Article: Early Exposure is Necessary for the Lifespan Extension Effects of Cocoa in
Nutrition and metabolic insights
2021 Volume 14, Page(s) 11786388211029443
Abstract: Background: We previously showed that cocoa, a rich source of polyphenols improved the age-associated health and extended the lifespan in : Aim: In this study, we aimed to find out the effects of timing of cocoa exposure on longevity improving ... ...
Abstract | Background: We previously showed that cocoa, a rich source of polyphenols improved the age-associated health and extended the lifespan in Aim: In this study, we aimed to find out the effects of timing of cocoa exposure on longevity improving effects and the mechanisms and pathways involved in lifespan extension in Methods: The standard Results: Cocoa exposure starting from L1 stage till the death and till adult day 1 significantly extended the lifespan of worms. However, cocoa supplementation at other larval stages as well as at adulthood could not extend the lifespan, instead the lifespan was significantly reduced. Cocoa could not extend the lifespan of Conclusion: Early-start supplementation is essential for cocoa-mediated lifespan extension which is dependent on insulin/IGF-1 signaling pathway and mitochondrial respiration. |
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Language | English |
Publishing date | 2021-07-11 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 2594646-8 |
ISSN | 1178-6388 |
ISSN | 1178-6388 |
DOI | 10.1177/11786388211029443 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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