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  1. Article ; Online: Clinical course and prognostic factors of COVID-19 infection in an elderly hospitalized population.

    Mostaza, Jose M / García-Iglesias, Francisca / González-Alegre, Teresa / Blanco, Francisco / Varas, Marta / Hernández-Blanco, Clara / Hontañón, Victor / Jaras-Hernández, María J / Martínez-Prieto, Mónica / Menéndez-Saldaña, Araceli / Cachán, María L / Estirado, Eva / Lahoz, Carlos

    Archives of gerontology and geriatrics

    2020  Volume 91, Page(s) 104204

    Abstract: Introduction: Older subjects have a higher risk of COVID-19 infection and a greater mortality. However, there is a lack of studies evaluating the characteristics of this infection at advanced age.: Patients and methods: We studied 404 patients ≥ 75 ... ...

    Abstract Introduction: Older subjects have a higher risk of COVID-19 infection and a greater mortality. However, there is a lack of studies evaluating the characteristics of this infection at advanced age.
    Patients and methods: We studied 404 patients ≥ 75 years (mean age 85.2 ± 5.3 years, 55 % males), with PCR-confirmed COVID-19 infection, attended in two hospitals in Madrid (Spain). Patients were followed-up until they were discharged from the hospital or until death.
    Results: Symptoms started 2-7 days before admission, and consisted of fever (64 %), cough (59 %), and dyspnea (57 %). A total of 145 patients (35.9 %) died a median of 9 days after hospitalization. In logistic regression analysis, predictive factors of death were age (OR 1.086; 1.015-1.161 per year, p = 0.016), heart rate (1.040; 1.018-1.061 per beat, p < 0.0001), a decline in renal function during hospitalization (OR 7.270; 2.586-20.441, p < 0.0001) and worsening dyspnea during hospitalization (OR 73.616; 30.642-176.857, p < 0.0001). Factors predicting survival were a female sex (OR 0.271; 0.128-0.575, p = 0.001), previous treatment with RAAS inhibitors (OR 0.459; 0.222-0.949, p = 0.036), a higher oxygen saturation at admission (OR 0.901; 0.842-0.963 per percentage point increase, p = 0.002), and a greater platelet count (OR 0.995; 0.991-0.999 per 10
    Conclusion: Elderly patients with COVID-19 infection have a similar clinical course to younger individuals. Previous treatment with RAAS inhibitors, and demographic, clinical and laboratory data influence prognosis.
    Keywords covid19
    Language English
    Publishing date 2020-07-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 603162-6
    ISSN 1872-6976 ; 0167-4943
    ISSN (online) 1872-6976
    ISSN 0167-4943
    DOI 10.1016/j.archger.2020.104204
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  2. Article ; Online: Effect of EARLY administration of DEXamethasone in patients with COVID-19 pneumonia without acute hypoxemic respiratory failure and risk of development of acute respiratory distress syndrome (EARLY-DEX COVID-19): study protocol for a randomized controlled trial.

    Franco-Moreno, Anabel / Acedo-Gutiérrez, María Soledad / Martín, Nicolás Labrador-San / Hernández-Blanco, Clara / Rodríguez-Olleros, Celia / Ibáñez-Estéllez, Fátima / Suárez-Simón, Ana / Balado-Rico, Mateo / Romero-Paternina, Ana Rocío / Alonso-Menchén, David / Escolano-Fernández, Belén / Piniella-Ruiz, Esther / Alonso-Monge, Ester / Notario-Leo, Helena / Bibiano-Guillén, Carlos / Peña-Lillo, Gabriela / Antiqueira-Pérez, Armando / Romero-Pareja, Rodolfo / Cabello-Clotet, Noemí /
    Estrada-Pérez, Vicente / Troya-García, Jesús / de Carranza-López, María / Escobar-Rodríguez, Ismael / Vallejo-Maroto, Nacho / Torres-Macho, Juan

    Trials

    2022  Volume 23, Issue 1, Page(s) 784

    Abstract: Background: Corticosteroids are one of the few drugs that have shown a reduction in mortality in coronavirus disease 2019 (COVID-19). In the RECOVERY trial, the use of dexamethasone reduced 28-day mortality compared to standard care in hospitalized ... ...

    Abstract Background: Corticosteroids are one of the few drugs that have shown a reduction in mortality in coronavirus disease 2019 (COVID-19). In the RECOVERY trial, the use of dexamethasone reduced 28-day mortality compared to standard care in hospitalized patients with suspected or confirmed COVID-19 requiring supplemental oxygen or invasive mechanical ventilation. Evidence has shown that 30% of COVID-19 patients with mild symptoms at presentation will progress to acute respiratory distress syndrome (ARDS), particularly patients in whom laboratory inflammatory biomarkers associated with COVID-19 disease progression are detected. We postulated that dexamethasone treatment in hospitalized patients with COVID-19 pneumonia without additional oxygen requirements and at risk of progressing to severe disease might lead to a decrease in the development of ARDS and thereby reduce death.
    Methods/design: This is a multicenter, randomized, controlled, parallel, open-label trial testing dexamethasone in 252 adult patients with COVID-19 pneumonia who do not require supplementary oxygen on admission but are at risk factors for the development of ARDS. Risk for the development of ARDS is defined as levels of lactate dehydrogenase > 245 U/L, C-reactive protein > 100 mg/L, and lymphocyte count of < 0.80 × 10
    Discussion: If our hypothesis is correct, the results of this study will provide additional insights into the management and progression of this specific subpopulation of patients with COVID-19 pneumonia without additional oxygen requirements and at risk of progressing to severe disease.
    Trial registration: ClinicalTrials.gov NCT04836780. Registered on 8 April 2021 as EARLY-DEX COVID-19.
    MeSH term(s) Adrenal Cortex Hormones/adverse effects ; Adult ; C-Reactive Protein ; COVID-19/complications ; COVID-19/drug therapy ; Dexamethasone/adverse effects ; Humans ; Lactate Dehydrogenases ; Multicenter Studies as Topic ; Oxygen ; Pneumonia/drug therapy ; Randomized Controlled Trials as Topic ; Respiratory Distress Syndrome/epidemiology ; Respiratory Insufficiency/epidemiology
    Chemical Substances Adrenal Cortex Hormones ; Dexamethasone (7S5I7G3JQL) ; C-Reactive Protein (9007-41-4) ; Lactate Dehydrogenases (EC 1.1.-) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2022-09-15
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1745-6215
    ISSN (online) 1745-6215
    ISSN 1468-6694 ; 1745-6215
    DOI 10.1186/s13063-022-06722-x
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  3. Article ; Online: Results of phase 2 randomized multi-center study to evaluate the safety and efficacy of infusion of memory T cells as adoptive therapy in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia and/or lymphopenia (RELEASE NCT04578210).

    Ferreras, Cristina / Hernández-Blanco, Clara / Martín-Quirós, Alejandro / Al-Akioui-Sanz, Karima / Mora-Rillo, Marta / Ibáñez, Fátima / Díaz-Almirón, Mariana / Cano-Ochando, Jordi / Lozano-Ojalvo, Daniel / Jiménez-González, María / Goterris, Rosa / Sánchez-Zapardiel, Elena / de Paz, Raquel / Guerra-García, Pilar / Queiruga-Parada, Javier / Molina, Pablo / Briones, María Luisa / Ruz-Caracuel, Beatriz / Borobia, Alberto M /
    Carcas, Antonio J / Planelles, Dolores / Vicario, José Luis / Moreno, Miguel Ángel / Balas, Antonio / Llano, Marta / Llorente, Andrea / Del Balzo, Álvaro / Cañada, Carlos / García, Miguel Ángel / Calvin, María Elena / Arenas, Isabel / Pérez de Diego, Rebeca / Eguizábal, Cristina / Soria, Bernat / Solano, Carlos / Pérez-Martínez, Antonio

    Cytotherapy

    2023  Volume 26, Issue 1, Page(s) 25–35

    Abstract: Background aims: There are currently no effective anti-viral treatments for coronavirus disease 2019 (COVID-19)-hospitalized patients with hypoxemia. Lymphopenia is a biomarker of disease severity usually present in patients who are hospitalized. ... ...

    Abstract Background aims: There are currently no effective anti-viral treatments for coronavirus disease 2019 (COVID-19)-hospitalized patients with hypoxemia. Lymphopenia is a biomarker of disease severity usually present in patients who are hospitalized. Approaches to increasing lymphocytes exerting an anti-viral effect must be considered to treat these patients. Following our phase 1 study, we performed a phase 2 randomized multicenter clinical trial in which we evaluated the efficacy of the infusion of allogeneic off-the-shelf CD45RA
    Methods: Eighty-four patients were enrolled in three Spanish centers. The patients were randomized into the infusion of 1 × 10
    Results: We analyzed data from 81 patients. The primary outcome for recovery, defined as the proportion of participants in each group with normalization of fever, oxygen saturation sustained for at least 24 hours and lymphopenia recovery through day 14 or at discharge, was met for the experimental arm. We also observed faster lymphocyte recovery in the experimental group. We did not observe any treatment-related adverse events.
    Conclusions: Adoptive cell therapy with off-the-shelf CD45RA
    Trial registration: NCT04578210.
    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19/therapy ; Memory T Cells ; Treatment Outcome ; Lymphopenia/therapy ; Antiviral Agents
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2023-10-29
    Publishing country England
    Document type Randomized Controlled Trial ; Multicenter Study ; Clinical Trial, Phase I ; Clinical Trial, Phase II ; Journal Article
    ZDB-ID 2039821-9
    ISSN 1477-2566 ; 1465-3249
    ISSN (online) 1477-2566
    ISSN 1465-3249
    DOI 10.1016/j.jcyt.2023.10.002
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  4. Article: Melanoma rectal con metástasis pulmonares.

    Hernández-Blanco, Clara / Mao, Laura / Cigüenza, Ramón / Antolín, José

    Medicina clinica

    2007  Volume 130, Issue 15, Page(s) 600

    Title translation Rectal melanoma with lung metastasis.
    MeSH term(s) Female ; Humans ; Lung Neoplasms/secondary ; Melanoma/secondary ; Middle Aged ; Rectal Neoplasms/pathology
    Language Spanish
    Publishing date 2007-11-28
    Publishing country Spain
    Document type Case Reports ; Journal Article
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1157/13119983
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  5. Article: Clinical course and prognostic factors of COVID-19 infection in an elderly hospitalized population

    Mostaza, Jose M / García-Iglesias, Francisca / González-Alegre, Teresa / Blanco, Francisco / Varas, Marta / Hernández-Blanco, Clara / Hontañón, Victor / Jaras-Hernández, María J / Martínez-Prieto, Mónica / Menéndez-Saldaña, Araceli / Cachán, María L / Estirado, Eva / Lahoz, Carlos

    Arch Gerontol Geriatr

    Abstract: INTRODUCTION: Older subjects have a higher risk of COVID-19 infection and a greater mortality. However, there is a lack of studies evaluating the characteristics of this infection at advanced age. PATIENTS AND METHODS: We studied 404 patients ≥ 75 years ( ...

    Abstract INTRODUCTION: Older subjects have a higher risk of COVID-19 infection and a greater mortality. However, there is a lack of studies evaluating the characteristics of this infection at advanced age. PATIENTS AND METHODS: We studied 404 patients ≥ 75 years (mean age 85.2 ±â€¯5.3 years, 55 % males), with PCR-confirmed COVID-19 infection, attended in two hospitals in Madrid (Spain). Patients were followed-up until they were discharged from the hospital or until death. RESULTS: Symptoms started 2-7 days before admission, and consisted of fever (64 %), cough (59 %), and dyspnea (57 %). A total of 145 patients (35.9 %) died a median of 9 days after hospitalization. In logistic regression analysis, predictive factors of death were age (OR 1.086; 1.015-1.161 per year, p = 0.016), heart rate (1.040; 1.018-1.061 per beat, p < 0.0001), a decline in renal function during hospitalization (OR 7.270; 2.586-20.441, p < 0.0001) and worsening dyspnea during hospitalization (OR 73.616; 30.642-176.857, p < 0.0001). Factors predicting survival were a female sex (OR 0.271; 0.128-0.575, p = 0.001), previous treatment with RAAS inhibitors (OR 0.459; 0.222-0.949, p = 0.036), a higher oxygen saturation at admission (OR 0.901; 0.842-0.963 per percentage point increase, p = 0.002), and a greater platelet count (OR 0.995; 0.991-0.999 per 106/L, p = 0.025). CONCLUSION: Elderly patients with COVID-19 infection have a similar clinical course to younger individuals. Previous treatment with RAAS inhibitors, and demographic, clinical and laboratory data influence prognosis.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #671162
    Database COVID19

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  6. Article: Necrólisis epidérmica tóxica (síndrome de Lyell) en relación con la ingesta de ibuprofeno.

    Mao Martín, Laura / Hernández Blanco, Clara / Antolín Arias, José / Cabello Carro, Jorge

    Medicina clinica

    2007  Volume 131, Issue 8, Page(s) 320

    Title translation Toxic epidermal necrolysis.
    MeSH term(s) Adult ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Biopsy ; Female ; Humans ; Ibuprofen/adverse effects ; Skin/pathology ; Stevens-Johnson Syndrome/diagnosis ; Stevens-Johnson Syndrome/etiology ; Stevens-Johnson Syndrome/pathology
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Ibuprofen (WK2XYI10QM)
    Language Spanish
    Publishing date 2007-11-28
    Publishing country Spain
    Document type Case Reports ; Journal Article
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/s0025-7753(08)72268-1
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  7. Article ; Online: Clinical course and prognostic factors of COVID-19 infection in an elderly hospitalized population

    Mostaza, Jose M. / García-Iglesias, Francisca / González-Alegre, Teresa / Blanco, Francisco / Varas, Marta / Hernández-Blanco, Clara / Hontañón, Victor / Jaras-Hernández, María J. / Martínez-Prieto, Mónica / Menéndez-Saldaña, Araceli / Cachán, María L. / Estirado, Eva / Lahoz, Carlos / de Miguel, Rosa / Romero, Miriam / Lago, Mar / García-Quero, Cristina / Plaza, Cristina / Sainz-Costa, Talía /
    Rivas-Vila, Susana / Sánchez, Blanca / Torres, Celia García / Martínez-Tobar, Lucía / Hernandez-Pérez, María / Racionero, Pablo / Mir-Ihara, Patricia / Peña-López, Jesús / Bautista-Barea, Marta / Benítez, Alexa P. / Rodríguez-Merlos, Pablo / Barcenilla, María / Basilio, María San / Valencia, María / Romero-Martín, Ricardo / Boto de los Bueis, Ana / de la Hoz-Polo, Adriana / del Pino-Cidad, María / Coca-Robinot, Javier / González-Ferrer, Bárbara / Fernández-Pérez, Pedro / Mogollón, Isabel / Montoro-Romero, María S. / Villalaín, Isabel / del Hierro-Zarzuelo, Almudena / Hernández-Martín, Irene / Domínguez, Javier / Luna, Alberto / Montoro, Soledad / Sánchez-Orgaz, Margarita / Amorena, Gloria / Lavín-Dapena, Cosme / Negreiros, Aaron Zapata

    Archives of Gerontology and Geriatrics

    2020  Volume 91, Page(s) 104204

    Keywords Ageing ; Gerontology ; Health(social science) ; Geriatrics and Gerontology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 603162-6
    ISSN 0167-4943
    ISSN 0167-4943
    DOI 10.1016/j.archger.2020.104204
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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