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  1. Article ; Online: Correction to "Interview with Elijah Petersen, 2020 Chemical Research in Toxicology Young Investigator Award, American Chemical Society Division of Chemical Toxicology".

    Hernandez, Alfredo J

    Chemical research in toxicology

    2021  Volume 34, Issue 3, Page(s) 934

    Language English
    Publishing date 2021-02-10
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 639353-6
    ISSN 1520-5010 ; 0893-228X
    ISSN (online) 1520-5010
    ISSN 0893-228X
    DOI 10.1021/acs.chemrestox.1c00050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Measuring the Complex Effects of the Single-Stranded DNA-Binding Protein gp2.5 on Primer Synthesis and Extension by the Bacteriophage T7 Replisome.

    Hernandez, Alfredo J

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2281, Page(s) 323–332

    Abstract: The single-stranded DNA-binding protein gp2.5 of bacteriophage T7 plays myriad functions in the replication of phage genomes. In addition to interacting with ssDNA, gp2.5 binds to the T7 DNA polymerase and primase/helicase proteins, regulating their ... ...

    Abstract The single-stranded DNA-binding protein gp2.5 of bacteriophage T7 plays myriad functions in the replication of phage genomes. In addition to interacting with ssDNA, gp2.5 binds to the T7 DNA polymerase and primase/helicase proteins, regulating their enzymatic activities. Here we describe in vitro methods to examine the effects of gp2.5 on primer synthesis and extension by the T7 replisome.
    MeSH term(s) Bacteriophage T7/physiology ; DNA Primers/chemical synthesis ; DNA Primers/genetics ; DNA Replication ; DNA, Single-Stranded/metabolism ; DNA, Viral/metabolism ; DNA-Binding Proteins/metabolism ; DNA-Directed DNA Polymerase/metabolism ; Viral Proteins/metabolism ; Virus Replication
    Chemical Substances DNA Primers ; DNA, Single-Stranded ; DNA, Viral ; DNA-Binding Proteins ; Viral Proteins ; gene 2.5 protein, Enterobacteria phage T7 ; DNA-Directed DNA Polymerase (EC 2.7.7.7)
    Language English
    Publishing date 2021-04-13
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1290-3_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Interview with Elijah Petersen, 2020 Chemical Research in Toxicology Young Investigator Award, American Chemical Society Division of Chemical Toxicology.

    Hernandez, Alfredo J

    Chemical research in toxicology

    2020  Volume 34, Issue 1, Page(s) 5–6

    MeSH term(s) Awards and Prizes ; History, 21st Century ; Humans ; Toxicology/history ; United States
    Language English
    Publishing date 2020-12-24
    Publishing country United States
    Document type Biography ; Historical Article ; Interview
    ZDB-ID 639353-6
    ISSN 1520-5010 ; 0893-228X
    ISSN (online) 1520-5010
    ISSN 0893-228X
    DOI 10.1021/acs.chemrestox.0c00435
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Letter to the editor of "Sleep Medicine" regarding the publication entitled "Acoustic stimulation time-locked to the beginning of sleep apnea events reduces oxygen desaturations: a pilot-study", by Waeber et al.

    Hernández, Alfredo / Pépin, Jean-Louis

    Sleep medicine

    2021  Volume 93, Page(s) 100

    MeSH term(s) Acoustic Stimulation ; Humans ; Oxygen ; Pilot Projects ; Sleep ; Sleep Apnea Syndromes/therapy
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2021-11-07
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 2012041-2
    ISSN 1878-5506 ; 1389-9457
    ISSN (online) 1878-5506
    ISSN 1389-9457
    DOI 10.1016/j.sleep.2021.10.036
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5315: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MO 635: Show issues

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  5. Article ; Online: Age-Dependent Changes in the Occurrence and Segregation of GABA and Acetylcholine in the Rat Superior Cervical Ganglia.

    Hernández, Alfredo / González-Sierra, Constanza / Zetina, María Elena / Cifuentes, Fredy / Morales, Miguel Angel

    International journal of molecular sciences

    2024  Volume 25, Issue 5

    Abstract: The occurrence, inhibitory modulation, and trophic effects of GABA have been identified in the peripheral sympathetic nervous system. We have demonstrated that GABA and acetylcholine (ACh) may colocalize in the same axonal varicosities or be segregated ... ...

    Abstract The occurrence, inhibitory modulation, and trophic effects of GABA have been identified in the peripheral sympathetic nervous system. We have demonstrated that GABA and acetylcholine (ACh) may colocalize in the same axonal varicosities or be segregated into separate ones in the rat superior cervical ganglia (SCG). Neurotransmitter segregation varies with age and the presence of neurotrophic factors. Here, we explored age-dependent changes in the occurrence and segregation of GABA and ACh in rats ranging from 2 weeks old (wo) to 12 months old or older. Using immunohistochemistry, we characterized the expression of L-glutamic acid decarboxylase of 67 kDa (GAD67) and vesicular acetylcholine transporter (VAChT) in the rat SCG at 2, 4, 8, 12 wo and 12 months old or older. Our findings revealed that GAD67 was greater at 2 wo compared with the other ages, whereas VAChT levels were greater at 4 wo than at 12 wo and 12 months old or older. The segregation of these neurotransmitters was more pronounced at 2 and 4 wo. We observed a caudo-rostral gradient of segregation degree at 8 and 12 wo. Data point out that the occurrence and segregation of GABA and ACh exhibit developmental adaptative changes throughout the lifetime of rats. We hypothesize that during the early postnatal period, the increase in GABA and GABA-ACh segregation promotes the release of GABA alone which might play a role in trophic actions.
    MeSH term(s) Rats ; Animals ; Superior Cervical Ganglion ; Acetylcholine/metabolism ; Axons/metabolism ; gamma-Aminobutyric Acid/metabolism
    Chemical Substances Acetylcholine (N9YNS0M02X) ; gamma-Aminobutyric Acid (56-12-2)
    Language English
    Publishing date 2024-02-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25052588
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Parametric analysis of an integrated cardio-respiratory model in preterm newborns during apnea.

    Duport, Orlane / Rolle, Virginie Le / Guerrero, Gustavo / Beuchée, Alain / Hernández, Alfredo I

    Computers in biology and medicine

    2024  Volume 173, Page(s) 108343

    Abstract: The analysis of the complex interactions involved in the acute physiological response to apnea-bradycardia events in preterm newborns remains a challenging task. This paper presents a novel integrated model of cardio-respiratory interactions, adapted to ... ...

    Abstract The analysis of the complex interactions involved in the acute physiological response to apnea-bradycardia events in preterm newborns remains a challenging task. This paper presents a novel integrated model of cardio-respiratory interactions, adapted to preterm newborns. A sensitivity analysis, based Morris' screening method, was applied to study the effects of physiological parameters on heart rate and desaturation, during the simulation of a 15-seconds apnea-bradycardia episode. The most sensitive parameters are associated with fundamental, integrative physiological mechanisms involving: (i) respiratory mechanics (intermediate airways and lung compliance), (ii) fraction of inspired oxygen, (iii) metabolic rates (oxygen consumption rate), (iv) heart rate regulation and (v) chemoreflex (gain). Results highlight the relevant influence of physiological variables, involved in preterm apnea-bradycardia events.
    MeSH term(s) Infant, Newborn ; Humans ; Apnea ; Bradycardia ; Infant, Premature/physiology ; Respiration ; Respiratory Rate ; Oxygen
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 127557-4
    ISSN 1879-0534 ; 0010-4825
    ISSN (online) 1879-0534
    ISSN 0010-4825
    DOI 10.1016/j.compbiomed.2024.108343
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    Zs.A 653: Show issues Location:
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  7. Article: Response of dung beetle diversity to three livestock management systems in drylands of central Mexico

    Barragán, Felipe / Labastida, Javier / Ramírez-Hernández, Alfredo

    Journal of arid environments. 2021 Oct., v. 193

    2021  

    Abstract: Human activities such as livestock raising have modified the Mexican High Plateau in a land-use mosaic. We assessed the response of dung beetles to three livestock management systems with different intensities of cattle rearing, which determines their ... ...

    Abstract Human activities such as livestock raising have modified the Mexican High Plateau in a land-use mosaic. We assessed the response of dung beetles to three livestock management systems with different intensities of cattle rearing, which determines their respective vegetation coverage. We found significant differences in species diversity in the three systems, due mainly to Euoniticellus intermedius and Digitonthophagus gazella, which were dominant species in induced pasture. Species turnover showed that induced pasture was significantly different from managed and unmanaged pasture. Both exotic species were also an indicator for induced pasture, along with Aphodius pseudolividus. Our results are presumably related to the differences in land use that influence community composition, favoring the presence of opportunistic dung beetle species in induced pastures. Managed and unmanaged pasture probably represent a more stable habitat for species that are more susceptible to habitat perturbation. We propose E. intermedius, D. gazella and A. pseudolividus as the main indicator species of habitat perturbation because they are able to colonize open grasslands when not facing competition with native species. Maintaining habitat heterogeneity, including native vegetation and extensive livestock farming, can aid the ecosystem conservation services provided by dung beetles, ensuring cattle production and food security.
    Keywords Aphodius ; Euoniticellus intermedius ; arid lands ; cattle ; cattle production ; community structure ; dominant species ; dung beetles ; ecosystems ; feces ; food security ; habitats ; humans ; indicator species ; indigenous species ; introduced species ; land use ; livestock husbandry ; pastures ; species diversity ; Mexico
    Language English
    Dates of publication 2021-10
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 428507-4
    ISSN 1095-922X ; 0140-1963
    ISSN (online) 1095-922X
    ISSN 0140-1963
    DOI 10.1016/j.jaridenv.2021.104598
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 6073: Show issues

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  8. Article: Corrosion Induced on Aluminum by Biodiesel Components in Non-Oxygen Environments.

    Vergara-Juarez, Fabiola / Porcayo-Calderon, Jesus / Perez-Orozco, Juan Pablo / Acevedo-Quiroz, Macdiel Emilio / Bustos-Terrones, Victoria / Quinto-Hernandez, Alfredo

    Materials (Basel, Switzerland)

    2024  Volume 17, Issue 8

    Abstract: Biodiesel is a mixture of saturated and unsaturated Fatty Acid Methyl Esters (FAMEs) whose composition affects the corrosion behavior of metal containers during storage. This study examines the effect of the C=C bond present in selected FAMEs (Methyl ... ...

    Abstract Biodiesel is a mixture of saturated and unsaturated Fatty Acid Methyl Esters (FAMEs) whose composition affects the corrosion behavior of metal containers during storage. This study examines the effect of the C=C bond present in selected FAMEs (Methyl Stearate, Methyl Oleate, and Methyl Linoleate) in aluminum corrosion in the absence of oxygen. First, mass loss assays were carried out at 100, 200, and 280 °C for 1000 h using pure Methyl Stearate (MS), 5% Methyl Oleate in Methyl Stearate (MS-5% MO), and 5% Methyl Linoleate in Methyl Stearate (MS-5% ML). Next, chemical changes in FAMEs were studied using FTIR, TGA, and GC/MS. SEM/EDS analysis allowed us to inspect the aluminum surfaces and their chemical characterization. We estimated higher corrosion rates for MS assays than those of unsaturated methyl ester mixtures. In a separate set of experiments, we used electrochemical techniques (potentiodynamic polarization, linear polarization resistance, and electrochemical impedance spectroscopy) to investigate aluminum corrosion induced by thermal-degraded products from FAMEs at 100, 200, and 280 °C for 300 h able to dissolve in aqueous extracts. These electrochemical experiments revealed that the products in the aqueous extracts from the unsaturated methyl ester mixture form a passive layer on the Al surface thicker than pure MS at the corresponding degradation temperatures.
    Language English
    Publishing date 2024-04-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma17081821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Parametric Analysis of an Integrated Model of Cardio-respiratory Interactions in Adults in the Context of Obstructive Sleep Apnea.

    Guerrero, Gustavo / Le Rolle, Virginie / Hernández, Alfredo

    Annals of biomedical engineering

    2021  Volume 49, Issue 12, Page(s) 3374–3387

    Abstract: An original integrated model of cardio-respiratory interactions is presented in this paper with the objective of studying the acute physiological responses evoked by obstructive sleep apnea events in adults. A comprehensive sensitivity analysis of the ... ...

    Abstract An original integrated model of cardio-respiratory interactions is presented in this paper with the objective of studying the acute physiological responses evoked by obstructive sleep apnea events in adults. A comprehensive sensitivity analysis of the model is proposed during the simulation of a 20 s obstructive apnea episode using the Morris' screening method and local sensitivity analysis. The more relevant parameters are related to the following mechanisms of the physiology: (i) the fraction of oxygen in inspired air, (ii) metabolic rates (oxygen consumption rate, CO
    MeSH term(s) Adult ; Blood Circulation ; Computer Simulation ; Heart Conduction System/physiopathology ; Humans ; Models, Cardiovascular ; Oxygen Consumption ; Pulmonary Gas Exchange ; Respiratory Mechanics ; Sleep Apnea, Obstructive/physiopathology
    Language English
    Publishing date 2021-08-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 185984-5
    ISSN 1573-9686 ; 0191-5649 ; 0090-6964
    ISSN (online) 1573-9686
    ISSN 0191-5649 ; 0090-6964
    DOI 10.1007/s10439-021-02828-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1018: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  10. Article ; Online: Historiographical approaches to biogeography: a critical review.

    Bueno-Hernández, Alfredo / Barahona, Ana / J Morrone, Juan / Espinosa, David / Juárez-Barrera, Fabiola

    History and philosophy of the life sciences

    2023  Volume 45, Issue 3, Page(s) 27

    Abstract: We performed a critical review of the historiographical studies on biogeography. We began with the pioneering works of Augustin and Alphonse de Candolle. Then, we analyzed the historical accounts of biogeography developed by (1) Martin Fichman and his ... ...

    Abstract We performed a critical review of the historiographical studies on biogeography. We began with the pioneering works of Augustin and Alphonse de Candolle. Then, we analyzed the historical accounts of biogeography developed by (1) Martin Fichman and his history on the extensionism-permanentism debate; (2) Gareth Nelson and his critique of the Neo-Darwinian historiography of biogeography; (3) Ernst Mayr, with his dispersalist viewpoint; (4) Alan Richardson, who wrote a microhistory on the biogeographic model constructed by Darwin; (5) Michael Paul Kinch and the ideas discussed in the 19th century about the geographical distribution of living beings; (6) Janet Browne, who highlighted the importance of the pre-Darwinian naturalists; (7) Peter Bowler, who focused mainly on the influence of paleontology on biogeography; (8) James Larson, who looked into the practices of the naturalists of Northern Europe in the late 18th century; and (9) Malte Ebach, who like Larson, was more interested in analysing the practices rather than the ideas of naturalists who studied the geographical distribution of organisms. Finally, these works are compared with each other. There has not been a dominant paradigm in the construction of historical narratives of biogeography; however, they provide a useful context for understanding problems of biogeography that continue to be debated to this day.
    MeSH term(s) History, 20th Century ; History, 19th Century ; Historiography ; Europe ; Paleontology
    Language English
    Publishing date 2023-06-22
    Publishing country Switzerland
    Document type Historical Article ; Journal Article ; Review
    ZDB-ID 2094240-0
    ISSN 1742-6316 ; 0391-9714
    ISSN (online) 1742-6316
    ISSN 0391-9714
    DOI 10.1007/s40656-023-00580-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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