Article ; Online: Incidence, description, predictors, and consequences of persistent taxane-induced peripheral neuropathy.
Current opinion in supportive and palliative care
2024 Volume 18, Issue 1, Page(s) 30–38
Abstract: Purpose of review: This review aims to provide insights into persistent taxane-induced peripheral neuropathy (TIPN). The primary objective is to describe the incidence, predictors, and consequences of TIPN lasting at least 1 year after the end of taxane ...
| Abstract | Purpose of review: This review aims to provide insights into persistent taxane-induced peripheral neuropathy (TIPN). The primary objective is to describe the incidence, predictors, and consequences of TIPN lasting at least 1 year after the end of taxane treatment. Recent findings: Studies show varying rates of TIPN persistence, with an estimated 30-40% and 40-60% resolving by 1- and 3-year post-treatment. TIPN in the feet and motor symptoms show less resolution post-treatment. Patients who are older or have higher body weight may experience less TIPN resolution, but results may be confounded by TIPN development during treatment. Persistent TIPN negatively impacts long-term functional ability, including gait, balance, and the ability to work. It also reduces overall quality of life (QOL), particularly affecting physical and social aspects. Summary: Clinicians should be aware of the potential for persistent TIPN and its impact on patients' function and QOL. Future research should focus on large prospective studies with systematic TIPN assessments during and after treatment to better understand which symptoms and patient characteristics predict resolution. This information can guide treatment decisions, balancing the need for effective chemotherapy with minimizing long-term impairments in function and QOL. |
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| MeSH term(s) | Humans ; Quality of Life ; Prospective Studies ; Incidence ; Taxoids/adverse effects ; Peripheral Nervous System Diseases/chemically induced ; Peripheral Nervous System Diseases/epidemiology ; Bridged-Ring Compounds |
| Chemical Substances | taxane (1605-68-1) ; Taxoids ; Bridged-Ring Compounds |
| Language | English |
| Publishing date | 2024-12-06 |
| Publishing country | United States |
| Document type | Review ; Journal Article |
| ZDB-ID | 2633726-5 |
| ISSN | 1751-4266 ; 1751-4258 |
| ISSN (online) | 1751-4266 |
| ISSN | 1751-4258 |
| DOI | 10.1097/SPC.0000000000000684 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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