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  1. Article: Inflammatory macrophages prevent colonic goblet and enteroendocrine cell differentiation through Notch signaling.

    Atanga, Roger / Romero, Aaron S / Hernandez, Anthony Jimenez / Peralta-Herrera, Eduardo / Merkley, Seth D / In, Julie G / Castillo, Eliseo F

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Inflammatory macrophages in the intestine are a key pathogenic factor driving inflammatory bowel disease (IBD). Here, we report the role of inflammatory macrophage-mediated notch signaling on secretory lineage differentiation in the intestinal epithelium. ...

    Abstract Inflammatory macrophages in the intestine are a key pathogenic factor driving inflammatory bowel disease (IBD). Here, we report the role of inflammatory macrophage-mediated notch signaling on secretory lineage differentiation in the intestinal epithelium. Utilizing IL-10-deficient (
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.06.29.547119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Video selection and assessment for an app-based HIV prevention messaging intervention: formative research.

    Downing, Martin J / Wiatrek, Sarah E / Zahn, Ryan J / Mansergh, Gordon / Olansky, Evelyn / Gelaude, Deborah / Sullivan, Patrick S / Stephenson, Rob / Siegler, Aaron J / Bauermeister, José / Horvath, Keith J / Chiasson, Mary Ann / Yoon, Irene S / Houang, Steven T / Hernandez, Anthony Jimenez / Hirshfield, Sabina

    mHealth

    2023  Volume 9, Page(s) 2

    Abstract: Background: Gay, bisexual, and other men who have sex with men (GBMSM) continue to be overrepresented in human immunodeficiency virus (HIV) infection in the United States. HIV prevention and care interventions that are tailored to an individual's ... ...

    Abstract Background: Gay, bisexual, and other men who have sex with men (GBMSM) continue to be overrepresented in human immunodeficiency virus (HIV) infection in the United States. HIV prevention and care interventions that are tailored to an individual's serostatus have the potential to lower the rate of new infections among GBMSM. Mobile technology is a critical tool for disseminating targeted messaging and increasing uptake of basic prevention services including HIV testing, sexually transmitted infection (STI) testing, and pre-exposure prophylaxis (PrEP). Mobile Messaging for Men (M-Cubed) is a mobile health HIV prevention intervention designed to deliver video- and text-based prevention messages, provide STI and HIV information, and link GBMSM to prevention and healthcare resources. The current report describes an iterative process of identifying and selecting publicly available videos to be used as part of the M-Cubed intervention. We also conducted interviews with GBMSM to assess the acceptability, comprehension, and potential audience reach of the selected video messages.
    Methods: The selection of videos included balancing of specific criteria [e.g., accuracy of scientific information, video length, prevention domains: HIV/STI testing, antiretroviral therapy (ART), PrEP, engagement in care, and condom use] to ensure that they were intended for our GBMSM audiences: HIV-negative men who engage in condomless anal sex, HIV-negative men who do not engage in condomless anal sex, and men living with HIV. This formative study included in-person interviews with 26 GBMSM from three U.S. cities heavily impacted by the HIV epidemic-New York City, Detroit, and Atlanta.
    Results: Following a qualitative content analysis, the study team identified five themes across the interviews: participant reactions to the video messages, message comprehension, PrEP concerns, targeting of video messaging, and prompted action.
    Conclusions: Study results informed a final selection of 12 video messages for inclusion in a randomized controlled trial of M-Cubed. Findings may serve as a guide for researchers who plan to develop HIV prevention interventions that utilize publicly available videos to promote behavioral change. Further, the findings presented here suggest the importance of developing videos with broad age and gender diversity for use in interventions such as M-Cubed, and in other health promotion settings.
    Language English
    Publishing date 2023-01-28
    Publishing country China
    Document type Journal Article
    ISSN 2306-9740
    ISSN 2306-9740
    DOI 10.21037/mhealth-21-53
    Database MEDical Literature Analysis and Retrieval System OnLINE

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