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  1. Book ; Online: A Flexible Rolling Regression Framework for Time-Varying SIRD models

    Rubio-Herrero, Javier / Wang, Yuchen

    Application to COVID-19

    2021  

    Abstract: The present paper introduces a data-driven framework for describing the time-varying nature of an SIRD model in the context of COVID-19. By embedding a rolling regression in a mixed integer bilevel nonlinear programming problem, our aim is to provide the ...

    Abstract The present paper introduces a data-driven framework for describing the time-varying nature of an SIRD model in the context of COVID-19. By embedding a rolling regression in a mixed integer bilevel nonlinear programming problem, our aim is to provide the research community with a model that reproduces accurately the observed changes in the number of infected, recovered, and death cases, while providing information about the time dependency of the parameters that govern the SIRD model. We propose this optimization model and a genetic algorithm to tackle its solution. Moreover, we test this algorithm with 2020 COVID-19 data from the state of Minnesota and found that our results are consistent both qualitatively and quantitatively, thus proving that the framework proposed is an effective an flexible tool to describe the dynamics of a pandemic.
    Keywords Quantitative Biology - Populations and Evolution ; Physics - Physics and Society
    Publishing date 2021-03-02
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Modeling atmospheric data and identifying dynamics Temporal data-driven modeling of air pollutants

    Rubio-Herrero, Javier / Ortiz Marrero, Carlos / Fan, Wai-Tong (Louis)

    Journal of cleaner production. 2022 Jan. 20, v. 333

    2022  

    Abstract: Atmospheric modeling has recently experienced a surge with the advent of deep learning. Most of these models, however, predict concentrations of pollutants following a data-driven approach in which the physical laws that govern their behaviors and ... ...

    Abstract Atmospheric modeling has recently experienced a surge with the advent of deep learning. Most of these models, however, predict concentrations of pollutants following a data-driven approach in which the physical laws that govern their behaviors and relationships remain hidden. With the aid of real-world air quality data collected hourly in different stations throughout Madrid, we present an empirical approach using data-driven techniques with the following goals: (1) Find parsimonious systems of ordinary differential equations via sparse identification of nonlinear dynamics (SINDy) that model the concentration of pollutants and their changes over time; (2) assess the performance and limitations of our models using stability analysis; (3) reconstruct the time series of chemical pollutants not measured in certain stations using delay coordinate embedding results. Our results show that Akaike’s Information Criterion can work well in conjunction with best subset regression as to find an equilibrium between sparsity and goodness of fit. We also find that, due to the complexity of the chemical system under study, identifying the dynamics of this system over longer periods of time require higher levels of data filtering and smoothing. Stability analysis for the reconstructed ordinary differential equations (ODEs) reveals that more than half of the physically relevant critical points are saddle points, suggesting that the system is unstable even under the idealized assumption that all environmental conditions are constant over time.
    Keywords air ; air quality ; nonlinear models ; time series analysis
    Language English
    Dates of publication 2022-0120
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 0959-6526
    DOI 10.1016/j.jclepro.2021.129863
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  3. Article ; Online: The Many Ways to Deal with STING.

    Coderch, Claire / Arranz-Herrero, Javier / Nistal-Villan, Estanislao / de Pascual-Teresa, Beatriz / Rius-Rocabert, Sergio

    International journal of molecular sciences

    2023  Volume 24, Issue 10

    Abstract: The stimulator of interferon genes (STING) is an adaptor protein involved in the activation of IFN-β and many other genes associated with the immune response activation in vertebrates. STING induction has gained attention from different angles such as ... ...

    Abstract The stimulator of interferon genes (STING) is an adaptor protein involved in the activation of IFN-β and many other genes associated with the immune response activation in vertebrates. STING induction has gained attention from different angles such as the potential to trigger an early immune response against different signs of infection and cell damage, or to be used as an adjuvant in cancer immune treatments. Pharmacological control of aberrant STING activation can be used to mitigate the pathology of some autoimmune diseases. The STING structure has a well-defined ligand binding site that can harbor natural ligands such as specific purine cyclic di-nucleotides (CDN). In addition to a canonical stimulation by CDNs, other non-canonical stimuli have also been described, whose exact mechanism has not been well defined. Understanding the molecular insights underlying the activation of STING is important to realize the different angles that need to be considered when designing new STING-binding molecules as therapeutic drugs since STING acts as a versatile platform for immune modulators. This review analyzes the different determinants of STING regulation from the structural, molecular, and cell biology points of view.
    MeSH term(s) Animals ; Nucleotides, Cyclic ; Binding Sites ; Adjuvants, Immunologic
    Chemical Substances Nucleotides, Cyclic ; Adjuvants, Immunologic
    Language English
    Publishing date 2023-05-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24109032
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  4. Book ; Online: Evaposublimation from the snow in the Mediterranean mountains of Sierra Nevada (Spain)

    Herrero, Javier / Polo, María José

    eISSN: 1994-0424

    2018  

    Abstract: In this study we quantify the evaposublimation and the energy balance of the seasonal snowpack in the Mediterranean semiarid region of Sierra Nevada, Spain (37° N). In these kinds of regions, the incidence of this return of water to the atmosphere is ... ...

    Abstract In this study we quantify the evaposublimation and the energy balance of the seasonal snowpack in the Mediterranean semiarid region of Sierra Nevada, Spain (37° N). In these kinds of regions, the incidence of this return of water to the atmosphere is particularly important to the hydrology and water availability. The analysis of the evaposublimation from snow allows us to deduct the losses of water expected in the short and medium term and is critical for the efficient planning of this basic and scarce resource. To achieve this, we performed 10 field campaigns from 2009 to 2015, during which detailed measurements of mass fluxes of a controlled volume of snow were recorded using a modified version of an evaporation pan with lysimeter. Meteorological data at the site of the snow control volume were extensively monitored during the tests. With these data, a point energy balance snowmelt model was validated for the area. This model, fed with the complete meteorological data set available at the Refugio Poqueira Station (2500 m a.s.l.), let us estimate that evaposublimation losses for this site can range from 24 to 33 % of total annual ablation. This ratio is very variable throughout the year and between years, depending on the particular occurrence of snowfall and mild weather events, which is generally quite erratic in this semiarid region. Evaposublimation proceeds at maximum rates of up to 0.49 mm h −1 , an order of magnitude less than maximum melt rates. However, evaposublimation occurs during 60 % of the time that snow lies, while snowmelt only takes up 10 % of this time. Hence, both processes remain close in magnitude on the annual scale.
    Subject code 551
    Language English
    Publishing date 2018-09-27
    Publishing country de
    Document type Book ; Online
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  5. Article: On the unimodality of the price-setting newsvendor problem with additive demand under risk considerations

    Rubio-Herrero, Javier / Baykal-Gürsoy, Melike

    European journal of operational research : EJOR Vol. 265, No. 3 , p. 962-974

    2018  Volume 265, Issue 3, Page(s) 962–974

    Author's details Javier Rubio-Herrero, Melike Baykal-Gürsoy
    Keywords Inventory ; Pricing ; Revenue management ; Newsvendor ; Risk analysis
    Language English
    Publisher Elsevier
    Publishing place Amsterdam
    Document type Article
    ZDB-ID 243003-4
    ISSN 0377-2217
    Database ECONomics Information System

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  6. Article: Seasonal Climate Forecast Skill Assessment for the Management of Water Resources in a Run of River Hydropower System in the Poqueira River (Southern Spain)

    Contreras, Eva / Herrero, Javier / Crochemore, Louise / Aguilar, Cristina / Polo, María José

    Water. 2020 July 26, v. 12, no. 8

    2020  

    Abstract: Run of river (RoR) hydropower systems, despite being one of the most cost-effective and environmentally benign energy technologies, have the disadvantage that production is not constant because it is subject to a high variability in precipitation and ... ...

    Abstract Run of river (RoR) hydropower systems, despite being one of the most cost-effective and environmentally benign energy technologies, have the disadvantage that production is not constant because it is subject to a high variability in precipitation and snow cover. In addition, the management of RoR plants has to comply with some particular operating conditions, but also with some environmental flow requirements. This work presents the assessment of the main inputs included in a climate service, historical local data and the seasonal forecast of water inflow to RoR plants, which are used to predict the operability and the expected energy production. The analysis is presented through the application in a pilot RoR system located in the south of Spain, in a semi-arid Mediterranean area impacted by snow, where seasonal forecasting is especially challenging. The results show the high interannual variability of the operation in this kind of facilities. The outcomes indicate that seasonal climate forecast information would improve the prediction of observed river streamflow by 7.4% in reliability and 3.2% in sharpness compared to the current operational forecast based on historical data. The climate forecasts thus provide valuable information for the exploitation of available water resources, which generates a significant value for the operation of the plant and the energy production market.
    Keywords administrative management ; climate ; cost effectiveness ; energy ; flow ; information ; markets ; prediction ; reliability ; rivers ; snow ; snowpack ; stream flow ; variability ; water ; water management ; water power ; weather forecasting ; Mediterranean region ; Spain
    Language English
    Dates of publication 2020-0726
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ZDB-ID 2521238-2
    ISSN 2073-4441
    ISSN 2073-4441
    DOI 10.3390/w12082119
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Adaptation of the Multidimensional Body Self Relations Questionnaire for Young People Between 9 and 16 Years old.

    Fernández, María P / Coballes, Soraya / San Pedro, Belén / Martín, David / Labra, José / González, Carmen / Herrero, Javier

    Psicothema

    2022  Volume 34, Issue 3, Page(s) 479–487

    Abstract: Background: Young adolescents and pre-adolescents are the population most vulnerable to disorders derived from a distorted Body Image (BI). In this study, the Multidimensional Body Self Relations Questionnaire, MBSR®, was adapted and validated for young ...

    Abstract Background: Young adolescents and pre-adolescents are the population most vulnerable to disorders derived from a distorted Body Image (BI). In this study, the Multidimensional Body Self Relations Questionnaire, MBSR®, was adapted and validated for young Spanish people between 9 and 16 years old.
    Method: 719 young people of both sexes participated. The internal structure, the invariance of the measure according to sex and age, and evidence of validity and reliability of the measure were examined.
    Results: the dimensional model found in adults was not replicated in young people. The simplest, best-fitting BI construct in young people, examined from the perspective of the BI construct contained in the MBSRQ®, consisted of 20 items in 4 differentially correlated factors. The internal consistency of the factors contained in the MBSRQ-SA-a was shown to be satisfactory, as was the evidence of concurrent validity. Factor invariance was demonstrated as a function of gender and three age groups.
    Conclusions: the MBSRQ-SA-a is reliable and valid for the study of BI in young people aged 9-16 years to the extent permitted by the content of the 4 factors making it up.
    MeSH term(s) Adolescent ; Adult ; Body Image ; Child ; Factor Analysis, Statistical ; Female ; Humans ; Male ; Personal Satisfaction ; Psychometrics/methods ; Reproducibility of Results ; Surveys and Questionnaires
    Language English
    Publishing date 2022-07-20
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 2421645-8
    ISSN 1886-144X ; 1886-144X
    ISSN (online) 1886-144X
    ISSN 1886-144X
    DOI 10.7334/psicothema2022.19
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  8. Article ; Online: Curative Pericardiectomy in Interpheron-Resistant Severe Pericardial Erdheim-Chester Disease.

    Gómez-Herrero, Javier / Luis, Carolina Hernández / Moral, Elena Tapia / García, Gerardo Martínez / Palacid, Francisco Sebastián / Bustamante-Munguira, Juan / Fuentes, Roberto González

    JACC. Case reports

    2022  Volume 4, Issue 22, Page(s) 1534–1541

    Abstract: Erdheim-Chester disease is a rare clonal non-Langerhans cell histiocytosis with multisystemic involvement. It affects bones, large vessels, and retroperitoneum. Cardiac involvement is one of the main mortality predictors. ...

    Abstract Erdheim-Chester disease is a rare clonal non-Langerhans cell histiocytosis with multisystemic involvement. It affects bones, large vessels, and retroperitoneum. Cardiac involvement is one of the main mortality predictors.
    Language English
    Publishing date 2022-11-16
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2022.07.031
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  9. Article ; Online: Response by Amat-Santos et al to Letter Regarding Article, "Laser Coronary Atherectomy and Polymeric Coronary Wires in Uncrossable Lesions: a Word of Caution".

    Amat-Santos, Ignacio J / Marengo, Giorgio / Cortés, Carlos / Sánchez-Luna, Juan Pablo / Gonzalez-Gutiérrez, Jose Carlos / Gómez Herrero, Javier / Sanz-Sanchez, Jorge / Gutiérrez, Hipólito / Serrador, Ana / Campo, Alberto / Blasco-Turrión, Sara / Gasparini, Gabriele / San Román, J Alberto

    Circulation. Cardiovascular interventions

    2024  Volume 17, Issue 3, Page(s) e013996

    MeSH term(s) Humans ; Atherectomy, Coronary/adverse effects ; Treatment Outcome ; Angioplasty, Balloon, Coronary ; Coronary Occlusion ; Lasers
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2450797-0
    ISSN 1941-7632 ; 1941-7640
    ISSN (online) 1941-7632
    ISSN 1941-7640
    DOI 10.1161/CIRCINTERVENTIONS.124.013996
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  10. Article ; Online: Noncoding mutations drive persistence of a founder preleukemic clone which initiates late relapse in T-ALL.

    O'Connor, David / Valle-Inclán, Jose Espejo / Conde, Lucia / Bloye, Gianna / Rahman, Sunniyat / Costa, Joana R / Bartram, Jack / Adams, Stuart / Wright, Gary / Elrick, Hillary / Wall, Kerry / Dyer, Sara / Howell, Christopher / Jigoulina, Galina / Herrero, Javier / Cortes-Ciriano, Isidro / Moorman, Anthony V / Mansour, Marc R

    Blood

    2024  Volume 143, Issue 10, Page(s) 933–937

    Abstract: Abstract: T-ALL relapse usually occurs early but can occur much later, which has been suggested to represent a de novo leukemia. However, we conclusively demonstrate late relapse can evolve from a pre-leukemic subclone harbouring a non-coding mutation ... ...

    Abstract Abstract: T-ALL relapse usually occurs early but can occur much later, which has been suggested to represent a de novo leukemia. However, we conclusively demonstrate late relapse can evolve from a pre-leukemic subclone harbouring a non-coding mutation that evades initial chemotherapy.
    MeSH term(s) Humans ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Leukemia-Lymphoma, Adult T-Cell ; Mutation ; Recurrence ; Chronic Disease ; Clone Cells
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2023021906
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    Uh III Zs.140: Show issues Location:
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