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  1. Article: Longitudinal experience with Studer neobladders: Outcomes and complications.

    Chan, Ernest Pang / Nair, Shiva Madhwan / Hetou, Khalil / Stephenson, Emily / Power, Nicholas E / Izawa, Jonathan / Chin, Joseph L K

    Canadian Urological Association journal = Journal de l'Association des urologues du Canada

    2021  Volume 15, Issue 8, Page(s) E386–E392

    Abstract: Introduction: This study aims to assess the longer-term functional, anatomical, and metabolic outcomes of patients who underwent Studer neobladder (SNB) urinary diversion.: Methods: A retrospective review of patients who underwent SNB at a single ... ...

    Abstract Introduction: This study aims to assess the longer-term functional, anatomical, and metabolic outcomes of patients who underwent Studer neobladder (SNB) urinary diversion.
    Methods: A retrospective review of patients who underwent SNB at a single center from 1995-2017 (n=116) was performed. Demographics, comorbidities, pathological data, and longer-term functional, anatomical, and metabolic outcomes were collected from hospital records. The primary outcome was voiding function of patients at most recent followup. Secondary outcomes included postoperative complications, renal function, nephrolithiasis, infections, and metabolic outcomes.
    Results: Excluding those with incomplete followup data, 72 patients with a minimum followup of one year were included for analysis. Median followup was 70±11 months, with 52.8% of patients having ≥5 years of followup. Clean intermittent catheterization (CIC) was used by 22.2% of patient at most recent followup, which was mostly necessitated by bladder overdistension, deteriorating renal function, or recurrent urosepsis despite timed voiding. Patients experienced more daytime and nighttime urinary incontinence in the early postoperative setting, which improved over time. Generally, renal function declined over time; poorer long-term renal function was predicted by hydronephrosis within one year (p=0.002).
    Conclusions: Longer-term followup of SNB reveals significant but manageable complications. Gradual decline in renal function was common. Strict adherence to bladder emptying protocols (e.g., timed voiding or CIC) may reduce incidence of renal deterioration, metabolic disorders, and urinary dysfunction. Early onset (<1 year) of hydronephrosis may indicate a need for intervention to preserve long-term renal function.
    Language English
    Publishing date 2021-01-07
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2431403-1
    ISSN 1911-6470
    ISSN 1911-6470
    DOI 10.5489/cuaj.6893
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Long-term Testis Cancer Survivors in Canada-Mortality Risks in a Large Population-based Cohort.

    Lavi, Arnon / Clark, Roderick / Ly, Tina Luu / Nair, Shiva M / Hetou, Khalil / Haan, Michael / Power, Nicholas E

    European urology open science

    2020  Volume 22, Page(s) 54–60

    Abstract: Background: Testis cancer (TC) patients are young with excellent cancer prognosis. Hence, the risk of late-onset treatment-related morbidity and mortality is of concern due to longer survival after treatment.: Objective: We set to characterize long- ... ...

    Abstract Background: Testis cancer (TC) patients are young with excellent cancer prognosis. Hence, the risk of late-onset treatment-related morbidity and mortality is of concern due to longer survival after treatment.
    Objective: We set to characterize long-term survival of TC patients through a Canadian population dataset.
    Design setting and participants: We used a population-based dataset, the Canadian Census Health and Environment Cohort (CanCHEC), to identify individuals diagnosed with TC between 1991 and 2010. We compared them with all other male individuals without TC.
    Outcome measurements and statistical analysis: The primary outcome was mortality due to cardiovascular disease (CVD) or nontesticular malignancy. Mann-Whitney or chi-square test was used where applicable. Data were analyzed using a Cox proportional hazard model with and without matching.
    Results and limitations: We identified 1950 individuals with TC. We compared them with 1 300 295 men with no TC. There were 335 deaths in the study group during the study period (17.2%) with a mean follow-up of 19.6 yr. TC patients were at increased risk of death from secondary malignancies (hazard ratio [HR] 1.63, 95% confidence interval [CI] 1.39-1.91;
    Conclusions: NS patients are at increased risk of CVD-related death, whereas seminoma patients are at increased risk of death from non-testis-related malignancies.
    Patient summary: We report long-term mortality following diagnosis of testis cancer. Nonseminoma patients have an increased risk of death from cardiovascular disease, while seminoma patients have an increased risk of death from secondary malignancies.
    Language English
    Publishing date 2020-11-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 3040546-4
    ISSN 2666-1683 ; 2058-4881
    ISSN (online) 2666-1683
    ISSN 2058-4881
    DOI 10.1016/j.euros.2020.10.005
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  3. Article ; Online: A Randomized Controlled Trial of a Modified Cystoscopy Technique using the Peak-End Rule in order to Improve Pain and Anxiety.

    Hetou, Khalil / Halstuch, Daniel / Lavi, Arnon / Nair, Shiva M / Gan, Ailsa May Li / Huynh, Melissa J / Izawa, Jonathan / Chin, Joseph L / Power, Nicholas E

    Urology

    2021  Volume 154, Page(s) 33–39

    Abstract: Objective: To determine if a modified cystoscopy technique utilizing the peak-end rule cognitive bias decreases pain and anxiety during flexible cystoscopy in patients who undergo cystoscopy.: Methods: A total of 85 participants undergoing their ... ...

    Abstract Objective: To determine if a modified cystoscopy technique utilizing the peak-end rule cognitive bias decreases pain and anxiety during flexible cystoscopy in patients who undergo cystoscopy.
    Methods: A total of 85 participants undergoing their first diagnostic cystoscopy were enrolled in a blinded single-center, prospective, randomized controlled trial. Patients with lower urinary tract abnormalities, prior radiation and chronic pelvic pain were excluded. Participants were randomized to a standard cystoscopy (arm A) or a modified cystoscopy (arm B) where a two-minute period at the end of the procedure was completed during which the cystoscope was left in the bladder without being manipulated. Following the cystoscopy, participants completed a standard pain and anxiety questionnaire. Differences in mean pain and anxiety score between arms were evaluated using a Mann-Whitney test with a two-sided alpha of 0.05.
    Results: Eighty-five patients were randomized and underwent flexible cystoscopy. Three participants were ineligible, one required secondary procedures, and two did not complete the questionnaires. Among the 82 eligible patients, 45 were randomized to standard cystoscopy (arm A) and 37 to the modified cystoscopy (arm B) with mean pain scores of 23.20 and 11.97, respectively (P = .039). Mean anxiety scores were 2.09 and 0.88 for arm A and B, respectively (P = .013).
    Conclusion: This study demonstrated a clinically meaningful decrease in pain and anxiety for patients undergoing flexible cystoscopy when employing the modified cystoscopy technique versus the standard practice. This free and straightforward method to improve patient comfort and decrease stress during first time flexible cystoscopy should be considered by clinicians.
    MeSH term(s) Adult ; Aged ; Anxiety/prevention & control ; Cystoscopy/methods ; Female ; Humans ; Male ; Middle Aged ; Pain, Procedural/prevention & control ; Prospective Studies ; Single-Blind Method
    Language English
    Publishing date 2021-03-11
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 192062-5
    ISSN 1527-9995 ; 0090-4295
    ISSN (online) 1527-9995
    ISSN 0090-4295
    DOI 10.1016/j.urology.2021.02.033
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1142: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 275: Show issues

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  4. Article ; Online: Magnetic resonance imaging-guided transurethral ultrasound ablation in patients with localised prostate cancer: 3-year outcomes of a prospective Phase I study.

    Nair, Shiva M / Hatiboglu, Gencay / Relle, James / Hetou, Khalil / Hafron, Jason / Harle, Christopher / Kassam, Zahra / Staruch, Robert / Burtnyk, Mathieu / Bonekamp, David / Schlemmer, Heinz-Peter / Roethke, Matthias C / Mueller-Wolf, Maya / Pahernik, Sascha / Chin, Joseph L

    BJU international

    2020  Volume 127, Issue 5, Page(s) 544–552

    Abstract: Objectives: To report the 3-year follow-up of a Phase I study of magnetic resonance imaging (MRI)-guided transurethral ultrasound ablation (TULSA) in 30 men with localised prostate cancer. Favourable 12-month safety and ablation precision were ... ...

    Abstract Objectives: To report the 3-year follow-up of a Phase I study of magnetic resonance imaging (MRI)-guided transurethral ultrasound ablation (TULSA) in 30 men with localised prostate cancer. Favourable 12-month safety and ablation precision were previously described.
    Patients and methods: As a mandated safety criterion, TULSA was delivered as near whole-gland ablation, applying 3-mm margins sparing 10% of peripheral prostate tissue in 30 men. After 12-month biopsy and MRI, biannual follow-up included prostate-specific antigen (PSA), adverse events (AEs), and functional quality-of-life assessment, with repeat systematic biopsy at 3 years.
    Results: A 3-year follow-up was completed by 22 patients. Between 1 and 3 years, there were no new serious or severe AEs. Urinary and bowel function remained stable. Erectile function recovered by 1 year and was stable at 3 years. The PSA level decreased 95% to a median (interquartile range) nadir of 0.33 (0.1-0.4) ng/mL, stable to 0.8 (0.4-1.6) ng/mL at 3 years. Serial biopsies identified clinically significant disease in 10/29 men (34%) and any cancer in 17/29 (59%). By 3 years, seven men had recurrence (four histological, three biochemical) and had undergone salvage therapy without complications (including six prostatectomies). At 3 years, three of 22 men refused biopsy, and two of the 22 (9%) had clinically significant disease (one new, one persistent). Predictors of salvage therapy requirement included less extensive ablation coverage and higher PSA nadir.
    Conclusion: With 3-year Phase I follow-up, TULSA demonstrates safe and precise ablation for men with localised prostate cancer, providing predictable PSA and biopsy outcomes, without affecting functional abilities or precluding salvage therapy.
    Language English
    Publishing date 2020-11-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1462191-5
    ISSN 1464-410X ; 1464-4096 ; 1358-8672
    ISSN (online) 1464-410X
    ISSN 1464-4096 ; 1358-8672
    DOI 10.1111/bju.15268
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    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.107: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 13: Show issues

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  5. Article ; Online: A three-gene DNA methylation biomarker accurately classifies early stage prostate cancer.

    Patel, Palak G / Wessel, Thomas / Kawashima, Atsunari / Okello, John B A / Jamaspishvili, Tamara / Guérard, Karl-Philippe / Lee, Laura / Lee, Anna Ying-Wah / How, Nathan E / Dion, Dan / Scarlata, Eleonora / Jackson, Chelsea L / Boursalie, Suzanne / Sack, Tanya / Dunn, Rachel / Moussa, Madeleine / Mackie/, Karen / Ellis, Audrey / Marra, Elizabeth /
    Chin, Joseph / Siddiqui, Khurram / Hetou, Khalil / Pickard, Lee-Anne / Arthur-Hayward, Vinolia / Bauman, Glenn / Chevalier, Simone / Brimo, Fadi / Boutros, Paul C / Lapointe PhD, Jacques / Bartlett, John M S / Gooding, Robert J / Berman, David M

    The Prostate

    2019  Volume 79, Issue 14, Page(s) 1705–1714

    Abstract: Background: We identify and validate accurate diagnostic biomarkers for prostate cancer through a systematic evaluation of DNA methylation alterations.: Materials and methods: We assembled three early prostate cancer cohorts (total patients = 699) ... ...

    Abstract Background: We identify and validate accurate diagnostic biomarkers for prostate cancer through a systematic evaluation of DNA methylation alterations.
    Materials and methods: We assembled three early prostate cancer cohorts (total patients = 699) from which we collected and processed over 1300 prostatectomy tissue samples for DNA extraction. Using real-time methylation-specific PCR, we measured normalized methylation levels at 15 frequently methylated loci. After partitioning sample sets into independent training and validation cohorts, classifiers were developed using logistic regression, analyzed, and validated.
    Results: In the training dataset, DNA methylation levels at 7 of 15 genomic loci (glutathione S-transferase Pi 1 [GSTP1], CCDC181, hyaluronan, and proteoglycan link protein 3 [HAPLN3], GSTM2, growth arrest-specific 6 [GAS6], RASSF1, and APC) showed large differences between cancer and benign samples. The best binary classifier was the GAS6/GSTP1/HAPLN3 logistic regression model, with an area under these curves of 0.97, which showed a sensitivity of 94%, and a specificity of 93% after external validation.
    Conclusion: We created and validated a multigene model for the classification of benign and malignant prostate tissue. With false positive and negative rates below 7%, this three-gene biomarker represents a promising basis for more accurate prostate cancer diagnosis.
    MeSH term(s) Biomarkers, Tumor ; DNA/isolation & purification ; DNA Methylation/genetics ; Epigenesis, Genetic ; Extracellular Matrix Proteins/analysis ; Extracellular Matrix Proteins/genetics ; Glutathione S-Transferase pi/analysis ; Glutathione S-Transferase pi/genetics ; Humans ; Intercellular Signaling Peptides and Proteins/analysis ; Intercellular Signaling Peptides and Proteins/genetics ; Male ; Prostatic Neoplasms/chemistry ; Prostatic Neoplasms/classification ; Prostatic Neoplasms/pathology ; Proteoglycans/analysis ; Proteoglycans/genetics ; Reproducibility of Results ; Sensitivity and Specificity
    Chemical Substances Biomarkers, Tumor ; Extracellular Matrix Proteins ; HAPLN3 protein, human ; Intercellular Signaling Peptides and Proteins ; Proteoglycans ; growth arrest-specific protein 6 ; DNA (9007-49-2) ; GSTP1 protein, human (EC 2.5.1.18) ; Glutathione S-Transferase pi (EC 2.5.1.18)
    Language English
    Publishing date 2019-08-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604707-5
    ISSN 1097-0045 ; 0270-4137
    ISSN (online) 1097-0045
    ISSN 0270-4137
    DOI 10.1002/pros.23895
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    Zs.A 1608: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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