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  1. Article: Early Exposure is Necessary for the Lifespan Extension Effects of Cocoa in

    Munasinghe, Mihiri / Almotayri, Abdullah / Thomas, Jency / Heydarian, Deniz / Jois, Markandeya

    Nutrition and metabolic insights

    2021  Volume 14, Page(s) 11786388211029443

    Abstract: Background: We previously showed that cocoa, a rich source of polyphenols improved the age-associated health and extended the lifespan in : Aim: In this study, we aimed to find out the effects of timing of cocoa exposure on longevity improving ... ...

    Abstract Background: We previously showed that cocoa, a rich source of polyphenols improved the age-associated health and extended the lifespan in
    Aim: In this study, we aimed to find out the effects of timing of cocoa exposure on longevity improving effects and the mechanisms and pathways involved in lifespan extension in
    Methods: The standard
    Results: Cocoa exposure starting from L1 stage till the death and till adult day 1 significantly extended the lifespan of worms. However, cocoa supplementation at other larval stages as well as at adulthood could not extend the lifespan, instead the lifespan was significantly reduced. Cocoa could not extend the lifespan of
    Conclusion: Early-start supplementation is essential for cocoa-mediated lifespan extension which is dependent on insulin/IGF-1 signaling pathway and mitochondrial respiration.
    Language English
    Publishing date 2021-07-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2594646-8
    ISSN 1178-6388
    ISSN 1178-6388
    DOI 10.1177/11786388211029443
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Metabolic and behavioral effects of olanzapine and fluoxetine on the model organism

    Almotayri, Abdullah / Thomas, Jency / Munasinghe, Mihiri / Weerasinghe, Maneka / Heydarian, Deniz / Jois, Markandeya

    Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

    2021  Volume 29, Issue 8, Page(s) 917–929

    Abstract: The use of many psychotropic drugs (PDs) is associated with increased caloric intake, significant weight gain, and metabolic disorders. The ... ...

    Abstract The use of many psychotropic drugs (PDs) is associated with increased caloric intake, significant weight gain, and metabolic disorders. The nematode
    Language English
    Publishing date 2021-07-16
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 1378024-4
    ISSN 1319-0164
    ISSN 1319-0164
    DOI 10.1016/j.jsps.2021.07.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Quantification of behavioural variation among sheep grazing on pasture using accelerometer sensors

    Almasi, F. / Nguyen, H. / Heydarian, D. / Sohi, R. / Nikbin, S. / Jenvey, C. J. / Halliwell, E. / Ponnampalam, E. N. / Desai, A. / Jois, M. / Stear, M. J.

    Animal production science. 2022, v. 62, no. 15

    2022  

    Abstract: Context Monitoring the behaviour of animals can provide early warning signs of disease or indicate loss of appetite. Also, an understanding of the variation in behaviours among animals and their distributions is essential for meaningful statistical ... ...

    Abstract Context Monitoring the behaviour of animals can provide early warning signs of disease or indicate loss of appetite. Also, an understanding of the variation in behaviours among animals and their distributions is essential for meaningful statistical inference. Therefore, quantifying the variation of behaviours is of both biological and statistical interest. Aim The objectives of this study were to determine the distributions and quantify the variation among animals with respect to the times spent grazing, ruminating, idling, walking, and licking. Methods The activities of 147 (male=67, female=80) Merino lambs at 10–11months of age on a commercial farm in Edenhope, Victoria, Australia were recorded for 26days, using ActiGraph accelerometer sensors attached to the left side of the sheep’s muzzle. The male and female sheep were kept in separate paddocks. A Support Vector Machine algorithm was used to differentiate sheep behaviour into six categories: grazing, ruminating, idling, walking, licking, and other activities. The distributions of behaviours were analysed using energy statistics-based tests and Generalised Additive Models for Location, Scale, and Shape (GAMLSS). Different distributions were compared using Akaike Information Criterion (AIC) values. Key results Among the distributions that were considered, we found that times spent ruminating in both male and female sheep populations as well as idling in male sheep were best described by the skew exponential type 2 distribution. Grazing, walking and licking behaviours were best described by the Box–Cox t distribution. The distribution of time spent grazing was symmetrical and unimodal in males, and adequately modelled by a normal distribution, but the distribution in females had a prominent left skew. Also, we found that females typically grazed for a longer time than males. However, males spent more time ruminating than grazing. Conclusions The time spent by the animal in each activity varied during the day. Within each population, the variation among animals in the time spent grazing was best described by a Box–Cox t distribution. Implications This study has enhanced our understanding of grazing behaviour and will facilitate more appropriate analyses of the causes of variation among animals in grazing behaviour.
    Keywords Merino ; accelerometers ; actigraphy ; animal production ; anorexia ; commercial farms ; energy ; females ; males ; normal distribution ; pastures ; sheep ; statistical inference ; support vector machines ; Australia
    Language English
    Size p. 1527-1538.
    Publishing place CSIRO Publishing
    Document type Article
    ZDB-ID 2472524-9
    ISSN 1836-5787 ; 1836-0939
    ISSN (online) 1836-5787
    ISSN 1836-0939
    DOI 10.1071/AN21464
    Database NAL-Catalogue (AGRICOLA)

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