic, Metaphor, Power

    2014  

    Abstract: Engaging the thematic issues of the Web as a space where magic, metaphor, and power converge, the chapters cover such subjects as The Web and Corporate Media Systems, Conspiracy Theories and the Web; The Economy of Cyberpromotion, The Bias of the Web, ... ...

    Abstract Engaging the thematic issues of the Web as a space where magic, metaphor, and power converge, the chapters cover such subjects as The Web and Corporate Media Systems, Conspiracy Theories and the Web; The Economy of Cyberpromotion, The Bias of the Web, The Web and Issues of Gender, and so on
    Language English
    Size Online-Ressource (321 p)
    Publisher Taylor and Francis
    Publishing place Hoboken
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9780415925013 ; 0415925010
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  8. Article ; Online: Identification of a novel GR-ARID1a-P53BP1 protein complex involved in DNA damage repair and cell cycle regulation.

    Stubbs, Felicity E / Flynn, Benjamin P / Rivers, Caroline A / Birnie, Matthew T / Herman, Andrew / Swinstead, Erin E / Baek, Songjoon / Fang, Hai / Temple, Jillian / Carroll, Jason S / Hager, Gordon L / Lightman, Stafford L / Conway-Campbell, Becky L

    Oncogene

    2022  Volume 41, Issue 50, Page(s) 5347–5360

    Abstract: ARID1a (BAF250), a component of human SWI/SNF chromatin remodeling complexes, is frequently mutated across numerous cancers, and its loss of function has been putatively linked to glucocorticoid resistance. Here, we interrogate the impact of siRNA ... ...

    Abstract ARID1a (BAF250), a component of human SWI/SNF chromatin remodeling complexes, is frequently mutated across numerous cancers, and its loss of function has been putatively linked to glucocorticoid resistance. Here, we interrogate the impact of siRNA knockdown of ARID1a compared to a functional interference approach in the HeLa human cervical cancer cell line. We report that ARID1a knockdown resulted in a significant global decrease in chromatin accessibility in ATAC-Seq analysis, as well as affecting a subset of genome-wide GR binding sites determined by analyzing GR ChIP-Seq data. Interestingly, the specific effects on gene expression were limited to a relatively small subset of glucocorticoid-regulated genes, notably those involved in cell cycle regulation and DNA repair. The vast majority of glucocorticoid-regulated genes were largely unaffected by ARID1a knockdown or functional interference, consistent with a more specific role for ARID1a in glucocorticoid function than previously speculated. Using liquid chromatography-mass spectrometry, we have identified a chromatin-associated protein complex comprising GR, ARID1a, and several DNA damage repair proteins including P53 binding protein 1 (P53BP1), Poly(ADP-Ribose) Polymerase 1 (PARP1), DNA damage-binding protein 1 (DDB1), DNA mismatch repair protein MSH6 and splicing factor proline and glutamine-rich protein (SFPQ), as well as the histone acetyltransferase KAT7, an epigenetic regulator of steroid-dependent transcription, DNA damage repair and cell cycle regulation. Not only was this protein complex ablated with both ARID1a knockdown and functional interference, but spontaneously arising DNA damage was also found to accumulate in a manner consistent with impaired DNA damage repair mechanisms. Recovery from dexamethasone-dependent cell cycle arrest was also significantly impaired. Taken together, our data demonstrate that although glucocorticoids can still promote cell cycle arrest in the absence of ARID1a, the purpose of this arrest to allow time for DNA damage repair is hindered.
    MeSH term(s) Humans ; Cell Cycle ; Cell Cycle Checkpoints ; Cell Line, Tumor ; Chromatin/genetics ; DNA Damage ; DNA Repair ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Histone Acetyltransferases/metabolism ; Nuclear Proteins/metabolism ; Transcription Factors/genetics ; Receptors, Glucocorticoid/metabolism ; Tumor Suppressor p53-Binding Protein 1/metabolism
    Chemical Substances ARID1A protein, human ; Chromatin ; DNA-Binding Proteins ; Histone Acetyltransferases (EC 2.3.1.48) ; KAT7 protein, human (EC 2.3.1.48) ; Nuclear Proteins ; Transcription Factors ; Receptors, Glucocorticoid ; TP53BP1 protein, human ; Tumor Suppressor p53-Binding Protein 1
    Language English
    Publishing date 2022-11-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 639046-8
    ISSN 1476-5594 ; 0950-9232
    ISSN (online) 1476-5594
    ISSN 0950-9232
    DOI 10.1038/s41388-022-02516-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2218: Show issues Location:
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  9. Book ; Online: Theories of the Mobile Internet

    Herman, Andrew / Hadlaw, Jan / Swiss, Thom

    Materialities and Imaginaries

    (Routledge Studies in New Media and Cyberculture)

    2014  

    Abstract: ... This volume proposes the mobile Internet is best understood as a socio-technical ""assemblage"" of objects, practices, symbolic representations, experiences and affects. Authors from a variety of disciplines discuss practices mediated through mobile ... ...

    Series title Routledge Studies in New Media and Cyberculture
    Abstract

    This volume proposes the mobile Internet is best understood as a socio-technical ""assemblage"" of objects, practices, symbolic representations, experiences and affects. Authors from a variety of disciplines discuss practices mediated through mobile communication, including current phone and tablet devices. The converging concepts of Materialities (ranging from the political economy of communication to physical devices) and Imaginaries (including cultural values, desires and perceptions) are touchstones for each of the chapters in the book.
    Language English
    Size Online-Ressource (273 p)
    Publisher Taylor and Francis
    Publishing place Hoboken
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9780415731003 ; 0415731003
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  10. Article ; Online: Heimlich Maneuver-Induced Diaphragmatic Rupture and Hiatal Hernia.

    Herman, Andrew / Maiti, Abhishek / Cherian, Sujith V / Estrada-Y-Martin, Rosa M

    The American journal of the medical sciences

    2018  Volume 355, Issue 4, Page(s) e13

    MeSH term(s) Aged, 80 and over ; Airway Obstruction/therapy ; Female ; Heimlich Maneuver/adverse effects ; Hernia, Diaphragmatic, Traumatic/diagnostic imaging ; Hernia, Diaphragmatic, Traumatic/etiology ; Hernia, Diaphragmatic, Traumatic/surgery ; Hernia, Hiatal/diagnostic imaging ; Hernia, Hiatal/etiology ; Hernia, Hiatal/surgery ; Humans ; Tomography, X-Ray Computed ; Treatment Outcome
    Language English
    Publishing date 2018-01-06
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 82078-7
    ISSN 1538-2990 ; 0002-9629
    ISSN (online) 1538-2990
    ISSN 0002-9629
    DOI 10.1016/j.amjms.2017.11.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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