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  1. Book: Cytoskeleton

    Hesketh, John

    (Advances in molecular and cell biology ; 12)

    1995  

    Author's details guest ed.: John Hesketh
    Series title Advances in molecular and cell biology ; 12
    Collection
    Keywords Zellskelett ; Molekularbiologie ; Cytologie
    Subject Zellbiologie ; Zellenlehre ; Zellforschung ; Zellkunde ; Zelluologie ; Zytologie ; Zelle ; Cytoskelett ; Zytoskelett ; Molekulare Biologie
    Language English
    Size XI, 239 S. : Ill.
    Publisher JAI Press
    Publishing place Greenwich, Conn. u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT011244419
    ISBN 1-55938-845-5 ; 978-1-55938-845-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 2797 -12- not available for loan Zeitschriften-Lesesaal

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  2. Book: The cytoskeleton / 3

    Hesketh, John E.

    a multi-volume treatise

    1996  

    Author's details ed.: John E. Hesketh
    Collection The cytoskeleton
    Language English
    Size XIII, 526 S. : zahlr. Ill., graph. Darst.
    Publisher Jai Press
    Publishing place Greenwich, Conn. u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT007406306
    ISBN 1-55938-689-4 ; 978-1-55938-689-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1997 A 3870 -3- order for loan Magazin

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  3. Book: The cytoskeleton / 2

    Hesketh, John E.

    a multi-volume treatise

    1996  

    Author's details ed.: John E. Hesketh
    Collection The cytoskeleton
    Keywords Zellskelett ; Cytologie ; Molekularbiologie
    Subject Cytoskelett ; Zytoskelett ; Zellbiologie ; Zellenlehre ; Zellforschung ; Zellkunde ; Zelluologie ; Zytologie ; Zelle ; Molekulare Biologie
    Language English
    Size X, 288 S. : Ill., graph. Darst.
    Publisher Jai Press
    Publishing place Greenwich, Conn. u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT007406297
    ISBN 1-55938-688-6 ; 978-1-55938-688-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1997 A 3870 -2- order for loan Magazin

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  4. Book: The cytoskeleton / 1

    Hesketh, John E.

    a multi-volume treatise

    1995  

    Author's details ed.: John E. Hesketh
    Collection The cytoskeleton
    Language English
    Size XII, 307 S. : Ill., graph. Darst.
    Publisher Jai Press
    Publishing place Greenwich, Conn. u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT007406229
    ISBN 1-55938-687-8 ; 978-1-55938-687-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1997 A 3870 -1- order for loan Magazin

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  5. Article ; Online: The Role of rs713041 Glutathione Peroxidase 4 (

    Barbosa, Priscila / Abo El-Magd, Nada F / Hesketh, John / Bermano, Giovanna

    International journal of molecular sciences

    2022  Volume 23, Issue 24

    Abstract: Aim: The single-nucleotide polymorphism (SNP) rs713041, located in the regulatory region, is required to incorporate selenium into the selenoprotein glutathione peroxidase 4 (GPX4) and has been found to have functional consequences. This systematic ... ...

    Abstract Aim: The single-nucleotide polymorphism (SNP) rs713041, located in the regulatory region, is required to incorporate selenium into the selenoprotein glutathione peroxidase 4 (GPX4) and has been found to have functional consequences. This systematic review aimed to conduct a meta-analysis to determine whether there is an association between GPX4 (rs713041) SNP and the risk of diseases in humans and its correlation with selenium status. Material and methods: A systematic search for English-language manuscripts published between January 1990 and November 2022 was carried out using six databases: CINAHL, Cochrane, Medline, PubMed, Scopus and Web of Science. Odds ratios (ORs) and 95% confidence intervals (CIs) were applied to assess a relationship between GPX4 (rs713041) SNP and the risk of different diseases based on three genetic models. Review Manager 5.4 and Comprehensive Meta-Analysis 4 software were used to perform the meta-analysis and carry out Egger’s test for publication bias. Results: Data from 21 articles were included in the systematic review. Diseases were clustered according to the physiological system affected to understand better the role of GPX4 (rs713041) SNP in developing different diseases. Carriers of the GPX4 (rs173041) T allele were associated with an increased risk of developing colorectal cancer in additive and dominant models (p = 0.02 and p = 0.004, respectively). In addition, carriers of the T allele were associated with an increased risk of developing stroke and hypertension in the additive, dominant and recessive models (p = 0.002, p = 0.004 and p = 0.01, respectively). On the other hand, the GPX4 (rs713041) T allele was associated with a decreased risk of developing pre-eclampsia in the additive, dominant and recessive models (p < 0.0001, p = 0.002 and p = 0.0005, respectively). Moreover, selenium levels presented lower mean values in cancer patients relative to control groups (SMD = −0.39 µg/L; 95% CI: −0.64, −0.14; p = 0.002, I2 = 85%). Conclusion: GPX4 (rs713041) T allele may influence colorectal cancer risk, stroke, hypertension and pre-eclampsia. In addition, low selenium levels may play a role in the increased risk of cancer.
    MeSH term(s) Female ; Humans ; Pregnancy ; Colorectal Neoplasms ; Genetic Predisposition to Disease ; Glutathione Peroxidase/genetics ; Hypertension ; Phospholipid Hydroperoxide Glutathione Peroxidase/genetics ; Polymorphism, Single Nucleotide ; Pre-Eclampsia/genetics ; Selenium ; Stroke/genetics
    Chemical Substances Glutathione Peroxidase (EC 1.11.1.9) ; Phospholipid Hydroperoxide Glutathione Peroxidase (EC 1.11.1.12) ; Selenium (H6241UJ22B) ; GPX4 protein, human (EC 1.11.1.12)
    Language English
    Publishing date 2022-12-12
    Publishing country Switzerland
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232415762
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Invited Letter to Editor in response to: Finland's handling of selenium is a model in these times of coronavirus infections.

    Bermano, Giovanna / Méplan, Catherine / Mercer, Derry K / Hesketh, John E

    The British journal of nutrition

    2020  Volume 125, Issue 12, Page(s) 1439–1440

    MeSH term(s) Coronavirus Infections/prevention & control ; Finland ; Humans ; Selenium
    Chemical Substances Selenium (H6241UJ22B)
    Keywords covid19
    Language English
    Publishing date 2020-09-29
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 280396-3
    ISSN 1475-2662 ; 0007-1145
    ISSN (online) 1475-2662
    ISSN 0007-1145
    DOI 10.1017/S0007114520003839
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.184: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Selenium and viral infection: are there lessons for COVID-19?

    Bermano, Giovanna / Méplan, Catherine / Mercer, Derry K / Hesketh, John E

    The British journal of nutrition

    2020  Volume 125, Issue 6, Page(s) 618–627

    Abstract: Se is a micronutrient essential for human health. Sub-optimal Se status is common, occurring in a significant proportion of the population across the world including parts of Europe and China. Human and animal studies have shown that Se status is a key ... ...

    Abstract Se is a micronutrient essential for human health. Sub-optimal Se status is common, occurring in a significant proportion of the population across the world including parts of Europe and China. Human and animal studies have shown that Se status is a key determinant of the host response to viral infections. In this review, we address the question whether Se intake is a factor in determining the severity of response to coronavirus disease 2019 (COVID-19). Emphasis is placed on epidemiological and animal studies which suggest that Se affects host response to RNA viruses and on the molecular mechanisms by which Se and selenoproteins modulate the inter-linked redox homeostasis, stress response and inflammatory response. Together these studies indicate that Se status is an important factor in determining the host response to viral infections. Therefore, we conclude that Se status is likely to influence human response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and that Se status is one (of several) risk factors which may impact on the outcome of SARS-CoV-2 infection, particularly in populations where Se intake is sub-optimal or low. We suggest the use of appropriate markers to assess the Se status of COVID-19 patients and possible supplementation may be beneficial in limiting the severity of symptoms, especially in countries where Se status is regarded as sub-optimal.
    MeSH term(s) Animals ; COVID-19/physiopathology ; COVID-19/virology ; Humans ; Inflammation/virology ; Micronutrients/pharmacology ; Nutritional Status ; Oxidation-Reduction/drug effects ; RNA, Viral/drug effects ; SARS-CoV-2/drug effects ; Selenium/pharmacology ; Stress, Physiological/drug effects ; Virus Diseases/physiopathology ; Virus Diseases/virology
    Chemical Substances Micronutrients ; RNA, Viral ; Selenium (H6241UJ22B)
    Keywords covid19
    Language English
    Publishing date 2020-08-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 280396-3
    ISSN 1475-2662 ; 0007-1145
    ISSN (online) 1475-2662
    ISSN 0007-1145
    DOI 10.1017/S0007114520003128
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.184: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  8. Article: Nutrigenomics and selenium: gene expression patterns, physiological targets, and genetics.

    Hesketh, John

    Annual review of nutrition

    2008  Volume 28, Page(s) 157–177

    Abstract: Dietary selenium intake is regarded as an important factor in determining optimal health and susceptibility to disease. Therefore, it is critical to understand the interaction between selenium intake and molecular events at the genetic and cellular level. ...

    Abstract Dietary selenium intake is regarded as an important factor in determining optimal health and susceptibility to disease. Therefore, it is critical to understand the interaction between selenium intake and molecular events at the genetic and cellular level. This article addresses two facets of this interaction. The first facet is how genomics is contributing to understanding the molecular mechanisms by which selenium affects cell function through selenoproteins and downstream targets of Se supply in other metabolic pathways. The contribution of transgenic animals in this field is emphasized, and the more recent studies using transcriptomics are discussed. The second facet is the extent to which single nucleotide polymorphisms (SNPs) in genes encoding selenoproteins and components of the selenoprotein synthetic machinery affect individual dietary requirements for optimal health. The state of knowledge of known functional SNPs in selenoprotein genes is presented, and a strategy for future studies is discussed.
    MeSH term(s) Animals ; Animals, Genetically Modified ; Gene Expression Regulation ; Genetic Predisposition to Disease ; Humans ; Nutrigenomics ; Nutritional Requirements ; Polymorphism, Single Nucleotide ; Selenium/administration & dosage ; Selenium/metabolism ; Selenoproteins/genetics ; Selenoproteins/physiology
    Chemical Substances Selenoproteins ; Selenium (H6241UJ22B)
    Language English
    Publishing date 2008
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 406980-8
    ISSN 1545-4312 ; 0199-9885
    ISSN (online) 1545-4312
    ISSN 0199-9885
    DOI 10.1146/annurev.nutr.28.061807.155446
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1786: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Selenium and cancer: a story that should not be forgotten-insights from genomics.

    Méplan, Catherine / Hesketh, John

    Cancer treatment and research

    2014  Volume 159, Page(s) 145–166

    Abstract: Selenium (Se) is an essential micronutrient that is incorporated into selenoproteins. Although epidemiological studies suggest that low Se intake is associated with increased risk of various cancers, the results of supplementation trials have been ... ...

    Abstract Selenium (Se) is an essential micronutrient that is incorporated into selenoproteins. Although epidemiological studies suggest that low Se intake is associated with increased risk of various cancers, the results of supplementation trials have been confusing. These conflicting results may be due to different baseline Se status and/or genetic factors. In addition, mechanistic links between Se intake, selenoproteins and carcinogenesis are not clear. In this article, we discuss the functional significance of single-nucleotide polymorphisms (SNP) in selenoprotein genes and the evidence as to whether or not they influence risk of colorectal, prostate, lung or breast cancers. Both in vitro and in vivo studies have shown that a small number of SNPs in genes encoding glutathione peroxidases 1 and 4, selenoprotein P, selenoprotein S and 15-kDa selenoprotein have functional consequences. Data from case-control studies suggest that a variant at codon 198 in glutathione peroxidase 1 influences the effect of Se status on prostate cancer and risk, and it has also been associated with breast cancer and lung cancer risk, whereas variants in glutathione peroxidase 4, selenoprotein P and selenoprotein S may influence the risk of colorectal cancer. In addition, the results of gene microarray (transcriptomic) studies have identified novel selenoprotein biomarkers of Se status and novel downstream Se-targeted pathways. The work highlights the need to take baseline Se status and genetic factors into account in the design of future intervention trials.
    MeSH term(s) Genetic Predisposition to Disease ; Genomics ; Humans ; Neoplasms/etiology ; Polymorphism, Single Nucleotide/genetics ; Risk Factors ; Selenium/metabolism ; Selenoproteins/genetics ; Selenoproteins/metabolism
    Chemical Substances Selenoproteins ; Selenium (H6241UJ22B)
    Language English
    Publishing date 2014
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 0927-3042
    ISSN 0927-3042
    DOI 10.1007/978-3-642-38007-5_9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Invited Letter to Editor in response to: Finland's handling of selenium is a model in these times of coronavirus infections

    Bermano, Giovanna / Méplan, Catherine / Mercer, Derry K / Hesketh, John E

    Br J Nutr

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #808214
    Database COVID19

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