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  1. Article ; Online: Calprotectin as a new inflammatory marker of abdominal aortic aneurysm: A pilot study.

    Plana, Emma / Oto, Julia / Herranz, Raquel / Medina, Pilar / Cana, Fernando / Miralles, Manuel

    Vascular medicine (London, England)

    2024  Volume 29, Issue 2, Page(s) 189–199

    Abstract: Introduction: Abdominal aortic aneurysm (AAA) is a relevant clinical problem due to the risk of rupture of progressively dilated infrarenal aorta. It is characterized by degradation of elastic fibers, extracellular matrix, and inflammation of the ... ...

    Abstract Introduction: Abdominal aortic aneurysm (AAA) is a relevant clinical problem due to the risk of rupture of progressively dilated infrarenal aorta. It is characterized by degradation of elastic fibers, extracellular matrix, and inflammation of the arterial wall. Though neutrophil infiltration is a known feature of AAA, markers of neutrophil activation are scarcely analyzed; hence, the main objective of this study.
    Methods: Plasma levels of main neutrophil activation markers were quantified in patients with AAA and a double control group (CTL) formed by healthy volunteers (HV) and patients with severe atherosclerosis submitted for carotid endarterectomy (CE). Calprotectin, a cytoplasmic neutrophil protein, was quantified, by Western blot, in arterial tissue samples from patients with AAA and organ donors. Colocalization of calprotectin and neutrophil elastase was assessed by immunofluorescence.
    Results: Plasma calprotectin and IL-6 were both elevated in patients with AAA compared with CTL (
    Conclusions: Circulating calprotectin could be a specific AAA marker and a potential therapeutical target. Calprotectin is related to inflammation and neutrophil activation in arterial wall and independent of other atherosclerotic events.
    MeSH term(s) Humans ; Pilot Projects ; Leukocyte L1 Antigen Complex/metabolism ; Interleukin-6/metabolism ; Aortic Aneurysm, Abdominal/diagnosis ; Aortic Aneurysm, Abdominal/surgery ; Aorta, Abdominal/surgery ; Inflammation
    Chemical Substances Leukocyte L1 Antigen Complex ; Interleukin-6
    Language English
    Publishing date 2024-03-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1311628-9
    ISSN 1477-0377 ; 1358-863X
    ISSN (online) 1477-0377
    ISSN 1358-863X
    DOI 10.1177/1358863X241231494
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    Zs.A 4409: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article: Hereditary GIST syndrome secondary to germline mutation in KIT.

    Rojo, Eukene / Miranda, Pablo / Herranz, Raquel / de la Morena, Felipe

    Gastroenterologia y hepatologia

    2023  Volume 46, Issue 8, Page(s) 645–646

    Title translation Síndrome de GIST hereditario y secundario a una mutación germinal en KIT.
    MeSH term(s) Humans ; Germ-Line Mutation ; Gastrointestinal Stromal Tumors/genetics ; Neoplastic Syndromes, Hereditary/genetics ; Exons ; Proto-Oncogene Proteins c-kit/genetics ; Mutation ; Antineoplastic Agents
    Chemical Substances Proto-Oncogene Proteins c-kit (EC 2.7.10.1) ; Antineoplastic Agents
    Language Spanish
    Publishing date 2023-01-09
    Publishing country Spain
    Document type Letter
    ZDB-ID 632502-6
    ISSN 0210-5705
    ISSN 0210-5705
    DOI 10.1016/j.gastrohep.2022.12.011
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    Zs.A 2044: Show issues Location:
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  3. Article ; Online: Thrombospondins in human aortic aneurysms.

    Plana, Emma / Oto, Julia / Medina, Pilar / Herranz, Raquel / Fernández-Pardo, Álvaro / Requejo, Lucia / Miralles, Manuel

    IUBMB life

    2022  Volume 74, Issue 10, Page(s) 982–994

    Abstract: Thrombospondins are a family of matricellular proteins with a multimeric structure that is known to be involved in several biological and pathological processes. Their relationship with vascular disorders has raised special interest recently. Aortic ... ...

    Abstract Thrombospondins are a family of matricellular proteins with a multimeric structure that is known to be involved in several biological and pathological processes. Their relationship with vascular disorders has raised special interest recently. Aortic aneurysms are related to the impairment of vascular remodeling, in which extracellular matrix proteins seem to play an important role. Thus, research in thrombospondins, and their potential role in aneurysm development is progressively gaining importance. Nevertheless, studies showing thrombospondin dysregulation in human samples are still scarce. Although studies performed in vitro and in vivo models are essential to understand the molecular mechanisms and pathways underlying the disorder, descriptive studies in human samples are also necessary to ascertain their real value as biomarkers and/or novel therapeutic targets. The present article reviews the latest findings regarding the role of thrombospondins in aortic aneurysm development, paying particular attention to the studies performed in human samples.
    MeSH term(s) Aortic Aneurysm/genetics ; Aortic Aneurysm/metabolism ; Aortic Aneurysm/pathology ; Biomarkers ; Extracellular Matrix Proteins ; Humans ; Thrombospondins/genetics
    Chemical Substances Biomarkers ; Extracellular Matrix Proteins ; Thrombospondins
    Language English
    Publishing date 2022-03-16
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1492141-8
    ISSN 1521-6551 ; 1521-6543
    ISSN (online) 1521-6551
    ISSN 1521-6543
    DOI 10.1002/iub.2610
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    Zs.A 1611: Show issues Location:
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  4. Article ; Online: Bladder cancer patients have increased NETosis and impaired DNaseI-mediated NET degradation that can be therapeutically restored

    Herranz, Raquel / Oto, Julia / Hueso, Marta / Plana, Emma / Cana, Fernando / Castaño, María / Cordón, Lourdes / Ramos-Soler, David / Bonanad, Santiago / Vera-Donoso, César D / Martínez-Sarmiento, Manuel / Medina, Pilar

    Frontiers in immunology

    2023  Volume 14, Page(s) 1171065

    Abstract: Background: Neutrophils, key players of the immune system, also promote tumor development through the formation of neutrophil extracellular traps (NETs) in a process called NETosis. NETs are extracellular networks of DNA, histones and cytoplasmic and ... ...

    Abstract Background: Neutrophils, key players of the immune system, also promote tumor development through the formation of neutrophil extracellular traps (NETs) in a process called NETosis. NETs are extracellular networks of DNA, histones and cytoplasmic and granular proteins (calprotectin, myeloperoxidase, elastase, etc.) released by neutrophils upon activation. NETs regulate tumor growth while promoting angiogenesis and invasiveness, and tumor cells also stimulate NETosis. Although NETosis seems to be increased in cancer patients, an increase of NETs in plasma may also be mediated by an impaired degradation by plasma DNaseI, as evidenced in several immunological disorders like lupus nephritis. However, this has never been evidenced in bladder cancer (BC) patients. Herein, we aimed to evaluate the occurrence of increased NETosis in plasma and tumor tissue of BC patients, to ascertain whether it is mediated by a reduced DNaseI activity and degradation, and to
    Methods: We recruited 71 BC patients from whom we obtained a plasma sample before surgery and a formalin-fixed paraffin embedded tumor tissue sample, and 64 age- and sex-matched healthy controls from whom we obtained a plasma sample. We measured NETs markers (cell-free fDNA, calprotectin, nucleosomes and neutrophil elastase) and the DNaseI activity in plasma with specific assays. We also measured NETs markers in BC tissue by immunofluorescence. Finally, we evaluated the ability of BC and control plasma to degrade
    Results: NETosis occurs in BC tissue, more profusely in the muscle-invasive subtype (
    Conclusion: To the best of our knowledge, this is the first report demonstrating that BC patients have an increased NETosis systemically and in the tumor microenvironment, in part caused by an impaired DNaseI-mediated NET degradation. Remarkably, this defect can be therapeutically restored
    MeSH term(s) Humans ; Extracellular Traps/metabolism ; Neutrophils/metabolism ; Histones/metabolism ; Nucleosomes/metabolism ; Urinary Bladder Neoplasms/therapy ; Urinary Bladder Neoplasms/metabolism ; Tumor Microenvironment
    Chemical Substances Histones ; Nucleosomes
    Language English
    Publishing date 2023-05-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1171065
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  5. Article ; Online: New Roles for Old Friends: Involvement of the Innate Immune System in Tumor Progression.

    Castaño, María / González-Cantó, Eva / Aghababyan, Cristina / Tomás-Pérez, Sarai / Oto, Julia / Herranz, Raquel / Medina, Pilar / Götte, Martin / Mc Cormack, Bárbara Andrea / Marí-Alexandre, Josep / Gilabert-Estellés, Juan

    International journal of molecular sciences

    2023  Volume 24, Issue 8

    Abstract: The association between the immune system and tumor progression has attracted much interest in the research community in recent years [ ... ]. ...

    Abstract The association between the immune system and tumor progression has attracted much interest in the research community in recent years [...].
    MeSH term(s) Humans ; Immunity, Innate ; Neoplasms/pathology ; Friends ; Immune System/pathology
    Language English
    Publishing date 2023-04-20
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24087604
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  6. Article ; Online: Optimization of Plant Production by Seed Treatment in Two Wild Subspecies of

    Herranz, Raquel / Copete, Miguel A / Herranz, José M / Copete, Elena / Ferrandis, Pablo

    Molecules (Basel, Switzerland)

    2020  Volume 25, Issue 19

    Abstract: ... The ... ...

    Abstract The daffodil
    MeSH term(s) Alkaloids/metabolism ; Germination ; Narcissus/classification ; Narcissus/growth & development ; Plant Dormancy ; Seedlings/classification ; Seedlings/growth & development ; Seeds/growth & development
    Chemical Substances Alkaloids
    Language English
    Publishing date 2020-09-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules25194439
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    Zs.MO 81: Show issues

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  7. Article: Biomarkers of Immunotherapy Response in Patients with Non-Small-Cell Lung Cancer: Microbiota Composition, Short-Chain Fatty Acids, and Intestinal Permeability.

    Moratiel-Pellitero, Alba / Zapata-García, María / Gascón-Ruiz, Marta / Sesma, Andrea / Quílez, Elisa / Ramirez-Labrada, Ariel / Martínez-Lostao, Luis / Domingo, María Pilar / Esteban, Patricia / Yubero, Alfonso / Barbero-Herranz, Raquel / Moreno-Blanco, Ana / Paño, José Ramón / Lastra, Rodrigo / Pardo, Julián / Isla, Dolores / Del Campo, Rosa / Gálvez, Eva

    Cancers

    2024  Volume 16, Issue 6

    Abstract: Immune checkpoint inhibitors have been proposed as the standard treatment for different stages of non-small-cell lung cancer in multiple indications. Not all patients benefit from these treatments, however, and certain patients develop immune-related ... ...

    Abstract Immune checkpoint inhibitors have been proposed as the standard treatment for different stages of non-small-cell lung cancer in multiple indications. Not all patients benefit from these treatments, however, and certain patients develop immune-related adverse events. Although the search for predictors of response to these drugs is a major field of research, these issues have yet to be resolved. It has been postulated that microbiota could play a relevant role in conditioning the response to cancer treatments; however, the human factor of intestinal permeability also needs to be considered as it is closely related to the regulation of host-microbiota interaction. In this article, we analyzed the possible relationship between the response to immune checkpoint inhibitors and the onset of immune-related adverse events, gut microbiota status, and intestinal membrane permeability. In a pioneering step, we also measured short-chain fatty acid content in feces. Although the correlation analyses failed to identify predictive biomarkers, even when all variables were integrated, our patients' microbial gut ecosystems were rich and diverse, and the intestinal barrier's integrity was preserved. These results add new knowledge on the composition of microbiota and its correlation with barrier permeability and short-chain fatty acids and suggest that more studies are required before these potential biomarkers can be incorporated into the clinical management of patients via immune checkpoint inhibitor treatment.
    Language English
    Publishing date 2024-03-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16061144
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  8. Article ; Online: The Impact of Colistin Resistance on the Activation of Innate Immunity by Lipopolysaccharide Modification.

    Avendaño-Ortiz, José / Ponce-Alonso, Manuel / Llanos-González, Emilio / Barragán-Prada, Hugo / Barbero-Herranz, Raquel / Lozano-Rodríguez, Roberto / Márquez-Garrido, Francesc J / Hernández-Pérez, José María / Morosini, María-Isabel / Cantón, Rafael / Del Campo, Rosa / López-Collazo, Eduardo

    Infection and immunity

    2023  Volume 91, Issue 2, Page(s) e0001223

    Abstract: Colistin resistance is acquired by different lipopolysaccharide (LPS) modifications. We proposed to evaluate the of ... ...

    Abstract Colistin resistance is acquired by different lipopolysaccharide (LPS) modifications. We proposed to evaluate the of effect
    MeSH term(s) Humans ; Colistin/pharmacology ; Lipopolysaccharides/pharmacology ; Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/genetics ; Immunity, Innate ; Klebsiella pneumoniae ; Cytokines ; Klebsiella Infections/microbiology ; Drug Resistance, Bacterial/genetics ; Microbial Sensitivity Tests
    Chemical Substances Colistin (Z67X93HJG1) ; Lipopolysaccharides ; Anti-Bacterial Agents ; Bacterial Proteins ; Cytokines
    Language English
    Publishing date 2023-02-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/iai.00012-23
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    Zs.A 684: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: LC-MS metabolomics of urine reveals distinct profiles for non-muscle-invasive and muscle-invasive bladder cancer.

    Oto, Julia / Fernández-Pardo, Álvaro / Roca, Marta / Plana, Emma / Cana, Fernando / Herranz, Raquel / Pérez-Ardavín, Javier / Vera-Donoso, César David / Martínez-Sarmiento, Manuel / Medina, Pilar

    World journal of urology

    2022  Volume 40, Issue 10, Page(s) 2387–2398

    Abstract: Purpose: Bladder cancer (BC) is among the most frequent malignancies worldwide. Novel non-invasive markers are needed to diagnose and stage BC with more accuracy than invasive procedures like cystoscopy. To date, no study has identified urine ... ...

    Abstract Purpose: Bladder cancer (BC) is among the most frequent malignancies worldwide. Novel non-invasive markers are needed to diagnose and stage BC with more accuracy than invasive procedures like cystoscopy. To date, no study has identified urine metabolites characteristic of all BC stages. To discover novel urine metabolomic profiles to diagnose and stage non-muscle-invasive (NMIBC) and muscle-invasive (MIBC) patients using mass spectrometry-based metabolomics.
    Methods: We prospectively recruited 198 BC patients and 98 age- and sex-matched healthy volunteers without evidence of renal or bladder condition confirmed by ultrasound, from whom we collected a first morning urine sample (before surgery in patients). In a discovery stage, an untargeted metabolomic analysis was conducted in urine samples of a selection of 64 BC patients (19 TaG1, 11 TaG3, 20 T1G3, 12 T2G3, 1 T2G2, 1 T3G3) and 20 controls to identify dysregulated metabolites. Next, after exhaustive multivariate analysis, confirmed dysregulated metabolites were validated in an independent cohort of 134 BC patients (19 TaG1, 62 TaG2, 9 TaG3, 15 T1G2, 16 T1G3, 4 T2G2, 9 T2G3) and 78 controls.
    Results: We validated p-cresol glucuronide as potential diagnostic biomarker for BC patients compared to controls (AUC = 0.79). For NMIBC, p-cresol glucuronide was valuable as staging biomarker (AUC = 0.803). And among NMIBCs, p-coumaric acid may be a potential specific staging biomarker for the TaG1 NMIBC; however, future validation experiments should be conducted once the precise version of the standard is commercially available. Remarkably, for MIBC we validated spermine as potential specific staging biomarker (AUC = 0.882).
    Conclusion: Ours is the first metabolomics study conducted in urine of a thoroughly characterized cohort comprising all stages of NMIBC, MIBC and healthy controls in which we identified non-invasive diagnostic and staging biomarkers. These may improve BC management, thus reducing the use of current harmful diagnostic techniques.
    MeSH term(s) Biomarkers ; Biomarkers, Tumor/urine ; Chromatography, Liquid ; Cresols ; Glucuronides ; Humans ; Spermine ; Tandem Mass Spectrometry ; Urinary Bladder Neoplasms/pathology
    Chemical Substances Biomarkers ; Biomarkers, Tumor ; Cresols ; Glucuronides ; 4-cresol (1MXY2UM8NV) ; Spermine (2FZ7Y3VOQX)
    Language English
    Publishing date 2022-09-04
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 380333-8
    ISSN 1433-8726 ; 0724-4983
    ISSN (online) 1433-8726
    ISSN 0724-4983
    DOI 10.1007/s00345-022-04136-7
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    Zs.A 1832: Show issues Location:
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  10. Article: Circulating Cell-Free DNA in Liquid Biopsies as Potential Biomarker for Bladder Cancer: A Systematic Review.

    Herranz, Raquel / Oto, Julia / Plana, Emma / Fernández-Pardo, Álvaro / Cana, Fernando / Martínez-Sarmiento, Manuel / Vera-Donoso, César D / España, Francisco / Medina, Pilar

    Cancers

    2021  Volume 13, Issue 6

    Abstract: Bladder cancer (BC) is among the most frequent cancer types in the world and is the most lethal urological malignancy. Presently, diagnostic and follow-up methods for BC are expensive and invasive. Thus, the identification of novel predictive biomarkers ... ...

    Abstract Bladder cancer (BC) is among the most frequent cancer types in the world and is the most lethal urological malignancy. Presently, diagnostic and follow-up methods for BC are expensive and invasive. Thus, the identification of novel predictive biomarkers for diagnosis, progression, and prognosis of BC is of paramount importance. To date, several studies have evidenced that cell-free DNA (cfDNA) found in liquid biopsies such as blood and urine may play a role in the particular scenario of urologic tumors, and its analysis may improve BC diagnosis report about cancer progression or even evaluate the effectiveness of a specific treatment or anticipate whether a treatment would be useful for a specific patient depending on the tumor characteristics. In the present review, we have summarized the up-to-date studies evaluating the value of cfDNA as potential diagnostic, prognostic, or monitoring biomarker for BC in several biofluids.
    Language English
    Publishing date 2021-03-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13061448
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