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  1. Book ; Online ; E-Book: OSCEs for intensive care medicine

    Hersey, Peter / O'Connor, Laura / Sams, Tom / Sturman, Jon

    (Oxford higher specialty training)

    2020  

    Author's details Peter Herse, Laura O'Connor, Tom Sams, Jon Sturman
    Series title Oxford higher specialty training
    Keywords Critical care medicine-Examinations, questions, etc ; Electronic books
    Language English
    Size 1 Online-Ressource (xiv, 336 Seiten), Illustrationen
    Edition First edition
    Publisher Oxford University Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021184396
    ISBN 978-0-19-255773-5 ; 9780198824374 ; 0-19-255773-4 ; 0198824378
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: SITC's guide to managing immunotherapy toxicity

    Ernstoff, Marc S. / Puzanov, Igor / Robert, Caroline / Diab, Adi / Hersey, Peter

    2019  

    Title variant Guide to managing immunotherapy toxicity
    Author's details editors, Marc S. Ernstoff, Igor Puzanov, Caroline Robert, Adi Diab, Peter Hersey
    Keywords Antineoplastic Agents, Immunological / toxicity
    Language English
    Size 1 Online-Ressource (275 Seiten)
    Publisher Demos Medical Publishing
    Publishing place New York
    Publishing country United States
    Document type Book ; Online ; E-Book
    Note Includes bibliographical references and index
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020041668
    ISBN 9780826172150 ; 9780826172143 ; 0826172156 ; 0826172148
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Re: Pyrexia in patients treated with dabrafenib plus trametinib across clinical trials in BRAF-mutant cancers.

    Hersey, Peter

    European journal of cancer (Oxford, England : 1990)

    2021  Volume 162, Page(s) 241–242

    MeSH term(s) Fever/chemically induced ; Humans ; Imidazoles ; Neoplasms/chemically induced ; Neoplasms/drug therapy ; Neoplasms/genetics ; Oximes/adverse effects ; Proto-Oncogene Proteins B-raf/genetics ; Pyridones/adverse effects ; Pyrimidinones
    Chemical Substances Imidazoles ; Oximes ; Pyridones ; Pyrimidinones ; trametinib (33E86K87QN) ; BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; dabrafenib (QGP4HA4G1B)
    Language English
    Publishing date 2021-12-20
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 82061-1
    ISSN 1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
    ISSN (online) 1879-0852
    ISSN 0277-5379 ; 0959-8049 ; 0964-1947
    DOI 10.1016/j.ejca.2021.10.037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 456: Show issues Location:
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    Zs.MO 583: Show issues

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  4. Article ; Online: Community experience of vemurafenib for BRAF(V600) melanoma.

    Hersey, Peter

    The Lancet. Oncology

    2014  Volume 15, Issue 4, Page(s) 369–370

    MeSH term(s) Antineoplastic Agents/therapeutic use ; Humans ; Indoles/therapeutic use ; Melanoma/drug therapy ; Melanoma/secondary ; Mutation ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins B-raf/antagonists & inhibitors ; Proto-Oncogene Proteins B-raf/genetics ; Skin Neoplasms/drug therapy ; Sulfonamides/therapeutic use
    Chemical Substances Antineoplastic Agents ; Indoles ; Protein Kinase Inhibitors ; Sulfonamides ; vemurafenib (207SMY3FQT) ; BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1)
    Language English
    Publishing date 2014-04
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(14)70079-8
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    Zs.MO 460: Show issues

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  5. Article ; Online: BET inhibition sensitizes innate checkpoint inhibitor resistant melanoma to anti-CTLA-4 treatment.

    Tseng, Hsin-Yi / Alavi, Sara / Gallagher, Stuart / McGuire, Helen M / Hersey, Peter / Al Emran, Abdullah / Tiffen, Jessamy

    Pigment cell & melanoma research

    2024  

    Abstract: Approximately 50% of melanoma patients fail to respond to immune checkpoint blockade (ICB), and acquired resistance hampers long-term survival in about half of initially responding patients. Whether targeting BET reader proteins, implicated in epigenetic ...

    Abstract Approximately 50% of melanoma patients fail to respond to immune checkpoint blockade (ICB), and acquired resistance hampers long-term survival in about half of initially responding patients. Whether targeting BET reader proteins, implicated in epigenetic dysregulation, can enhance ICB response rates and durability, remains to be determined. Here we show elevated BET proteins correlate with poor survival and ICB responses in melanoma patients. The BET inhibitor IBET151, combined with anti-CTLA-4, overcame innate ICB resistance however, sequential BET inhibition failed against acquired resistance in mouse models. Combination treatment response in the innate resistance model induced changes in tumor-infiltrating immune cells, reducing myeloid-derived suppressor cells (MDSCs). CD4+ and CD8+ T cells showed decreased expression of inhibitory receptors, with reduced TIM3, LAG3, and BTLA checkpoint expression. In human PBMCs in vitro, BET inhibition reduced expression of immune checkpoints in CD4+ and CD8+ T cells, restoring effector cytokines and downregulating the transcriptional driver TOX. BET proteins in melanoma may play an oncogenic role by inducing immune suppression and driving T cell dysfunction. The study demonstrates an effective combination for innately unresponsive melanoma patients to checkpoint inhibitor immunotherapy, yet highlights BET inhibitors' limitations in an acquired resistance context.
    Language English
    Publishing date 2024-05-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2409570-9
    ISSN 1755-148X ; 1600-0749 ; 0893-5785 ; 1755-1471
    ISSN (online) 1755-148X ; 1600-0749
    ISSN 0893-5785 ; 1755-1471
    DOI 10.1111/pcmr.13174
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2444: Show issues Location:
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  6. Article: Lysine Demethylases: Promising Drug Targets in Melanoma and Other Cancers.

    Punnia-Moorthy, Gaya / Hersey, Peter / Emran, Abdullah Al / Tiffen, Jessamy

    Frontiers in genetics

    2021  Volume 12, Page(s) 680633

    Abstract: Epigenetic dysregulation has been implicated in a variety of pathological processes including carcinogenesis. A major group of enzymes that influence epigenetic modifications are lysine demethylases (KDMs) also known as "erasers" which remove methyl ... ...

    Abstract Epigenetic dysregulation has been implicated in a variety of pathological processes including carcinogenesis. A major group of enzymes that influence epigenetic modifications are lysine demethylases (KDMs) also known as "erasers" which remove methyl groups on lysine (K) amino acids of histones. Numerous studies have implicated aberrant lysine demethylase activity in a variety of cancers, including melanoma. This review will focus on the structure, classification and functions of KDMs in normal biology and the current knowledge of how KDMs are deregulated in cancer pathogenesis, emphasizing our interest in melanoma. We highlight the current knowledge gaps of KDMs in melanoma pathobiology and describe opportunities to increases our understanding of their importance in this disease. We summarize the progress of several pre-clinical compounds that inhibit KDMs and represent promising candidates for further investigation in oncology.
    Language English
    Publishing date 2021-06-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2021.680633
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Sex bias of females in survival from cancer and infections. Is X the answer?

    Emran, Abdullah Al / Gallagher, Stuart J / Tiffen, Jessamy C / Hersey, Peter

    British journal of cancer

    2021  Volume 124, Issue 7, Page(s) 1184–1186

    Abstract: Major differences in survival of men and women from infectious diseases and cancers have been highlighted by death rates from COVID-19 infections. In cancer, attention has been focussed on differences in gene expression from X chromosomes in men and ... ...

    Abstract Major differences in survival of men and women from infectious diseases and cancers have been highlighted by death rates from COVID-19 infections. In cancer, attention has been focussed on differences in gene expression from X chromosomes in men and women with a preponderance of genes involved in immune responses being expressed in women. Important findings have been that some of the genes are important epigenetic regulators that play fundamental roles in immune responses.
    MeSH term(s) COVID-19/mortality ; COVID-19/virology ; Chromosomes, Human, X ; Chromosomes, Human, Y ; Female ; Genetic Predisposition to Disease ; Humans ; Infections/metabolism ; Neoplasms/mortality ; SARS-CoV-2/isolation & purification ; Sex Factors ; Survival Rate
    Language English
    Publishing date 2021-01-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-020-01245-1
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    Uh III Zs.142: Show issues Location:
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  8. Article ; Online: Immunotherapy of melanoma.

    Hersey, Peter

    Asia-Pacific journal of clinical oncology

    2010  Volume 6 Suppl 1, Page(s) S2–8

    Abstract: A number of studies have shown that melanoma is a particularly immunogenic tumour, at least in the early stages of its development. A range of clinical phenomena also suggests that immune responses play an important role in the natural history of the ... ...

    Abstract A number of studies have shown that melanoma is a particularly immunogenic tumour, at least in the early stages of its development. A range of clinical phenomena also suggests that immune responses play an important role in the natural history of the disease, including the total or partial regression of primary melanomas associated with lymphoid infiltrates. Immunization with a variety of vaccines can increase immune responses to melanoma, but whether this is of therapeutic benefit remains unclear. Various trials of melanoma vaccines have shown benefits but their significance has been marginal to date. Two trials have actually shown an adverse effect on survival. Stimulation of immune responses by blocking down-regulatory mechanisms in the immune system has evolved as a potential therapeutic approach following studies that have shown that immune responses are finely regulated by a series of receptors and ligands on lymphocytes and antigen presenting cells. The best studied of these approaches is the blockade of the cytotoxic T-lymphocyte antigen 4 receptor on T cells, which allows the generation of more effector cells for longer periods. Agents targeting this receptor have shown promising results and continue to be studied.
    MeSH term(s) Animals ; Cancer Vaccines/immunology ; Cancer Vaccines/therapeutic use ; Clinical Trials as Topic ; Humans ; Immunotherapy/methods ; Melanoma/immunology ; Melanoma/therapy
    Chemical Substances Cancer Vaccines
    Language English
    Publishing date 2010-03
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 2187409-8
    ISSN 1743-7563 ; 1743-7555
    ISSN (online) 1743-7563
    ISSN 1743-7555
    DOI 10.1111/j.1743-7563.2010.01269.x
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  9. Article: Developing an e-learning resource for nurse airway assistants in the emergency department.

    Hersey, Peter / McAleer, Sean

    British journal of nursing (Mark Allen Publishing)

    2017  Volume 26, Issue 4, Page(s) 217–221

    Abstract: The aims of this project were to determine the required competencies for a nurse in the emergency department assisting with a rapid sequence induction of anaesthesia (RSI), and to produce a relevant e-learning resource. A three-round multidisciplinary ... ...

    Abstract The aims of this project were to determine the required competencies for a nurse in the emergency department assisting with a rapid sequence induction of anaesthesia (RSI), and to produce a relevant e-learning resource. A three-round multidisciplinary Delphi process produced the following competencies: ability to describe the steps and sequence of events of an RSI, familiarity with the equipment used during an RSI, ability to recognise and help manage problems occurring during an RSI, ability to prepare for an RSI, ability to apply cricoid pressure, and understanding the modification of an RSI in special circumstances. An interactive e-learning package was produced and made available online. Twelve emergency department nurses took part in an evaluation of the e-learning package. All either agreed or strongly agreed that they had increased their knowledge and found the learning useful, and 11 out of 12 nurses reported being somewhat or very confident in the role of airway assistant following completion of the learning.
    MeSH term(s) Airway Management/nursing ; Anesthesia/nursing ; Anesthetists/education ; Clinical Competence ; Computer-Assisted Instruction/methods ; Delphi Technique ; Education, Nursing, Continuing/methods ; Emergency Nursing/education ; Emergency Service, Hospital ; Humans ; Internet ; Learning
    Language English
    Publishing date 2017-02-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1119191-0
    ISSN 0966-0461
    ISSN 0966-0461
    DOI 10.12968/bjon.2017.26.4.217
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Shedding light on dabrafenib-induced fevers in patients with melanoma.

    Hersey, Peter / Tiffen, Jessamy C / Gallagher, Stuart J

    The Lancet. Oncology

    2019  Volume 20, Issue 12, Page(s) 1637–1638

    MeSH term(s) Fever ; Humans ; Imidazoles ; Melanoma ; Oximes
    Chemical Substances Imidazoles ; Oximes ; dabrafenib (QGP4HA4G1B)
    Language English
    Publishing date 2019-12-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(19)30681-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5696: Show issues Location:
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