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  1. Article: Experten aus eigener Erfahrung - Peer Counseling in Beratungs- und Unterstützungskontexten

    Hermes, Gisela

    Case Management

    2019  Volume 16, Issue 1, Page(s) 32

    Language German
    Document type Article
    ZDB-ID 2204426-7
    ISSN 1861-0102
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6165: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Community based buprenorphine micro-induction in the context of methadone maintenance treatment and fentanyl - Case report.

    Kaliamurthy, Sivabalaji / Jegede, Oluwole / Hermes, Gretchen

    Journal of addictive diseases

    2022  Volume 41, Issue 2, Page(s) 175–180

    Abstract: Introduction: The micro-induction method of initiating buprenorphine is becoming a popular method for initiating buprenorphine in patients with Opioid Use Disorder, who are on full opioid agonists, either prescribed or non-prescribed, in order to avoid ... ...

    Abstract Introduction: The micro-induction method of initiating buprenorphine is becoming a popular method for initiating buprenorphine in patients with Opioid Use Disorder, who are on full opioid agonists, either prescribed or non-prescribed, in order to avoid precipitated withdrawal. Given the rising concerns around illicit fentanyl use, this method of initiating buprenorphine has become another tool for clinicians to help patients with Opioid Use Disorder, even when multiple full opioid agonists are involved. While the process for initiating buprenorphine through this process is well studied, the characteristics of patients who are able to tolerate this initiation method in an outpatient setting is not.
    Case(s): We present the cases of two patients with Opioid Use Disorder in a community-based methadone maintenance program in whom micro-induction methods were used to initiate buprenorphine without lowering the methadone dose. Both patients successfully transitioned to buprenorphine without precipitated withdrawal. One of the patients was also using fentanyl at the time of induction and was able to abstain from fentanyl use following the induction process.
    Conclusion: Initiating Buprenorphine using micro-induction strategies in a community based outpatient clinic in patients who are already on full opioid agonists is feasible, in these particular cases, the methadone dose or concurrent fentanyl use did not affect the outcome. We present the characteristics of the patient and the community clinic hoping that this helps more clinicians in replicating this induction strategy.
    MeSH term(s) Humans ; Buprenorphine/therapeutic use ; Methadone/therapeutic use ; Analgesics, Opioid/therapeutic use ; Fentanyl/therapeutic use ; Opiate Substitution Treatment/methods ; Opioid-Related Disorders/drug therapy ; Opioid-Related Disorders/rehabilitation
    Chemical Substances Buprenorphine (40D3SCR4GZ) ; Methadone (UC6VBE7V1Z) ; Analgesics, Opioid ; Fentanyl (UF599785JZ)
    Language English
    Publishing date 2022-04-04
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1077616-3
    ISSN 1545-0848 ; 1055-0887
    ISSN (online) 1545-0848
    ISSN 1055-0887
    DOI 10.1080/10550887.2022.2051985
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1696: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Book ; Thesis: Antagonistische Wirkung von Milch und Phytat auf die Resorption von Spurenelementen

    Hermes, Gesa

    1995  

    Author's details vorgelegt von Gesa Hermes
    Size 123 S. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Kiel, Univ., Diss., 1995
    Note Zsfassung in engl. Sprache
    Remark Abt. Nussallee/Bereichsbibl. ZBMed: AY 17590
    HBZ-ID HT006854222
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    968/168 available for loan (reading room) Freihandmagazin (U1)

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  4. Article ; Online: Pregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder.

    Milivojevic, Verica / Charron, Lily / Fogelman, Nia / Hermes, Gretchen / Sinha, Rajita

    Biomolecules

    2022  Volume 12, Issue 11

    Abstract: Chronic cocaine use leads to adaptations in stress biology and in neuroactive steroid system. These adaptations are associated with high cocaine craving and increased relapse risk. This study tested whether potentiation of the neuroactive steroid system ... ...

    Abstract Chronic cocaine use leads to adaptations in stress biology and in neuroactive steroid system. These adaptations are associated with high cocaine craving and increased relapse risk. This study tested whether potentiation of the neuroactive steroid system with the precursor pregnenolone (PREG) affects stress- and cue-induced cocaine craving, anxiety and autonomic response in individuals with cocaine use disorder (CUD). Thirty treatment-seeking individuals (21 Male, 9 Female) with CUD were randomized to placebo (PBO) or supraphysiologic PREG doses of 300 mg or 500 mg per day for 8 weeks. After 2 weeks of treatment, participants were exposed to 5-min personalized guided imagery provocation of stress, cocaine, or neutral/relaxing cues in a 3-day experiment, one condition per day on separate days, in a random, counterbalanced order. Repeated assessment of cocaine craving, anxiety, heart rate (HR), systolic (SBP) and diastolic blood pressure (DBP) were assessed on each day. PREG significantly increased pregnenolone levels compared to PBO. Both PREG doses decreased stress- and cocaine cue-induced craving and reduced both stress- and cue-induced anxiety only in the 500 mg/day group. The 500 mg/day PREG group also displayed decreased stress-induced HR, SBP and DBP. Findings indicate that pregnenolone decreases stress- and cocaine cue-provoked craving and anxiety and reduces stress-induced autonomic arousal in individuals with CUD.
    MeSH term(s) Humans ; Male ; Female ; Craving ; Pregnenolone ; Neurosteroids ; Stress, Psychological/complications ; Anxiety/drug therapy ; Arousal ; Cocaine
    Chemical Substances Pregnenolone (73R90F7MQ8) ; Neurosteroids ; Cocaine (I5Y540LHVR)
    Language English
    Publishing date 2022-10-29
    Publishing country Switzerland
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom12111593
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Differential effects of recent versus past traumas on mood, social support, binge drinking, emotional eating and BMI, and on neural responses to acute stress.

    Hermes, Gretchen / Fogelman, Nia / Seo, Dongju / Sinha, Rajita

    Stress (Amsterdam, Netherlands)

    2021  Volume 24, Issue 6, Page(s) 686–695

    Abstract: Traumatic stress is associated with risk of psychiatric and physical illnesses. However, the differential and separable effects of past versus recent traumas on maladaptive coping and neural responses are not known. We conducted two studies to assess ... ...

    Abstract Traumatic stress is associated with risk of psychiatric and physical illnesses. However, the differential and separable effects of past versus recent traumas on maladaptive coping and neural responses are not known. We conducted two studies to assess separate and combined effects of cumulative recent and past trauma on health outcomes (study 1) and on neural responses to acute stress exposure in a subsample of individuals (study 2). Study 1 assessed a large cohort of 677 community adults cross-sectionally, and findings indicated that both high recent (within the last 12 months) and past trauma (prior to the last twelve months) were associated with more physical and psychological symptoms, including increased depression (all
    MeSH term(s) Adult ; Binge Drinking ; Body Mass Index ; Emotions/physiology ; Humans ; Magnetic Resonance Imaging ; Prefrontal Cortex ; Social Support ; Stress, Psychological
    Language English
    Publishing date 2021-02-17
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1387706-9
    ISSN 1607-8888 ; 1025-3890
    ISSN (online) 1607-8888
    ISSN 1025-3890
    DOI 10.1080/10253890.2021.1877271
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5673: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Thesis ; Online: Mining the human intestinal microbiota for biomarkers associated with metabolic disorders

    Hermes, Gerben

    2016  

    Abstract: After birth, our gastrointestinal (GI) tract is colonized by a highly complex assemblage of microbes, collectively termed the GI microbiota, that develop intimate interactions with our body. Recent evidence indicates that the GI microbiota and its ... ...

    Abstract After birth, our gastrointestinal (GI) tract is colonized by a highly complex assemblage of microbes, collectively termed the GI microbiota, that develop intimate interactions with our body. Recent evidence indicates that the GI microbiota and its products may contribute to the development of obesity and related diseases. This, coupled with the current worldwide epidemic of obesity, has moved microbiome research into the spotlight of attention. Although the main cause of obesity and its associated metabolic complications is excess caloric intake compared with expenditure, differences in GI tract microbial ecology between individuals might be an important biomarker, mediator or even new therapeutic target. Nevertheless, it is currently still unclear which bacterial groups play a role in the development of the metabolic syndrome in humans. This might partly be explained by: 1. Biological factors such as the heterogeneity in genotype, lifestyle, diet; and the often complex aetiology of human disease of which the metabolic syndrome is no exception. 2. Technological factors, such as the use of miscellaneous incompatible methods to assess the gut microbiota, often enumerating specific groups rather than using broad 16S rRNA gene surveys or metagenomics. 3. Studies vary greatly in the populations considered, their designs, and the degree of control for potential confounding factors such as lifestyle and diet. Nevertheless, recent research on this matter has shown a conceptual shift by focusing on more homogenous subpopulations, based on stricter control over variables such age range or through the use of both anthropometric (weight, total body fat) as well as biochemical variables (insulin resistance, hyperlipidaemia) to define groups. Perturbations in microbial diversity and community structure in adults with overweight and obesity may be partly due to long-term dietary habits or physiological changes in these subjects. As such, exploring the association between the gut microbiota and variation in BMI and weight in ...
    Keywords antibiotics ; biomarkers ; dna sequencing ; gastrointestinal microbiota ; intestinal microorganisms ; metabolic disorders ; obesity ; ribosomal rna ; rna ; antibiotica ; darmmicro-organismen ; dna-sequencing ; microbiota van het spijsverteringskanaal ; obesitas ; ribosomaal rna ; stofwisselingsstoornissen
    Subject code 610
    Language English
    Publisher Wageningen University
    Publishing country nl
    Document type Thesis ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Book ; Online: Wayne County Volunteers Feed Hundreds of Families During Pandemic Thousands of pounds of food distributed to low-income Metro Detroit families in need

    Hermes, Grant / Johncox, Cassidy

    Pandemic Response and Religion in the USA: Material Culture

    2020  

    Abstract: This article features the efforts of volunteers from the Islamic Center of North America, Mount Moriah Baptist Church, and the Wayne County Executive Office to deliver food to low-income families and individuals in Wayne County, Michigan who have been ... ...

    Abstract This article features the efforts of volunteers from the Islamic Center of North America, Mount Moriah Baptist Church, and the Wayne County Executive Office to deliver food to low-income families and individuals in Wayne County, Michigan who have been impacted by the COVID-19 pandemic. Dr. Muhammed Nassar of the Islamic Center of America is featured in the article.
    Keywords Christianity ; Food Distribution ; Islam ; Low-Income Families ; Metro-Detroit ; Midwest ; American Studies ; Religion ; Virus Diseases ; covid19
    Publishing date 2020-06-06T07:00:00Z
    Publisher ScholarWorks at WMU
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Pregnenolone effects on provoked alcohol craving, anxiety, HPA axis, and autonomic arousal in individuals with alcohol use disorder.

    Milivojevic, Verica / Sullivan, Liam / Tiber, Jessica / Fogelman, Nia / Simpson, Christine / Hermes, Gretchen / Sinha, Rajita

    Psychopharmacology

    2022  Volume 240, Issue 1, Page(s) 101–114

    Abstract: Rationale: Chronic alcohol intake down-regulates GABAergic transmission and reduces levels of neuroactive steroids. These changes are associated with greater stress dysregulation and high alcohol craving which in turn increases relapse risk.: ... ...

    Abstract Rationale: Chronic alcohol intake down-regulates GABAergic transmission and reduces levels of neuroactive steroids. These changes are associated with greater stress dysregulation and high alcohol craving which in turn increases relapse risk.
    Objectives: This study tested whether potentiation of the neurosteroid system with pregnenolone (PREG), a precursor to neuroactive steroids and known to increase GABAergic transmission, will normalize chronic alcohol-related stress adaptations in the hypothalamic-pituitary-adrenal (HPA) axis and autonomic responses and reduce alcohol craving to significantly impact relapse risk.
    Methods: Forty-three treatment-seeking individuals with alcohol use disorder (AUD) were randomized to placebo (PBO) or supraphysiologic pregnenolone doses of 300 mg or 500 mg treatment using a parallel-between subject design as part of a larger 8-week pilot clinical trial. In week 2, they participated in a 3-day laboratory experiment where on each day they self-administered the assigned study drug in the laboratory and were then exposed to 5-min personalized guided imagery provocation of stress, alcohol, or neutral/relaxing cues, one condition per day on separate days, in a random, counterbalanced order. Repeated assessments of alcohol craving, anxiety, HPA axis, heart rate (HR), systolic (SBP), and diastolic blood pressure (DBP) and serum pregnenolone levels were made on each day.
    Results: Pregnenolone levels were significantly increased in the PREG groups versus PBO. PREG treatment decreased stress- and alcohol cue- induced craving and dose-specifically reduced stress-induced anxiety in the 300 mg/day group. Both PREG doses compared to PBO also normalized CORT/ACTH and increased stress-induced HR, stress- and cue-induced SBP, and in the 300 mg PREG group cue-induced DBP responses relative to neutral condition.
    Conclusions: Findings indicate that pregnenolone decreases stress- and alcohol cue-provoked craving and normalizes HPA axis and autonomic arousal in individuals with AUD, thereby supporting the need for further assessment of pregnenolone in the treatment of AUD.
    MeSH term(s) Humans ; Alcoholism/drug therapy ; Craving ; Hypothalamo-Hypophyseal System ; Pregnenolone/pharmacology ; Neurosteroids/pharmacology ; Pituitary-Adrenal System ; Anxiety/drug therapy ; Alcohol Drinking ; Ethanol/pharmacology ; Arousal ; Recurrence ; Cues
    Chemical Substances Pregnenolone (73R90F7MQ8) ; Neurosteroids ; Ethanol (3K9958V90M)
    Language English
    Publishing date 2022-11-29
    Publishing country Germany
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 130601-7
    ISSN 1432-2072 ; 0033-3158
    ISSN (online) 1432-2072
    ISSN 0033-3158
    DOI 10.1007/s00213-022-06278-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui I Zs.240: Show issues Location:
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  9. Article: Das öffentliche Recht auf der Suche nach seinem Gegenstand

    Hermes, Georg

    100 Jahre Rechtswissenschaft in Frankfurt : Erfahrungen, Herausforderungen, Erwartungen , p. 133-154

    2014  , Page(s) 133–154

    Author's details Georg Hermes
    Language German
    Publisher Klostermann
    Publishing place Frankfurt am Main
    Document type Article
    ISBN 978-3-465-03860-3 ; 3-465-03860-6
    Database Former special subject collection: coastal and deep sea fishing

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  10. Article: Modified CLEC3A-Derived Antimicrobial Peptides Lead to Enhanced Antimicrobial Activity against Drug-Resistant Bacteria.

    Meinberger, Denise / Drexelius, Marco G / Grabeck, Joshua / Hermes, Gabriele / Roth, Annika / Elezagic, Dzemal / Neundorf, Ines / Streichert, Thomas / Klatt, Andreas R

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 10

    Abstract: Antimicrobial peptides (AMPs) represent a promising alternative to conventional antibiotics. Sequence changes can significantly improve the therapeutic properties of antimicrobial peptides. In our study, we apply different sequence modifications to ... ...

    Abstract Antimicrobial peptides (AMPs) represent a promising alternative to conventional antibiotics. Sequence changes can significantly improve the therapeutic properties of antimicrobial peptides. In our study, we apply different sequence modifications to enhance the performance of the CLEC3A-derived AMPs HT-16 and HT-47. We truncated their sequences, inserting a triple-glycine linker, adding an N-terminal tryptophan residue, and generating a D-amino acid variant, resulting in the generation of seven new peptides. We investigated their antimicrobial activity against gram-positive and gram-negative bacteria, their cytotoxicity to murine cells, and the biostability of the modified peptides in serum. We identified a novel antimicrobial peptide, WRK-30, with enhanced antimicrobial potency against
    Language English
    Publishing date 2023-10-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12101532
    Database MEDical Literature Analysis and Retrieval System OnLINE

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