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  1. AU="Hickenlooper, Samuel M"
  2. AU="Sayantani B. Sindher"

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  1. Article ; Online: Correction to "Histone H4K20 Trimethylation Is Decreased in Murine Models of Heart Disease".

    Hickenlooper, Samuel M / Davis, Kathryn / Szulik, Marta W / Sheikh, Hanin / Miller, Mickey / Valdez, Steven / Bia, Ryan / Franklin, Sarah

    ACS omega

    2023  Volume 8, Issue 6, Page(s) 6124–6125

    Abstract: This corrects the article DOI: 10.1021/acsomega.2c00984.]. ...

    Abstract [This corrects the article DOI: 10.1021/acsomega.2c00984.].
    Language English
    Publishing date 2023-01-31
    Publishing country United States
    Document type Published Erratum
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c00112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Histone H4K20 Trimethylation Is Decreased in Murine Models of Heart Disease.

    Hickenlooper, Samuel M / Davis, Kathryn / Szulik, Marta W / Sheikh, Hanin / Miller, Mickey / Valdez, Steven / Bia, Ryan / Franklin, Sarah

    ACS omega

    2022  Volume 7, Issue 35, Page(s) 30710–30719

    Abstract: Heart disease is the leading cause of death in the developed world, and its comorbidities such as hypertension, diabetes, and heart failure are accompanied by major transcriptomic changes in the heart. During cardiac dysfunction, which leads to heart ... ...

    Abstract Heart disease is the leading cause of death in the developed world, and its comorbidities such as hypertension, diabetes, and heart failure are accompanied by major transcriptomic changes in the heart. During cardiac dysfunction, which leads to heart failure, there are global epigenetic alterations to chromatin that occur concomitantly with morphological changes in the heart in response to acute and chronic stress. These epigenetic alterations include the reversible methylation of lysine residues on histone proteins. Lysine methylations on histones H3K4 and H3K9 were among the first methylated lysine residues identified and have been linked to gene activation and silencing, respectively. However, much less is known regarding other methylated histone residues, including histone H4K20. Trimethylation of histone H4K20 has been shown to repress gene expression; however, this modification has never been examined in the heart. Here, we utilized immunoblotting and mass spectrometry to quantify histone H4K20 trimethylation in three models of cardiac dysfunction. Our results show that lysine methylation at this site is differentially regulated in the cardiomyocyte, leading to increased H4K20 trimethylation during acute hypertrophic stress in cell models and decreased H4K20 trimethylation during sustained ischemic injury and cardiac dysfunction in animal models. In addition, we examined publicly available data sets to analyze enzymes that regulate H4K20 methylation and identified two demethylases (KDM7B and KDM7C) and two methyltransferases (KMT5A and SMYD5) that were all differentially expressed in heart failure patients. This is the first study to examine histone H4K20 trimethylation in the heart and to determine how this post-translational modification is differentially regulated in multiple models of cardiac disease.
    Language English
    Publishing date 2022-08-23
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c00984
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Barriers for Extrusion of a Guest from the Interior Binding Cavity of a Host: Gas Phase Experimental and Computational Results for Ion-Capped Decamethylcucurbit[5]uril Complexes.

    Hickenlooper, Samuel M / Harper, Conner C / Pope, Brigham L / Mortensen, Daniel N / Dearden, David V

    The journal of physical chemistry. A

    2018  Volume 122, Issue 47, Page(s) 9224–9232

    Abstract: Factors affecting the extrusion of guests from metal ion-capped decamethylcucurbit[5]uril (mc5) molecular container complexes are investigated using both collision-induced dissociation techniques and molecular mechanics simulations. For guests without ... ...

    Abstract Factors affecting the extrusion of guests from metal ion-capped decamethylcucurbit[5]uril (mc5) molecular container complexes are investigated using both collision-induced dissociation techniques and molecular mechanics simulations. For guests without polar bonds, the extrusion barrier increases with increasing guest volume. This is likely because escape of larger guests requires more displacement of the metal ion caps and, thus, more disruption of the ion-dipole interactions between the ion caps and the electronegative rim oxygens of mc5. However, guests larger than the optimum size for encapsulation displace the ion caps prior to collision-induced dissociation, resulting in less stable complexes and lower dissociation thresholds. The extrusion barriers obtained for guests with polar bonds are smaller than those obtained for similarly sized guests without polar bonds. This is likely because the partial charges on the guest allow electrostatic interactions with the ion cap and rim oxygens of mc5 during extrusion, thus stabilizing the extrusion transition state and reducing the extrusion barrier. Results from this study demonstrate simple principles to consider for designing host-guest complexes with specific guest-loss behaviors. Similar trends are observed between the experimental and computational results, demonstrating that molecular mechanics simulations can be used to approximate the relative stability of mc5 molecular container complexes and likely those of other similar complexes.
    Language English
    Publishing date 2018-11-16
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5215
    ISSN (online) 1520-5215
    DOI 10.1021/acs.jpca.8b08031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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