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Article ; Online: Péritonite du nouveau-né.

Hervieux, Erik

2020 Volume 70, Issue 5, Page(s) e183

Title translation	Newborn peritonitis.
MeSH term(s)	Humans ; Infant ; Infant, Newborn ; Infant, Newborn, Diseases ; Peritonitis/diagnosis
Language	French
Publishing date	2020-10-15
Publishing country	France
Document type	Journal Article
ZDB-ID	205365-2
ISSN	2101-017X ; 0035-2640
ISSN (online)	2101-017X
ISSN	0035-2640
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Article ; Online: Péritonite aiguë chez l’enfant.

Hervieux, Erik

La Revue du praticien

2020 Volume 70, Issue 5, Page(s) e177–e182

Title translation	Acute peritonitis in children.
MeSH term(s)	Acute Disease ; Child ; Humans ; Infant ; Peritonitis/diagnosis ; Peritonitis/etiology
Language	French
Publishing date	2020-10-15
Publishing country	France
Document type	Journal Article
ZDB-ID	205365-2
ISSN	2101-017X ; 0035-2640
ISSN (online)	2101-017X
ISSN	0035-2640
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Article ; Online: Pulmonary mucoepidermoid carcinoma in a 7-year-old child.

Denamur, Sophie / Hervieux, Erik / Cosson, Laure / Sileo, Chiara / Coulomb, Aurore / Nathan, Nadia / Corvol, Harriet

Pediatric pulmonology

2024 Volume 59, Issue 4, Page(s) 1095–1098

Abstract: A 7-year-old boy presented with exertional dyspnea and cough, initially misdiagnosed as asthma. Imaging revealed a mass obstructing the left main bronchus, later identified as a pulmonary mucoepidermoid carcinoma (MEC). Following surgical sleeve ... ...

Abstract	A 7-year-old boy presented with exertional dyspnea and cough, initially misdiagnosed as asthma. Imaging revealed a mass obstructing the left main bronchus, later identified as a pulmonary mucoepidermoid carcinoma (MEC). Following surgical sleeve resection, complete tumor removal occurred without malignancy in surrounding lymph nodes, resulting in symptom resolution without additional therapy. Pulmonary MEC, uncommon in pediatric patients, poses diagnostic challenges due to nonspecific symptoms, resulting in delayed diagnosis. Typically managed via complete surgical resection, MEC offers a favorable prognosis, primarily affecting central airways and requiring conservative surgical approaches to preserve lung tissue. This case underscores the diagnostic challenges of primary pulmonary MEC in pediatric patients. It stresses the need to consider unusual causes in pediatric respiratory symptoms and highlights the critical role of precise diagnostic methods and personalized surgical strategies in managing such rare pulmonary malignancies for optimal outcomes.
MeSH term(s)	Male ; Humans ; Child ; Carcinoma, Mucoepidermoid/diagnostic imaging ; Carcinoma, Mucoepidermoid/surgery ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/surgery ; Lung Neoplasms/pathology ; Prognosis ; Bronchi/pathology ; Asthma
Language	English
Publishing date	2024-01-15
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	632784-9
ISSN	1099-0496 ; 8755-6863
ISSN (online)	1099-0496
ISSN	8755-6863
DOI	10.1002/ppul.26864
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Zs.A 2143: Show issues

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Article ; Online: Pulmonary cystic echinococcosis in a child.

Peulier-Maitre, Elora / Hervieux, Erik / Bigot, Jeanne / Sileo, Chiara / Denamur, Sophie / Corvol, Harriet

Pediatric pulmonology

2023 Volume 58, Issue 10, Page(s) 2960–2963

Abstract: This case report describes the presentation, diagnosis, and treatment of a 13-year-old boy with pulmonary cystic echinococcosis. The patient presented with low-volume hemoptysis, and lung imaging revealed a large cystic mass, as well as smaller pseudo- ... ...

Abstract	This case report describes the presentation, diagnosis, and treatment of a 13-year-old boy with pulmonary cystic echinococcosis. The patient presented with low-volume hemoptysis, and lung imaging revealed a large cystic mass, as well as smaller pseudo-nodular lesions, suggesting a large intrathoracic hydatid cyst and ruptured cysts. The diagnosis was confirmed by a positive echinococcosis Western Blot assay, despite equivocal serology. The treatment consisted of surgical removal of the large cyst using thoracoscopy, along with a two-week course of albendazole and praziquantel, followed by albendazole alone for two years. Analysis of the cyst membrane revealed an Echinococcus granulosus protoscolex. The patient had a successful recovery.
MeSH term(s)	Male ; Animals ; Humans ; Child ; Adolescent ; Albendazole/therapeutic use ; Echinococcosis/diagnostic imaging ; Echinococcosis/drug therapy ; Echinococcus granulosus ; Cysts ; Lung/diagnostic imaging ; Echinococcosis, Pulmonary/diagnostic imaging ; Echinococcosis, Pulmonary/drug therapy
Chemical Substances	Albendazole (F4216019LN)
Language	English
Publishing date	2023-07-04
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	632784-9
ISSN	1099-0496 ; 8755-6863
ISSN (online)	1099-0496
ISSN	8755-6863
DOI	10.1002/ppul.26579
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Article ; Online: How can we improve perinatal care in isolated multiple intestinal atresia? A retrospective study with a 30-year literature review.

Vinit, N / Mitanchez, D / Lemale, J / Garel, C / Jouannic, J-M / Hervieux, E / Audry, G / Irtan, S

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie

2021 Volume 28, Issue 3, Page(s) 226–233

Abstract: Introduction: Multiple intestinal atresia (MIA) is a rare cause of neonatal intestinal obstruction. To provide an overview of the current prenatal, surgical, and nutritional management of MIA, we report our experience and a literature review of papers ... ...

Abstract	Introduction: Multiple intestinal atresia (MIA) is a rare cause of neonatal intestinal obstruction. To provide an overview of the current prenatal, surgical, and nutritional management of MIA, we report our experience and a literature review of papers published after 1990. Methods: All cases of isolated MIA (non-hereditary, not associated with apple-peel syndrome or gastroschisis) treated at our institution between 2005 and 2016 were reviewed and compared with cases found in the literature. Results: Seven patients were prenatally suspected of having intestinal obstruction and were postnatally diagnosed with MIA, with a mean 1.7 (1-2) resections-anastomoses (RA) and 6 (1-10) strictureplasties performed, resulting in a mean resected bowel length of 15.1cm (15-25 cm). Median time to full oral feed was 46 days (14-626 days). All patients were alive and none had orality disorder after a mean follow-up of 3.1 years (0.2-8.1 years). Three surgical strategies were found in the literature review: multiple RA (68%, 34/50) including Santulli's technique in four of 34 (12%) and anastomoses over a transanastomotic tube (32%, 16/50), with a 98% survival rate, and short-bowel syndrome for only two patients. Conclusion: Bowel-sparing surgery and appropriate medical management are key to ensuring a favorable nutritional and gastrointestinal outcome and a good prognosis. Prenatal assessment and standardization of the surgical course of treatment remain challenging.
MeSH term(s)	Combined Modality Therapy ; Digestive System Surgical Procedures/methods ; Digestive System Surgical Procedures/standards ; Female ; Follow-Up Studies ; Humans ; Infant, Newborn ; Intestinal Atresia/diagnosis ; Intestinal Atresia/therapy ; Male ; Nutritional Support/methods ; Nutritional Support/standards ; Perinatal Care/methods ; Perinatal Care/standards ; Pregnancy ; Quality Improvement ; Retrospective Studies ; Treatment Outcome ; Ultrasonography, Prenatal
Language	English
Publishing date	2021-03-03
Publishing country	France
Document type	Journal Article
ZDB-ID	1181947-9
ISSN	1769-664X ; 0929-693X
ISSN (online)	1769-664X
ISSN	0929-693X
DOI	10.1016/j.arcped.2020.12.010
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Zs.A 3942: Show issues

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Article ; Online: Acinar Dysplasia in a Full-Term Newborn with a NKX2.1 Variant.

Soreze, Yohan / Nathan, Nadia / Jegard, Julien / Hervieux, Erik / Clermidi, Pauline / Sileo, Chiara / Louvrier, Camille / Legendre, Marie / Coulomb L'Herminé, Aurore

Neonatology

2023 Volume 121, Issue 1, Page(s) 133–136

Abstract: Acinar dysplasia (AcDys) is one of the three main diffuse developmental disorders of the lung. The transcription factor NK2 homeobox 1 (NKX2.1) partly controls the synthesis of surfactant proteins by type 2 alveolar epithelial cells (AEC2), and germline ... ...

Abstract	Acinar dysplasia (AcDys) is one of the three main diffuse developmental disorders of the lung. The transcription factor NK2 homeobox 1 (NKX2.1) partly controls the synthesis of surfactant proteins by type 2 alveolar epithelial cells (AEC2), and germline mutations are known to be associated with brain-lung thyroid syndrome. We report the case of a full-term neonate who developed refractory respiratory failure with pulmonary hypertension requiring venoarterial extracorporeal membrane oxygenation. Histological examination of the lung biopsy specimen was consistent with the diagnosis of AcDys. Molecular analyses led to the identification of the missense heterozygous variant in NKX2.1 (NM_001079668) c.731A>G p.(Tyr244Cys), which is predicted to be pathogenic. After 5 weeks, because AcDys is a fatal disorder and the patient's status worsened, life-sustaining therapies were withdrawn, and she died after a few hours. This study is the first to extend the phenotype of NKX2.1 pathogenic variant, to a fatal form of AcDys.
MeSH term(s)	Infant, Newborn ; Female ; Humans ; Mutation ; Lung/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Respiratory Insufficiency/genetics ; Respiratory Insufficiency/therapy ; Respiratory Distress Syndrome, Newborn/diagnosis ; Respiratory Distress Syndrome, Newborn/genetics
Chemical Substances	Transcription Factors
Language	English
Publishing date	2023-11-30
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2266911-5
ISSN	1661-7819 ; 1661-7800
ISSN (online)	1661-7819
ISSN	1661-7800
DOI	10.1159/000534076
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Zs.A 391: Show issues

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Article ; Online: Diagnostic post-natal d’un volvulus gastrique révélant une hernie diaphragmatique congénitale.

Aprahamian, A / Nouyrigat, V / Grévent, D / Hervieux, E / Chéron, G

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie

2017 Volume 24, Issue 5, Page(s) 464–467

Abstract: Postnatally diagnosed congenital diaphragmatic hernias (CDH) are rare and have a better prognosis than those diagnosed prenatally. Postnatal symptoms can be respiratory, digestive, or mixed. Gastric volvulus can reveal CDH. Symptoms are pain, abdominal ... ...

Title translation	Postnatal diagnosis of gastric volvulus revealing congenital diaphragmatic hernia.
Abstract	Postnatally diagnosed congenital diaphragmatic hernias (CDH) are rare and have a better prognosis than those diagnosed prenatally. Postnatal symptoms can be respiratory, digestive, or mixed. Gastric volvulus can reveal CDH. Symptoms are pain, abdominal distension, and/or vomiting. Upper gastrointestinal barium X-ray radiography provides the diagnosis. Prognosis is related to early surgical management in complicated forms with intestinal occlusion or sub-occlusion. We report on an infant who presented with vomiting, which revealed gastric volvulus associated with a CDH. Progression was favorable after surgical treatment.
Language	French
Publishing date	2017-05
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	1181947-9
ISSN	1769-664X ; 0929-693X
ISSN (online)	1769-664X
ISSN	0929-693X
DOI	10.1016/j.arcped.2017.02.028
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Article ; Online: Diagnostic prénatal et issue néonatale des calcifications intra-abdominales isolées : étude rétrospective sur 10 ans.

Maisonneuve, E / Debain, L / Garel, C / Hervieux, E / Lafon, B / Dhombres, F / Kayem, G / Jouannic, J-M

Gynecologie, obstetrique, fertilite & senologie

2019 Volume 47, Issue 9, Page(s) 643–649

Abstract: Introduction: Intra-abdominal calcifications (iAC) detected during fetal ultrasound examinations are characterized by their isolated or associated nature, as well as their location. Our objective was to describe all cases of isolated iAC along with ... ...

Title translation	Prenatal diagnosis and postnatal outcome of isolated intra-abdominal calcifications: A 10-year experience from a referral fetal medicine center.
Abstract	Introduction: Intra-abdominal calcifications (iAC) detected during fetal ultrasound examinations are characterized by their isolated or associated nature, as well as their location. Our objective was to describe all cases of isolated iAC along with their etiological investigations and neonatal outcome, during a 10-year practice in a referral center. Methods: We conducted a retrospective descriptive monocentric study on neonates diagnosed with isolated iAC after antenatal expert ultrasound scan and referred to the Multidisciplinary Center for Prenatal Diagnosis at Trousseau Hospital and born between January 1st, 2008 and June 30th, 2018. The exclusion criteria were: retroperitoneal calcifications, iAC associated with other digestive abnormalities or with congenital malformations. Results: The 32 isolated iAC cases accounted for 46% of all iAC. Nine cases were excluded for missing neonatal data. Among the 23 remaining isolated iAC cases, we observed 15 intra-hepatic calcifications, 5 peri-hepatic and two peritoneal calcifications. One fetus had both intra- and peri-hepatic calcifications. The majority of iAC remained stable throughout pregnancy. No cases of aneuploidy, fetal infection, or cystic fibrosis were detected. The neonatal outcome was favorable in all cases. Conclusions: In case of isolated and stable iAC after expert ultrasound scan, after having ruled out infectious diseases of the fetus and looked for the most frequent mutations of cystic fibrosis in the parents, the prognosis is favorable. Fetal karyotyping is recommended when additional structural anomalies are present.
MeSH term(s)	Aneuploidy ; Calcinosis/diagnostic imaging ; Calcinosis/embryology ; Cystic Fibrosis/diagnosis ; Cystic Fibrosis/genetics ; Female ; Fetal Diseases/diagnosis ; Humans ; Infant, Newborn ; Infections/diagnosis ; Infections/embryology ; Liver Diseases/diagnostic imaging ; Liver Diseases/embryology ; Peritoneal Diseases/diagnostic imaging ; Peritoneal Diseases/embryology ; Pregnancy ; Pregnancy Outcome ; Retrospective Studies ; Ultrasonography, Prenatal
Language	French
Publishing date	2019-08-06
Publishing country	France
Document type	Journal Article
ZDB-ID	2887456-0
ISSN	2468-7189
ISSN (online)	2468-7189
DOI	10.1016/j.gofs.2019.07.018
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Article ; Online: Lung biopsies in infants and children in critical care situation.

Levy, Yaël / Bitton, Lauren / Sileo, Chiara / Rambaud, Jérôme / Soreze, Yohan / Louvrier, Camille / Ducou le Pointe, Hubert / Corvol, Harriet / Hervieux, Erik / Irtan, Sabine / Leger, Pierre-Louis / Prévost, Blandine / Coulomb L'Herminé, Aurore / Nathan, Nadia

Pediatric pulmonology

2024 Volume 59, Issue 4, Page(s) 907–914

Abstract: Introduction: Lung biopsy is considered as the last step investigation for diagnosing lung diseases; however, its indication must be carefully balanced with its invasiveness. The present study aims to evaluate the diagnostic yield of lung biopsy in ... ...

Abstract	Introduction: Lung biopsy is considered as the last step investigation for diagnosing lung diseases; however, its indication must be carefully balanced with its invasiveness. The present study aims to evaluate the diagnostic yield of lung biopsy in critically ill patients hospitalized in the pediatric intensive care unit (ICU). Material and methods: Children who underwent a lung biopsy in the ICU between 1995 and 2022 were included. Biopsies performed in the operating room and post-mortem biopsies were excluded. Results: Thirty-one patients were included, with a median age of 18 days (2 days to 10.8 years); 21 (67.7%) were newborns. All patients required invasive mechanical ventilation, 26 (89.7%) had a pulmonary hypertension, and 22 (70.9%) were placed under extracorporeal membrane oxygenation (ECMO). The lung biopsy led to a diagnosis in 81% of the patients. The diagnostic reliability seemed to decrease with age (95% in newborns, 71% in 1 month to 2 years and 0/3 patients aged over 2 years old). Diffuse developmental disorders of the lung accounted for 15 (49%) patients, primarily alveolar capillary dysplasia, followed by surfactant disorders in 5 (16%) patients. Complications occurred in 9/31 (29%) patients including eight under ECMO, with massive hemorrhages in seven cases. Discussion and conclusion: In critical situations, lung biopsy should be performed. Lung biopsy is a reliable diagnostic procedure for neonates in critical situation when a diffuse developmental disorder of the lung is suspected. The majority of lung biopsy complication was associated with the use of ECMO. The prospective evaluation of the complications of such procedure under ECMO, and particularly over 10 days of ECMO and in children over 2-year-old remains to be ascertained.
MeSH term(s)	Infant ; Child ; Infant, Newborn ; Humans ; Aged ; Child, Preschool ; Reproducibility of Results ; Lung/pathology ; Pulmonary Alveoli ; Critical Care ; Biopsy/adverse effects ; Biopsy/methods ; Retrospective Studies
Language	English
Publishing date	2024-01-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	632784-9
ISSN	1099-0496 ; 8755-6863
ISSN (online)	1099-0496
ISSN	8755-6863
DOI	10.1002/ppul.26845
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Article ; Online: Biliary and duodenal complications after « en bloc» liver-small bowel transplantation in children. A single center cohort study.

Hervieux, Erik / Capito, Carmen / Franchi-Abella, Stéphanie / Pariente, Danièle / Lozach, Cécile / Sauvat, Frédérique / Lacaille, Florence / Chardot, Christophe

Pediatric transplantation

2021 Volume 25, Issue 6, Page(s) e14014

Abstract: Background: The technique of « en bloc» liver and small bowel transplantation (L-BT) spares a biliary anastomosis, but does not protect against biliary complications. We analyze biliary and duodenal complications (BDC) in our pediatric series.: ... ...

Abstract	Background: The technique of « en bloc» liver and small bowel transplantation (L-BT) spares a biliary anastomosis, but does not protect against biliary complications. We analyze biliary and duodenal complications (BDC) in our pediatric series. Methods: Between 1994 and 2020, 54 L-BT were performed in 53 children. The procurement technique included in situ vascular dissection and pancreatic reduction to the head until 2009 (group A). Thereafter, the whole pancreas was recovered (group B). Results: Nine BDCs occurred in 8/53 (15%) patients (7 in group A and 1 in group B): leak of the donor's duodenal stump (2), stenosis of the extra-pancreatic bile duct (5), and intra-pancreatic bile duct stenosis (2). Median delay for diagnosis of stricture was 8 months (4-168). Interventional radiology was successful in one child only, the others required reoperations. Two patients died, of biliary cirrhosis or cholangitis, 15-month and 12-year post-L-BT. One was listed and liver re-transplanted 13 years post-L-BT. At last follow-up, two patients only had normal liver tests and ultrasound. Conclusion: BDC after L-BT can cause severe morbidities. Pancreatic reduction might increase this risk. Early surgical complications or chronic pancreatic rejection might be co-factors. Early diagnosis and treatment are key to the long-term prognosis.
MeSH term(s)	Adolescent ; Biliary Tract Diseases/epidemiology ; Child ; Child, Preschool ; Duodenal Diseases/epidemiology ; Female ; France/epidemiology ; Humans ; Infant ; Intestine, Small/transplantation ; Liver Transplantation ; Male ; Pancreas/surgery ; Postoperative Complications/epidemiology ; Retrospective Studies
Language	English
Publishing date	2021-06-13
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1390284-2
ISSN	1399-3046 ; 1397-3142
ISSN (online)	1399-3046
ISSN	1397-3142
DOI	10.1111/petr.14014
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