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Article ; Conference proceedings: A Machine Learning Approach to Identify Patients at Risk for Long-Term Consequences after Pulmonary Embolism

Nopp, S. / Spielvogel, C. / Bikdeli, B. / Francisco, I. / Hernández-Blasco, L. / Peris, L. / Otero, R. / Jiménez, D. / Monreal, M. / Ay, C.

Hämostaseologie

2024 Volume 44, Issue S 01

Event/congress	GTH Congress 2024 - 68th Annual Meeting of the Society of Thrombosis and Haemostasis Research - Building Bridges in Coagulation, Vienna, Austria, 2024-03-27
Language	English
Publishing date	2024-02-01
Publisher	Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	801512-0
ISSN	2567-5761 ; 0720-9355
ISSN (online)	2567-5761
ISSN	0720-9355
DOI	10.1055/s-0044-1779064
Database	Thieme publisher's database

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Article ; Online: Acoustic analysis of vowels in patients with sleep apnea syndrome in sitting and supine positions.

Zamora-Molina, Lucia / Hernandez-Blasco, Luis / Garcia-Pachon, Eduardo

Sleep & breathing = Schlaf & Atmung

2021 Volume 25, Issue 4, Page(s) 2107–2108

MeSH term(s)	Acoustics ; Humans ; Polysomnography ; Sitting Position ; Sleep Apnea Syndromes/diagnosis ; Supine Position
Language	English
Publishing date	2021-01-22
Publishing country	Germany
Document type	Letter ; Comment
ZDB-ID	1500381-4
ISSN	1522-1709 ; 1520-9512
ISSN (online)	1522-1709
ISSN	1520-9512
DOI	10.1007/s11325-021-02304-4
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Zs.A 5658: Show issues

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Article: Radiological usual interstitial pneumonia pattern is associated with two-year mortality in patients with idiopathic pulmonary fibrosis.

Gayá García-Manso, Ignacio / Arenas Jiménez, Juan / Hernández Blasco, Luis / García Garrigós, Elena / Nofuentes Pérez, Ester / Sirera Matilla, Marina / Ruiz Alcaraz, Sandra / García Sevila, Raquel

Heliyon

2024 Volume 10, Issue 5, Page(s) e26623

Abstract: Introduction: The new diagnostic guidelines for idiopathic pulmonary fibrosis (IPF) did not rule out the possibility of combining the radiological patterns of usual interstitial pneumonia (UIP) and probable UIP, given the similar management and ... ...

Abstract	Introduction: The new diagnostic guidelines for idiopathic pulmonary fibrosis (IPF) did not rule out the possibility of combining the radiological patterns of usual interstitial pneumonia (UIP) and probable UIP, given the similar management and diagnostic capacity. However, the prognostic implications of these patterns have not been fully elucidated, with different studies showing heterogeneous results. We applied the new criteria to a retrospective series of patients with IPF, assessing survival based on radiological patterns, findings, and their extension. Methods: Two thoracic radiologists reviewed high-resolution computed tomography images taken at diagnosis in 146 patients with IPF, describing the radiological findings and patterns. The association of each radiological finding and radiological patterns with two-year mortality was analysed. Results: The two-year mortality rate was 40.2% in IPF patients with an UIP radiological pattern versus 7.1% in those with probable UIP. Compared to the UIP pattern, probable UIP was protective against mortality, even after adjusting for age, sex, pulmonary function, and extent of fibrosis (hazard ratio (HR) 0.23, 95% confidence interval (CI) 0.06-0.99). Receiving antifibrotic treatment was also a protective factor (HR 0.51, 95%CI 0.27-0.98). Honeycombing (HR 3.62, 95%CI 1.27-10.32), an acute exacerbation pattern (HR 4.07, 95%CI 1.84-8.96), and the overall extent of fibrosis (HR 1.04, 95%CI 1.02-1.06) were predictors of mortality. Conclusions: In our series, two-year mortality was higher in patients with IPF who presented a radiological pattern of UIP versus probable UIP on the initial scan. Honeycombing, an acute exacerbation pattern, and a greater overall extent of fibrosis were also predictors of increased mortality. The prognostic differences between the radiological pattern of UIP and probable UIP in our series would support maintaining them as two differentiated patterns.
Language	English
Publishing date	2024-02-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e26623
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Article ; Online: Transcriptomic Profiling of Pleural Effusions: Differences in Malignant and Infectious Fluids.

Zamora-Molina, Lucía / García-Pachón, Eduardo / Amorós, Marta / Gijón-Martínez, Julia / Sánchez-Almendro, Judith / Baeza-Martínez, Carlos / Hernández-Blasco, Luis / Galiana, Antonio

Medicina (Kaunas, Lithuania)

2024 Volume 60, Issue 3

Abstract: Background and ... ...

Abstract	Background and Objectives
MeSH term(s)	Humans ; Pleural Effusion, Malignant/genetics ; Pleural Effusion/genetics ; Exudates and Transudates/metabolism ; Pleura/metabolism ; Gene Expression Profiling
Language	English
Publishing date	2024-03-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina60030424
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Article ; Online: Venous thromboembolism (VTE) developing after ankle sprain. Comparison with VTE after knee arthroplasty.

Gutiérrez-Guisado, Javier / Calvo-Sotelo, Alejo Erice / Hernández-Blasco, Luis / Fidalgo, Ángeles / Gómez-Cuervo, Covadonga / López-Ruiz, Antonio / Aibar, Jesús / Verhamme, Peter / Meireles, José / Monreal, Manuel

Thrombosis research

2024 Volume 237, Page(s) 94–99

Abstract: Background: Venous thromboembolism (VTE) is a critical complication after non-major trauma or surgery. While the risk and severity of VTE following major orthopedic surgery is well-documented, there is significant knowledge gap regarding, non-major ... ...

Abstract	Background: Venous thromboembolism (VTE) is a critical complication after non-major trauma or surgery. While the risk and severity of VTE following major orthopedic surgery is well-documented, there is significant knowledge gap regarding, non-major trauma such as ankle sprains. Methods: We analyzed data from the RIETE registry to assess the clinical characteristics, VTE prophylaxis usage, and outcomes in patients with VTE following ankle sprain versus those post elective knee arthroplasty. We aimed to assess the risk and severity of VTE in a population traditionally considered at lower risk. Risk stratification was performed using the TRiP(cast) score. Results: Among 1,250 patients with VTE, those with ankle sprain (n = 459) were much younger than those post knee arthroplasty (n = 791), less often female, had fewer comorbidities, and received VTE prophylaxis less often (27% vs. 93 %). During anticoagulation, 26 patients developed recurrent VTE, 31 had major bleeding, and 12 died (fatal PE 3, fatal bleeding 2). There were no differences between the two groups in the rates of VTE recurrences (rate ratio (RR): 1.65; 95%CI: 0.69-3.88) or death (RR: 1.12; 95%CI: 0.33-3.46), but patients with VTE after ankle sprain had a lower rate of major bleeding (RR: 0.39; 95%CI: 0.13-0.99). Conclusions: Ankle sprain patients are often undertreated for VTE prophylaxis and have similar severity of VTE than those undergoing elective knee surgery, indicating the need for a more customized approach to VTE management.
MeSH term(s)	Humans ; Venous Thromboembolism/etiology ; Venous Thromboembolism/prevention & control ; Female ; Male ; Arthroplasty, Replacement, Knee/adverse effects ; Middle Aged ; Aged ; Ankle Injuries/surgery ; Ankle Injuries/complications ; Adult ; Risk Factors ; Registries ; Anticoagulants/therapeutic use
Chemical Substances	Anticoagulants
Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Journal Article ; Comparative Study ; Review
ZDB-ID	121852-9
ISSN	1879-2472 ; 0049-3848
ISSN (online)	1879-2472
ISSN	0049-3848
DOI	10.1016/j.thromres.2024.03.018
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Zs.A 863: Show issues

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Article ; Online: Environmental Microplastics in the Lower Airway of Shoe Manufacturing Workers.

Baeza-Martínez, Carlos / Zamora-Molina, Lucía / Garcia-Pachon, Eduardo / Masiá, Mar / Hernandez-Blasco, Luis / Bayo, Javier

Open respiratory archives

2022 Volume 4, Issue 4, Page(s) 100209

Language	English
Publishing date	2022-09-16
Publishing country	Spain
Document type	Case Reports
ISSN	2659-6636
ISSN (online)	2659-6636
DOI	10.1016/j.opresp.2022.100209
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Article ; Online: Tobacco as a Source of Microplastics and Respiratory Health.

Baeza-Martinez, Carlos / Ruiz-Alcaraz, Sandra / Soler-Sempere, María J / Garcia-Pachon, Eduardo / Hernandez-Blasco, Luis / Bayo, Javier

Archivos de bronconeumologia

2022 Volume 58, Issue 12, Page(s) 845

MeSH term(s)	Humans ; Microplastics ; Plastics ; Nicotiana ; Environmental Monitoring
Chemical Substances	Microplastics ; Plastics
Language	Spanish
Publishing date	2022-08-19
Publishing country	Spain
Document type	Letter ; Comment
ZDB-ID	733126-5
ISSN	1579-2129 ; 0300-2896
ISSN (online)	1579-2129
ISSN	0300-2896
DOI	10.1016/j.arbres.2022.08.003
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Zs.B 2655: Show issues

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Article ; Online: Comparison of Presentation, Treatment, and Outcomes of Venous Thromboembolism in Long-Term Immobile Patients Based on Age.

Weinberg, Ido / Elgendy, Islam Y / Dicks, Andrew B / Marchena, Pablo J / Malý, Radovan / Francisco, Iria / Pedrajas, José M / Font, Carme / Hernández-Blasco, Luis / Monreal, Manuel

Journal of general internal medicine

2023 Volume 38, Issue 8, Page(s) 1877–1886

Abstract: Background: Chronic immobility is prevalent, especially as people age. However, little is known about venous thromboembolism (VTE) outcomes in this population.: Objective: To compare the presentation, treatment, and outcomes in chronically immobile (> ...

Abstract	Background: Chronic immobility is prevalent, especially as people age. However, little is known about venous thromboembolism (VTE) outcomes in this population. Objective: To compare the presentation, treatment, and outcomes in chronically immobile (>8 weeks) patients older vs. younger than 75 who presented with VTE. Design: An observational international registry of patients with VTE. Participants: Patients with acute VTE from the "Registro Informatizado Enfermedad TromboEmbolica" (RIETE) registry who were chronically immobile. Main measures: Baseline characteristics, presenting signs and symptoms, treatment and outcomes including major bleeding, recurrent VTE, and mortality. Key results: Among 4612 immobile patients (mean age 75.7 years, 34% male), 2127 (46%) presented with pulmonary embolism (PE). Patients >75 years presented more often with dyspnea (44% vs. 38%) or altered mental status (23% vs. 8.1%) and less often with chest pain (13% vs. 18%). The median duration of anticoagulation was shorter in older compared with younger patients [126 vs. 169 days]. During the first 90 days of anticoagulation, major bleeding (4.0% vs. 2.2%), PE-related death (2.5% vs. 1.1%), and bleeding-related death (0.78% vs. 0.26%) occurred more frequently among older patients. In 3550 patients who received anticoagulation beyond 90 days, older patients had more major bleeding [4.23 vs. 2.21 events per 100 patient years]. After anticoagulation discontinuation, recurrent VTE and major bleeding occurred in 11.8 and 9.25 and 1.49 and 0.69 events per 100 patient years, respectively, both in similar rates in both groups. In multivariable analysis, after stopping anticoagulation, VTE recurrence was inversely associated with long-term facility residence [OR 0.51 (0.28-0.92)], anemia [OR 0.63 (0.42-0.95)], and anticoagulation duration < 90 days [OR 0.38 (0.27-0.54)]. Conclusions: Chronically immobilized patients older than 75 years presenting with VTE experience a high rate of adverse events including major bleeding and recurrent VTE. When considering treatment beyond 90 days, we should account for bleeding, recurrence risk, and associated mortality.
MeSH term(s)	Humans ; Male ; Aged ; Female ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/drug therapy ; Venous Thromboembolism/epidemiology ; Anticoagulants/adverse effects ; Recurrence ; Hemorrhage/chemically induced ; Hemorrhage/epidemiology ; Hemorrhage/complications ; Pulmonary Embolism/diagnosis ; Pulmonary Embolism/epidemiology ; Pulmonary Embolism/therapy ; Registries
Chemical Substances	Anticoagulants
Language	English
Publishing date	2023-02-07
Publishing country	United States
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639008-0
ISSN	1525-1497 ; 0884-8734
ISSN (online)	1525-1497
ISSN	0884-8734
DOI	10.1007/s11606-023-08058-x
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Article ; Online: Cell Therapy of Vascular and Neuropathic Complications of Diabetes: Can We Avoid Limb Amputation?

Soria, Bernat / Escacena, Natalia / Gonzaga, Aitor / Soria-Juan, Barbara / Andreu, Etelvina / Hmadcha, Abdelkrim / Gutierrez-Vilchez, Ana Maria / Cahuana, Gladys / Tejedo, Juan R / De la Cuesta, Antonio / Miralles, Manuel / García-Gómez, Susana / Hernández-Blasco, Luis

International journal of molecular sciences

2023 Volume 24, Issue 24

Abstract: Globally, a leg is amputated approximately every 30 seconds, with an estimated 85 percent of these amputations being attributed to complications arising from diabetic foot ulcers (DFU), as stated by the American Diabetes Association. Peripheral arterial ... ...

Abstract	Globally, a leg is amputated approximately every 30 seconds, with an estimated 85 percent of these amputations being attributed to complications arising from diabetic foot ulcers (DFU), as stated by the American Diabetes Association. Peripheral arterial disease (PAD) is a risk factor resulting in DFU and can, either independently or in conjunction with diabetes, lead to recurring, slow-healing ulcers and amputations. According to guidelines amputation is the recommended treatment for patients with no-option critical ischemia of the limb (CTLI). In this article we propose cell therapy as an alternative strategy for those patients. We also suggest the optimal time-frame for an effective therapy, such as implanting autologous mononuclear cells (MNCs), autologous and allogeneic mesenchymal stromal cells (MSC) as these treatments induce neuropathy relief, regeneration of the blood vessels and tissues, with accelerated ulcer healing, with no serious side effects, proving that advanced therapy medicinal product (ATMPs) application is safe and effective and, hence, can significantly prevent limb amputation.
MeSH term(s)	Humans ; Diabetic Foot/etiology ; Diabetic Foot/therapy ; Risk Factors ; Peripheral Arterial Disease/therapy ; Peripheral Arterial Disease/complications ; Peripheral Nervous System Diseases/complications ; Amputation, Surgical ; Cell- and Tissue-Based Therapy ; Ischemia/therapy ; Ischemia/complications ; Diabetes Mellitus
Language	English
Publishing date	2023-12-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242417512
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Article ; Online: Mosaic attenuation in non-fibrotic areas as a predictor of non-usual interstitial pneumonia pathologic diagnosis.

Gayá García-Manso, Ignacio / Arenas-Jiménez, Juan / García-Sevila, Raquel / Ruiz-Alcaraz, Sandra / Sirera-Matilla, Marina / García-Garrigós, Elena / Martínez-García, María Ángeles / Hernández-Blasco, Luis

Scientific reports

2022 Volume 12, Issue 1, Page(s) 7289

Abstract: The new radiological diagnostic criteria for diagnosing idiopathic pulmonary fibrosis (IPF) seek to optimize the indications for surgical lung biopsy (SLB). We applied the new criteria to a retrospective series of patients with interstitial lung disease ( ...

Abstract	The new radiological diagnostic criteria for diagnosing idiopathic pulmonary fibrosis (IPF) seek to optimize the indications for surgical lung biopsy (SLB). We applied the new criteria to a retrospective series of patients with interstitial lung disease (ILD) who underwent SLB in order to analyse the correlation between the radiological findings suggestive of another diagnosis (especially mosaic attenuation and its location with respect to fibrotic areas) and the usual interstitial pneumonia (UIP) pathologic diagnosis. Two thoracic radiologists reviewed the HRCT images of 83 patients with ILD and SLB, describing the radiological findings and patterns based on the new criteria. The association of each radiological finding with radiological patterns and histology was analysed. Mosaic attenuation is highly prevalent in both the UIP and non-UIP pathologic diagnosis and with similar frequency (80.0% vs. 78.6%). However, the presence of significant mosaic attenuation (≥ 3 lobes) only in non-fibrotic areas was observed in 60.7% of non-UIP pathologic diagnosis compared to 20.0% in UIP. This finding was associated with other diagnoses different from IPF, mostly connective tissue disease-associated interstitial lung disease (CTD-ILD) and hypersensitivity pneumonitis (HP). In our series of pathologically confirmed ILD, mosaic attenuation in non-fibrotic areas was a predictor of non-UIP pathologic diagnosis, and was associated with other diagnoses different from UIP, mostly CTD-ILD and HP. If confirmed in larger series, this finding could constitute a valuable tool for improving the interpretation of radiological.
MeSH term(s)	Alveolitis, Extrinsic Allergic ; Biopsy/methods ; Humans ; Idiopathic Pulmonary Fibrosis/diagnostic imaging ; Idiopathic Pulmonary Fibrosis/pathology ; Lung/diagnostic imaging ; Lung/pathology ; Lung Diseases, Interstitial/diagnostic imaging ; Lung Diseases, Interstitial/pathology ; Retrospective Studies ; Tomography, X-Ray Computed/methods
Language	English
Publishing date	2022-05-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-10750-7
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