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Article ; Online: The association between respiratory diseases and periodontitis: A systematic review and meta-analysis.

Molina, Ana / Huck, Olivier / Herrera, David / Montero, Eduardo

2023 Volume 50, Issue 6, Page(s) 842–887

Abstract: Aim: To evaluate (1) whether periodontitis has an influence on the prevalence/incidence of respiratory diseases (chronic obstructive pulmonary disease [COPD], asthma, community-acquired pneumonia [CAP], obstructive sleep apnoea [OSA] and COVID-19), and ( ...

Abstract	Aim: To evaluate (1) whether periodontitis has an influence on the prevalence/incidence of respiratory diseases (chronic obstructive pulmonary disease [COPD], asthma, community-acquired pneumonia [CAP], obstructive sleep apnoea [OSA] and COVID-19), and (2) what is the impact of periodontal therapy on the onset or progression of respiratory diseases. Materials and methods: An electronic search was performed on Pubmed, Cochrane Library and Scopus databases up to October 2021, to identify studies answering the PECOS and PICOS questions. Results: Seventy-five articles were selected. Meta-analyses identified statistically significant associations of periodontitis with COPD (n Conclusions: A positive association between periodontitis and COPD, OSA and COVID-19 complications has been found, while there is a lack of intervention studies.
MeSH term(s)	Humans ; COVID-19/complications ; COVID-19/epidemiology ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Asthma/complications ; Asthma/epidemiology ; Periodontitis/complications ; Periodontitis/epidemiology ; Periodontitis/therapy ; Pneumonia/complications ; Pneumonia/epidemiology ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/epidemiology ; Sleep Apnea, Obstructive/therapy
Language	English
Publishing date	2023-02-05
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	188647-2
ISSN	1600-051X ; 0303-6979
ISSN (online)	1600-051X
ISSN	0303-6979
DOI	10.1111/jcpe.13767
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Article ; Online: Scaling and Root Planning is Recommended in the Nonsurgical Treatment of Chronic Periodontitis.

Herrera, David

The journal of evidence-based dental practice

2016 Volume 16, Issue 1, Page(s) 56–58

Abstract: Article title and bibliographic information: Systematic review and meta-analysis on the nonsurgical treatment of chronic periodontitis by means of scaling and root planing with or without adjuncts. Smiley CJ, Tracy SL, Abt E, Michalowicz BS, John MT, ... ...

Abstract	Article title and bibliographic information: Systematic review and meta-analysis on the nonsurgical treatment of chronic periodontitis by means of scaling and root planing with or without adjuncts. Smiley CJ, Tracy SL, Abt E, Michalowicz BS, John MT, Gunsolley J, Cobb CM, Rossmann J, Harrel SK, Forrest JL, Hujoel PP, Noraian KW, Greenwell H, Frantsve-Hawley J, Estrich C, Hanson N. J Am Dent Assoc 2015;146(7):508-524.e5. Source of funding: The study was funded by the American Dental Association Type of study/design: Systematic review with meta-analysis.
MeSH term(s)	Chronic Periodontitis ; Dental Scaling ; Humans ; Periodontitis ; Plant Roots ; Root Planing
Language	English
Publishing date	2016-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2056058-8
ISSN	1532-3390 ; 1532-3382
ISSN (online)	1532-3390
ISSN	1532-3382
DOI	10.1016/j.jebdp.2016.01.005
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Book ; Online: COVID-19. Normas de Orientação Clínica - Medicina Dentária

2020

Size	1 electronic resource (180 pages)
Publisher	Coimbra University Press
Document type	Book ; Online
Note	Dental Medicine, Dentistry Guidelines, Evidence based Medicine, SARS CoV 2 , Covid 19 ; Open Access
HBZ-ID	HT020589140
ISBN	9789892619859 ; 9892619854
DOI	10.14195/978-989-26-1986-6
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: The Impact of

Bravo, Enrique / Arce, Marion / Ribeiro-Vidal, Honorato / Herrera, David / Sanz, Mariano

International journal of molecular sciences

2024 Volume 25, Issue 6

Abstract: This study aimed to evaluate the impact ... ...

Abstract	This study aimed to evaluate the impact of
MeSH term(s)	Candida albicans ; Cell Survival ; Dental Implants ; Biofilms ; Porphyromonas gingivalis
Chemical Substances	Dental Implants
Language	English
Publishing date	2024-03-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25063277
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Article ; Online: Oral and systemic health: is there a "new" link with COVID-19?

Herrera, David / Serrano, Jorge / Roldán, Silvia / Alonso, Bettina / Sanz, Mariano

Clinical oral investigations

2023 Volume 27, Issue Suppl 1, Page(s) 3–13

Abstract: Objectives: The objective of the present narrative review was to evaluate the evidence of a possible association between periodontitis and COVID-19, and its biological plausibility, using as models the potential associations with cardiovascular diseases, ...

Abstract	Objectives: The objective of the present narrative review was to evaluate the evidence of a possible association between periodontitis and COVID-19, and its biological plausibility, using as models the potential associations with cardiovascular diseases, diabetes, and some respiratory diseases. Methods: A recent systematic review was used as main reference to explore the associations of periodontitis with different respiratory diseases, including COVID-19, following two focussed questions: a PECOS question, aimed to explore epidemiological evidence, and a PICOS question, designed to explore the evidence derived from intervention studies. In addition to that evidence, other relevant scientific documents, including consensus papers, were carefully selected and appraised. Findings: Convincing evidence was found to support the association of periodontitis and cardiovascular diseases, diabetes, and some respiratory diseases. The biological plausibility behind those associations is based on four factors: (1) bacteraemia of oral bacteria and periodontal pathogens, (2) increased systemic inflammation, (3) common genetic factors, and (4) common environmental risk factors. Limited initial evidence is available to support an association between periodontitis and COVID-19 complications. Among the proposed factors to explain the suggested association, a combination of the previously mentioned factors, plus additional factors related with SARS-CoV-2 characteristics and pathogenicity, has been suggested. Conclusions: Initial evidence suggests that periodontitis may be associated with a more severe COVID-19 and with a higher risk of death due to COVID-19. Clinical relevance: Due to the possible association between periodontitis and an increased severity for COVID-19, additional efforts should be made to improve oral and periodontal health, including the promotion of oral healthy habits, such as oral hygiene.
MeSH term(s)	Humans ; COVID-19/complications ; Cardiovascular Diseases ; SARS-CoV-2 ; Periodontitis/complications ; Periodontitis/epidemiology ; Diabetes Mellitus ; Respiratory Tract Diseases/complications
Language	English
Publishing date	2023-04-20
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1364490-7
ISSN	1436-3771 ; 1432-6981
ISSN (online)	1436-3771
ISSN	1432-6981
DOI	10.1007/s00784-023-04950-2
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Article ; Online: The subgingival cultivable bacteria of Albanian subjects with different periodontal status compared to a similar population of Spanish subjects: a case control study.

Tafaj, Gerila / Iniesta, Margarita / Sanz, Mariano / Herrera, David

BMC oral health

2022 Volume 22, Issue 1, Page(s) 89

Abstract: Background: The objective was to qualitatively and quantitatively describe the subgingival cultivable bacteria in Albanian subjects and to compare it with a similar Spanish population.: Materials and methods: Consecutive patients, diagnosed as ... ...

Abstract	Background: The objective was to qualitatively and quantitatively describe the subgingival cultivable bacteria in Albanian subjects and to compare it with a similar Spanish population. Materials and methods: Consecutive patients, diagnosed as periodontitis in stages I-II or III-IV, and as periodontally healthy or with gingivitis, were studied clinically and microbiologically by means of microbiological culture, including total anaerobic counts, proportions, and frequency of detection of target species. Outcome variables were analysed by Mann-Whitney, Kruskal-Wallis, ANOVA, ANCOVA and Chi-square tests. Results: In this cross-sectional study, 83 (Albania) and 90 (Spain) subjects were included. No statistically significant differences were observed between test and control populations regarding demographic variables or smoking habit. Significantly higher total anaerobic counts in the Albanian population (p = 0.022) were observed, especially in the periodontal health/gingivitis group (p = 0.001). In the test population, the proportions of the cultivable bacteria of Fusobacterium nucleatum were significantly lower in both the healthy/gingivitis (p = 0.022) and stages I-II periodontitis (p = 0.034) groups. Conclusions: The subgingival cultivable bacteria in both periodontitis and non-periodontitis subjects from Albania showed significantly higher total anaerobic counts and lower proportions of the cultivable bacteria of F. nucleatum than a similar population of subjects from Spain.
MeSH term(s)	Case-Control Studies ; Cross-Sectional Studies ; Gingivitis/microbiology ; Humans ; Periodontitis/microbiology ; Porphyromonas gingivalis
Language	English
Publishing date	2022-03-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2091511-1
ISSN	1472-6831 ; 1472-6831
ISSN (online)	1472-6831
ISSN	1472-6831
DOI	10.1186/s12903-022-02121-5
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Article ; Online: Radicalización mediática y abuso del derecho en la doctrina del Tribunal Europeo de Derechos Humanos

Martín Herrera, David

Estudios de Deusto: revista de la Universidad de Deusto, ISSN 0423-4847, Vol. 68, Nº. 1, 2020 (Ejemplar dedicado a: Five Centuries Sailing The Legal World (II)), pags. 397-424

2020

Abstract: The Right to be informed and to inform has undergone a real revolution in what refers to the current vast range of possibilities. The liberation of the information services underwent a decisive step with the opening of the informative offer, but the ... ...

Abstract	The Right to be informed and to inform has undergone a real revolution in what refers to the current vast range of possibilities. The liberation of the information services underwent a decisive step with the opening of the informative offer, but the arrival of the Internet, and its immeasurable immensity of information sources, has ended up forging Galeano’s thesis in which he assured that more and more people have the right to listen and look, but fewer and fewer people have the privilege to report, think and create.This type of law sui generis seems to have ended up transforming in recent years the fundamental right of access to information and to inform, into a dictatorship of the word and the unique image that Galeano considered even more devastating than that arising from a single-party system.Not only because of the risks involved in spreading falsehood; also for imposing a way of life that states as an exemplary citizen a docile consumer and a passive spectator who seems to have been molded at the whim of the commercial information society model.A good example of this is the media management of the health crisis around COVID-19. An epidemic with remote origins but which has ended up spreading infinitely more quickly than the media had intended in order to reassure citizens and try to ensure the continuity of the markets. All this has generated the disaster and the dramatic consequences that we are all suffering.Received: 02.04.2020Accepted: 12.06.2020Published online: 03.07.2020 El Derecho de ser informado y de informar ha experimentado una auténtica revolución en cuanto a lo que se refiere al actual inmenso elenco de posibilidades. Si la liberación de los servicios de la información experimentó un paso decisivo con la apertura de la oferta informativa, la irrupción de Internet, y su inabarcable inmensidad de fuentes de información, ha terminado por sacralizar aquella tesis de Galeano en la que aseguraba que cada vez son más los que tienen el derecho de escuchar y de mirar, pero cada vez son menos los que tienen el privilegio de informar, opinar y crear.Este tipo de Derecho sui generis parece haber terminado transformando en los últimos años el Derecho fundamental de acceso a la información, y a informar, en una dictadura de la palabra y la imagen única que, este autor, consideraba aún más devastadora que aquella surgida del modelo del partido único.No solo por los riesgos que implica la divulgación de la falsedad; también por imponer un modo de vida que tiene por ciudadano ejemplar aquel consumidor dócil y el espectador pasivo que parece haber sido moldeado al capricho del modelo de la sociedad de la información comercial1.Un buen ejemplo de ello lo podemos encontrar en la gestión mediática de la crisis sanitaria en torno al COVID-19. Una epidemia con orígenes remotos pero que ha terminado por propagarse infinitamente más rápido de lo que ha pretendido la contención mediática con el fin de tranquilizar a la ciudadanía y tratar de asegurar la continuidad de los mercados. El resultado de esa maniobra ha propiciado el desastre y las dramáticas consecuencias que todos ahora sufrimos. 1 «Los cuatro puntos cardinales del globo, y la propia Europa, han sido conquistados por ese moral cóctel de sangre, valium y publicidad que dicta las pautas de la televisión privada». Vid. GALEANO, E., La comunicación desigual, Conferencia en la Unidad Xochimilco, México, 1995. Recibido: 02.04.2020Aceptado: 12.06.2020Publicación en línea: 03.07.2020
Keywords	Freedom of information ; public watchdog ; chilling effect ; abuse of rights ; propaganda ; Libertad de información ; abuso del derecho ; covid19
Language	Spanish
Publishing country	es
Document type	Article ; Online
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Article: Osteogenic differentiation of adipose-derived canine mesenchymal stem cells seeded in porous calcium-phosphate scaffolds.

Herrera, David / Lodoso-Torrecilla, Irene / Ginebra, Maria-Pau / Rappe, Katrin / Franch, Jordi

Frontiers in veterinary science

2023 Volume 10, Page(s) 1149413

Abstract: Introduction: Engineered bone graft substitutes are a promising alternative and supplement to autologous bone grafts as treatments for bone healing impairment. Advances in human medicine extend an invitation to pursue these biomimetic strategies in ... ...

Abstract	Introduction: Engineered bone graft substitutes are a promising alternative and supplement to autologous bone grafts as treatments for bone healing impairment. Advances in human medicine extend an invitation to pursue these biomimetic strategies in animal patients, substantiated by the theory that specialized scaffolds, multipotent cells, and biological cues may be combined into a bioactive implant intended for the enhancement of tissue regeneration. Methods: This proof-of-concept study was designed to evaluate and validate the feasibility of beta-tricalcium phosphate foam scaffolds seeded with canine mesenchymal stem cells derived from adipose tissue. Cell-inoculated samples and sham controls were cultured statically for 72 hours in complete growth medium to evaluate seeding capacity, while a subset of loaded scaffolds was further induced with osteogenic culture medium for 21 days. Produced implants were characterized and validated with a combination of immunofluorescence and reflection confocal microscopy, scanning electron microscopy, and polymerase chain reaction to confirm osteogenic differentiation in tridimensional-induced samples. Results: After 72 hours of culture, all inoculated scaffolds presented widespread yet heterogeneous surface seeding, distinctively congregating stem cells around pore openings. Furthermore, at 21 days of osteogenic culture conditions, robust osteoblastic differentiation of the seeded cells was confirmed by the change of cell morphology and evident deposition of extra-cellular matrix, accompanied by mineralization and scaffold remodeling; furthermore, all induced cell-loaded implants lost specific stemness immunophenotype expression and simultaneously upregulated genomic expression of osteogenic genes Osterix and Ostecalcin. Conclusions: β-TCP bio-ceramic foam scaffolds proved to be suitable carriers and hosts of canine adipose-derived MSCs, promoting not only surface attachment and proliferation, but also demonstrating strong
Language	English
Publishing date	2023-06-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2023.1149413
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Article ; Online: Reducción de la presión arterial sistólica en pacientes con hemorragia intracraneal y pronóstico funcional.

Rodríguez-Herrera, David Alejandro / Hernández-Plata, Alma Erika / Hernández-González, Martha Alicia / Solorio-Meza, Sergio Eduardo

Revista medica del Instituto Mexicano del Seguro Social

2023 Volume 61, Issue Suppl 2, Page(s) S200–S206

Abstract: Background: Acute intracerebral hemorrhage affects annually more than 1 million people worldwide. Chronic systemic arterial hypertension is the most important modifiable risk factor for spontaneous intracerebral hemorrhage.: Objective: To determine ... ...

Title translation	Systolic blood pressure reduction in patients with intracranial hemorrhage and functional prognosis.
Abstract	Background: Acute intracerebral hemorrhage affects annually more than 1 million people worldwide. Chronic systemic arterial hypertension is the most important modifiable risk factor for spontaneous intracerebral hemorrhage. Objective: To determine the relationship between the decrease in systolic blood pressure (SBP) in patients with intracranial hemorrhage and their short-term functional prognosis. Material and methods: Observational, longitudinal, prospective study in patients with intraparenchymal hemorrhage secondary to hypertensive dyscontrol, older than 18 years, of both sexes. Blood pressure was recorded at admission, every hour during the first 6 hours and every two hours from 8 to 24 hours after admission. Functionality was assessed using the modified Rankin scale at admission, at 6 and 24 hours after admission. Results: 58 patients were included, in whom the reduction of systolic blood pressure at admission was 17.04% and at 24 hours was 31.3 mm Hg; the mean systolic blood pressure was 183.62 mm Hg as opposed to 152.3 mm Hg at discharge (p < 0.001). Conclusions: In the first 6 hours, reduction in ASR is significantly associated with hospital outcome in patients with intracranial hemorrhage. A linear association was observed with improvement and favorable functional prognosis as measured by the modified Rankin scale.
MeSH term(s)	Male ; Female ; Humans ; Blood Pressure/physiology ; Antihypertensive Agents/therapeutic use ; Prospective Studies ; Treatment Outcome ; Hypertension/complications ; Hypertension/diagnosis ; Hypertension/drug therapy ; Prognosis ; Cerebral Hemorrhage/chemically induced ; Cerebral Hemorrhage/complications
Chemical Substances	Antihypertensive Agents
Language	Spanish
Publishing date	2023-09-18
Publishing country	Mexico
Document type	English Abstract ; Journal Article ; Observational Study
ZDB-ID	732133-8
ISSN	2448-5667 ; 0443-5117 ; 0484-7849
ISSN (online)	2448-5667
ISSN	0443-5117 ; 0484-7849
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Article ; Online: Clinical, microbiological and biochemical impact of a supportive care protocol with an air-polishing device, after surgical treatment of peri-implantitis: Randomized clinical trial.

Luengo, Fernando / Sanz-Esporrín, Javier / Sanz-Sánchez, Ignacio / Solonko, Myroslav / Herrera, David / Sanz, Mariano

Clinical oral implants research

2023 Volume 34, Issue 4, Page(s) 378–392

Abstract: Objectives: The aim of the present study was to evaluate the efficacy of a supportive peri-implant care (SPIC) protocol after surgical therapy of peri-implantitis, combining ultrasonic mechanical debridement and glycine powder air polishing.: ... ...

Abstract	Objectives: The aim of the present study was to evaluate the efficacy of a supportive peri-implant care (SPIC) protocol after surgical therapy of peri-implantitis, combining ultrasonic mechanical debridement and glycine powder air polishing. Materials and methods: Thirty subjects diagnosed with peri-implantitis and treated by means of access flap were randomized 6 months later into two different SPIC groups: the test group combined a piezoelectric ultrasonic instrumentation with a specific implant PEEK tip and glycine powder air polishing, while control group received the same ultrasonic instrumentation together with a rubber cup and a polishing paste. Patients were followed for 12 months, with intermediate SPIC visits every 3 months. Clinical, radiological, microbiological and biochemical outcome variables were registered and calculated. Results: After 12 months of SPIC, probing depths (PD) showed a mean reduction of 0.33 ± 0.11 mm, with significant differences (p < .001) between the test (-0.84 ± 0.43 mm) and the control group (+0.18 ± 0.73 mm). Healthy peri-implant tissues defined by PD <5 mm, absence of BoP (or in only one site around the implant), and no additional bone loss (<0.5 mm), were observed at the final visit in 83% of the implants (87% in the test group and 80% in the control group, p = .255). No adverse events were reported by the subjects participating in the study. Conclusions: The SPIC protocol including mechanical ultrasonic debridement and glycine powder air-polishing demonstrated significantly better efficacy in terms of PD reductions. A strict SPIC protocol can maintain for 1 year, or even improve, the results obtained after surgical treatment of peri-implantitis.
MeSH term(s)	Humans ; Peri-Implantitis/surgery ; Peri-Implantitis/drug therapy ; Powders/therapeutic use ; Glycine ; Dental Implants ; Treatment Outcome ; Randomized Controlled Trials as Topic
Chemical Substances	Powders ; Glycine (TE7660XO1C) ; Dental Implants
Language	English
Publishing date	2023-02-24
Publishing country	Denmark
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	1067626-0
ISSN	1600-0501 ; 0905-7161
ISSN (online)	1600-0501
ISSN	0905-7161
DOI	10.1111/clr.14049
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