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  1. Article ; Online: Search for hits and early leads from soil bacteria to combat infectious diseases.

    Herrmann, Jennifer

    Journal of infection in developing countries

    2018  Volume 12, Issue 2.1, Page(s) 24S

    Abstract: Introduction: Natural products are the source of a large fraction of the current pharmaceutics available against human disease. However, the discovery of novel compounds with new mechanisms of action is becoming increasingly challenging. We focused our ... ...

    Abstract Introduction: Natural products are the source of a large fraction of the current pharmaceutics available against human disease. However, the discovery of novel compounds with new mechanisms of action is becoming increasingly challenging. We focused our work on soil-dwelling Myxobacteria from highly diverse samples, which are more and more recognized as an important natural product source.
    Methodology: Our discovery pipeline combines traditional whole cell-based activity screens with state-of-the-art analytical techniques and a comprehensive dereplication process. Having identified an antimicrobial compound we aim at elucidating its target, MOA and MOR in diverse microbiological screens and by applying 'omic' technologies.
    Results: Two case studies of currently investigated compound classes will be highlighted. Cystobactamids are novel topoisomerase inhibitors that display very pronounced activity on Gram-positive and Gram-negative bacteria. Telomycins from Streptomyces canus bind to cardiolipin and our studies revealed other putative cellular targets.
    Conclusion: We were able to isolate several new natural products with potent and selective activity against clinically relevant pathogens. Interestingly, underlying MOAs often differ from those of already described antimicrobial agents.
    Language English
    Publishing date 2018-02-22
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2394024-4
    ISSN 1972-2680 ; 2036-6590
    ISSN (online) 1972-2680
    ISSN 2036-6590
    DOI 10.3855/jidc.10096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Correction: Fries et al. Impact of Drug Administration Routes on the

    Fries, Franziska / Kany, Andreas M / Rasheed, Sari / Hirsch, Anna K H / Müller, Rolf / Herrmann, Jennifer

    International journal of molecular sciences

    2024  Volume 25, Issue 4

    Abstract: The authors would like to make the following corrections to the original publication [ ... ]. ...

    Abstract The authors would like to make the following corrections to the original publication [...].
    Language English
    Publishing date 2024-02-07
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25042011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Optimization of Mass Spectrometry Imaging for Drug Metabolism and Distribution Studies in the Zebrafish Larvae Model: A Case Study with the Opioid Antagonist Naloxone.

    Park, Yu Mi / Meyer, Markus R / Müller, Rolf / Herrmann, Jennifer

    International journal of molecular sciences

    2023  Volume 24, Issue 12

    Abstract: Zebrafish (ZF; ...

    Abstract Zebrafish (ZF;
    MeSH term(s) Animals ; Humans ; Narcotic Antagonists/pharmacology ; Zebrafish ; Naloxone/pharmacology ; Larva ; Pilot Projects ; Mass Spectrometry
    Chemical Substances Narcotic Antagonists ; Naloxone (36B82AMQ7N)
    Language English
    Publishing date 2023-06-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241210076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Tartrolon sensing and detoxification by the Listeria monocytogenes timABR resistance operon.

    Engelgeh, Tim / Herrmann, Jennifer / Jansen, Rolf / Müller, Rolf / Halbedel, Sven

    Molecular microbiology

    2023  Volume 120, Issue 5, Page(s) 629–644

    Abstract: Listeria monocytogenes is a foodborne bacterium that naturally occurs in the soil. Originating from there, it contaminates crops and infects farm animals and their consumption by humans may lead to listeriosis, a systemic life-threatening infectious ... ...

    Abstract Listeria monocytogenes is a foodborne bacterium that naturally occurs in the soil. Originating from there, it contaminates crops and infects farm animals and their consumption by humans may lead to listeriosis, a systemic life-threatening infectious disease. The adaptation of L. monocytogenes to such contrastive habitats is reflected by the presence of virulence genes for host infection and other genes for survival under environmental conditions. Among the latter are ABC transporters for excretion of antibiotics produced by environmental competitors; however, most of these transporters have not been characterized. Here, we generated a collection of promoter-lacZ fusions for genes encoding ABC-type drug transporters of L. monocytogenes and screened this reporter strain collection for induction using a library of natural compounds produced by various environmental microorganisms. We found that the timABR locus (lmo1964-lmo1962) was induced by the macrodiolide antibiotic tartrolon B, which is synthesized by the soil myxobacterium Sorangium cellulosum. Tartrolon B resistance of L. monocytogenes was dependent on timAB, encoding the ATPase and the permease component of a novel ABC transporter. Moreover, transplantation of timAB was sufficient to confer tartrolon B resistance to Bacillus subtilis. Expression of the timABR locus was found to be auto-repressed by the TimR repressor, whose repressing activity was lost in the presence of tartrolon B. We also demonstrate that tartrolon sensitivity was suppressed by high external potassium concentrations, suggesting that tartrolon acts as potassium ionophore. Our results help to map the ecological interactions of an important human pathogen with its co-residing species within their joint natural reservoir.
    MeSH term(s) Animals ; Humans ; Listeria monocytogenes/metabolism ; ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/metabolism ; Membrane Transport Proteins/metabolism ; Listeriosis ; Operon/genetics ; Soil ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism
    Chemical Substances tartrolon B ; ATP-Binding Cassette Transporters ; Membrane Transport Proteins ; Soil ; Bacterial Proteins
    Language English
    Publishing date 2023-10-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 619315-8
    ISSN 1365-2958 ; 0950-382X
    ISSN (online) 1365-2958
    ISSN 0950-382X
    DOI 10.1111/mmi.15178
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2502: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Search for hits and early leads from soil bacteria to combat infectious diseases.

    Herrmann, Jennifer

    Journal of infection in developing countries

    2018  

    Keywords myxobacteria ; streptomyces ; natural products
    Language English
    Publishing date 2018-02-22
    Publisher Open Learning on Enteric Pathogens
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  6. Article ; Online: Examination of date tampering on Abraham Lincoln's pardon of Patrick Murphy, RG 153 entry 15, case MM761 (ARC identifier: 1839980).

    Herrmann, Jennifer K / Strumfels, Yoonjoo / Ludwig, Kathy

    Forensic science international. Synergy

    2021  Volume 3, Page(s) 100210

    Abstract: On January 26, 2011, the Pardon of Patrick Murphy, a document in the U.S. National Archives and Records Administration (NARA) Record Group 153 (RG 153) Records of the Office of the Judge Advocate General (Army), was submitted to conservation for ... ...

    Abstract On January 26, 2011, the Pardon of Patrick Murphy, a document in the U.S. National Archives and Records Administration (NARA) Record Group 153 (RG 153) Records of the Office of the Judge Advocate General (Army), was submitted to conservation for examination. The record was examined with special focus on the handwritten "1865" to the left of Abraham Lincoln's signature. All analysis techniques were non-sampling, non-invasive, and non-damaging as retaining the integrity of cultural heritage is very similar to the forensic handling of evidence. Microscopy, transmitted light, Ultraviolet-induced visible fluorescence, and X-Ray Fluorescence (XRF) spectroscopy analysis confirmed that the ink used to write the "5", in the April 14, 1865 date is different from the remaining text written by Lincoln and these analytical forensic-inspired techniques allowed scientists and conservators to "set the record straight" about the modern forged "5" for future generations of researchers.
    Language English
    Publishing date 2021-11-19
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2589-871X
    ISSN (online) 2589-871X
    DOI 10.1016/j.fsisyn.2021.100210
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Inter-library loan at ZB MED

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  7. Article: Zebrafish: An Attractive Model to Study

    Rasheed, Sari / Fries, Franziska / Müller, Rolf / Herrmann, Jennifer

    Pharmaceuticals (Basel, Switzerland)

    2021  Volume 14, Issue 6

    Abstract: Non-mammalian in vivo disease models are particularly popular in early drug discovery. Zebrafish ( ...

    Abstract Non-mammalian in vivo disease models are particularly popular in early drug discovery. Zebrafish (
    Language English
    Publishing date 2021-06-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph14060594
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  8. Article ; Online: Hydrochlorothiazide-induced photosensitivity in a psoriasis patient following exposure to narrow-band ultraviolet B excimer therapy.

    Rosenthal, Amanda / Herrmann, Jennifer

    Photodermatology, photoimmunology & photomedicine

    2019  Volume 35, Issue 5, Page(s) 369–371

    Abstract: Drug-induced photosensitivity develops when the use of oral or topical photosensitizing medications creates a rash after exposure to ultraviolet (UV) radiation. Medications most commonly implicated in photosensitive drug reactions include amiodarone, ... ...

    Abstract Drug-induced photosensitivity develops when the use of oral or topical photosensitizing medications creates a rash after exposure to ultraviolet (UV) radiation. Medications most commonly implicated in photosensitive drug reactions include amiodarone, nonsteroidal anti-inflammatories, thiazides, tetracycline antibiotics, chlorpromazine, and fluoroquinolones. It is generally believed that drug-induced photosensitivity is an UVA phenomenon, caused by UV wavelengths between 315 and 400 nm. Here, we present a case of hydrochlorothiazide (HCTZ)-induced photosensitivity following exposure to 308-nm narrow-band (nb) UVB light emitted from an excimer laser in a patient undergoing treatment for plaque psoriasis. This patient had received biweekly treatments with the excimer laser for years prior without any history of adverse reactions. We believe that our patient suffered an acute photosensitivity to UVB due to new-onset HCTZ. Because nb UVB-emitting lasers are used to treat many dermatologic conditions, physicians should be aware of potential photosensitivity reactions, review medication lists and counsel patients accordingly.
    MeSH term(s) Aged ; Female ; Humans ; Hydrochlorothiazide/administration & dosage ; Hydrochlorothiazide/adverse effects ; Photosensitivity Disorders/chemically induced ; Photosensitivity Disorders/pathology ; Photosensitizing Agents/administration & dosage ; Photosensitizing Agents/adverse effects ; Psoriasis/pathology ; Psoriasis/therapy ; Ultraviolet Therapy/adverse effects
    Chemical Substances Photosensitizing Agents ; Hydrochlorothiazide (0J48LPH2TH)
    Language English
    Publishing date 2019-06-06
    Publishing country England
    Document type Case Reports
    ZDB-ID 1028855-7
    ISSN 1600-0781 ; 0108-9684 ; 0905-4383
    ISSN (online) 1600-0781
    ISSN 0108-9684 ; 0905-4383
    DOI 10.1111/phpp.12471
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1951: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Making connections: enhancers in cellular differentiation.

    Herrmann, Jennifer C / Beagrie, Robert A / Hughes, Jim R

    Trends in genetics : TIG

    2021  Volume 38, Issue 4, Page(s) 395–408

    Abstract: Deciphering the process by which hundreds of distinct cell types emerge from a single zygote to form a complex multicellular organism remains one of the greatest challenges in biological research. Enhancers are known to be central to cell type-specific ... ...

    Abstract Deciphering the process by which hundreds of distinct cell types emerge from a single zygote to form a complex multicellular organism remains one of the greatest challenges in biological research. Enhancers are known to be central to cell type-specific gene expression, yet many questions regarding how these genomic elements interact both temporally and spatially with other cis- and trans-acting factors to control transcriptional activity during differentiation and development remain unanswered. Here, we review our current understanding of the role of enhancers and their interactions in this context and highlight recent progress achieved with experimental methods of unprecedented resolution.
    MeSH term(s) Cell Differentiation/genetics ; Enhancer Elements, Genetic ; Promoter Regions, Genetic ; Trans-Activators/genetics
    Chemical Substances Trans-Activators
    Language English
    Publishing date 2021-11-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 619240-3
    ISSN 1362-4555 ; 0168-9525 ; 0168-9479
    ISSN (online) 1362-4555
    ISSN 0168-9525 ; 0168-9479
    DOI 10.1016/j.tig.2021.10.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2272: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Nitroxoline resistance is associated with significant fitness loss and diminishes

    Deschner, Felix / Risch, Timo / Baier, Claas / Schlüter, Dirk / Herrmann, Jennifer / Müller, Rolf

    Microbiology spectrum

    2023  Volume 12, Issue 1, Page(s) e0307923

    Abstract: Importance: Antimicrobial resistance (AMR) poses a global threat and requires the exploration of underestimated treatment options. Nitroxoline, an effective broad-spectrum antibiotic, does not suffer from high resistance rates in the clinics but ... ...

    Abstract Importance: Antimicrobial resistance (AMR) poses a global threat and requires the exploration of underestimated treatment options. Nitroxoline, an effective broad-spectrum antibiotic, does not suffer from high resistance rates in the clinics but surprisingly, it is not heavily used yet. Our findings provide compelling evidence that Nitroxoline resistance renders bacteria unable to cause an infection
    MeSH term(s) Humans ; Escherichia coli ; Anti-Infective Agents, Urinary ; Urinary Tract Infections/microbiology ; Virulence ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Escherichia coli Infections/drug therapy ; Escherichia coli Infections/microbiology ; Nitroquinolines
    Chemical Substances nitroxoline (A8M33244M6) ; Anti-Infective Agents, Urinary ; Anti-Bacterial Agents ; Nitroquinolines
    Language English
    Publishing date 2023-12-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.03079-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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