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Article: Predictors of Revascularization in Patients with Unstable Angina.

Budzianowski, Jan / Faron, Wojciech / Rzeźniczak, Janusz / Słomczyński, Marek / Hiczkiewicz, Dariusz / Olejniczak, Jacek / Hiczkiewicz, Jarosław / Burchardt, Paweł

Journal of clinical medicine

2024 Volume 13, Issue 4

Abstract: Background: The factors that determine the necessity of coronary artery revascularization in patients with unstable angina (UA) have been supported by limited data. Therefore, this study aimed to identify the predictors of revascularization in patients ... ...

Abstract	Background: The factors that determine the necessity of coronary artery revascularization in patients with unstable angina (UA) have been supported by limited data. Therefore, this study aimed to identify the predictors of revascularization in patients with UA. Methods: The study included the recorded data of 3668 patients with UA who underwent cardiac catheterization (age 66 ± 9.2, men 70%); 2615 of them (71%) underwent revascularization (percutaneous transluminal coronary angioplasty (PTCA), coronary artery bypass graft (CABG), or hybrid revascularization. The remaining 1053 patients (29%) had no significant coronary stenosis and were regarded as controls. Multivariable logistic regression analysis was performed to separate the predictors of revascularization. Results: It was found that severe angina (OR 2.7, 95%CI 1.9-3.7), male gender (OR 1.4, 95%CI 1.1-1.7), and hyperlipidemia were the predictors of revascularization. It was also noted that intraventricular conduction disorders including left and right bundle branch blocks and a history of previous revascularization and myocardial infarction were associated with lower odds of revascularization. Conclusion: Overall, however, the predictive value of the studied factors proved to be poor and may still point to the multifactorial nature of significant coronary artery stenosis and the need for revascularization in patients with UA.
Language	English
Publishing date	2024-02-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13041096
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Article ; Online: Intravascular lithotripsy of an underexpanded stent following unsuccessful rotational atherectomy in a patient with severely calcified coronary artery.

Faron, Wojciech / Hiczkiewicz, Jarosław / Budzianowski, Jan / Lesiak, Maciej

Cardiology journal

2021 Volume 28, Issue 4, Page(s) 634–635

MeSH term(s)	Atherectomy, Coronary/adverse effects ; Coronary Angiography ; Coronary Artery Disease/complications ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/surgery ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/surgery ; Humans ; Lithotripsy ; Stents ; Treatment Outcome ; Vascular Calcification/diagnosis ; Vascular Calcification/diagnostic imaging
Language	English
Publishing date	2021-07-08
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2488680-4
ISSN	1898-018X ; 1897-5593
ISSN (online)	1898-018X
ISSN	1897-5593
DOI	10.5603/CJ.2021.0067
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Article ; Online: The Comparative Method Based on Coronary Computed Tomography Angiography for Assessing the Hemodynamic Significance of Coronary Artery Stenosis.

Małota, Zbigniew / Sadowski, Wojciech / Pieszko, Konrad / Zimoląg, Rafał / Czekała, Filip / Malinowska, Renata / Hiczkiewicz, Jarosław

Cardiovascular engineering and technology

2023 Volume 14, Issue 3, Page(s) 364–379

Abstract: Purpose: An important aspect in the prevention and treatment of coronary artery disease is the functional evaluation of narrowed blood vessels. Medical image-based Computational Fluid Dynamic methods are currently increasingly being used in the clinical ...

Abstract	Purpose: An important aspect in the prevention and treatment of coronary artery disease is the functional evaluation of narrowed blood vessels. Medical image-based Computational Fluid Dynamic methods are currently increasingly being used in the clinical setting for flow studies of cardio vascular system. The aim of our study was to confirm the feasibility and functionality of a non-invasive computational method providing information about hemodynamic significance of coronary stenosis. Methods: A comparative method was used to simulate the flow energy losses in real (stenotic) and reconstructed models without (reference) stenosis of the coronary arteries under stress test conditions, i.e. for maximum blood flow and minimal, constant vascular resistance. In addition to the absolute pressure drop in the stenotic arteries (FFR Results: The greater the degree of narrowing of the vessel, the greater drop of flow energy. Each parameter introduces an additional diagnostic value. In contrast to FFR Conclusion: The study presented promising results of non-invasive, comparative test to support of prevention of coronary disease and functional evaluation of stenosed vessels.
MeSH term(s)	Humans ; Computed Tomography Angiography ; Constriction, Pathologic ; Retrospective Studies ; Fractional Flow Reserve, Myocardial ; Coronary Stenosis ; Coronary Artery Disease/diagnostic imaging ; Tomography, X-Ray Computed ; Coronary Angiography/methods ; Hemodynamics ; Coronary Vessels/diagnostic imaging
Language	English
Publishing date	2023-03-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2543111-0
ISSN	1869-4098 ; 1869-408X
ISSN (online)	1869-4098
ISSN	1869-408X
DOI	10.1007/s13239-023-00658-2
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Article ; Online: Percutaneous coronary intervention using a mechanical circulatory support system with an Impella centrifugal pump device combined with subsequent cryoablation for atrial fibrillation.

Winnicka-Zielińska, Anna / Musielak, Bogdan / Budzianowski, Jan / Hiczkiewicz, Jarosław / Burchardt, Paweł

Cardiology journal

2022 Volume 28, Issue 6, Page(s) 995–996

MeSH term(s)	Atrial Fibrillation/complications ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/surgery ; Catheter Ablation ; Cryosurgery ; Heart-Assist Devices ; Humans ; Percutaneous Coronary Intervention ; Shock, Cardiogenic/surgery ; Treatment Outcome
Language	English
Publishing date	2022-01-05
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2488680-4
ISSN	1898-018X ; 1897-5593
ISSN (online)	1898-018X
ISSN	1897-5593
DOI	10.5603/CJ.2021.0145
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Article: Predictors of Early-Recurrence Atrial Fibrillation after Catheter Ablation in Women and Men with Abnormal Body Weight.

Budzianowski, Jan / Hiczkiewicz, Jarosław / Łojewska, Katarzyna / Kawka, Edyta / Rutkowski, Rafał / Korybalska, Katarzyna

Journal of clinical medicine

2021 Volume 10, Issue 12

Abstract: Our study aimed to select factors that affect the rate of early recurrence (up to 3 months) of atrial fibrillation (AF) (ERAF) following pulmonary veins isolation (PVI) in obese women and men. The study comprised 114 patients: 54 women (age: 63.8 ± 6.3, ... ...

Abstract	Our study aimed to select factors that affect the rate of early recurrence (up to 3 months) of atrial fibrillation (AF) (ERAF) following pulmonary veins isolation (PVI) in obese women and men. The study comprised 114 patients: 54 women (age: 63.8 ± 6.3, BMI 31 ± 4 kg/m
Language	English
Publishing date	2021-06-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10122694
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Article ; Online: A Review of Acute Coronary Syndrome and its Potential Impact on Cognitive Function.

Kasprzak, Dominika / Rzeźniczak, Janusz / Ganowicz, Teresa / Łuczak, Tomasz / Słomczyński, Marek / Hiczkiewicz, Jarosław / Burchardt, Paweł

Global heart

2021 Volume 16, Issue 1, Page(s) 53

Abstract: According to the World Health Organization (WHO) forecasts, in 2030, the number of people suffering from dementia will reach 82 million people worldwide, representing a huge burden on health and social care systems. Epidemiological data indicates a ... ...

Abstract	According to the World Health Organization (WHO) forecasts, in 2030, the number of people suffering from dementia will reach 82 million people worldwide, representing a huge burden on health and social care systems. Epidemiological data indicates a relationship between coronary heart disease (CHD) and the occurrence of cognitive impairment (CI) and dementia. It is known that both diseases have common risk factors. However, the impact of myocardial infarction (MI) on cognitive function remains controversial and largely unknown. The main goal of this study is to attempt to summarize and discuss selected scientific reports on the causes, mechanisms and effects of CI in patients after acute coronary syndrome (ACS), especially after MI. The risk of CI can increase in patients after ACS, and can therefore also adversely affect the further course of treatment. A late diagnosis of CI can lead to serious clinical implications, such as an increase in the number of hospitalizations and mortality.
MeSH term(s)	Acute Coronary Syndrome/epidemiology ; Cognition ; Coronary Disease ; Humans ; Myocardial Infarction ; Risk Factors
Language	English
Publishing date	2021-08-04
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2629633-0
ISSN	2211-8179 ; 2211-8160
ISSN (online)	2211-8179
ISSN	2211-8160
DOI	10.5334/gh.934
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Article ; Online: Immunosenescence in Aging-Related Vascular Dysfunction.

Tylutka, Anna / Morawin, Barbara / Wawrzyniak-Gramacka, Edyta / Wacka, Eryk / Nowicka, Wiktoria / Hiczkiewicz, Jaroslaw / Zembron-Lacny, Agnieszka

International journal of molecular sciences

2022 Volume 23, Issue 21

Abstract: The immunosenescence-related disproportion in T lymphocytes may have important consequences for endothelial dysfunction, which is a key event in vascular aging. The study was designed to assess the prognostic values of the inflammatory-immune profile to ... ...

Abstract	The immunosenescence-related disproportion in T lymphocytes may have important consequences for endothelial dysfunction, which is a key event in vascular aging. The study was designed to assess the prognostic values of the inflammatory-immune profile to better predict and prevent vascular diseases associated with old age. Eighty individuals aged 70.9 ± 5.3 years were allocated to a low- (LGI) or high-grade inflammation (HGI) group based on CRP (<3 or ≥3 mg/L) as a conventional risk marker of cardiovascular diseases. Significant changes in inflammatory and endothelium-specific variables IL-1β, IL-6, TNFα, oxLDL, H2O2, NO, 3-nitrotyrosine, and endothelial progenitor cells (OR 7.61, 95% CI 2.56−29.05, p < 0.0001), confirmed their interplay in vascular inflammation. The flow-cytometry analysis demonstrated a high disproportion in T lymphocytes CD4+ and CD8+ between LGI and HGI groups. CRP was <3 mg/mL for the CD4/CD8 ratio within the reference values ≥ 1 or ≤2.5, unlike for the CD4/CD8 ratio < 1 and >2.5. The odds ratios for the distribution of CD4+ (OR 5.98, 95% CI 0.001−0.008, p < 0.001), CD8+ (OR 0.23, 95% CI 0.08−0.59, p < 0.01), and CD8CD45RO+ T naïve cells (OR 0.27, 95% CI 0.097−0.695, p < 0.01) and CD4/CD8 (OR 5.69, 95% CI 2.07−17.32, p < 0.001) indicated a potential diagnostic value of T lymphocytes for clinical prognosis in aging-related vascular dysfunction.
MeSH term(s)	Humans ; Immunosenescence ; CD8-Positive T-Lymphocytes ; Hydrogen Peroxide ; CD4-Positive T-Lymphocytes ; Aging ; Flow Cytometry ; Inflammation
Chemical Substances	Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2022-10-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms232113269
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Article ; Online: Retrospective Study to Identify Risk Factors for Severe Disease and Mortality Using the Modified Early Warning Score in 5127 Patients with COVID-19 Admitted to an Emergency Department in Poland Between March 2020 and April 2021.

Butkiewicz, Sławomir / Zaczyński, Artur / Pańkowski, Igor / Tomaka, Piotr / Rzońca, Ewa / Ślęzak, Daniel / Podgórski, Marcin / Gałązkowski, Robert / Hiczkiewicz, Jarosław / Rzońca, Patryk

Medical science monitor : international medical journal of experimental and clinical research

2022 Volume 28, Page(s) e938647

Abstract: BACKGROUND COVID-19, a disease caused by SARS-CoV-2, has posed a threat to global public health. This retrospective study of 5127 patients with COVID-19 admitted to an Emergency Department in Poland between March 2020 and April 2021 aimed to identify ... ...

Abstract	BACKGROUND COVID-19, a disease caused by SARS-CoV-2, has posed a threat to global public health. This retrospective study of 5127 patients with COVID-19 admitted to an Emergency Department in Poland between March 2020 and April 2021 aimed to identify risk factors for severe disease and mortality using the modified early warning score (MEWS). MATERIAL AND METHODS The study was based on a retrospective analysis of patients with SARS-CoV-2 infection admitted to the Emergency Department between March 2020 and April 2021. A total of 5127 cases were included in the final analysis. Identifying the group of high-risk patients with COVID-19 was determined based on the MEWS score. RESULTS Most of the patients studied were male (53.38%). The in-hospital mortality rate among the patients was 21.53%. The factors associated with the risk of in-hospital mortality from COVID-19 were age (>60 years, hazard ratio [HR]=2.27, P<0.001), comorbidities (cancer, HR=1.39, P=0.005; heart failure, HR=1.31, P=0.009; renal failure, HR=1.37, P=0.004), higher MEWS score (MEWS ≥5, HR=1.43, P<0.001), higher percentage of lung parenchyma affected (>50%, HR=2.10, P=0.001), and higher respiratory rate (>24 breaths per min, HR=2.10, P<0.001). CONCLUSIONS This study produced real-world data of risk factors for mortality from COVID-19 and the use of the MEWS for a faster identification of patients with COVID-19 requiring more intensive medical care.
Language	English
Publishing date	2022-12-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1439041-3
ISSN	1643-3750 ; 1234-1010
ISSN (online)	1643-3750
ISSN	1234-1010
DOI	10.12659/MSM.938647
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Article ; Online: Anticoagulation for Atrial Fibrillation in Acute Coronary Syndrome Survivors Reduces Major Cardiovascular Events and Mortality.

Pyka, Łukasz / Hudzik, Bartosz / Bartuś, Stanisław / Buszman, Paweł / Gierlotka, Marek / Wojakowski, Wojciech / Hiczkiewicz, Jarosław / Kleinrok, Andrzej / Skrzypek, Michał / Kuliczkowski, Wiktor / Gąsior, Mariusz

Journal of cardiovascular pharmacology and therapeutics

2023 Volume 28, Page(s) 10742484231212106

Abstract: The prevalence of atrial fibrillation (AF) in acute coronary syndrome (ACS) patients is increasing. Data on outcomes of anticoagulation in ACS patients with AF are lacking.: The aim of our study was to investigate the prevalence of stroke, myocardial ... ...

Abstract	The prevalence of atrial fibrillation (AF) in acute coronary syndrome (ACS) patients is increasing. Data on outcomes of anticoagulation in ACS patients with AF are lacking. The aim of our study was to investigate the prevalence of stroke, myocardial infarction, bleeding complications, and all-cause mortality in this population. PL-ACS and AMI-PL registries gather an all-comer population of ACS patients in Poland, exceeding half a million records. We have selected ACS survivors with concomitant AF on admission, divided them into subgroups with regard to the administered anticoagulation, and followed up with them for a 12-month period ( The study population was divided with regard to the administration of anticoagulation. Anticoagulation was prescribed in 2,466 patients (17.6%). The (D)OAC+ patients were younger; however, comorbidities were more prevalent in this group. The 12-month follow-up showed that the (D)OAC+ patients had significantly lower rates of all-cause mortality, myocardial infarction, and ischemic stroke, with no significant increase in bleeding events. After matching, the study groups consisted of 2,194 patients each and showed no differences in baseline characteristics. The outcomes of the 12-month observation were similar to the findings before matching. This all-comer national registry analysis shows that the use of guideline-recommended therapy and anticoagulation in ACS survivors with AF is associated with a lower rate of all-cause mortality, recurrent myocardial infarction, and ischemic stroke.
MeSH term(s)	Humans ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/complications ; Acute Coronary Syndrome/diagnosis ; Acute Coronary Syndrome/drug therapy ; Platelet Aggregation Inhibitors/adverse effects ; Anticoagulants/adverse effects ; Myocardial Infarction/complications ; Hemorrhage/chemically induced ; Stroke/diagnosis ; Stroke/epidemiology ; Stroke/prevention & control ; Ischemic Stroke/chemically induced ; Ischemic Stroke/complications ; Registries ; Risk Factors
Chemical Substances	Platelet Aggregation Inhibitors ; Anticoagulants
Language	English
Publishing date	2023-11-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1329372-2
ISSN	1940-4034 ; 1074-2484
ISSN (online)	1940-4034
ISSN	1074-2484
DOI	10.1177/10742484231212106
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Zs.A 4895: Show issues

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Article ; Online: Machine learning model for predicting late recurrence of atrial fibrillation after catheter ablation.

Budzianowski, Jan / Kaczmarek-Majer, Katarzyna / Rzeźniczak, Janusz / Słomczyński, Marek / Wichrowski, Filip / Hiczkiewicz, Dariusz / Musielak, Bogdan / Grydz, Łukasz / Hiczkiewicz, Jarosław / Burchardt, Paweł

Scientific reports

2023 Volume 13, Issue 1, Page(s) 15213

Abstract: Late recurrence of atrial fibrillation (LRAF) in the first year following catheter ablation is a common and significant clinical problem. Our study aimed to create a machine-learning model for predicting arrhythmic recurrence within the first year since ... ...

Abstract	Late recurrence of atrial fibrillation (LRAF) in the first year following catheter ablation is a common and significant clinical problem. Our study aimed to create a machine-learning model for predicting arrhythmic recurrence within the first year since catheter ablation. The study comprised 201 consecutive patients (age: 61.8 ± 8.1; women 36%) with paroxysmal, persistent, and long-standing persistent atrial fibrillation (AF) who underwent cryoballoon (61%) and radiofrequency ablation (39%). Five different supervised machine-learning models (decision tree, logistic regression, random forest, XGBoost, support vector machines) were developed for predicting AF recurrence. Further, SHapley Additive exPlanations were derived to explain the predictions using 82 parameters based on clinical, laboratory, and procedural variables collected from each patient. The models were trained and validated using a stratified fivefold cross-validation, and a feature selection was performed with permutation importance. The XGBoost model with 12 variables showed the best performance on the testing cohort, with the highest AUC of 0.75 [95% confidence interval 0.7395, 0.7653]. The machine-learned model, based on the easily available 12 clinical and laboratory variables, predicted LRAF with good performance, which may provide a valuable tool in clinical practice for better patient selection and personalized AF strategy following the procedure.
MeSH term(s)	Humans ; Female ; Middle Aged ; Aged ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/surgery ; Catheter Ablation/adverse effects ; Machine Learning ; Radiofrequency Ablation ; Supervised Machine Learning
Language	English
Publishing date	2023-09-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-42542-y
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