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  1. AU="Heuer, Lauren B"
  2. AU="Pan, Judy"
  3. AU="Doro, M."
  4. AU="Navarro-Zapata, Alfonso"
  5. AU="Martin, Emanuel H"
  6. AU="Biswas, Arnab"
  7. AU="Kurt Pfister"
  8. AU="Stefano Brignola"
  9. AU="Nierzwicki, Łukasz"
  10. AU="Benvin, Iva"
  11. AU="Sardesai, S. C."
  12. AU="Aldrees, Rana"

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  1. Artikel: Psychotic symptoms are associated with elevated tau PET signal in the amygdala independent of Alzheimer's disease clinical severity and amyloid burden.

    Johnson, Aubrey S / Ziaggi, Galen / Smith, Anna C / Houlihan, Hannah / Heuer, Lauren B / Guzmán, Diana S / Okafor, Amarachukwu / Huey, Edward D / Talmasov, Daniel / Provenzano, Frank / Kreisl, William C / Lao, Patrick J

    medRxiv : the preprint server for health sciences

    2024  

    Abstract: Background: Psychosis in Alzheimer's disease (AD) is associated with worse outcomes, yet no established biomarkers exist for early diagnosis and intervention. We compared tau PET burden across older individuals with and without psychotic symptoms.: ... ...

    Abstract Background: Psychosis in Alzheimer's disease (AD) is associated with worse outcomes, yet no established biomarkers exist for early diagnosis and intervention. We compared tau PET burden across older individuals with and without psychotic symptoms.
    Methods: [
    Results: Tau was greater in individuals with psychotic symptoms in the amygdala in region-of-interest analyses, and in amygdala, thalamus, putamen, right hippocampus, right entorhinal cortex, and right frontal cortex in voxel-based analyses. When considering different onset and type of psychotic symptoms, tau binding was greatest in those with concurrent delusions.
    Conclusion: Elevated tau in limbic regions may be relevant for psychotic symptoms in aging and AD.
    Sprache Englisch
    Erscheinungsdatum 2024-01-13
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2024.01.12.24301221
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Health-Related Quality of Life and Depression Symptoms in a Cross Section of Patients with Advanced Lung Cancer before and during the COVID-19 Pandemic.

    Petrillo, Laura A / El-Jawahri, Areej / Heuer, Lauren B / Post, Kathryn / Gallagher, Emily R / Trotter, Chardria / Elyze, Madeleine / Vyas, Charu / Plotke, Rachel / Turk, Yael R / Han, Jacqueline / Temel, Jennifer S / Greer, Joseph A

    Journal of palliative medicine

    2022  Band 25, Heft 11, Seite(n) 1639–1645

    Abstract: Background: ...

    Abstract Background:
    Mesh-Begriff(e) Adult ; Humans ; Quality of Life ; COVID-19 ; Pandemics ; Depression ; Lung Neoplasms
    Sprache Englisch
    Erscheinungsdatum 2022-05-19
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1427361-5
    ISSN 1557-7740 ; 1096-6218
    ISSN (online) 1557-7740
    ISSN 1096-6218
    DOI 10.1089/jpm.2022.0049
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Study protocol for a randomised trial evaluating the non-inferiority of stepped palliative care versus early integrated palliative care for patients with advanced lung cancer.

    Post, Kathryn E / Heuer, Lauren B / Kamal, Arif H / Kumar, Pallavi / Elyze, Madeleine / Griffith, Sarah / Han, Jacqueline / Friedman, Fred / Jackson, Ashley / Trotter, Chardria / Plotke, Rachel / Vyas, Charu / Jackson, Vicki / Rabideau, Dustin J / Greer, Joseph A / Temel, Jennifer S

    BMJ open

    2022  Band 12, Heft 2, Seite(n) e057591

    Abstract: Introduction: Integrating palliative care (PC) early in the illness course for patients with serious cancers improves their outcomes and is recommended by national organisations such as the American Society of Clinical Oncology. However, monthly visits ... ...

    Abstract Introduction: Integrating palliative care (PC) early in the illness course for patients with serious cancers improves their outcomes and is recommended by national organisations such as the American Society of Clinical Oncology. However, monthly visits with PC clinicians from the time of diagnosis can be challenging to implement due to the lack of specialty-trained PC clinicians and resources. Therefore, we developed a stepped care model to triage PC service based on patients' needs.
    Methods and analysis: We are conducting a non-blinded, randomised trial to evaluate the non-inferiority of a stepped PC model compared with an early integrated PC model for improving patients' quality of life (QOL) at 24 weeks (primary outcome). Patients assigned to early integrated PC meet with PC every 4 weeks throughout their illness. Patients assigned to stepped PC have PC visits only at clinically significant points in their illness (eg, cancer progression) unless their QOL decreases, at which time they are 'stepped up' and meet with PC every 4 weeks throughout the remainder of their illness. Secondary aims include assessing whether stepped PC is non-inferior to early integrated PC regarding patient-clinician communication about end of life care and length of stay on hospice as well as comparing resource utilisation. Patients are recruited from the Massachusetts General Hospital Cancer Center, Boston, Massachusetts; Duke Cancer Center, Durham, North Carolina and University of Pennsylvania Abramson Cancer Center, Philadelphia, Pennsylvania. The target sample size is 510 patients.
    Ethics and dissemination: The study is funded by the National Cancer Institute, approved by the Dana-Farber/Harvard Cancer Center Institutional Review Board and will be reported in accordance with the Consolidated Standards of Reporting Trials statement. We will disseminate results through professional society meetings, peer-reviewed publications and presentations to patient organisations.
    Trial registration number: NCT03337399.
    Mesh-Begriff(e) Hospice and Palliative Care Nursing ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/therapy ; Palliative Care/methods ; Quality of Life ; Randomized Controlled Trials as Topic ; Terminal Care/methods
    Sprache Englisch
    Erscheinungsdatum 2022-02-10
    Erscheinungsland England
    Dokumenttyp Clinical Trial Protocol ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2021-057591
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: A discrete parasubthalamic nucleus subpopulation plays a critical role in appetite suppression.

    Kim, Jessica H / Kromm, Grace H / Barnhill, Olivia K / Sperber, Jacob / Heuer, Lauren B / Loomis, Sierra / Newman, Matthew C / Han, Kenneth / Gulamali, Faris F / Legan, Theresa B / Jensen, Katharine E / Funderburk, Samuel C / Krashes, Michael J / Carter, Matthew E

    eLife

    2022  Band 11

    Abstract: Food intake behavior is regulated by a network of appetite-inducing and appetite-suppressing neuronal populations throughout the brain. The parasubthalamic nucleus (PSTN), a relatively unexplored population of neurons in the posterior hypothalamus, has ... ...

    Abstract Food intake behavior is regulated by a network of appetite-inducing and appetite-suppressing neuronal populations throughout the brain. The parasubthalamic nucleus (PSTN), a relatively unexplored population of neurons in the posterior hypothalamus, has been hypothesized to regulate appetite due to its connectivity with other anorexigenic neuronal populations and because these neurons express Fos, a marker of neuronal activation, following a meal. However, the individual cell types that make up the PSTN are not well characterized, nor are their functional roles in food intake behavior. Here, we identify and distinguish between two discrete PSTN subpopulations, those that express tachykinin-1 (PSTN
    Mesh-Begriff(e) Animals ; Appetite ; Appetite Regulation ; Corticotropin-Releasing Hormone/metabolism ; Eating/physiology ; Mice ; Neurons/physiology ; Optogenetics
    Chemische Substanzen Corticotropin-Releasing Hormone (9015-71-8)
    Sprache Englisch
    Erscheinungsdatum 2022-05-04
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.75470
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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