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  1. Article ; Online: We Asked the Experts: How Do We Maintain Surgical Quality Standards for Enhanced Recovery Programs After Cancer Surgery During the COVID-19 Outbreak?

    Doussot, Alexandre / Heyd, Bruno / Lakkis, Zaher

    World journal of surgery

    2020  Volume 44, Issue 7, Page(s) 2051–2052

    Keywords covid19
    Language English
    Publishing date 2020-04-24
    Publishing country United States
    Document type Editorial
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1007/s00268-020-05546-7
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    Zs.A 1336: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Anatomic patterns of anastomotic leaks after Ivor Lewis esophagectomy for cancer: Impact on management and outcomes.

    Laydi, Maxime / Doussot, Alexandre / Lakkis, Zaher / Mathieu, Pierre / Gandon, Anne / Dubois, Clément / Degisors, Sébastien / Martin, Louis / Heyd, Bruno / Piessen, Guillaume

    Surgery

    2023  Volume 174, Issue 2, Page(s) 247–251

    Abstract: Background: Anastomotic leakage presentation after Ivor Lewis esophagectomy may vary on imaging. Such variations may influence anastomotic leakage management and outcomes.: Methods: All consecutive patients who underwent Ivor Lewis esophagectomy for ... ...

    Abstract Background: Anastomotic leakage presentation after Ivor Lewis esophagectomy may vary on imaging. Such variations may influence anastomotic leakage management and outcomes.
    Methods: All consecutive patients who underwent Ivor Lewis esophagectomy for cancer between 2012 and 2019 in 2 referral centers were included. Anatomical patterns of anastomotic leakage were defined on imaging as follows: eso-mediastinal anastomotic leakage was a leak contained in the posterior mediastinum, eso-pleural anastomotic leakage was a leak involving the pleural cavity, and eso-bronchial anastomotic leakage was a leak communicating with the tracheobronchial tract. According to the Esophageal Complications Consensus Group definition, management and 90-day mortality were evaluated according to these patterns.
    Results: Among 731 patients, 111 (15%) developed anastomotic leakage consisting of eso-mediastinal anastomotic leakage (n = 87, 79%), eso-pleural anastomotic leakage (n = 16, 14%) and eso-bronchial anastomotic leakage (n = 8, 7%). There was no difference among these groups regarding preoperative characteristics or time to anastomotic leakage diagnosis. There was a significant difference in initial management according to anastomotic leakage anatomic patterns (P = .001). More than half of patients who experienced eso-mediastinal anastomotic leakage (n = 46, 53%) were initially treated conservatively without requiring intervention (Esophageal Complications Consensus Group type I), whereas most patients with eso-pleural anastomotic leakage (n = 14, 87.5%) and all with eso-bronchial anastomotic leakage (n = 8, 100%) initially required interventional or surgical treatment (Esophageal Complications Consensus Group type II-III). Anastomotic leakage anatomic patterns had a statistically significant impact on 90-day mortality, intensive care unit stay, and total hospital stay (P < .001).
    Conclusion: Anastomotic leakage anatomic patterns after Ivor Lewis esophagectomy influence outcomes. Further studies are warranted to validate it in a prospective setting. Anastomotic leakage anatomic patterns may help in guiding anastomotic leakage management.
    MeSH term(s) Humans ; Anastomotic Leak/diagnosis ; Anastomotic Leak/epidemiology ; Anastomotic Leak/etiology ; Esophagectomy/adverse effects ; Esophagectomy/methods ; Anastomosis, Surgical/adverse effects ; Anastomosis, Surgical/methods ; Prospective Studies ; Esophageal Neoplasms ; Retrospective Studies ; Postoperative Complications/diagnosis ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2023.04.034
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    Uk I Zs.129: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Fluorescence-based pancreas stump perfusion is associated with postoperative acute pancreatitis after pancreatoduodenectomy a prospective cohort study.

    Doussot, Alexandre / Decrock, Marc / Calame, Paul / Georges, Pauline / Turco, Célia / Lakkis, Zaher / Heyd, Bruno

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.

    2021  

    Abstract: Background: Postoperative acute pancreatitis (POAP) emerges as a distinct pancreas-specific complication increasing both the risk and the burden of POPF after pancreatoduodenectomy. Among various risk factors, pancreas stump (PS) hypoperfusion might ... ...

    Abstract Background: Postoperative acute pancreatitis (POAP) emerges as a distinct pancreas-specific complication increasing both the risk and the burden of POPF after pancreatoduodenectomy. Among various risk factors, pancreas stump (PS) hypoperfusion might play a role in POAP occurrence but has never been investigated. The current study aimed at evaluating the feasibility of intraoperative fluorescence angiography (IOFA) of the PS using ICG and its association with POAP.
    Methods: Consecutive patients who underwent pancreatoduodenectomy for a periampullary tumor with pancreatojejunostomy and PS perfusion assessment using IOFA between January 2020 and November 2020 were prospectively included. Perioperative management and surgical strategy were standardized. IOFA of the pancreas stump was performed before fashioning pancreatojejunostomy. POAP was defined according to the Connor definition and was confirmed upon radiological blind review. Outcomes between patients with normally perfused and hypoperfused PS were compared. POAP was the primary endpoint.
    Results: Among 30 patients, nine patients (30%) developed POAP according to the Connor definition, and six patients (20%) had CT-confirmed POAP. Upon IOFA, six patients (20%) presented PS hypoperfusion; of which one patient underwent extended pancreatectomy further to the left. PS hypoperfusion was statistically associated with the occurrence of POAP (80% vs. 16%; p = 0.011) and CT-confirmed POAP (60% vs. 12%; p = 0.041). Clinically relevant POPF rate was 40% in case of PS hypoperfusion and 4% in case of normal PS perfusion (p = 0.064).
    Conclusions: PS perfusion assessment using IOFA seems safe and reliable to anticipate POAP. PS IOFA could be considered as a potential tool for perioperative assessment of surgical risk after pancreatoduodenectomy.
    Language English
    Publishing date 2021-05-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2056680-3
    ISSN 1424-3911 ; 1424-3903
    ISSN (online) 1424-3911
    ISSN 1424-3903
    DOI 10.1016/j.pan.2021.05.009
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    Zs.A 5553: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Local invasion of hepatic alveolar echinococcosis should not be underestimated: Lessons learned from imaging-pathologic correlation.

    Calame, Paul / Doussot, Alexandre / Turco, Celia / Colpart, Prudence / Heyd, Bruno / Delabrousse, Eric

    Diagnostic and interventional imaging

    2021  Volume 102, Issue 3, Page(s) 189–192

    MeSH term(s) Echinococcosis, Hepatic/diagnostic imaging ; Echinococcosis, Hepatic/pathology ; Hepatectomy ; Humans ; Tomography, X-Ray Computed
    Language English
    Publishing date 2021-01-23
    Publishing country France
    Document type Case Reports ; Letter
    ZDB-ID 2648283-6
    ISSN 2211-5684 ; 2211-5684
    ISSN (online) 2211-5684
    ISSN 2211-5684
    DOI 10.1016/j.diii.2021.01.002
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  5. Article ; Online: Tissue-resident memory T cells in gastrointestinal cancer immunology and immunotherapy: ready for prime time?

    Abdeljaoued, Syrine / Arfa, Sara / Kroemer, Marie / Ben Khelil, Myriam / Vienot, Angélique / Heyd, Bruno / Loyon, Romain / Doussot, Alexandre / Borg, Christophe

    Journal for immunotherapy of cancer

    2022  Volume 10, Issue 4

    Abstract: Tissue-resident memory T ( ... ...

    Abstract Tissue-resident memory T (T
    MeSH term(s) Epigenesis, Genetic ; Gastrointestinal Neoplasms/therapy ; Humans ; Immunotherapy ; Memory T Cells ; Tumor Microenvironment
    Language English
    Publishing date 2022-04-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2719863-7
    ISSN 2051-1426 ; 2051-1426
    ISSN (online) 2051-1426
    ISSN 2051-1426
    DOI 10.1136/jitc-2021-003472
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  6. Article ; Online: Preoperative prediction of inadvertent enterotomy during adhesive small bowel obstruction surgery using combination of CT features.

    Zein, Lisa / Calame, Paul / Chausset, Clara / Doussot, Alexandre / Turco, Celia / Malakhia, Alexandre / Heyd, Bruno / Lakkis, Zaher / Delabrousse, Eric

    European radiology

    2022  Volume 32, Issue 10, Page(s) 6646–6657

    Abstract: Objectives: The purpose of this study was to identify the preoperative CT features that are associated with inadvertent enterotomy (IE) during adhesive small bowel obstruction (ASBO) surgery.: Methods: From January 2015 to December 2019, all patients ...

    Abstract Objectives: The purpose of this study was to identify the preoperative CT features that are associated with inadvertent enterotomy (IE) during adhesive small bowel obstruction (ASBO) surgery.
    Methods: From January 2015 to December 2019, all patients with ASBO who underwent an abdominal CT were reviewed. Abdominal CT were retrospectively reviewed by two radiologists with a consensus read in case of disagreement. IE during ASBO surgery was retrospectively recorded. Univariate and multivariate analyses of CT features associated with IE were performed and a simple CT score was built to stratify the risk of IE. This score was validated in an independent retrospective cohort. Abdominal CT of the validation cohort was reviewed by a third independent reader.
    Results: Among the 368 patients with ASBO during the study period, 169 were surgically treated, including 129 ASBO for single adhesive band and 40 for matted adhesions. Among these, there were 47 IE. By multivariate analysis, angulation of the transitional zone (OR = 4.19, 95% CI [1.10-18.09]), diffuse intestinal adhesions (OR = 4.87, 95% CI [1.37-19.76]), a fat notch sign (OR = 0.32, 95% CI [0.12-0.85]), and mesenteric haziness (OR = 0.13, 95% CI [0.03-0.48]) were independently associated with inadvertent enterotomy occurrence. The simple CT score built to stratify risk of IE displayed an AUC of 0.85 (95% CI [0.80-0.90]) in the study sample and 0.88 (95% CI [0.80-0.96]) in the validation cohort.
    Conclusion: A simple preoperative CT score is able to inform the surgeon about a high risk of IE and therefore influence the surgical procedure.
    Key points: • In this retrospective study of 169 patients undergoing abdominal surgery for adhesive small bowel obstruction, 47 (28%) inadvertent enterotomy occurred. • A simple preoperative CT score enables accurate stratification of inadvertent enterotomy risk (area under the curve 0.85). • By multivariable analysis, diffuse intestinal adhesions and angulation of the transitional zone were predictive of inadvertent enterotomy occurrence.
    MeSH term(s) Adhesives ; Humans ; Intestinal Obstruction/diagnostic imaging ; Intestinal Obstruction/etiology ; Intestinal Obstruction/surgery ; Intestine, Small/diagnostic imaging ; Intestine, Small/surgery ; Retrospective Studies ; Tomography, X-Ray Computed/methods
    Chemical Substances Adhesives
    Language English
    Publishing date 2022-06-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-022-08951-9
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3300: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Prognostic Factors in Non-occlusive mesenteric ischemia: A pragmatic pre-operative score for the prediction of 28-day mortality.

    Calame, Paul / Winiszewski, Hadrien / Lakkis, Zaher / Verdot, Pierre / Pili-Floury, Sebastien / Heyd, Bruno / Piton, Gael / Delabrousse, Eric / Doussot, Alexandre

    American journal of surgery

    2022  Volume 224, Issue 1 Pt B, Page(s) 617–623

    Abstract: Background: The prognosis of critical ill patients with non-occlusive mesenteric ischemia (NOMI) is poor and not fully understood. We aimed to determine preoperative factors associated with 28-day mortality in NOMI.: Methods: Variables associated ... ...

    Abstract Background: The prognosis of critical ill patients with non-occlusive mesenteric ischemia (NOMI) is poor and not fully understood. We aimed to determine preoperative factors associated with 28-day mortality in NOMI.
    Methods: Variables associated with 28-day mortality were entered into a multivariate cox regression model and were used to compute a NOMI mortality score.
    Results: 154 patients were included. The 28-day mortality rate was 56%. Multivariable analyses including variables at the time of the CT identified three variables (i.e. lactates > 7 mmoL/l, prothrombin rate <60% and kidney infarction), included in a simple score. Among the study population, the probability of 28-day mortality was 26% (11/42), 54% (26/48), 77% (23/30) and 100% (21/21) for a survival score of 0, 1, 2 and 3, respectively.
    Conclusion: A simple score combining these three variables, calculated preoperatively, was able to accurately predict 28-day mortality and might help to avoid futile laparotomies.
    MeSH term(s) Humans ; Ischemia/surgery ; Laparotomy ; Mesenteric Ischemia/diagnosis ; Mesenteric Ischemia/surgery ; Prognosis
    Language English
    Publishing date 2022-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2953-1
    ISSN 1879-1883 ; 0002-9610
    ISSN (online) 1879-1883
    ISSN 0002-9610
    DOI 10.1016/j.amjsurg.2022.03.048
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    Uk I Zs.42: Show issues Location:
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  8. Article ; Online: Acute fulminant hepatitis related to the use of dasatinib: First case report.

    Clément, Morgane / Cervoni, Jean-Paul / Renosi, Florian / Thévenot, Thierry / Felix, Sophie / Doussot, Alexandre / Heyd, Bruno / Deconinck, Éric / Martino, Vincent Di

    Clinics and research in hepatology and gastroenterology

    2022  Volume 46, Issue 8, Page(s) 102004

    MeSH term(s) Acute Disease ; Dasatinib/adverse effects ; Hepatitis/etiology ; Humans ; Liver Failure, Acute/chemically induced ; Massive Hepatic Necrosis
    Chemical Substances Dasatinib (RBZ1571X5H)
    Language English
    Publishing date 2022-08-10
    Publishing country France
    Document type Case Reports
    ZDB-ID 2594333-9
    ISSN 2210-741X ; 2210-7401
    ISSN (online) 2210-741X
    ISSN 2210-7401
    DOI 10.1016/j.clinre.2022.102004
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  9. Article: We Asked the Experts: How Do We Maintain Surgical Quality Standards for Enhanced Recovery Programs After Cancer Surgery During the COVID-19 Outbreak?

    Doussot, Alexandre / Heyd, Bruno / Lakkis, Zaher

    World J Surg

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32335691
    Database COVID19

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  10. Article ; Online: We Asked the Experts

    Doussot, Alexandre / Heyd, Bruno / Lakkis, Zaher

    World Journal of Surgery

    How Do We Maintain Surgical Quality Standards for Enhanced Recovery Programs After Cancer Surgery During the COVID-19 Outbreak?

    2020  Volume 44, Issue 7, Page(s) 2051–2052

    Keywords Surgery ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1007/s00268-020-05546-7
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    ab Jg. 2022: Lesesaal (EG)

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