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  1. Article ; Online: Neurotransmitter Release of Reprogrammed Cells Using Electrochemical Detection Methods.

    Heuer, Andreas

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2352, Page(s) 201–226

    Abstract: The detection of neurotransmitter release from reprogrammed human cell is an important demonstration of their functionality. Electrochemistry has the distinct advantages over alternative methods that it allows for the measuring of the analyte of interest ...

    Abstract The detection of neurotransmitter release from reprogrammed human cell is an important demonstration of their functionality. Electrochemistry has the distinct advantages over alternative methods that it allows for the measuring of the analyte of interest at a high temporal resolution. This is necessary for fast events, such as neurotransmitter release and reuptake, which happen in the order of milliseconds to seconds. The precise description of these kinetic events can lead to insights into the function of cells in health and disease and allows for the exploration of events that might be missed using methods that look at absolute concentration values or methods that have a slower sampling rate. In the present chapter, we describe the use of constant potential amperometry and enzyme-coated multielectrode arrays for the detection of glutamate in vitro. These biosensors have the distinct advantage of "self-referencing," a method providing high selectivity while retaining outstanding temporal resolution. Here, we provide a step-by-step user guide for a commercially available system and its application for in vitro systems such as reprogrammed cells.
    MeSH term(s) Cell Culture Techniques ; Cellular Reprogramming/genetics ; Data Analysis ; Electrochemical Techniques/instrumentation ; Electrochemical Techniques/methods ; Electrochemistry/instrumentation ; Electrochemistry/methods ; Neurotransmitter Agents/biosynthesis ; Software ; Synaptic Transmission
    Chemical Substances Neurotransmitter Agents
    Language English
    Publishing date 2021-07-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1601-7_14
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  2. Article ; Online: Hydrodynamic interactions in ion transport-Theory and simulation.

    Diddens, Diddo / Heuer, Andreas

    The Journal of chemical physics

    2023  Volume 158, Issue 15

    Abstract: We present a hydrodynamic theory describing pair diffusion in systems with periodic boundary conditions, thereby generalizing earlier work on self-diffusion [B. Dünweg and K. Kremer, J. Chem. Phys. 99, 6983-6997 (1993) and I.-C. Yeh and G. Hummer, J. ... ...

    Abstract We present a hydrodynamic theory describing pair diffusion in systems with periodic boundary conditions, thereby generalizing earlier work on self-diffusion [B. Dünweg and K. Kremer, J. Chem. Phys. 99, 6983-6997 (1993) and I.-C. Yeh and G. Hummer, J. Phys. Chem. B 108, 15873-15879 (2004)]. Its predictions are compared with Molecular Dynamics simulations for a liquid carbonate electrolyte and two ionic liquids, for which we characterize the correlated motion between distinct ions. Overall, we observe good agreement between theory and simulation data, highlighting that hydrodynamic interactions universally dictate ion correlations. However, when summing over all ion pairs in the system to obtain the cross-contributions to the total cationic or anionic conductivity, the hydrodynamic interactions between ions with like and unlike charges largely cancel. Consequently, significant conductivity contributions only arise from deviations from a hydrodynamic flow field of an ideal fluid, which is from the local electrolyte structure as well as the relaxation processes in the subdiffusive regime. In the case of ionic liquids, the momentum-conservation constraint additionally is vital, which we study by employing different ionic masses in the simulations. Our formalism will likely also be helpful to estimate finite-size effects of the conductivity or of Maxwell-Stefan diffusivities in simulations.
    Language English
    Publishing date 2023-04-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/5.0147339
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  3. Article: Neutrophil Extracellular Traps (NETs) im Gefäßsystem.

    Koepke, L-G / Simon, F / Heuer, A

    Gefasschirurgie : Zeitschrift fur vaskulare und endovaskulare Chirurgie : Organ der Deutschen und der Osterreichischen Gesellschaft fur Gefasschirurgie unter Mitarbeit der Schweizerischen Gesellschaft fur Gefasschirurgie

    2022  Volume 27, Issue 6, Page(s) 444–448

    Title translation The Vascular System Caught in a Dark-NET.
    Language German
    Publishing date 2022-09-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1317513-0
    ISSN 0948-7034
    ISSN 0948-7034
    DOI 10.1007/s00772-022-00934-w
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    Zs.A 4660: Show issues Location:
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  4. Article ; Online: Electron transfer reaction of TEMPO-based organic radical batteries in different solvent environments: comparing quantum and classical approaches.

    Mitra, Souvik / Heuer, Andreas / Diddens, Diddo

    Physical chemistry chemical physics : PCCP

    2024  Volume 26, Issue 4, Page(s) 3020–3028

    Abstract: In this study, we delve into the complex electron transfer reactions associated with the redox-active (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO), a common component in organic radical batteries (ORBs). Our approach estimates quantum electron- ... ...

    Abstract In this study, we delve into the complex electron transfer reactions associated with the redox-active (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO), a common component in organic radical batteries (ORBs). Our approach estimates quantum electron-transfer (ET) energies using Density Functional Theory (DFT) calculations by sampling from structures simulated classically. This work presents a comparative study of reorganization energies in ET reactions across different solvents. Furthermore, we investigate how changes in the electrolyte environment can modify the reorganization energy and, consequently, impact ET dynamics. We also explore the relationship between classical and quantum vertical energies using linear regression models. Importantly, this comparison between quantum and classical vertical energies underscores the role of quantum effects, like charge delocalization, in offering added stabilization post-redox reactions. These effects are not adequately represented by the classical vertical energy distribution. Our study shows that, although we find a significant correlation between the vertical energies computed by DFT and the classical force field, the regression parameters depend on the solvent, highlighting that classical methods should be benchmarked by DFT before applying them to novel electrolyte materials.
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp04111e
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  5. Article ; Online: Temporal and spatial reference frames in visual working memory are defined by ordinal and relational properties.

    Heuer, Anna / Rolfs, Martin

    Journal of experimental psychology. Learning, memory, and cognition

    2022  Volume 49, Issue 9, Page(s) 1361–1375

    Abstract: Natural environments provide a rich spatiotemporal context that allows for visual objects to be differentiated based on different types of information: their absolute or relative spatial or temporal coordinates, or their ordinal positions in a spatial or ...

    Abstract Natural environments provide a rich spatiotemporal context that allows for visual objects to be differentiated based on different types of information: their absolute or relative spatial or temporal coordinates, or their ordinal positions in a spatial or temporal sequence. Here, we investigated which spatial and temporal properties are incidentally encoded along with to-be-remembered features to provide reference frames in visual working memory (VWM). We tested the different possibilities in a spatiotemporal color change-detection task by transforming spatial and/or temporal structures of item presentation at retrieval relative to encoding. More precisely, spatial and/or temporal coordinates were (a) switched, changing the order of items in a spatial or temporal sequence (ordinal transformation); (b) multiplied by different factors, changing interitem distances (relational transformation); or (c) multiplied by a constant factor, expanding or shrinking the entire configuration (global transformation). Such transformations of the external reference frame at retrieval should only interfere with VWM if the internal reference frame relies on the spatial or temporal properties affected by the respective transformation. We found that ordinal and relational transformations of either the spatial or temporal structure impaired performance, whereas global transformations did not. Thus, reference frames appear to be primarily defined by interitem relations-including relative distances between items as well as their order-rather than absolute positions in space or time. These results corroborate and extend previous findings for the spatial domain, and highlight functional similarities of the spatial and temporal dimensions in VWM by revealing the same metrical properties for temporal reference frames. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
    MeSH term(s) Humans ; Memory, Short-Term ; Mental Recall ; Visual Perception
    Language English
    Publishing date 2022-08-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 627313-0
    ISSN 1939-1285 ; 0278-7393
    ISSN (online) 1939-1285
    ISSN 0278-7393
    DOI 10.1037/xlm0001175
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2253: Show issues Location:
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  6. Article ; Online: Influence of the coordination defects on the dynamics and the potential energy landscape of two-dimensional silica.

    Roy, Projesh Kumar / Heuer, Andreas

    The Journal of chemical physics

    2022  Volume 157, Issue 17, Page(s) 174506

    Abstract: The main cause of the fragile-to-strong crossover of 3D silica was previously attributed to the presence of a low-energy cutoff in the potential energy landscape. An important question emerges about the microscopic origin of this crossover and its ... ...

    Abstract The main cause of the fragile-to-strong crossover of 3D silica was previously attributed to the presence of a low-energy cutoff in the potential energy landscape. An important question emerges about the microscopic origin of this crossover and its generalizibility to other glass-formers. In this work, the fragile-to-strong crossover of a model two-dimensional (2D) glassy system is analyzed via molecular dynamics simulation, which represents 2D-silica. By separating the sampled defect and defect-free inherent structures, we are able to identify their respective density of state distributions with respect to energy. A low energy cutoff is found in both distributions. It is shown that the fragile-to-strong crossover can be quantitatively related to the parameters of the energy landscape, involving, in particular, the low-energy cutoff of the energy distribution. It is also shown that the low-energy cutoff of the defect-states is determined by the formation energy of a specific defect configuration, involving two silicon and no oxygen defects. The low-temperature behavior of 2D silica is quantitatively compared with that of 3D silica, showing surprisingly similar behavior.
    Language English
    Publishing date 2022-10-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/5.0118797
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  7. Article ; Online: A review on the evolution of simulation-based training to help build a safer future.

    Bienstock, Jared / Heuer, Albert

    Medicine

    2022  Volume 101, Issue 25, Page(s) e29503

    Abstract: Abstract: Throughout history, simulation has been used to demonstrate various techniques, acquire skills, and maintain best practices in healthcare. Simulation has evolved significantly, primarily because of the extent to which it can enhance both ... ...

    Abstract Abstract: Throughout history, simulation has been used to demonstrate various techniques, acquire skills, and maintain best practices in healthcare. Simulation has evolved significantly, primarily because of the extent to which it can enhance both clinical proficiency and patient care. Although simulation-based training (SBT) in healthcare has grown exponentially in the 21st century, it has been around for centuries. This paper aims to reflect on the history and evolution of simulation in healthcare and review its current applications in order to provide a foundation for developing new applications for future expanded use.
    MeSH term(s) Clinical Competence ; Computer Simulation ; Humans ; Simulation Training/methods
    Language English
    Publishing date 2022-06-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000029503
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  8. Article ; Online: Inadequate reporting of the use of simulation-based training by certified clinical perfusionists.

    Bienstock, Jared / Heuer, Albert

    Perfusion

    2022  Volume 38, Issue 2, Page(s) 441–442

    MeSH term(s) Humans ; Cardiopulmonary Bypass/education ; Perfusion
    Language English
    Publishing date 2022-01-08
    Publishing country England
    Document type Letter
    ZDB-ID 645038-6
    ISSN 1477-111X ; 0267-6591
    ISSN (online) 1477-111X
    ISSN 0267-6591
    DOI 10.1177/02676591211053823
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  9. Article ; Online: Elucidating the Membrane Binding Process of a Disordered Protein: Dynamic Interplay of Anionic Lipids and the Polybasic Region.

    Alavizargar, Azadeh / Gass, Maximilian / Krahn, Michael P / Heuer, Andreas

    ACS physical chemistry Au

    2024  Volume 4, Issue 2, Page(s) 167–179

    Abstract: Intrinsically disordered regions of proteins are responsible for many biological processes such as in the case of liver kinase B1 (LKB1)-a serine/threonine kinase relevant for cell proliferation and cell polarity. LKB1 becomes fully activated upon ... ...

    Abstract Intrinsically disordered regions of proteins are responsible for many biological processes such as in the case of liver kinase B1 (LKB1)-a serine/threonine kinase relevant for cell proliferation and cell polarity. LKB1 becomes fully activated upon recruitment to the plasma membrane by binding of its disordered C-terminal polybasic motif consisting of eight lysines/arginines to phospholipids. Here, we present extensive molecular dynamics (MD) simulations of the polybasic motif interacting with a model membrane composed of 1-palmitoyl-2-oleoyl-
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article
    ISSN 2694-2445
    ISSN (online) 2694-2445
    DOI 10.1021/acsphyschemau.3c00051
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  10. Book ; Thesis: Untersuchungen zur Expression von Östradiol- und Progesteronrezeptoren in klassischen u. nicht klassischen Zielorganen des Menschen

    Heuer, Andreas

    2001  

    Author's details vorgelegt von Andreas Heuer
    Language German
    Size 82 Bl., Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Erlangen, Nürnberg, Univ., Diss., 2001
    HBZ-ID HT013369517
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2002 E 2325 order for loan Magazin

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