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  1. Article: [Nutritional approach for chronic liver injury and treatment for alcoholic liver diseases].

    Tokumoto, Yoshio / Hiasa, Yoichi

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology

    2023  Volume 120, Issue 9, Page(s) 717–725

    MeSH term(s) Humans ; Liver Diseases, Alcoholic/diet therapy
    Language Japanese
    Publishing date 2023-09-09
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 708695-7
    ISSN 1349-7693 ; 0446-6586
    ISSN (online) 1349-7693
    ISSN 0446-6586
    DOI 10.11405/nisshoshi.120.717
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Thread and Streak Sign at Microvascular Flow Imaging and Contrast-enhanced US.

    Hirooka, Masashi / Hiasa, Yoichi

    Radiology

    2023  Volume 308, Issue 3, Page(s) e230961

    MeSH term(s) Humans ; Diagnostic Imaging ; Software
    Language English
    Publishing date 2023-09-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.230961
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [Management of complications associated with liver cirrhosis].

    Tokumoto, Yoshio / Hiasa, Yoichi

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology

    2021  Volume 118, Issue 1, Page(s) 30–40

    MeSH term(s) Esophageal and Gastric Varices ; Humans ; Liver Cirrhosis/complications ; Liver Cirrhosis/therapy
    Language Japanese
    Publishing date 2021-01-11
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 708695-7
    ISSN 1349-7693 ; 0446-6586
    ISSN (online) 1349-7693
    ISSN 0446-6586
    DOI 10.11405/nisshoshi.118.30
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Editorial.

    Hiasa, Yoichi

    Euroasian journal of hepato-gastroenterology

    2015  Volume 5, Issue 1, Page(s) v

    Language English
    Publishing date 2015-01-06
    Publishing country India
    Document type Editorial
    ZDB-ID 2651614-7
    ISSN 2231-5128 ; 2231-5047
    ISSN (online) 2231-5128
    ISSN 2231-5047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Immune therapies against chronic hepatitis B.

    Akbar, Sheikh Mohammad Fazle / Yoshida, Osamu / Hiasa, Yoichi

    Journal of gastroenterology

    2022  Volume 57, Issue 8, Page(s) 517–528

    Abstract: Patients with chronic hepatitis B (CHB) represent a living and permanent reservoir of hepatitis B virus (HBV). Millions of these CHB patients will eventually develop complications such as liver cirrhosis, hepatic failure, and hepatocellular carcinoma if ... ...

    Abstract Patients with chronic hepatitis B (CHB) represent a living and permanent reservoir of hepatitis B virus (HBV). Millions of these CHB patients will eventually develop complications such as liver cirrhosis, hepatic failure, and hepatocellular carcinoma if they are not treated properly. Accordingly, several antiviral drugs have been developed for the treatment of CHB, but these drugs can neither eradicate all forms of HBV nor contain the progression of complications in most patients with CHB. Thus, the development of new and novel therapeutics for CHB remains a pressing need. The molecular and cellular mechanisms underlying the pathogenesis of CHB indicate that immune dysregulations may be responsible for HBV persistence and progressive liver damage in CHB. This provided the scientific and ethical basis for the immune therapy of CHB patients. Around 30 years have passed since the initiation of immune therapies for CHB in the early 1990s, and hundreds of clinical trials have been accomplished to substantiate this immune treatment. Despite these approaches, an acceptable regimen of immune therapy is yet to be realized. However, most immune therapeutic agents are safe for human usage, and many of these protocols have inspired considerable optimism. In this review, the pros and cons of different immune therapies, observed in patients with CHB during the last 30 years, will be discussed to derive insights into the development of an evidence-based, effective, and patient-friendly regimen of immune therapy for the treatment of CHB.
    MeSH term(s) Antiviral Agents/adverse effects ; Carcinoma, Hepatocellular/therapy ; Hepatitis B virus ; Hepatitis B, Chronic/complications ; Hepatitis B, Chronic/drug therapy ; Humans ; Liver Neoplasms/therapy
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2022-06-16
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1186495-3
    ISSN 1435-5922 ; 0944-1174
    ISSN (online) 1435-5922
    ISSN 0944-1174
    DOI 10.1007/s00535-022-01890-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Observational Study on Unhealthy Eating Behavior and the Effect of Sodium-Glucose Cotransporter 2 Inhibitors: The Luseogliflozin Ehime Diabetes Study.

    Furukawa, Shinya / Miyake, Teruki / Miyaoka, Hiroaki / Matsuura, Bunzo / Hiasa, Yoichi

    Diabetes therapy : research, treatment and education of diabetes and related disorders

    2022  Volume 13, Issue 5, Page(s) 1073–1082

    Abstract: Introduction: Luseogliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor. Unhealthy eating behavior is associated with diabetes, hypertension, and obesity. However, evidence regarding the effect of medications, including SGLT2 inhibitors, on ... ...

    Abstract Introduction: Luseogliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor. Unhealthy eating behavior is associated with diabetes, hypertension, and obesity. However, evidence regarding the effect of medications, including SGLT2 inhibitors, on unhealthy eating behavior is limited. This study investigated the association between unhealthy eating behavior and the laboratory and physical findings of Japanese patients with type 2 diabetes given luseogliflozin once daily for 24 weeks.
    Methods: Twenty-nine patients with type 2 diabetes mellitus were enrolled in a 24-week prospective, open-label, single-arm pilot study. The information regarding unhealthy eating behaviors (eating fast, late dinner, nighttime snack, skipping breakfast, and eating until full) was obtained using self-reported questionnaires.
    Results: The baseline rate of eating fast, late dinner, nighttime snack, skipping breakfast, and eating until full was 51.7%, 24.1%, 24.1%, 10.3% and 55.2%, respectively. After administration of luseogliflozin, fasting plasma glucose, HbA1c, aspartate aminotransferase (ALT), weight, body mass index, and waist measurement all decreased significantly. High-density lipoprotein cholesterol and hematocrit increased significantly. In the healthy eating behavior group, the improvements of fasting plasma glucose and ALT, but not other variables, were attenuated. HbA1c level was significantly improved in patients with eating fast, while other unhealthy eating behaviors attenuated the effect of luseogliflozin for HbA1c. The effect of leseogliflozin on the relationship between eating behavior and weight reduction was inconsistent after administration luseogliflozin.
    Conclusion: Luseogliflozin might be more effective for controlling plasma glucose in patients with type 2 diabetes who have a tendency to eat fast, but it might have less effect on those with other unhealthy eating habits.
    Language English
    Publishing date 2022-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2566702-6
    ISSN 1869-6961 ; 1869-6953
    ISSN (online) 1869-6961
    ISSN 1869-6953
    DOI 10.1007/s13300-022-01261-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Pancreatic Pseudocyst after Fully Covered Self-expandable Metallic Stent Placement: A Case Report.

    Koizumi, Mitsuhito / Ishikawa, Sho / Marui, Kaori / Kokubu, Masahito / Okujima, Yusuke / Numata, Yuki / Imamura, Yoshiki / Kumagi, Teru / Hiasa, Yoichi

    Internal medicine (Tokyo, Japan)

    2024  

    Abstract: A 70-year-old woman presented with stage III pancreatic head cancer. After endoscopic sphincterotomy, a fully covered self-expandable metallic stent (FCSEMS) was placed in the common bile duct to manage jaundice. The patient developed a fever and ... ...

    Abstract A 70-year-old woman presented with stage III pancreatic head cancer. After endoscopic sphincterotomy, a fully covered self-expandable metallic stent (FCSEMS) was placed in the common bile duct to manage jaundice. The patient developed a fever and abdominal pain 40 days after stent placement, with a suspected diagnosis of infected pancreatic pseudocyst. Purulent discharge from the papilla was observed during FCSEMS removal, and pancreatography revealed a pseudocyst connected to the main pancreatic duct. The pancreatic pseudocyst resolved after transpapillary drainage. Pancreatic pseudocysts should be suspected after biliary FCSEMS placement, and prompt removal and endoscopic drainage of the FCSEMS should be considered.
    Language English
    Publishing date 2024-02-26
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.3178-23
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  8. Article ; Online: Correction to: Deep attenuation transducer to measure liver stiffness in obese patients with liver disease.

    Hirooka, Masashi / Koizumi, Yohei / Nakamura, Yoshiko / Yano, Ryo / Hirooka, Kana / Morita, Makoto / Imai, Yusuke / Tokumoto, Yoshio / Abe, Masanori / Hiasa, Yoichi

    Journal of medical ultrasonics (2001)

    2024  

    Language English
    Publishing date 2024-03-05
    Publishing country Japan
    Document type Published Erratum
    ZDB-ID 1396630-3
    ISSN 1613-2254 ; 0287-0592 ; 1346-4523
    ISSN (online) 1613-2254
    ISSN 0287-0592 ; 1346-4523
    DOI 10.1007/s10396-024-01423-1
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  9. Article ; Online: A case of hepatocellular carcinoma with pseudoaneurysm formation upon lenvatinib administration.

    Yano, Ryo / Hirooka, Masashi / Nakamura, Yoshiko / Imai, Yusuke / Koizumi, Yohei / Watanabe, Takao / Yoshida, Osamu / Tokumoto, Yoshio / Abe, Masanori / Hiasa, Yoichi

    Clinical journal of gastroenterology

    2024  Volume 17, Issue 2, Page(s) 319–326

    Abstract: A 79-year-old man received treatment for multiple intrahepatic hepatocellular carcinoma with atezolizumab + bevacizumab. However, he developed lower back pain attributed to spinal metastases upon tumor enlargement; thus, he was admitted to our hospital ... ...

    Abstract A 79-year-old man received treatment for multiple intrahepatic hepatocellular carcinoma with atezolizumab + bevacizumab. However, he developed lower back pain attributed to spinal metastases upon tumor enlargement; thus, he was admitted to our hospital for a change from atezolizumab + bevacizumab to lenvatinib and radiation therapy for the spinal metastases. On the 11th day after starting lenvatinib treatment, a pulsatile aneurysm appeared in the tumor, detected using abdominal ultrasonography Micro B-flow imaging, which visualized blood flow at a high frame rate; this was diagnosed as a pseudoaneurysm. The patient refused treatment for the pseudoaneurysm; therefore, he was carefully followed up. Fortunately, the pseudoaneurysm disappeared on the 17th day. One month later, the tumor had become completely necrotic. Lenvatinib demonstrated effectiveness in inhibiting angiogenesis in the tumor, as evidenced by a decrease in tumor blood flow. This case report suggests that pseudoaneurysm formation within the tumor occurs early after the administration of lenvatinib; thus, clinicians must be aware of the potential risk of pseudoaneurysm rupture.
    MeSH term(s) Male ; Humans ; Aged ; Carcinoma, Hepatocellular/drug therapy ; Aneurysm, False/chemically induced ; Aneurysm, False/diagnostic imaging ; Bevacizumab ; Spinal Neoplasms ; Liver Neoplasms/drug therapy ; Phenylurea Compounds ; Quinolines
    Chemical Substances lenvatinib (EE083865G2) ; Bevacizumab (2S9ZZM9Q9V) ; Phenylurea Compounds ; Quinolines
    Language English
    Publishing date 2024-01-28
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 2429411-1
    ISSN 1865-7265 ; 1865-7257
    ISSN (online) 1865-7265
    ISSN 1865-7257
    DOI 10.1007/s12328-023-01914-7
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  10. Article: No Association Between Allergic Diseases and Constipation in Japanese Ulcerative Colitis Patients: A Cross-Sectional Study.

    Yagi, Sen / Furukawa, Shinya / Suzuki, Seiyuu / Ohashi, Katsuhisa / Tomida, Hideomi / Yamamoto, Yasunori / Takeshita, Eiji / Ikeda, Yoshio / Hiasa, Yoichi

    Cureus

    2024  Volume 16, Issue 3, Page(s) e55912

    Abstract: Background: Constipation is a common gastrointestinal symptom in patients with ulcerative colitis (UC). Several studies on the general population have demonstrated a link between allergic diseases and constipation. However, evidence regarding the ... ...

    Abstract Background: Constipation is a common gastrointestinal symptom in patients with ulcerative colitis (UC). Several studies on the general population have demonstrated a link between allergic diseases and constipation. However, evidence regarding the association between allergic diseases and constipation in UC is limited. This study aims to evaluate this issue in Japanese patients with UC.
    Methods: This cross-sectional study recruited consecutive 387 patients with UC. We used a self-administered questionnaire to estimate the prevalence of physician-diagnosed allergic diseases. The definition of constipation was based on Rome I criteria and/or medication for constipation.
    Results: The prevalence of constipation was 12.5%. The prevalence rates of asthma, atopic dermatitis, pollen allergy, food allergy, and drug allergy were 11.8%, 9.0%, 36.3%, 6.2%, and 8.3%, respectively. Allergic diseases were not associated with constipation (adjusted odds ratio [OR] with asthma (adjusted OR 0.98 [95% confidence interval [CI] 0.27-2.80]), atopic dermatitis (adjusted OR 0.67 [95% CI 0.10-2.56]), pollen allergy (adjusted OR 0.92 [95% CI 0.41-1.97]), food allergy (adjusted OR 0.76 [95% CI 0.11-2.95]), and drug allergy (adjusted OR 1.06 [95% CI 0.28-3.24]). Additionally, the number of allergic diseases was not associated with the prevalence of constipation.
    Conclusions: In Japanese UC patients, no association between allergic diseases and constipation was found.
    Language English
    Publishing date 2024-03-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.55912
    Database MEDical Literature Analysis and Retrieval System OnLINE

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