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Article ; Online: Adhesions in abdomino-pelvic surgeries

Perrine Capmas / Florent Payen / Anais Lemaire / Hervé Fernandez

PLoS ONE, Vol 17, Iss 10, p e

A real economic impact?

2022 Volume 0276810

Abstract: Study objective To evaluate the epidemiologic and economic burden related to adhesions and their complications for the French healthcare system. Design A descriptive and economic retrospective analysis. Setting Medicalized information system program ( ... ...

Abstract	Study objective To evaluate the epidemiologic and economic burden related to adhesions and their complications for the French healthcare system. Design A descriptive and economic retrospective analysis. Setting Medicalized information system program (PMSI), national scale of costs. Patients Female patients operated on to treat adhesions related complications in 2019. Interventions All patients with coded adhesiolysis acts were selected in order to identify the characteristics of Diagnosis related groups (DRG) and compare them with the general DRGs. Then, a sub-analysis on surgery types (laparoscopy or open procedures) was performed to evaluate impact adhesions development and Length of Stay. Lastly, direct costs of adhesions for the healthcare system were quantified based upon adhesiolysis acts coded as main diagnosis. Measurements and main results 26.387 adhesiolysis procedures were listed in France in 2019 through 8 adhesiolysis acts regrouping open surgeries and laparoscopic procedures. Adhesiolysis was coded in up to 34% in some DRGs for laparoscopic procedures. 1551 (1461 studied in our study) surgeries have been realized in 2019 with main procedure: adhesiolysis. These surgeries were associated with an expense of €4 million for the healthcare system for rehospitalizations and reoperations only. Social costs such as sick leaves, drugs and other cares haven't been taken in consideration. Conclusion Adhesions related complications represent a massive burden for patients and an expensive problem for society. These difficulties may likely to be reduced by a broader use of antiadhesion barriers, at least in some targeted procedures.
Keywords	Medicine ; R ; Science ; Q
Subject code	360
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
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Article ; Online: Organic contamination detection for isotopic analysis of water by laser spectroscopy.

Millar, Cody / Janzen, Kim / Nehemy, Magali F / Koehler, Geoff / Hervé-Fernández, Pedro / McDonnell, Jeffrey J

Rapid communications in mass spectrometry : RCM

2021 , Page(s) e9118

Abstract: Rationale: Hydrogen and oxygen stable isotope ratios (δ: Methods: Errors induced by methanol and ethanol water mixtures on measured IRIS and IRMS results were evaluated. For IRIS analyses both liquid and vapour-mode (via direct vapour equilibration) ... ...

Abstract	Rationale: Hydrogen and oxygen stable isotope ratios (δ Methods: Errors induced by methanol and ethanol water mixtures on measured IRIS and IRMS results were evaluated. For IRIS analyses both liquid and vapour-mode (via direct vapour equilibration) methods are used. The δ Results: Organic contamination induced significant errors in IRIS results which were not seen in IRMS results. Methanol caused larger errors than ethanol. Results from vapour-IRIS analyses had larger errors than those from liquid-IRIS analyses. The Conclusion: Organic contamination caused significant errors in IRIS stable isotope results. These errors were larger during vapour analysis than during liquid IRIS analyses, and larger for methanol than ethanol contamination. The
Language	English
Publishing date	2021-05-03
Publishing country	England
Document type	Journal Article
ZDB-ID	58731-x
ISSN	1097-0231 ; 0951-4198
ISSN (online)	1097-0231
ISSN	0951-4198
DOI	10.1002/rcm.9118
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Article ; Online: Impact of uterine fibroids on quality of life: a national cross-sectional survey.

Hervé, Fernandez / Katty, Ardaens / Isabelle, Queval / Céline, Solignac

European journal of obstetrics, gynecology, and reproductive biology

2018 Volume 229, Page(s) 32–37

Abstract: Objective: To study clinical impact of symptomatic uterine fibroids on women's health-related perceived quality of life regarding several dimensions.: Study design: A prospective cross-sectional web-based survey was conducted from August 18: ... ...

Abstract	Objective: To study clinical impact of symptomatic uterine fibroids on women's health-related perceived quality of life regarding several dimensions. Study design: A prospective cross-sectional web-based survey was conducted from August 18 Results: Almost two thirds of surveyed women (n = 193; 64%) reported moderate to severe fibroid-related symptoms (symptom severity score between 40 and 100). The global HRQL score showed that 64% of women (n = 193) reported a moderate to very important impact of fibroids on quality of life (HRQL global score between 0 and 50). The worse HRQL scores were reported for concern (57.5 ± 26.7), energy (58.1 ± 23.2) and self-conscious subscales (63.4 ± 24.3). The mean overall well-being score was lower in women with symptomatic uterine fibroids (6.6 ± 1.7) than in women without (7.3 ± 1.5). The mean overall discomfort score rated by women with symptomatic uterine fibroid was 5.7 ± 2.5 with a score between 6 and 10 reported by 56% of them. Conclusions: We observed that 64% of surveyed women reported a moderate to very important impact of fibroids on their quality of life. This perceived alteration of quality of life together with the severity of symptomatic fibroids have a significant impact on the overall level of discomfort perceived by women and on their personal quality of life.
MeSH term(s)	Adolescent ; Adult ; Cross-Sectional Studies ; Female ; France ; Humans ; Leiomyoma/psychology ; Middle Aged ; Prospective Studies ; Quality of Life ; Surveys and Questionnaires ; Uterine Neoplasms/psychology ; Young Adult
Language	English
Publishing date	2018-08-01
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	190605-7
ISSN	1872-7654 ; 0301-2115 ; 0028-2243
ISSN (online)	1872-7654
ISSN	0301-2115 ; 0028-2243
DOI	10.1016/j.ejogrb.2018.07.032
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Article ; Online: Hydraulic redistribution of foliar absorbed water causes turgor-driven growth in mangrove seedlings.

Schreel, Jeroen D M / Van de Wal, Bart A E / Hervé-Fernandez, Pedro / Boeckx, Pascal / Steppe, Kathy

Plant, cell & environment

2019 Volume 42, Issue 8, Page(s) 2437–2447

Abstract: Although foliar water uptake (FWU) has been shown in mature Avicennia marina trees, the importance for its seedlings remains largely unknown. A series of experiments were therefore performed using artificial rainfall events in a greenhouse environment to ...

Abstract	Although foliar water uptake (FWU) has been shown in mature Avicennia marina trees, the importance for its seedlings remains largely unknown. A series of experiments were therefore performed using artificial rainfall events in a greenhouse environment to assess the ecological implications of FWU in A. marina seedlings. One-hour artificial rainfall events resulted in an increased leaf water potential, a reversed sap flow, and a rapid diameter increment signifying a turgor-driven growth of up to 30.1 ± 5.4 μm. Furthermore, the application of an artificial rainfall event with deuterated water showed that the amount of water absorbed by the leaves and transported to the stem was directly and univocally correlated to the observed growth spurts. The observations in this process-based study show that FWU is an important water acquisition mechanism under certain circumstances and might be of ecological importance for the establishment of A. marina seedlings. Distribution of mangrove trees might hence be more significantly disturbed by climate change-driven changes in rainfall patterns than previously assumed.
MeSH term(s)	Avicennia/growth & development ; Avicennia/metabolism ; Climate Change ; Plant Leaves/growth & development ; Plant Leaves/metabolism ; Pressure ; Rain ; Seedlings/growth & development ; Seedlings/metabolism ; Temperature ; Water/metabolism
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2019-05-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391893-2
ISSN	1365-3040 ; 0140-7791
ISSN (online)	1365-3040
ISSN	0140-7791
DOI	10.1111/pce.13556
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Article ; Online: Accuracy of fetal fibronectin for the prediction of preterm birth in symptomatic twin pregnancies

Florent Fuchs / Clémentine Lefevre / Marie-Victoire Senat / Hervé Fernandez

Scientific Reports, Vol 8, Iss 1, Pp 1-

a pilot study

2018 Volume 7

Abstract: Abstract Our goal was to evaluate the performance of fetal fibronectin (fFN) test alone or combined with cervical length (CL), to predict spontaneous preterm birth (PTB) in symptomatic twin pregnancies. We carry out a short pilot study including all ... ...

Abstract	Abstract Our goal was to evaluate the performance of fetal fibronectin (fFN) test alone or combined with cervical length (CL), to predict spontaneous preterm birth (PTB) in symptomatic twin pregnancies. We carry out a short pilot study including all uncomplicated diamniotic twin pregnancies with symptoms of preterm labor (PTL) and intact membranes at 24–33 weeks + 6 days of gestation. Studied outcome were spontaneous delivery within 7 and 14 days of testing and spontaneous PTB at <34 and <37 weeks of gestation. Among 40 women, fFN test was positive in 3 of them (7.5%). Regardless of the outcome studied CL did not significantly predict PTB. Performance of fFN was sensitivity (66.7%), specificity (97.2%), positive predictive value (66.7%), negative predictive value (97.2%), positive likelihood ratio (LR) (24.0), and negative LR (0.3) to predict spontaneous PTB within 7 days (p = 0.01). Thus, 66.1% of patients with a positive fFN test would deliver within 7 days versus 2.4% if negative testing; starting with a pre-test probability of 7.5%. Combining CL and fFN did not enable to increase enough positive LR or decrease significantly negative LR. In conclusion, fFN test alone might have a better ability to detect spontaneous delivery within 7 days among symptomatic twin pregnancies.
Keywords	Medicine ; R ; Science ; Q
Subject code	150
Language	English
Publishing date	2018-02-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
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Article ; Online: Robust Estimation of Absorbing Root Surface Distributions From Xylem Water Isotope Compositions With an Inverse Plant Hydraulic Model

Hannes P. T. De Deurwaerder / Marco D. Visser / Félicien Meunier / Matteo Detto / Pedro Hervé-Fernández / Pascal Boeckx / Hans Verbeeck

Frontiers in Forests and Global Change, Vol

2021 Volume 4

Abstract: The vertical distribution of absorbing roots is one of the most influential plant traits determining plant strategy to access below ground resources. Yet little is known of natural variability in root distribution since collecting field data is ... ...

Abstract	The vertical distribution of absorbing roots is one of the most influential plant traits determining plant strategy to access below ground resources. Yet little is known of natural variability in root distribution since collecting field data is challenging and labor-intensive. Studying stable water isotope compositions in plants could offer a cost-effective and practical solution to estimate the absorbing root surfaces distribution. However, such an approach requires developing realistic inverse modeling techniques that enable robust estimation of rooting distributions and associated uncertainty from xylem water isotopic composition observations. This study introduces an inverse modeling method that supports the assessment of the root allocation parameter (β) that defines the exponential vertical decay of a plants’ absorbing root surfaces distribution with soil depth. The method requires measurements obtained from xylem and soil water isotope composition, soil water potentials, and sap flow velocities when plants’ xylem water is sampled at a certain height above the rooting point. In a simulation study, we show that the approach can provide unbiased estimates of β and its associated uncertainty due to measuring errors and unmeasured environmental factors that can impact the xylem water isotopic data. We also recommend improving the accuracy and power of β estimation, highlighting the need for considering accurate soil water potential and sap flow monitoring. Finally, we apply the inverse modeling method to xylem water isotope data of lianas and trees collected in French Guiana. Our work shows that the inverse modeling procedure provides a robust analytical and statistical framework to estimate β. The method accounts for potential bias due to extraction errors and unmeasured environmental factors, which improves the viability of using stable water isotope compositions to estimate the distribution of absorbing root surfaces complementary to the assessment of relative root water uptake profiles.
Keywords	absorbing root surfaces distribution ; ecohydrology ; lianas ; stable water isotopes ; tropical trees ; water competition ; Forestry ; SD1-669.5 ; Environmental sciences ; GE1-350
Subject code	580 ; 550
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article ; Online: On the urgent need for standardization in isotope‐based ecohydrological investigations

Millar, Cody / Janzen, Kim / Nehemy, Magali F. / Koehler, Geoff / Hervé‐Fernández, Pedro / Wang, Hongxiu / Orlowski, Natalie / Barbeta, Adrià / McDonnell, Jeffrey J.

Hydrological Processes. 2022 Oct., v. 36, no. 10 p.e14698-

2022

Abstract: Ecohydrological investigations commonly use the stable isotopes of water (hydrogen and oxygen) as conservative ecosystem tracers. This approach requires accessing and analysing water from plant and soil matrices. Generally, there are six steps involved ... ...

Abstract	Ecohydrological investigations commonly use the stable isotopes of water (hydrogen and oxygen) as conservative ecosystem tracers. This approach requires accessing and analysing water from plant and soil matrices. Generally, there are six steps involved to retrieve hydrogen and oxygen isotope values from these matrices: (1) sampling, (2) sample storage and transport, (3) extraction, (4) pre‐analysis processing, (5) isotopic analysis, and (6) post‐processing and correction. At each step, cumulative errors can be introduced which sum to non‐trivial magnitudes. These can impact subsequent interpretations about water cycling and partitioning through the soil–plant‐atmosphere continuum. At each of these steps, there are multiple possible options to select from resulting in tens of thousands of possible combinations used by researchers to go from plant and soil samples to isotopic data. In a newly emerging field, so many options can create interpretive confusion and major issues with data comparability. This points to the need for development of shared standardized approaches. Here we critically examine the state of the process chain, reflecting on the issues associated with each step, and provide suggestions to move our community towards standardization. Assessing this shared ‘process chain’ will help us see the problem in its entirety and facilitate community action towards agreed upon standardized approaches.
Keywords	community development ; ecosystems ; hydrogen ; hydrologic cycle ; isotope labeling ; oxygen ; oxygen isotopes ; soil
Language	English
Dates of publication	2022-10
Publishing place	John Wiley & Sons, Inc.
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	1479953-4
ISSN	1099-1085 ; 0885-6087
ISSN (online)	1099-1085
ISSN	0885-6087
DOI	10.1002/hyp.14698
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Liana and tree below-ground water competition-evidence for water resource partitioning during the dry season.

De Deurwaerder, Hannes / Hervé-Fernández, Pedro / Stahl, Clément / Burban, Benoit / Petronelli, Pascal / Hoffman, Bruce / Bonal, Damien / Boeckx, Pascal / Verbeeck, Hans

Tree physiology

2018 Volume 38, Issue 7, Page(s) 1071–1083

Abstract: To date, reasons for the increase in liana abundance and biomass in the Neotropics are still unclear. One proposed hypothesis suggests that lianas, in comparison with trees, are more adaptable to drought conditions. Moreover, previous studies have ... ...

Abstract	To date, reasons for the increase in liana abundance and biomass in the Neotropics are still unclear. One proposed hypothesis suggests that lianas, in comparison with trees, are more adaptable to drought conditions. Moreover, previous studies have assumed that lianas have a deeper root system, which provides access to deeper soil layers, thereby making them less susceptible to drought stress. The dual stable water isotope approach (δ18O and δ2H) enables below-ground vegetation competition for water to be studied. Based on the occurrence of a natural gradient in soil water isotopic signatures, with enriched signatures in shallow soil relative to deep soil, the origin of vegetation water sources can be derived. Our study was performed on canopy trees and lianas reaching canopy level in tropical forests of French Guiana. Our results show liana xylem water isotopic signatures to be enriched in heavy isotopes in comparison with those from trees, indicating differences in water source depths and a more superficial root activity for lianas during the dry season. This enables them to efficiently capture dry season precipitation. Our study does not support the liana deep root water extraction hypothesis. Additionally, we provide new insights into water competition between tropical canopy lianas and trees. Results suggest that this competition is mitigated during the dry season due to water resource partitioning.
MeSH term(s)	Droughts ; Groundwater ; Plant Physiological Phenomena ; Plant Roots/physiology ; Plant Transpiration ; Plants ; Seasons ; Trees/physiology ; Tropical Climate ; Xylem/physiology
Language	English
Publishing date	2018-03-05
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	743341-4
ISSN	1758-4469 ; 0829-318X
ISSN (online)	1758-4469
ISSN	0829-318X
DOI	10.1093/treephys/tpy002
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Article ; Online: The surgical treatment of idiopathic abnormal uterine bleeding

Lucie de Léotoing / Gwendoline Chaize / Jérôme Fernandes / Dusan Toth / Philippe Descamps / Gil Dubernard / Thomas Lafon / Ludovic Lamarsalle / Hervé Fernandez

PLoS ONE, Vol 14, Iss 6, p e

An analysis of 88 000 patients from the French exhaustive national hospital discharge database from 2009 to 2015.

2019 Volume 0217579

Abstract: Objective The objective of the study was to compare success rates, complications and management costs of different surgical techniques for abnormal uterine bleeding (AUB). Methods This was a retrospective analysis of the French national hospital ... ...

Abstract	Objective The objective of the study was to compare success rates, complications and management costs of different surgical techniques for abnormal uterine bleeding (AUB). Methods This was a retrospective analysis of the French national hospital discharge database. All hospital stays with a diagnostic code for AUB and an appropriate surgical procedure code between 2009 and 2015 inclusive were identified, concerning 109,884 women overall. Outcomes were compared between second generation procedures (2G surgery), first-generation procedures (1G surgery), curettage and hysterectomy. Clinical outcomes were treatment failure and complications during the follow-up period. Costs were attributed using standard French hospital tariffs. Results 7,863 women underwent a 2G procedure (7.2%), 39,935 a 1G procedure, (36.3%), 38,923 curettage (35.4%) and 23,163 hysterectomy (21.1%). Failure rates at 18 months were 9.9% for 2G surgery, 12.7% for 1G surgery, 20.6% for curettage and 2.8% for hysterectomy. Complication rates at 18 months were 1.9% for 2G surgery, 1.5% for 1G surgery, 1.4% for curettage and 5.3% for hysterectomy. Median 18-month costs were € 1 173 for 2G surgery, € 1 059 for 1G surgery, € 782 for curettage and € 3 090 for hysterectomy. Conclusion Curettage has the highest failure rate. Hysterectomy has the lowest failure rate but the highest complication rate and is also the most expensive. Despite good clinical outcomes and relatively low cost, 1G and 2G procedures are not widely used. Current guidelines for treatment of AUB are not respected, the recommended 2G procedures being only used in <10% of cases.
Keywords	Medicine ; R ; Science ; Q
Subject code	670
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
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Article ; Online: Performance of cervical phIGFBP-1 test alone or combined with short cervical length to predict spontaneous preterm birth in symptomatic women

Florent Fuchs / Marie Houllier / Soizic Leparco / Anne Guyot / Marie-Victoire Senat / Hervé Fernandez

Scientific Reports, Vol 7, Iss 1, Pp 1-

2017 Volume 6

Abstract: Abstract We aimed to assess the accuracy of cervical phosphorylated insulin-like growth factor binding protein-1 (phIGFBP-1) test alone or in combination with cervical length (CL), to predict preterm birth (PTB) in symptomatic women. We performed a ... ...

Abstract	Abstract We aimed to assess the accuracy of cervical phosphorylated insulin-like growth factor binding protein-1 (phIGFBP-1) test alone or in combination with cervical length (CL), to predict preterm birth (PTB) in symptomatic women. We performed a prospective cohort study from 2012 to 2015 including singleton pregnancies with symptoms of preterm labor, intact membranes and CL < 25 mm at 24–34 weeks of gestation. Studied outcome were spontaneous delivery within 7 and 14 days of testing and spontaneous PTB at <34 and <37 weeks of gestation. Among 180 women, 21 (11.7%) had a positive phIGFBP-1 test. Spontaneous PTB occurred within 7 days, 14 days of testing and before 34 weeks and 37 weeks in 7.8%, 10.6%, 12.9% and 28.8%, respectively. The phIGFBP-1 test had a low predictive performance for all studied outcomes varying for positive likelihood ratios (2.8 to 3.4) and negative likelihood ratios (0.8). Combining phIGFBP-1 and CL did not increase its predictive ability. After adjustment, positive phIGFBP-1 test was no more independently associated with a delivery within 7 days (p = 0.55), unlike CL < 15 mm (p = 0.04). In conclusion, phIGFBP-1 test alone or in combination with CL has a low predictive accuracy to predict PTB in symptomatic women.
Keywords	Medicine ; R ; Science ; Q
Subject code	150
Language	English
Publishing date	2017-09-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
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