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  1. AU="Herrmann, Christian"
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  1. Book ; Online: Video-to-Video Face Recognition for Low-Quality Surveillance Data

    Herrmann, Christian

    2018  

    Abstract: The availability of video data is an opportunity and a challenge for law enforcement agencies. Face recognition methods can play a key role in the automated search for persons in the data. This work targets efficient representations of low-quality face ... ...

    Abstract The availability of video data is an opportunity and a challenge for law enforcement agencies. Face recognition methods can play a key role in the automated search for persons in the data. This work targets efficient representations of low-quality face sequences to enable fast and accurate face search. Novel concepts for multi-scale analysis, dataset augmentation, CNN loss function, and sequence description lead to improvements over state-of-the-art methods on surveillance video footage
    Keywords Electronic computers. Computer science
    Size 1 electronic resource (IX, 153 p. p.)
    Publisher KIT Scientific Publishing
    Publishing place Verlagsort nicht ermittelbar
    Document type Book ; Online
    Note ENGLISH ; Open Access
    HBZ-ID HT020196256
    ISBN 9783731507994 ; 3731507994
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Thesis: Nachuntersuchung von Knaben nach Schoemaker-Operation mittels farbcodierter Dopplersonographie

    Herrmann, Christian

    2005  

    Author's details vorgelegt von Christian Herrmann
    Language German
    Size 57 Bl. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Humboldt-Univ., Diss., 2005
    HBZ-ID HT014627548
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2006 E 119 order for loan Magazin

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  3. Book ; Thesis: Assoziation des QTc-Intervalls mit drei häufigen Haplotypen des KCNQ1-Gens in der MONICA-Augsburg-Population

    Herrmann, Christian

    2004  

    Author's details vorgelegt von Christian Herrmann
    Language German
    Size 46 Bl., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Regensburg, Univ., Diss., 2004
    HBZ-ID HT016026350
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 E 1807 order for loan Magazin

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  4. Article ; Audio / Video ; Online: Sicherheit bei Virenforschung

    Herrmann, Christian

    Laborunfälle sind keine Seltenheit

    2021  

    Abstract: Gut anderthalb Jahre nach dem Ausbruch der Corona-Pandemie ist der Ursprung des Virus nach wie vor unklar. Zuletzt wird die Labor-Theorie in der Öffentlichkeit wieder offener diskutiert. Das liegt auch daran, dass Unfälle in Hochsicherheitseinrichtungen ... ...

    Abstract Gut anderthalb Jahre nach dem Ausbruch der Corona-Pandemie ist der Ursprung des Virus nach wie vor unklar. Zuletzt wird die Labor-Theorie in der Öffentlichkeit wieder offener diskutiert. Das liegt auch daran, dass Unfälle in Hochsicherheitseinrichtungen keinesfalls selten sind. Jens Teifke leitet am Friedrich-Loeffler-Institut auf der Forschungsinsel Riems die Abteilung für experimentelle Tierhaltung und Biosicherheit. Er erklärt im "Wieder was gelernt"-Podcast, was in einem Labor der höchsten Risikostufe 4 alles schieflaufen kann.
    Keywords Text ; ddc:610 ; Pressespiegel -- Friedrich-Loeffler-Institut -- Biosicherheit -- Coronavirus -- SARS-CoV-2 -- Covid-19 -- Herkunft -- Virus -- Labor -- Unfall -- Hochsicherheitslabor
    Language German
    Publishing date 2021-06-13
    Publishing country de
    Document type Article ; Audio / Video ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Development and validation of a test instrument for the assessment of perceived basic motor competencies in first and second graders: the SEMOK-1-2 instrument.

    Bretz, Kathrin / Strotmeyer, Anne / Seelig, Harald / Herrmann, Christian

    Frontiers in psychology

    2024  Volume 15, Page(s) 1358170

    Abstract: Both actual motor competencies (AMC) and perceived motor competencies (PMC) play an important role in motor development research and children's physical and psychological development. PMC refer to children's perceptions of their motor competencies. To ... ...

    Abstract Both actual motor competencies (AMC) and perceived motor competencies (PMC) play an important role in motor development research and children's physical and psychological development. PMC refer to children's perceptions of their motor competencies. To assess the PMC of first and second grade children (aged 6-9 years), the SEMOK-1-2 instrument was developed. The instrument is aligned to the validated MOBAK-1-2 instrument which assesses AMC in the competence areas "object movement" and "self-movement" Accounting for possible reading difficulties in younger children, the motor tasks and answer options were illustrated and explained verbally. The purpose of this study was to test and validate the SEMOK-1-2 instrument and investigate the associations between the constructs AMC, PMC and physical activity (PA), whereby PA was measured by the participation in team and individual sports. Data from
    Language English
    Publishing date 2024-03-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2024.1358170
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Structural insights into the activation mechanism of antimicrobial GBP1.

    Weismehl, Marius / Chu, Xiaofeng / Kutsch, Miriam / Lauterjung, Paul / Herrmann, Christian / Kudryashev, Misha / Daumke, Oliver

    The EMBO journal

    2024  Volume 43, Issue 4, Page(s) 615–636

    Abstract: The dynamin-related human guanylate-binding protein 1 (GBP1) mediates host defenses against microbial pathogens. Upon GTP binding and hydrolysis, auto-inhibited GBP1 monomers dimerize and assemble into soluble and membrane-bound oligomers, which are ... ...

    Abstract The dynamin-related human guanylate-binding protein 1 (GBP1) mediates host defenses against microbial pathogens. Upon GTP binding and hydrolysis, auto-inhibited GBP1 monomers dimerize and assemble into soluble and membrane-bound oligomers, which are crucial for innate immune responses. How higher-order GBP1 oligomers are built from dimers, and how assembly is coordinated with nucleotide-dependent conformational changes, has remained elusive. Here, we present cryo-electron microscopy-based structural data of soluble and membrane-bound GBP1 oligomers, which show that GBP1 assembles in an outstretched dimeric conformation. We identify a surface-exposed helix in the large GTPase domain that contributes to the oligomerization interface, and we probe its nucleotide- and dimerization-dependent movements that facilitate the formation of an antimicrobial protein coat on a gram-negative bacterial pathogen. Our results reveal a sophisticated activation mechanism for GBP1, in which nucleotide-dependent structural changes coordinate dimerization, oligomerization, and membrane binding to allow encapsulation of pathogens within an antimicrobial protein coat.
    MeSH term(s) Humans ; Cryoelectron Microscopy ; GTP Phosphohydrolases/metabolism ; Dynamins/metabolism ; Nucleotides/metabolism ; Anti-Infective Agents ; GTP-Binding Proteins/genetics ; GTP-Binding Proteins/metabolism
    Chemical Substances GTP Phosphohydrolases (EC 3.6.1.-) ; Dynamins (EC 3.6.5.5) ; Nucleotides ; Anti-Infective Agents ; GBP1 protein, human ; GTP-Binding Proteins (EC 3.6.1.-)
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 586044-1
    ISSN 1460-2075 ; 0261-4189
    ISSN (online) 1460-2075
    ISSN 0261-4189
    DOI 10.1038/s44318-023-00023-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1808: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 100: Show issues

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  7. Article ; Online: The interaction strength of an intrinsically disordered protein domain with its binding partner is little affected by very different cosolutes.

    Schnatwinkel, Jan / Herrmann, Christian

    Physical chemistry chemical physics : PCCP

    2020  Volume 22, Issue 47, Page(s) 27903–27911

    Abstract: A common feature of intrinsically disordered proteins (IDPs) is a disorder-to-order transition upon binding to other proteins, which has been tied to multiple benefits, including accelerated association rates or binding with low affinity, yet high ... ...

    Abstract A common feature of intrinsically disordered proteins (IDPs) is a disorder-to-order transition upon binding to other proteins, which has been tied to multiple benefits, including accelerated association rates or binding with low affinity, yet high specificity. Given the balanced equilibrium concentrations of folded and unfolded state of an IDP we asked the question if changes in the chemical environment, such as the presence of osmolytes or crowding agents, have a strong influence on the interaction of an IDP. Here, we demonstrate the impact of cosolutes on the interaction of the intrinsically disordered transcription factor c-Myb and its binding partner, the kinase-inducible interaction domain (KIX) of the CREB-binding protein. Temperature jump relaxation kinetics and microscale thermophoresis were employed in order to quantify the rate constants and the binding affinity of the c-Myb/KIX complex, respectively, in the presence of various cosolutes. We find the binding free energy of the c-Myb/KIX complex only marginally modulated by cosolutes, whereas the enthalpy and entropy of the interaction are very sensitive to the respective solvent conditions. For different cosolutes we observe substantial changes in enthalpy, both favorable and unfavorable, which are going with entropy changes largely compensating the enthalpy effects in each case. These characteristics might reflect a potential mechanism by which c-Myb offsets changes in the physico-chemical environment to maintain a roughly unaltered binding affinity.
    MeSH term(s) Betaine/chemistry ; CREB-Binding Protein/chemistry ; CREB-Binding Protein/metabolism ; Entropy ; Glycine/chemistry ; Humans ; Intrinsically Disordered Proteins/chemistry ; Intrinsically Disordered Proteins/metabolism ; Kinetics ; Methylamines/chemistry ; Protein Binding ; Protein Domains ; Proto-Oncogene Proteins c-myb/chemistry ; Proto-Oncogene Proteins c-myb/metabolism ; Temperature ; Urea/chemistry
    Chemical Substances Intrinsically Disordered Proteins ; MYB protein, human ; Methylamines ; Proto-Oncogene Proteins c-myb ; Betaine (3SCV180C9W) ; Urea (8W8T17847W) ; CREB-Binding Protein (EC 2.3.1.48) ; CREBBP protein, human (EC 2.3.1.48) ; trimethyloxamine (FLD0K1SJ1A) ; Glycine (TE7660XO1C)
    Language English
    Publishing date 2020-12-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d0cp03040f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Purification of Farnesylated hGBP1 and Characterization of Its Polymerization and Membrane Binding.

    Sistemich, Linda / Herrmann, Christian

    Methods in molecular biology (Clifton, N.J.)

    2020  Volume 2159, Page(s) 67–81

    Abstract: The human guanylate-binding protein 1 (hGBP1) is the best characterized isoform of the seven human GBPs belonging to the superfamily of dynamin-like proteins (DLPs). As known for other DLPs, hGBP1 also exhibits antiviral and antimicrobial activity within ...

    Abstract The human guanylate-binding protein 1 (hGBP1) is the best characterized isoform of the seven human GBPs belonging to the superfamily of dynamin-like proteins (DLPs). As known for other DLPs, hGBP1 also exhibits antiviral and antimicrobial activity within the cell. hGBP 1, like hGBPs 2 and 5, carries a CAAX motive at the C-terminus leading to isoprenylation in the living cells. The attachment of a farnesyl anchor and its unique GTPase cycle provides hGBP1 the ability of a nucleotide- stimulated polymerization and membrane binding. In this chapter, we want to show how to prepare farnesylated hGBP1 (hGBP1
    MeSH term(s) Cell Membrane/metabolism ; Enzyme Activation ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Fluorescence Resonance Energy Transfer ; GTP Phosphohydrolases/chemistry ; GTP Phosphohydrolases/metabolism ; GTP-Binding Proteins/chemistry ; GTP-Binding Proteins/genetics ; GTP-Binding Proteins/isolation & purification ; GTP-Binding Proteins/metabolism ; Gene Expression ; Humans ; Prenylation ; Protein Binding ; Protein Multimerization ; Recombinant Proteins ; Spectrum Analysis
    Chemical Substances GBP1 protein, human ; Recombinant Proteins ; GTP Phosphohydrolases (EC 3.6.1.-) ; GTP-Binding Proteins (EC 3.6.1.-)
    Language English
    Publishing date 2020-06-12
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-0676-6_6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Thesis: Ewing-Sarkom und maligner peripherer neuroektodermaler Tumor

    Herrmann, Christian

    Vorschlag einer neuen Klassifikation

    1992  

    Author's details vorgelegt von Christian Herrmann
    Size 55 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Kiel, Univ., Diss., 1992
    HBZ-ID HT004435277
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    93 D 545 order for loan Magazin

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  10. Article ; Online: Effects of an Intervention for Promoting Basic Motor Competencies in Middle Childhood.

    Strotmeyer, Anne / Kehne, Miriam / Herrmann, Christian

    International journal of environmental research and public health

    2021  Volume 18, Issue 14

    Abstract: The development of motor competencies is necessary for participation in the culture of sport, exercise, and physical activity, which in turn supports the development of a healthy lifestyle. A lack of physical activity in childhood and deficits in motor ... ...

    Abstract The development of motor competencies is necessary for participation in the culture of sport, exercise, and physical activity, which in turn supports the development of a healthy lifestyle. A lack of physical activity in childhood and deficits in motor performance emphasize the relevance of interventions for promoting basic motor competencies. However, there are research desiderata with regard to such interventions. This article describes an intervention program for promoting basic motor competencies in middle childhood (around 6 to 10 years of age). The intervention was investigated in a longitudinal study from June 2019 to January 2020 (
    MeSH term(s) Child ; Exercise ; Female ; Humans ; Longitudinal Studies ; Male ; Motor Skills ; Physical Education and Training ; Schools ; Sports
    Language English
    Publishing date 2021-07-09
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph18147343
    Database MEDical Literature Analysis and Retrieval System OnLINE

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