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Article ; Online: Péritonite du nouveau-né.

Hervieux, Erik

2020 Volume 70, Issue 5, Page(s) e183

Title translation	Newborn peritonitis.
MeSH term(s)	Humans ; Infant ; Infant, Newborn ; Infant, Newborn, Diseases ; Peritonitis/diagnosis
Language	French
Publishing date	2020-10-15
Publishing country	France
Document type	Journal Article
ZDB-ID	205365-2
ISSN	2101-017X ; 0035-2640
ISSN (online)	2101-017X
ISSN	0035-2640
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Ua VI Zs.433: Show issues

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Article ; Online: Péritonite aiguë chez l’enfant.

Hervieux, Erik

La Revue du praticien

2020 Volume 70, Issue 5, Page(s) e177–e182

Title translation	Acute peritonitis in children.
MeSH term(s)	Acute Disease ; Child ; Humans ; Infant ; Peritonitis/diagnosis ; Peritonitis/etiology
Language	French
Publishing date	2020-10-15
Publishing country	France
Document type	Journal Article
ZDB-ID	205365-2
ISSN	2101-017X ; 0035-2640
ISSN (online)	2101-017X
ISSN	0035-2640
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Article ; Online: Pulmonary mucoepidermoid carcinoma in a 7-year-old child.

Denamur, Sophie / Hervieux, Erik / Cosson, Laure / Sileo, Chiara / Coulomb, Aurore / Nathan, Nadia / Corvol, Harriet

Pediatric pulmonology

2024 Volume 59, Issue 4, Page(s) 1095–1098

Abstract: A 7-year-old boy presented with exertional dyspnea and cough, initially misdiagnosed as asthma. Imaging revealed a mass obstructing the left main bronchus, later identified as a pulmonary mucoepidermoid carcinoma (MEC). Following surgical sleeve ... ...

Abstract	A 7-year-old boy presented with exertional dyspnea and cough, initially misdiagnosed as asthma. Imaging revealed a mass obstructing the left main bronchus, later identified as a pulmonary mucoepidermoid carcinoma (MEC). Following surgical sleeve resection, complete tumor removal occurred without malignancy in surrounding lymph nodes, resulting in symptom resolution without additional therapy. Pulmonary MEC, uncommon in pediatric patients, poses diagnostic challenges due to nonspecific symptoms, resulting in delayed diagnosis. Typically managed via complete surgical resection, MEC offers a favorable prognosis, primarily affecting central airways and requiring conservative surgical approaches to preserve lung tissue. This case underscores the diagnostic challenges of primary pulmonary MEC in pediatric patients. It stresses the need to consider unusual causes in pediatric respiratory symptoms and highlights the critical role of precise diagnostic methods and personalized surgical strategies in managing such rare pulmonary malignancies for optimal outcomes.
MeSH term(s)	Male ; Humans ; Child ; Carcinoma, Mucoepidermoid/diagnostic imaging ; Carcinoma, Mucoepidermoid/surgery ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/surgery ; Lung Neoplasms/pathology ; Prognosis ; Bronchi/pathology ; Asthma
Language	English
Publishing date	2024-01-15
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	632784-9
ISSN	1099-0496 ; 8755-6863
ISSN (online)	1099-0496
ISSN	8755-6863
DOI	10.1002/ppul.26864
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Zs.A 2143: Show issues

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Article ; Online: Pulmonary cystic echinococcosis in a child.

Peulier-Maitre, Elora / Hervieux, Erik / Bigot, Jeanne / Sileo, Chiara / Denamur, Sophie / Corvol, Harriet

Pediatric pulmonology

2023 Volume 58, Issue 10, Page(s) 2960–2963

Abstract: This case report describes the presentation, diagnosis, and treatment of a 13-year-old boy with pulmonary cystic echinococcosis. The patient presented with low-volume hemoptysis, and lung imaging revealed a large cystic mass, as well as smaller pseudo- ... ...

Abstract	This case report describes the presentation, diagnosis, and treatment of a 13-year-old boy with pulmonary cystic echinococcosis. The patient presented with low-volume hemoptysis, and lung imaging revealed a large cystic mass, as well as smaller pseudo-nodular lesions, suggesting a large intrathoracic hydatid cyst and ruptured cysts. The diagnosis was confirmed by a positive echinococcosis Western Blot assay, despite equivocal serology. The treatment consisted of surgical removal of the large cyst using thoracoscopy, along with a two-week course of albendazole and praziquantel, followed by albendazole alone for two years. Analysis of the cyst membrane revealed an Echinococcus granulosus protoscolex. The patient had a successful recovery.
MeSH term(s)	Male ; Animals ; Humans ; Child ; Adolescent ; Albendazole/therapeutic use ; Echinococcosis/diagnostic imaging ; Echinococcosis/drug therapy ; Echinococcus granulosus ; Cysts ; Lung/diagnostic imaging ; Echinococcosis, Pulmonary/diagnostic imaging ; Echinococcosis, Pulmonary/drug therapy
Chemical Substances	Albendazole (F4216019LN)
Language	English
Publishing date	2023-07-04
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	632784-9
ISSN	1099-0496 ; 8755-6863
ISSN (online)	1099-0496
ISSN	8755-6863
DOI	10.1002/ppul.26579
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Zs.A 2143: Show issues

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Article ; Online: Acinar Dysplasia in a Full-Term Newborn with a NKX2.1 Variant.

Soreze, Yohan / Nathan, Nadia / Jegard, Julien / Hervieux, Erik / Clermidi, Pauline / Sileo, Chiara / Louvrier, Camille / Legendre, Marie / Coulomb L'Herminé, Aurore

Neonatology

2023 Volume 121, Issue 1, Page(s) 133–136

Abstract: Acinar dysplasia (AcDys) is one of the three main diffuse developmental disorders of the lung. The transcription factor NK2 homeobox 1 (NKX2.1) partly controls the synthesis of surfactant proteins by type 2 alveolar epithelial cells (AEC2), and germline ... ...

Abstract	Acinar dysplasia (AcDys) is one of the three main diffuse developmental disorders of the lung. The transcription factor NK2 homeobox 1 (NKX2.1) partly controls the synthesis of surfactant proteins by type 2 alveolar epithelial cells (AEC2), and germline mutations are known to be associated with brain-lung thyroid syndrome. We report the case of a full-term neonate who developed refractory respiratory failure with pulmonary hypertension requiring venoarterial extracorporeal membrane oxygenation. Histological examination of the lung biopsy specimen was consistent with the diagnosis of AcDys. Molecular analyses led to the identification of the missense heterozygous variant in NKX2.1 (NM_001079668) c.731A>G p.(Tyr244Cys), which is predicted to be pathogenic. After 5 weeks, because AcDys is a fatal disorder and the patient's status worsened, life-sustaining therapies were withdrawn, and she died after a few hours. This study is the first to extend the phenotype of NKX2.1 pathogenic variant, to a fatal form of AcDys.
MeSH term(s)	Infant, Newborn ; Female ; Humans ; Mutation ; Lung/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Respiratory Insufficiency/genetics ; Respiratory Insufficiency/therapy ; Respiratory Distress Syndrome, Newborn/diagnosis ; Respiratory Distress Syndrome, Newborn/genetics
Chemical Substances	Transcription Factors
Language	English
Publishing date	2023-11-30
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2266911-5
ISSN	1661-7819 ; 1661-7800
ISSN (online)	1661-7819
ISSN	1661-7800
DOI	10.1159/000534076
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Zs.A 391: Show issues

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Article ; Online: Lung biopsies in infants and children in critical care situation.

Levy, Yaël / Bitton, Lauren / Sileo, Chiara / Rambaud, Jérôme / Soreze, Yohan / Louvrier, Camille / Ducou le Pointe, Hubert / Corvol, Harriet / Hervieux, Erik / Irtan, Sabine / Leger, Pierre-Louis / Prévost, Blandine / Coulomb L'Herminé, Aurore / Nathan, Nadia

Pediatric pulmonology

2024 Volume 59, Issue 4, Page(s) 907–914

Abstract: Introduction: Lung biopsy is considered as the last step investigation for diagnosing lung diseases; however, its indication must be carefully balanced with its invasiveness. The present study aims to evaluate the diagnostic yield of lung biopsy in ... ...

Abstract	Introduction: Lung biopsy is considered as the last step investigation for diagnosing lung diseases; however, its indication must be carefully balanced with its invasiveness. The present study aims to evaluate the diagnostic yield of lung biopsy in critically ill patients hospitalized in the pediatric intensive care unit (ICU). Material and methods: Children who underwent a lung biopsy in the ICU between 1995 and 2022 were included. Biopsies performed in the operating room and post-mortem biopsies were excluded. Results: Thirty-one patients were included, with a median age of 18 days (2 days to 10.8 years); 21 (67.7%) were newborns. All patients required invasive mechanical ventilation, 26 (89.7%) had a pulmonary hypertension, and 22 (70.9%) were placed under extracorporeal membrane oxygenation (ECMO). The lung biopsy led to a diagnosis in 81% of the patients. The diagnostic reliability seemed to decrease with age (95% in newborns, 71% in 1 month to 2 years and 0/3 patients aged over 2 years old). Diffuse developmental disorders of the lung accounted for 15 (49%) patients, primarily alveolar capillary dysplasia, followed by surfactant disorders in 5 (16%) patients. Complications occurred in 9/31 (29%) patients including eight under ECMO, with massive hemorrhages in seven cases. Discussion and conclusion: In critical situations, lung biopsy should be performed. Lung biopsy is a reliable diagnostic procedure for neonates in critical situation when a diffuse developmental disorder of the lung is suspected. The majority of lung biopsy complication was associated with the use of ECMO. The prospective evaluation of the complications of such procedure under ECMO, and particularly over 10 days of ECMO and in children over 2-year-old remains to be ascertained.
MeSH term(s)	Infant ; Child ; Infant, Newborn ; Humans ; Aged ; Child, Preschool ; Reproducibility of Results ; Lung/pathology ; Pulmonary Alveoli ; Critical Care ; Biopsy/adverse effects ; Biopsy/methods ; Retrospective Studies
Language	English
Publishing date	2024-01-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	632784-9
ISSN	1099-0496 ; 8755-6863
ISSN (online)	1099-0496
ISSN	8755-6863
DOI	10.1002/ppul.26845
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Zs.A 2143: Show issues

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Article ; Online: Biliary and duodenal complications after « en bloc» liver-small bowel transplantation in children. A single center cohort study.

Hervieux, Erik / Capito, Carmen / Franchi-Abella, Stéphanie / Pariente, Danièle / Lozach, Cécile / Sauvat, Frédérique / Lacaille, Florence / Chardot, Christophe

Pediatric transplantation

2021 Volume 25, Issue 6, Page(s) e14014

Abstract: Background: The technique of « en bloc» liver and small bowel transplantation (L-BT) spares a biliary anastomosis, but does not protect against biliary complications. We analyze biliary and duodenal complications (BDC) in our pediatric series.: ... ...

Abstract	Background: The technique of « en bloc» liver and small bowel transplantation (L-BT) spares a biliary anastomosis, but does not protect against biliary complications. We analyze biliary and duodenal complications (BDC) in our pediatric series. Methods: Between 1994 and 2020, 54 L-BT were performed in 53 children. The procurement technique included in situ vascular dissection and pancreatic reduction to the head until 2009 (group A). Thereafter, the whole pancreas was recovered (group B). Results: Nine BDCs occurred in 8/53 (15%) patients (7 in group A and 1 in group B): leak of the donor's duodenal stump (2), stenosis of the extra-pancreatic bile duct (5), and intra-pancreatic bile duct stenosis (2). Median delay for diagnosis of stricture was 8 months (4-168). Interventional radiology was successful in one child only, the others required reoperations. Two patients died, of biliary cirrhosis or cholangitis, 15-month and 12-year post-L-BT. One was listed and liver re-transplanted 13 years post-L-BT. At last follow-up, two patients only had normal liver tests and ultrasound. Conclusion: BDC after L-BT can cause severe morbidities. Pancreatic reduction might increase this risk. Early surgical complications or chronic pancreatic rejection might be co-factors. Early diagnosis and treatment are key to the long-term prognosis.
MeSH term(s)	Adolescent ; Biliary Tract Diseases/epidemiology ; Child ; Child, Preschool ; Duodenal Diseases/epidemiology ; Female ; France/epidemiology ; Humans ; Infant ; Intestine, Small/transplantation ; Liver Transplantation ; Male ; Pancreas/surgery ; Postoperative Complications/epidemiology ; Retrospective Studies
Language	English
Publishing date	2021-06-13
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1390284-2
ISSN	1399-3046 ; 1397-3142
ISSN (online)	1399-3046
ISSN	1397-3142
DOI	10.1111/petr.14014
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Zs.A 4947: Show issues

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Article ; Online: Preoperative 3D reconstruction images for paediatric tumours: Advantages and drawbacks.

Irtan, Sabine / Hervieux, Erik / Boutroux, Hélène / Becmeur, François / Ducou-le-Pointe, Hubert / Leverger, Guy / Audry, Georges

Pediatric blood & cancer

2020 Volume 68, Issue 1, Page(s) e28670

Abstract: Rationale: Three-dimensional reconstruction (3DR) of preoperative images may improve the presurgical assessment of tumours prior to removal. We aimed to analyse the advantages and discrepancies of preoperative 3DR in paediatric tumours.: Methods: We ... ...

Abstract	Rationale: Three-dimensional reconstruction (3DR) of preoperative images may improve the presurgical assessment of tumours prior to removal. We aimed to analyse the advantages and discrepancies of preoperative 3DR in paediatric tumours. Methods: We conducted a prospective observational study from 2016 to 2019, including patients with thoraco-abdominal tumours having predictable surgical risks on preoperative images (encasement of vessels posing vascular risks, ie, neuroblastic and soft tissue tumours or parenchyma preservation of the invaded organ, ie, liver and kidney). A comparison of 2D/3DR and surgical findings was performed. Results: Twenty-four patients, with a median age at surgery of 68.2 months (13 days-203 months), were operated on for neuroblastoma (n = 7), renal tumour (n = 7), hepatic tumour (n = 4) and others (n = 6; bone sarcoma of the iliac branch, abdominal lymph nodes of a recurrent testicular germ cell tumour, pseudoinflammatory tumour of the omentum, thoracic lipoblastoma, desmoplastic tumour, solid and pseudopapillar tumour of the pancreas). Reconstruction was of poor quality in two patients with renal tumours because computed tomography (CT) had no excretory phase. Discrepancies between 3DR and surgical findings occurred in two patients, one because of poor assessment of caliceal infiltration by renal nodules and the other because of inadequate reconstruction of renal vein thrombosis. For all the other tumours, 3DR improved the visualisation and precise location of vessels during surgery. Conclusion: High-quality preoperative images are mandatory to provide the best 3DR. In the majority of cases, 3DR is of significant help during surgery to better identify vascular structures within tumours and preserve parenchyma.
MeSH term(s)	Adolescent ; Child ; Child, Preschool ; Female ; Follow-Up Studies ; Humans ; Image Processing, Computer-Assisted/methods ; Imaging, Three-Dimensional/methods ; Infant ; Infant, Newborn ; Male ; Neoplasms/diagnostic imaging ; Neoplasms/pathology ; Neoplasms/surgery ; Preoperative Care ; Prognosis ; Prospective Studies ; Tomography, X-Ray Computed/methods
Language	English
Publishing date	2020-08-22
Publishing country	United States
Document type	Case Reports ; Journal Article ; Observational Study
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.28670
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Zs.A 1131: Show issues

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Article: Different Fecal Microbiota in Hirschsprung's Patients With and Without Associated Enterocolitis.

Arnaud, Alexis P / Cousin, Ianis / Schmitt, Françoise / Petit, Thierry / Parmentier, Benoit / Levard, Guillaume / Podevin, Guillaume / Guinot, Audrey / DeNapoli, Stéphan / Hervieux, Erik / Flaum, Valérie / De Vries, Philine / Randuineau, Gwénaëlle / David-Le Gall, Sandrine / Buffet-Bataillon, Sylvie / Boudry, Gaëlle

Frontiers in microbiology

2022 Volume 13, Page(s) 904758

Abstract: Background and objectives: Patients with Hirschsprung's disease are at risk of developing Hirschsprung-associated enterocolitis, especially in the first 2 years of life. The pathophysiology of this inflammatory disease remains unclear, and intestinal ... ...

Abstract	Background and objectives: Patients with Hirschsprung's disease are at risk of developing Hirschsprung-associated enterocolitis, especially in the first 2 years of life. The pathophysiology of this inflammatory disease remains unclear, and intestinal dysbiosis has been proposed in the last decade. The primary objective of this study was to evaluate in a large cohort if Hirschsprung-associated enterocolitis was associated with alterations of fecal bacterial composition compared with HD without enterocolitis in different age groups. Methods: We analyzed the fecal microbiota structure of 103 Hirschsprung patients from 3 months to 16 years of age, all of whom had completed definitive surgery for rectosigmoid Hirschsprung. 16S rRNA gene sequencing allowed us to compare the microbiota composition between Hirschsprung's disease patients with (HAEC group) or without enterocolitis (HD group) in different age groups (0-2, 2-6, 6-12, and 12-16 years). Results: Richness and diversity increased with age group but did not differ between HD and HAEC patients, irrespective of the age group. Relative abundance of Actinobacteria was lower in HAEC than in HD patients under 2 years of age (-66%, Conclusion: Hirschsprung-associated enterocolitis was associated with features of intestinal dysbiosis in infants (0-2 years) but not in older patients. This could explain the highest rate of enterocolitis in this age group. Clinical trial registration: https://clinicaltrials.gov/ct2/show/NCT02857205, MICROPRUNG, NCT02857205, 02/08/2016.
Language	English
Publishing date	2022-06-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2022.904758
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Article ; Online: Feasibility of open abdomen surgery treatment for near fatal necrotizing enterocolitis in preterm infants.

Irtan, Sabine / Reignier, Pierre-Louis / Durandy, Amélie / Hervieux, Erik / Constant, Isabelle / Lemale, Julie / Soreze, Yohan / Leger, Pierre-Louis / Audry, Georges / Rambaud, Jérôme / Guellec, Isabelle

Journal of pediatric surgery

2021 Volume 57, Issue 7, Page(s) 1336–1341

Abstract: Introduction: Necrotizing Enterocolitis (NEC) remained a dramatic complication leading to death or neonatal morbidities in preterms. For some, Intra-Abdominal Hypertension (IAH) and Abdominal Compartment Syndrome worsened the multi-organ failure. An ... ...

Abstract	Introduction: Necrotizing Enterocolitis (NEC) remained a dramatic complication leading to death or neonatal morbidities in preterms. For some, Intra-Abdominal Hypertension (IAH) and Abdominal Compartment Syndrome worsened the multi-organ failure. An open abdomen surgery could be an alternative to conventional surgical treatment to move beyond this stage. Objectives: To retrospectively describe the clinical course, pre- and post-operative features of preterms suffering from severe NEC with IAH treated by open abdomen surgery and referred to our center from October 2007 to September 2019. Our secondary objective is to identify various risk factors for mortality in this population. Methods: Data on neonatal, clinical, biological, pre and post-operative features and outcome were collected. Univariate analyses were performed to compare their pre and post-operative features stratifying on outcome. Results: Among 29 included patients, 14 (48%) survived to discharge without short bowel syndrome. Death was associated with an earlier postnatal age at NEC (16.3 ± 9.1 versus 31.3 ± 25.9 days; p = 0.004) and followed a withdrawal of treatment in 60% of cases. Surgery was associated with a significant improvement of respiratory and hemodynamic features (decrease of mean ventilator pressure from 13.1 ± 5.4 to 11.3 ± 4.0 cmH2O, p < 0.001), oxygen requirement (mean FiO2 decreased from 65.0% ± 31.2 to 49.0% ± 24.6, p < 0.001) and inotropic score (from 38.6 ± 70.1 to 29.9 ± 64.3, p < 0.001). In the survival group, pre and post-operative findings exhibited a significant increase of serum lactate concentrations from 2.7 ± 1.6 to 11.0 ± 20.3 mmol/L (p = 0.02) but a similar pH. Conclusion: Open abdomen surgery could be considered to rescue preterms with near fatal NEC. IAH and Abdominal Compartment Syndrome in these preterms should be investigated through further studies. Level of evidence: Level III.
MeSH term(s)	Abdomen ; Enterocolitis, Necrotizing ; Feasibility Studies ; Humans ; Infant ; Infant, Newborn ; Infant, Newborn, Diseases ; Infant, Premature ; Intra-Abdominal Hypertension/etiology ; Intra-Abdominal Hypertension/surgery ; Retrospective Studies
Language	English
Publishing date	2021-10-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	80165-3
ISSN	1531-5037 ; 0022-3468
ISSN (online)	1531-5037
ISSN	0022-3468
DOI	10.1016/j.jpedsurg.2021.09.044
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