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Article ; Online: Purulent pericarditis by Staphylococcus Panton-Valentine secondary to hair implants.

Anmad Shihadeh, Leydimar / Couto Comba, Patricia / Hernández Carballo, Carolina

2017 Volume 148, Issue 11, Page(s) 525

Title translation	Pericarditis purulenta por Estafilococo Panton-Valentine secundaria a implantes de cabello.
MeSH term(s)	Adult ; Bacterial Toxins/metabolism ; Biomarkers/metabolism ; Cosmetic Techniques/adverse effects ; Exotoxins/metabolism ; Female ; Hair/transplantation ; Humans ; Leukocidins/metabolism ; Methicillin-Resistant Staphylococcus aureus/isolation & purification ; Methicillin-Resistant Staphylococcus aureus/metabolism ; Pericarditis/diagnosis ; Pericarditis/etiology ; Scalp/microbiology ; Scalp/surgery ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/etiology
Chemical Substances	Bacterial Toxins ; Biomarkers ; Exotoxins ; Leukocidins ; Panton-Valentine leukocidin
Language	Spanish
Publishing date	2017-03-21
Publishing country	Spain
Document type	Case Reports ; Letter
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2017.02.003
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Article: Inflammatory Targets in Diabetic Nephropathy.

Donate-Correa, Javier / Luis-Rodríguez, Desirée / Martín-Núñez, Ernesto / Tagua, Víctor G / Hernández-Carballo, Carolina / Ferri, Carla / Rodríguez-Rodríguez, Ana Elena / Mora-Fernández, Carmen / Navarro-González, Juan F

Journal of clinical medicine

2020 Volume 9, Issue 2

Abstract: One of the most frequent complications in patients with diabetes mellitus is diabetic nephropathy (DN). At present, it constitutes the first cause of end stage renal disease, and the main cause of cardiovascular morbidity and mortality in these patients. ...

Abstract	One of the most frequent complications in patients with diabetes mellitus is diabetic nephropathy (DN). At present, it constitutes the first cause of end stage renal disease, and the main cause of cardiovascular morbidity and mortality in these patients. Therefore, it is clear that new strategies are required to delay the development and the progression of this pathology. This new approach should look beyond the control of traditional risk factors such as hyperglycemia and hypertension. Currently, inflammation has been recognized as one of the underlying processes involved in the development and progression of kidney disease in the diabetic population. Understanding the cascade of signals and mechanisms that trigger this maladaptive immune response, which eventually leads to the development of DN, is crucial. This knowledge will allow the identification of new targets and facilitate the design of innovative therapeutic strategies. In this review, we focus on the pathogenesis of proinflammatory molecules and mechanisms related to the development and progression of DN, and discuss the potential utility of new strategies based on agents that target inflammation.
Language	English
Publishing date	2020-02-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm9020458
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Article ; Online: Klotho expression in peripheral blood circulating cells is associated with vascular and systemic inflammation in atherosclerotic vascular disease.

Martín-Núñez, Ernesto / Pérez-Castro, Atteneri / Tagua, Víctor G / Hernández-Carballo, Carolina / Ferri, Carla / Pérez-Delgado, Nayra / Rodríguez-Ramos, Sergio / Cerro-López, Purificación / López-Castillo, Ángel / Delgado-Molinos, Alejandro / López-Tarruella, Victoria Castro / Arévalo-Gómez, Miguel A / González-Luis, Ainhoa / Martín-Olivera, Alberto / Morales-Estévez, Carmen Chaxiraxi / Mora-Fernández, Carmen / Donate-Correa, Javier / Navarro-González, Juan F

Scientific reports

2022 Volume 12, Issue 1, Page(s) 8422

Abstract: Cardiovascular disease is the leading cause of death worldwide. New therapeutic strategies are aimed to modulate the athero-inflammatory process that partially orchestrates underlying vascular damage. Peripheral blood circulating cells include different ... ...

Abstract	Cardiovascular disease is the leading cause of death worldwide. New therapeutic strategies are aimed to modulate the athero-inflammatory process that partially orchestrates underlying vascular damage. Peripheral blood circulating cells include different immune cells with a central role in the development of the atherogenic inflammatory response. The anti-aging protein α-Klotho has been related to protective effects against CVD. KL is expressed in monocytes, macrophages, and lymphocytes where it exerts anti-inflammatory effects. In this work, we analyse the relationships of the levels of inflammatory markers with the expression of the KL gene in PBCCs and with the serum levels of soluble KL in atherosclerotic vascular disease. For this, we conducted a cross-sectional single-center case-control study including a study group of 76 CVD patients and a control group of 16 cadaveric organ donors without medical antecedent or study indicating CVD. Vascular artery fragments and whole blood and serum samples were obtained during elective or organ retrieval surgery. Serum levels of sKL, TNFα and IL10, and gene expression levels of KL, TNF, IL10, NFKB1, DNMT1, and DNMT3A in PBCCs were measured. In these cells, we also determined KL promoter methylation percentage. Histological and immunohistochemical analyses were employed to visualize atherosclerotic lesions and to measure IL10 and TNFα levels in vascular fragments. Patients with CVD presented higher values of proinflammatory markers both at systemic and in the vasculature and in the PBCCs, compared to the control group. In PBCCs, CVD patients also presented lower gene expression levels of KL gene (56.4% difference, P < 0.001), higher gene expression levels of DNMT1 and DNMT3A (P < 0.0001, for both) and a higher methylation status of in the promoter region of KL (34.1 ± 4.1% vs. 14.6 ± 3.4%, P < 0.01). In PBCCs and vasculature, KL gene expression correlated inversely with pro-inflammatory markers and directly with anti-inflammatory markers. sKL serum levels presented similar associations with the expression levels of pro- and anti-inflammatory markers in PBCCs. The differences in KL expression levels in PBCCs and in serum sKL levels with respect to control group was even greater in those CVD patients with macroscopically observable atheromatous plaques. We conclude that promoter methylation-mediated downregulation of KL gene expression in PBCCs is associated with the pro-inflammatory status in atherosclerotic vascular disease.
MeSH term(s)	Atherosclerosis/genetics ; Biomarkers ; Cardiovascular Diseases ; Case-Control Studies ; Cross-Sectional Studies ; Glucuronidase/metabolism ; Humans ; Inflammation/genetics ; Inflammation/metabolism ; Interleukin-10 ; Klotho Proteins ; Tumor Necrosis Factor-alpha/genetics
Chemical Substances	Biomarkers ; Tumor Necrosis Factor-alpha ; Interleukin-10 (130068-27-8) ; Glucuronidase (EC 3.2.1.31) ; Klotho Proteins (EC 3.2.1.31)
Language	English
Publishing date	2022-05-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-12548-z
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Article ; Online: Preventing future fractures: effectiveness of an orthogeriatric fracture liaison service compared to an outpatient fracture liaison service and the standard management in patients with hip fracture.

Naranjo, Antonio / Fernández-Conde, Sonia / Ojeda, Soledad / Torres-Hernández, Laura / Hernández-Carballo, Carolina / Bernardos, Idoia / Rodríguez, Sinforiano / Laynez, Pedro

Archives of osteoporosis

2017 Volume 12, Issue 1, Page(s) 112

Abstract: An observational study was carried out in two hospitals in patients > 65 years admitted for hip fracture. At 6 months, 15% of patients in the hospital with orthogeriatric standard care and 75% in the hospital with fracture liaison service were receiving ... ...

Abstract	An observational study was carried out in two hospitals in patients > 65 years admitted for hip fracture. At 6 months, 15% of patients in the hospital with orthogeriatric standard care and 75% in the hospital with fracture liaison service were receiving bisphosphonates. Purpose: Many patients with fractures are discharged without preventive therapy against further fractures. We sought to compare the effectiveness of an orthogeriatric fracture liaison service (FLS), outpatient FLS, and the standard care after hip fractures in prevention of future fractures. Methods: An observational study was carried out in two hospitals in patients > 65 years of age, admitted between March and July 2016 for fractures. The Candelaria hospital (HUNSC) has no specific protocol for secondary prevention, while at the Negrin Hospital (HUGCDN), an FLS nurse visits the inpatients, gathers metabolic history, instructs regarding the diet, exercises, and fall prevention, and completes a discharge report regarding osteoporosis treatment. The prescription rate of osteoporosis treatment was analyzed at admission, discharge, and 6 months after discharge. We also analyzed the data of patients with hip fractures who attended the outpatient FLS before March 2016. Results: We included a total of 185 inpatients with a mean age of 82 years and 73% were women. At admission, 8% of the patients in HUNSC and 10% in HUGCDN were receiving bisphosphonates. At discharge, the percentages were 8 and 96%, while at 6 months they were 15 and 75%, respectively (p < 0.001). The outpatient FLS recorded 206 hip fractures (27% of discharges for fractures), with 77% adherence to treatment at 6 months. Conclusions: Compared with the conventional management, the FLS model for inpatients with hip fractures achieved a fivefold increase in the adherence to treatment at 6 months, similar to the rates of outpatient FLS.
MeSH term(s)	Aged ; Aged, 80 and over ; Ambulatory Care/methods ; Bone Density Conservation Agents/therapeutic use ; Diphosphonates/therapeutic use ; Female ; Health Services for the Aged ; Hip Fractures/prevention & control ; Humans ; Inpatients/statistics & numerical data ; Male ; Osteoporotic Fractures/prevention & control ; Outpatients/statistics & numerical data ; Patient Compliance ; Secondary Prevention/methods
Chemical Substances	Bone Density Conservation Agents ; Diphosphonates
Language	English
Publishing date	2017-12-11
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	2253231-6
ISSN	1862-3514 ; 1862-3522
ISSN (online)	1862-3514
ISSN	1862-3522
DOI	10.1007/s11657-017-0373-9
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Article: Pentoxifylline for Renal Protection in Diabetic Kidney Disease. A Model of Old Drugs for New Horizons.

Donate-Correa, Javier / Tagua, Víctor G / Ferri, Carla / Martín-Núñez, Ernesto / Hernández-Carballo, Carolina / Ureña-Torres, Pablo / Ruiz-Ortega, Marta / Ortiz, Alberto / Mora-Fernández, Carmen / Navarro-González, Juan F

Journal of clinical medicine

2019 Volume 8, Issue 3

Abstract: Diabetic kidney disease is one of the most relevant complications in diabetes mellitus patients, which constitutes the main cause of end-stage renal disease in the western world. Delaying the progression of this pathology requires new strategies that, in ...

Abstract	Diabetic kidney disease is one of the most relevant complications in diabetes mellitus patients, which constitutes the main cause of end-stage renal disease in the western world. Delaying the progression of this pathology requires new strategies that, in addition to the control of traditional risk factors (glycemia and blood pressure), specifically target the primary pathogenic mechanisms. Nowadays, inflammation is recognized as a critical novel pathogenic factor in the development and progression of renal injury in diabetes mellitus. Pentoxifylline is a nonspecific phosphodiesterase inhibitor with rheologic properties clinically used for more than 30 years in the treatment of peripheral vascular disease. In addition, this compound also exerts anti-inflammatory actions. In the context of diabetic kidney disease, pentoxifylline has shown significant antiproteinuric effects and a delay in the loss of estimated glomerular filtration rate, although at the present time there is no definitive evidence regarding renal outcomes. Moreover, recent studies have reported that this drug can be associated with a positive impact on new factors related to kidney health, such as Klotho. The use of pentoxifylline as renoprotective therapy for patients with diabetic kidney disease represents a new example of drug repositioning.
Language	English
Publishing date	2019-02-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm8030287
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Article ; Online: Association between serum levels of Klotho and inflammatory cytokines in cardiovascular disease: a case-control study.

Martín-Núñez, Ernesto / Donate-Correa, Javier / Ferri, Carla / López-Castillo, Ángel / Delgado-Molinos, Alejandro / Hernández-Carballo, Carolina / Pérez-Delgado, Nayra / Rodríguez-Ramos, Sergio / Cerro-López, Purificación / Tagua, Víctor G / Mora-Fernández, Carmen / Navarro-González, Juan F

Aging

2020 Volume 12, Issue 2, Page(s) 1952–1964

Abstract: Decrease in soluble anti-aging Klotho protein levels is associated to cardiovascular disease (CVD). Diverse studies have shown a bidirectional relationship between Klotho and inflammation, a risk factor for the development of CVD. In this work we aimed ... ...

Abstract	Decrease in soluble anti-aging Klotho protein levels is associated to cardiovascular disease (CVD). Diverse studies have shown a bidirectional relationship between Klotho and inflammation, a risk factor for the development of CVD. In this work we aimed to evaluate the association between Klotho and inflammatory cytokines levels in the context of human CVD.The study included 110 patients with established CVD and preserved renal function, and a control group of 22 individuals without previous history of cardiovascular events. Serum Klotho and IL10 levels were significantly lower in the CVD group. Inflammatory status, marked by the TNFα/IL10 ratio and the C-reactive protein (CRP) levels, was significantly increased in the group of patients with established CVD. Soluble Klotho levels were directly correlated with eGFR (r=0.217) and IL10 (r=0.209) and inversely correlated with age (r=-0.261), CRP (r=-0.203), and TNFα/IL10 (r=-0.219). This association with TNFα/IL10 remained significant in age-matched subgroups. Multiple logistic regression analysis showed that age, smoking and the neutrophil-to-lymphocyte ratio (NLR) constituted risk factors for the presence of CVD, while Klotho was a protective factor.In conclusion, in patients with established CVD, the reduction in soluble Klotho is associated with a pro-inflammatory status marked by lower IL10 concentrations and higher TNFα/IL10 ratio and CRP levels.
MeSH term(s)	Aged ; Biomarkers ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/therapy ; Case-Control Studies ; Comorbidity ; Cytokines/blood ; Female ; Glucuronidase/blood ; Humans ; Inflammation Mediators/blood ; Male ; Middle Aged ; Prognosis ; Risk Factors
Chemical Substances	Biomarkers ; Cytokines ; Inflammation Mediators ; Glucuronidase (EC 3.2.1.31) ; klotho protein (EC 3.2.1.31)
Language	English
Publishing date	2020-01-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.102734
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Article: Cost-effectiveness of the hospital nutrition screening tool CIPA.

Suárez-Llanos, José Pablo / Vallejo-Torres, Laura / García-Bello, Miguel Ángel / Hernández-Carballo, Carolina / Calderón-Ledezma, Eduardo Mauricio / Rosat-Rodrigo, Adriá / Delgado-Brito, Irina / Pereyra-García-Castro, Francisca / Benitez-Brito, Nestor / Felipe-Pérez, Nieves / Ramallo-Fariña, Yolanda / Romero-Pérez, Juan Carlos

Archives of medical science : AMS

2019 Volume 16, Issue 2, Page(s) 273–281

Abstract: Introduction: Hospital malnutrition is very common and worsens the clinical course of patients while increasing costs. Lacking clinical-economic studies on the implementation of nutrition screening encouraged the evaluation of the CIPA (Control of Food ... ...

Abstract	Introduction: Hospital malnutrition is very common and worsens the clinical course of patients while increasing costs. Lacking clinical-economic studies on the implementation of nutrition screening encouraged the evaluation of the CIPA (Control of Food Intake, Protein, Anthropometry) tool. Material and methods: An open, non-randomized, controlled clinical trial was conducted on patients admitted to internal medicine and general and digestive surgery wards, who were either assigned to a control (standard hospital clinical care) or to an intervention, CIPA-performing ward (412 and 411, respectively; Results: The mean length of stay was higher in the CIPA group, though not significantly (+ 0.95 days; Conclusions: The CIPA nutrition screening tool is likely to be cost-effective in surgical but not in internal medicine patients.
Language	English
Publishing date	2019-01-11
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2203781-0
ISSN	1734-1922
ISSN	1734-1922
DOI	10.5114/aoms.2018.81128
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Article ; Online: Anti-inflammatory profile of paricalcitol in kidney transplant recipients.

Donate-Correa, Javier / Henríquez-Palop, Fernando / Martín-Núñez, Ernesto / Hernández-Carballo, Carolina / Ferri, Carla / Pérez-Delgado, Nayra / Muros-de-Fuentes, Mercedes / Mora-Fernández, Carmen / Navarro-González, Juan F

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia

2017 Volume 37, Issue 6, Page(s) 622–629

Abstract: Background and objectives: Paricalcitol, a selective vitamin D receptor activator, is used to treat secondary hyperparathyroidism in kidney transplant patients. Experimental and clinical studies in non-transplant kidney disease patients have found this ... ...

Title translation	Perfil antiinflamatorio del paricalcitol en el receptor de trasplante renal.
Abstract	Background and objectives: Paricalcitol, a selective vitamin D receptor activator, is used to treat secondary hyperparathyroidism in kidney transplant patients. Experimental and clinical studies in non-transplant kidney disease patients have found this molecule to have anti-inflammatory properties. In this exploratory study, we evaluated the anti-inflammatory profile of paricalcitol in kidney-transplant recipients. Methods: Thirty one kidney transplant recipients with secondary hyperparathyroidism completed 3 months of treatment with oral paricalcitol (1μg/day). Serum concentrations and gene expression levels of inflammatory cytokines in peripheral blood mononuclear cells were analysed at the beginning and end of the study. Results: Paricalcitol significantly decreased parathyroid hormone levels with no changes in calcium and phosphorous. It also reduced serum concentrations of interleukin (IL)-6 and tumour necrosis factor-alpha (TNF-α) by 29% (P<0.05) and 9.5% (P<0.05) compared to baseline, respectively. Furthermore, gene expression levels of IL-6 and TNF-α in peripheral blood mononuclear cells decreased by 14.1% (P<0.001) and 34.1% (P<0.001), respectively. The ratios between pro-inflammatory cytokines (TNF-α and IL-6) and anti-inflammatory cytokines (IL-10), both regarding serum concentrations and gene expression, also experienced a significant reduction. Conclusions: Paricalcitol administration to kidney transplant recipients has been found to have beneficial effects on inflammation, which may be associated with potential clinical benefits.
MeSH term(s)	Adult ; Aged ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; C-Reactive Protein/analysis ; Cytokines/biosynthesis ; Cytokines/blood ; Cytokines/genetics ; Ergocalciferols/pharmacology ; Ergocalciferols/therapeutic use ; Female ; Gene Expression Regulation/drug effects ; Humans ; Hyperparathyroidism, Secondary/blood ; Hyperparathyroidism, Secondary/drug therapy ; Hyperparathyroidism, Secondary/etiology ; Inflammation ; Kidney Transplantation ; Leukocytes, Mononuclear/metabolism ; Male ; Middle Aged ; Postoperative Complications/drug therapy ; Postoperative Complications/etiology ; Prospective Studies ; Receptors, Calcitriol/agonists
Chemical Substances	Anti-Inflammatory Agents ; Cytokines ; Ergocalciferols ; Receptors, Calcitriol ; paricalcitol (6702D36OG5) ; C-Reactive Protein (9007-41-4)
Language	Spanish
Publishing date	2017-11
Publishing country	Spain
Document type	Journal Article
ZDB-ID	632512-9
ISSN	1989-2284 ; 0211-6995
ISSN (online)	1989-2284
ISSN	0211-6995
DOI	10.1016/j.nefro.2017.03.028
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Article ; Online: Fibroblast growth factor 23 expression in human calcified vascular tissues.

Donate-Correa, Javier / Martín-Núñez, Ernesto / Hernández-Carballo, Carolina / Ferri, Carla / Tagua, Víctor G / Delgado-Molinos, Alejandro / López-Castillo, Ángel / Rodríguez-Ramos, Sergio / Cerro-López, Purificación / López-Tarruella, Victoria Castro / Felipe-García, Raquel / Arévalo-Gomez, Miguel A / Pérez-Delgado, Nayra / Mora-Fernández, Carmen / Navarro-González, Juan F

Aging

2019 Volume 11, Issue 18, Page(s) 7899–7913

Abstract: Vascular calcification is a major risk for cardiovascular disease and implies the transformation of smooth muscle cells to an osteoblastic phenotype as a consequence of dysregulation of calcium and phosphate metabolism. Fibroblast growth factor (FGF) 23 ... ...

Abstract	Vascular calcification is a major risk for cardiovascular disease and implies the transformation of smooth muscle cells to an osteoblastic phenotype as a consequence of dysregulation of calcium and phosphate metabolism. Fibroblast growth factor (FGF) 23 is the most potent phosphate regulator. Observational studies suggest that high levels of FGF23 are related to cardiovascular morbidity and mortality. In this work, we determined the levels of both the intact and the carboxi-terminal fragments of circulating FGF23 in 133 patients with established cardiovascular disease, the expression of FGF23, its receptors 1 and 3, and its co-receptor Klotho in vascular fragments of aorta, carotid and femoral in 43 out of this group of patients, and in a control group of 20 organ donors. Patients with atherosclerosis and vascular calcification presented increased levels of FGF23 respect to the control group. Vascular immunoreactivity for FGF23 was also significantly increased in patients with vascular calcification as compared to patients without calcification and to controls. Finally, gene expression of
MeSH term(s)	Aged ; Aorta/metabolism ; Aorta/pathology ; Carotid Arteries/metabolism ; Carotid Arteries/pathology ; Female ; Femoral Artery/metabolism ; Femoral Artery/pathology ; Fibroblast Growth Factors/metabolism ; Glucuronidase ; Humans ; Male ; Middle Aged ; Muscle, Smooth, Vascular/metabolism ; Muscle, Smooth, Vascular/pathology ; Myocytes, Smooth Muscle/metabolism ; Myocytes, Smooth Muscle/pathology ; Vascular Calcification/metabolism ; Vascular Calcification/pathology
Chemical Substances	Fibroblast Growth Factors (62031-54-3) ; fibroblast growth factor 23 (7Q7P4S7RRE) ; Glucuronidase (EC 3.2.1.31) ; klotho protein (EC 3.2.1.31)
Language	English
Publishing date	2019-09-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.102297
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Article: FGF23 and Klotho Levels are Independently Associated with Diabetic Foot Syndrome in Type 2 Diabetes Mellitus.

Donate-Correa, Javier / Martín-Núñez, Ernesto / Ferri, Carla / Hernández-Carballo, Carolina / Tagua, Víctor G / Delgado-Molinos, Alejandro / López-Castillo, Ángel / Rodríguez-Ramos, Sergio / Cerro-López, Purificación / López-Tarruella, Victoria Castro / Arévalo-González, Miguel Angel / Pérez-Delgado, Nayra / Mora-Fernández, Carmen / Navarro-González, Juan F

Journal of clinical medicine

2019 Volume 8, Issue 4

Abstract: Background: Diabetic foot syndrome (DFS) is a prevalent complication in the diabetic population and a major cause of hospitalizations. Diverse clinical studies have related alterations in the system formed by fibroblast growth factor (FGF)-23 and Klotho ...

Abstract	Background: Diabetic foot syndrome (DFS) is a prevalent complication in the diabetic population and a major cause of hospitalizations. Diverse clinical studies have related alterations in the system formed by fibroblast growth factor (FGF)-23 and Klotho (KL) with vascular damage. In this proof-of-concept study, we hypothesize that the levels of FGF23 and Klotho are altered in DFS patients. Methods: Twenty patients with limb amputation due to DFS, 37 diabetic patients without DFS, and 12 non-diabetic cadaveric organ donors were included in the study. Serum FGF23/Klotho and inflammatory markers were measured by enzyme-linked immunosorbent assay (ELISA). Protein and gene expression levels in the vascular samples were determined by immunohistochemistry and quantitative real-time PCR, respectively. Results: Serum Klotho is significantly reduced and FGF23 is significantly increased in patients with DFS ( Conclusion: FGF23/Klotho system is associated with DFS, pointing to a new pathophysiological pathway involved in the development and progression of this complication.
Language	English
Publishing date	2019-04-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm8040448
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