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  1. Article ; Online: Inactivation of the Anti-Müllerian Hormone Receptor Type 2 (amhrII) Gene in Northern Pike (Esox lucius) Results in Male-To-Female Sex Reversal.

    Pan, Qiaowei / Herpin, Amaury / Guiguen, Yann

    Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation

    2022  Volume 16, Issue 4, Page(s) 289–294

    Abstract: Background: The anti-müllerian hormone (Amh) pathway is crucial for sexual development in teleosts. A male-specific duplicate of anti-müllerian hormone (amhby) was previously identified as the northern pike (Esox lucius) master sex determination gene. ... ...

    Abstract Background: The anti-müllerian hormone (Amh) pathway is crucial for sexual development in teleosts. A male-specific duplicate of anti-müllerian hormone (amhby) was previously identified as the northern pike (Esox lucius) master sex determination gene. However, the role of its putative cognate receptor, i.e., the anti-müllerian hormone receptor type 2 (amhrII) was unclear in this species.
    Objective: Here, we investigated the role of amhrII during sexual development of northern pike.
    Method: We generated stable mutants with deletions in exon 9 of amhrII, inactivating the AmhrII protein using a CRISPR-Cas9-mediated gene knockout strategy.
    Result: The inactivation of amhrII in northern pike results in a high level of male-to-female sex reversal.
    Conclusion: This result demonstrates that amhrII is necessary for male sexual development in northern pike and supports the idea that AmhrII is a conserved regulator of the teleosts sex differentiation network.
    MeSH term(s) Animals ; Male ; Female ; Anti-Mullerian Hormone/genetics ; Anti-Mullerian Hormone/metabolism ; Esocidae/metabolism ; Receptors, Peptide/genetics ; Receptors, Transforming Growth Factor beta/genetics
    Chemical Substances Anti-Mullerian Hormone (80497-65-0) ; anti-Mullerian hormone receptor ; Receptors, Peptide ; Receptors, Transforming Growth Factor beta
    Language English
    Publishing date 2022-03-18
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2253672-3
    ISSN 1661-5433 ; 1661-5425
    ISSN (online) 1661-5433
    ISSN 1661-5425
    DOI 10.1159/000521003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Development of Ovaries and Sex Change in Fish: Bringing Potential into Action.

    Adolfi, Mateus Contar / Depincé, Alexandra / Wen, Ming / Pan, Qiaowei / Herpin, Amaury

    Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation

    2023  Volume 17, Issue 2-3, Page(s) 84–98

    Abstract: Background: Encompassing about half of the 60,000 species of vertebrates, fish display the greatest diversity of sex determination mechanisms among metazoans. As such that phylum offers a unique playground to study the impressive variety of gonadal ... ...

    Abstract Background: Encompassing about half of the 60,000 species of vertebrates, fish display the greatest diversity of sex determination mechanisms among metazoans. As such that phylum offers a unique playground to study the impressive variety of gonadal morphogenetic strategies, ranging from gonochorism, with either genetic or environmental sex determination, to unisexuality, with either simultaneous or consecutive hermaphroditism.
    Summary: From the two main types of gonads, the ovaries embrace the important role to produce the larger and non-motile gametes, which is the basis for the development of a future organism. The production of the egg cells is complex and involves the formation of follicular cells, which are necessary for the maturation of the oocytes and the production of feminine hormones. In this vein, our review focuses on the development of ovaries in fish with special emphasis on the germ cells, including those that transition from one sex to the other as part of their life cycle and those that are capable of transitioning to the opposite sex depending on environmental cues.
    Key messages: Clearly, establishing an individual as either a female or a male is not accomplished by the sole development of two types of gonads. In most cases, that dichotomy, be it final or transient, is accompanied by coordinated transformations across the entire organism, leading to changes in the physiological sex as a whole. These coordinated transformations require both molecular and neuroendocrine networks, but also anatomical and behavioural adjustments. Remarkably, fish managed to tame the ins and outs of sex reversal mechanisms to take the most advantages of changing sex as adaptive strategies in some situations.
    MeSH term(s) Female ; Male ; Animals ; Ovary ; Gonads ; Fishes ; Oocytes ; Germ Cells
    Language English
    Publishing date 2023-03-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2253672-3
    ISSN 1661-5433 ; 1661-5425
    ISSN (online) 1661-5433
    ISSN 1661-5425
    DOI 10.1159/000526008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The replaceable master of sex determination: bottom-up hypothesis revisited.

    Adolfi, Mateus Contar / Herpin, Amaury / Schartl, Manfred

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences

    2021  Volume 376, Issue 1832, Page(s) 20200090

    Abstract: Different group of vertebrates and invertebrates demonstrate an amazing diversity of gene regulations not only at the top but also at the bottom of the sex determination genetic network. As early as 1995, based on emerging findings ... ...

    Abstract Different group of vertebrates and invertebrates demonstrate an amazing diversity of gene regulations not only at the top but also at the bottom of the sex determination genetic network. As early as 1995, based on emerging findings in
    MeSH term(s) Animals ; Female ; Gene Regulatory Networks ; Male ; Ovary/growth & development ; Sex Determination Processes/genetics ; Testis/growth & development ; Vertebrates/genetics ; Vertebrates/growth & development
    Language English
    Publishing date 2021-07-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 208382-6
    ISSN 1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
    ISSN (online) 1471-2970
    ISSN 0080-4622 ; 0264-3839 ; 0962-8436
    DOI 10.1098/rstb.2020.0090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Lessons from an unusual vertebrate sex-determining gene.

    Bertho, Sylvain / Herpin, Amaury / Schartl, Manfred / Guiguen, Yann

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences

    2021  Volume 376, Issue 1832, Page(s) 20200092

    Abstract: So far, very few sex-determining genes have been identified in vertebrates and most of them, the so-called 'usual suspects', evolved from genes which fulfil essential functions during sexual development and are thus already tightly linked to the process ... ...

    Abstract So far, very few sex-determining genes have been identified in vertebrates and most of them, the so-called 'usual suspects', evolved from genes which fulfil essential functions during sexual development and are thus already tightly linked to the process that they now govern. The single exception to this 'usual suspects' rule in vertebrates so far is the conserved salmonid sex-determining gene,
    MeSH term(s) Animals ; Salmonidae/genetics ; Sex Determination Processes ; Sex Differentiation/genetics
    Language English
    Publishing date 2021-07-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 208382-6
    ISSN 1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
    ISSN (online) 1471-2970
    ISSN 0080-4622 ; 0264-3839 ; 0962-8436
    DOI 10.1098/rstb.2020.0092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Lighting chaperone-mediated autophagy (CMA) evolution with an ancient LAMP: the existence of a functional CMA activity in fish.

    Herpin, Amaury / Lescat, Laury / Bobe, Julien / Jenny, Andreas / Seiliez, Iban

    Autophagy

    2020  Volume 16, Issue 10, Page(s) 1918–1920

    Abstract: Chaperone-mediated autophagy (CMA), as one of the main pathways of lysosomal catabolism, plays essential roles for the maintenance of cellular homeostasis. To date, the absence of any identifiable LAMP2A - the necessary and limiting protein required for ... ...

    Abstract Chaperone-mediated autophagy (CMA), as one of the main pathways of lysosomal catabolism, plays essential roles for the maintenance of cellular homeostasis. To date, the absence of any identifiable LAMP2A - the necessary and limiting protein required for CMA - in non-tetrapod lineages, led to the paradigm that this cellular process was restricted to mammals and birds. The recent findings of Lescat
    MeSH term(s) Animals ; Autophagy/genetics ; Chaperone-Mediated Autophagy ; Lighting ; Lysosomes ; Molecular Chaperones/genetics
    Chemical Substances Molecular Chaperones
    Language English
    Publishing date 2020-08-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2020.1797344
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Evolution of master sex determiners: TGF-β signalling pathways at regulatory crossroads.

    Pan, Qiaowei / Kay, Tomas / Depincé, Alexandra / Adolfi, Mateus / Schartl, Manfred / Guiguen, Yann / Herpin, Amaury

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences

    2021  Volume 376, Issue 1832, Page(s) 20200091

    Abstract: To date, more than 20 different vertebrate master sex-determining genes have been identified on different sex chromosomes of mammals, birds, frogs and fish. Interestingly, six of these genes are transcription factors ( ...

    Abstract To date, more than 20 different vertebrate master sex-determining genes have been identified on different sex chromosomes of mammals, birds, frogs and fish. Interestingly, six of these genes are transcription factors (
    MeSH term(s) Animals ; Evolution, Molecular ; Gene Regulatory Networks ; Phylogeny ; Sex Chromosomes/genetics ; Sex Determination Processes ; Signal Transduction ; Transforming Growth Factor beta/genetics ; Transforming Growth Factor beta/metabolism ; Vertebrates/genetics
    Chemical Substances Transforming Growth Factor beta
    Language English
    Publishing date 2021-07-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 208382-6
    ISSN 1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
    ISSN (online) 1471-2970
    ISSN 0080-4622 ; 0264-3839 ; 0962-8436
    DOI 10.1098/rstb.2020.0091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Diving into the Evolutionary History of HSC70-Linked Selective Autophagy Pathways: Endosomal Microautophagy and Chaperone-Mediated Autophagy.

    Schnebert, Simon / Goguet, Maxime / Vélez, Emilio J / Depincé, Alexandra / Beaumatin, Florian / Herpin, Amaury / Seiliez, Iban

    Cells

    2022  Volume 11, Issue 12

    Abstract: Autophagy is a pleiotropic and evolutionarily conserved process in eukaryotes that encompasses different types of mechanisms by which cells deliver cytoplasmic constituents to the lysosome for degradation. Interestingly, in mammals, two different and ... ...

    Abstract Autophagy is a pleiotropic and evolutionarily conserved process in eukaryotes that encompasses different types of mechanisms by which cells deliver cytoplasmic constituents to the lysosome for degradation. Interestingly, in mammals, two different and specialized autophagic pathways, (i) the chaperone-mediated autophagy (CMA) and (ii) the endosomal microautophagy (eMI), both rely on the use of the same cytosolic chaperone HSPA8 (also known as HSC70) for targeting specific substrates to the lysosome. However, this is not true for all organisms, and differences exist between species with respect to the coexistence of these two autophagic routes. In this paper, we present an in-depth analysis of the evolutionary history of the main components of CMA and eMI and discuss how the observed discrepancies between species may contribute to improving our knowledge of these two functions and their interplays.
    MeSH term(s) Animals ; Autophagy ; Chaperone-Mediated Autophagy ; Lysosomes/metabolism ; Macroautophagy ; Mammals ; Microautophagy
    Language English
    Publishing date 2022-06-16
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11121945
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Plasticity of gene-regulatory networks controlling sex determination: of masters, slaves, usual suspects, newcomers, and usurpators.

    Herpin, Amaury / Schartl, Manfred

    EMBO reports

    2015  Volume 16, Issue 10, Page(s) 1260–1274

    Abstract: Sexual dimorphism is one of the most pervasive and diverse features of animal morphology, physiology, and behavior. Despite the generality of the phenomenon itself, the mechanisms controlling how sex is determined differ considerably among various ... ...

    Abstract Sexual dimorphism is one of the most pervasive and diverse features of animal morphology, physiology, and behavior. Despite the generality of the phenomenon itself, the mechanisms controlling how sex is determined differ considerably among various organismic groups, have evolved repeatedly and independently, and the underlying molecular pathways can change quickly during evolution. Even within closely related groups of organisms for which the development of gonads on the morphological, histological, and cell biological level is undistinguishable, the molecular control and the regulation of the factors involved in sex determination and gonad differentiation can be substantially different. The biological meaning of the high molecular plasticity of an otherwise common developmental program is unknown. While comparative studies suggest that the downstream effectors of sex-determining pathways tend to be more stable than the triggering mechanisms at the top, it is still unclear how conserved the downstream networks are and how all components work together. After many years of stasis, when the molecular basis of sex determination was amenable only in the few classical model organisms (fly, worm, mouse), recently, sex-determining genes from several animal species have been identified and new studies have elucidated some novel regulatory interactions and biological functions of the downstream network, particularly in vertebrates. These data have considerably changed our classical perception of a simple linear developmental cascade that makes the decision for the embryo to develop as male or female, and how it evolves.
    MeSH term(s) Animals ; Biological Evolution ; Female ; Gene Expression Regulation, Developmental ; Gene Regulatory Networks ; Humans ; Male ; Ovary/physiology ; Sex Determination Processes/genetics ; Testis/physiology ; Transcription Factors/metabolism
    Chemical Substances Transcription Factors
    Language English
    Publishing date 2015-09-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.15252/embr.201540667
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5433: Show issues Location:
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  9. Article ; Online: Chaperone-mediated autophagy protects against hyperglycemic stress.

    Vélez, Emilio J / Schnebert, Simon / Goguet, Maxime / Balbuena-Pecino, Sara / Dias, Karine / Beauclair, Linda / Fontagné-Dicharry, Stéphanie / Véron, Vincent / Depincé, Alexandra / Beaumatin, Florian / Herpin, Amaury / Seiliez, Iban

    Autophagy

    2023  Volume 20, Issue 4, Page(s) 752–768

    Abstract: Chaperone-mediated autophagy (CMA) is a major pathway of lysosomal proteolysis critical for cellular homeostasis and metabolism, and whose defects have been associated with several human pathologies. While CMA has been well described in mammals, ... ...

    Abstract Chaperone-mediated autophagy (CMA) is a major pathway of lysosomal proteolysis critical for cellular homeostasis and metabolism, and whose defects have been associated with several human pathologies. While CMA has been well described in mammals, functional evidence has only recently been documented in fish, opening up new perspectives to tackle this function under a novel angle. Now we propose to explore CMA functions in the rainbow trout (RT,
    MeSH term(s) Animals ; Chaperone-Mediated Autophagy/drug effects ; Chaperone-Mediated Autophagy/physiology ; Chaperone-Mediated Autophagy/genetics ; Lysosomes/metabolism ; Lysosomes/drug effects ; Oncorhynchus mykiss/metabolism ; Glucose/metabolism ; Hyperglycemia/metabolism ; Hyperglycemia/pathology ; Reactive Oxygen Species/metabolism ; Lysosomal-Associated Membrane Protein 2/metabolism ; Lysosomal-Associated Membrane Protein 2/genetics ; Autophagy/physiology ; Autophagy/genetics ; Autophagy/drug effects ; Molecular Chaperones/metabolism ; Humans
    Chemical Substances Glucose (IY9XDZ35W2) ; Reactive Oxygen Species ; Lysosomal-Associated Membrane Protein 2 ; Molecular Chaperones
    Language English
    Publishing date 2023-10-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2023.2267415
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Crosstalk Between Retinoic Acid and Sex-Related Genes Controls Germ Cell Fate and Gametogenesis in Medaka.

    Adolfi, Mateus C / Herpin, Amaury / Martinez-Bengochea, Anabel / Kneitz, Susanne / Regensburger, Martina / Grunwald, David J / Schartl, Manfred

    Frontiers in cell and developmental biology

    2021  Volume 8, Page(s) 613497

    Abstract: Sex determination (SD) is a highly diverse and complex mechanism. In vertebrates, one of the first morphological differences between the sexes is the timing of initiation of the first meiosis, where its initiation occurs first in female and later in male. ...

    Abstract Sex determination (SD) is a highly diverse and complex mechanism. In vertebrates, one of the first morphological differences between the sexes is the timing of initiation of the first meiosis, where its initiation occurs first in female and later in male. Thus, SD is intimately related to the responsiveness of the germ cells to undergo meiosis in a sex-specific manner. In some vertebrates, it has been reported that the timing for meiosis entry would be under control of retinoic acid (RA), through activation of
    Language English
    Publishing date 2021-01-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2020.613497
    Database MEDical Literature Analysis and Retrieval System OnLINE

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