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  1. Book ; Online: Leukocyte Trafficking in Homeostasis and Disease

    Teixidó, Joaquin / Hidalgo, Andres / Carola Fagerholm, Susanna

    2019  

    Keywords Medicine ; Immunology ; leukocyte ; traffic ; homeostasis ; inflammation ; cancer
    Size 1 electronic resource (153 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021229923
    ISBN 9782889632961 ; 2889632962
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: A NET-thrombosis axis in COVID-19.

    Hidalgo, Andrés

    Blood

    2020  Volume 136, Issue 10, Page(s) 1118–1119

    MeSH term(s) Betacoronavirus/immunology ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/immunology ; Coronavirus Infections/pathology ; Extracellular Traps/immunology ; Humans ; Neutrophils/immunology ; Neutrophils/pathology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/immunology ; Pneumonia, Viral/pathology ; SARS-CoV-2 ; Thrombosis/complications ; Thrombosis/immunology ; Thrombosis/pathology
    Keywords covid19
    Language English
    Publishing date 2020-09-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2020007951
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Neutrophils as drivers of vascular injury in sickle cell disease

    Torres, Lidiane S. / Hidalgo, Andrés

    Immunological Reviews 2023 Mar., v. 314, no. 1, p. 302-312

    2023  , Page(s) 302–312

    Abstract: While neutrophils are the main effectors of protective innate immune responses, they are also key players in inflammatory pathologies. Sickle cell disease (SCD) is a genetic blood disorder in which red blood cells (RBCs) are constantly destroyed in the ... ...

    Abstract While neutrophils are the main effectors of protective innate immune responses, they are also key players in inflammatory pathologies. Sickle cell disease (SCD) is a genetic blood disorder in which red blood cells (RBCs) are constantly destroyed in the circulation which generates a highly inflammatory environment that culminates in vascular occlusions. Vaso‐occlusion is the hallmark of SCD and a predictor of disease severity. Neutrophils initiate and propagate SCD‐related vaso‐occlusion through adhesive interactions with the activated and dysfunctional endothelium, sickle RBCs, and platelets, leading to acute and chronic complications that progress to irreversible organ damage and ultimately death. The use of SCD humanized mouse models, in combination with in vivo imaging techniques, has emerged as a fundamental tool to understand the dynamics of neutrophils under complex inflammatory contexts and their contribution to vascular injury in SCD. In this review, we discuss the various mechanisms by which circulating neutrophils sense and respond to the wide range of stimuli present in the blood of SCD patients and mice. We argue that the central role of neutrophils in SCD can be rationalized to develop targets for the management of clinical complications in SCD patients.
    Keywords death ; disease severity ; endothelium ; mice ; neutrophils ; sickle cell anemia
    Language English
    Dates of publication 2023-03
    Size p. 302-312
    Publishing place John Wiley & Sons, Inc
    Document type Article ; Online
    Note REVIEW ; Wiley License Information
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.13146
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Lipid mediators in neutrophil biology: inflammation, resolution and beyond.

    Ghodsi, Anita / Hidalgo, Andres / Libreros, Stephania

    Current opinion in hematology

    2024  

    Abstract: Purpose of review: Acute inflammation is the body's first defense in response to pathogens or injury. Failure to efficiently resolve the inflammatory insult can severely affect tissue homeostasis, leading to chronic inflammation. Neutrophils play a ... ...

    Abstract Purpose of review: Acute inflammation is the body's first defense in response to pathogens or injury. Failure to efficiently resolve the inflammatory insult can severely affect tissue homeostasis, leading to chronic inflammation. Neutrophils play a pivotal role in eradicating infectious pathogens, orchestrating the initiation and resolution of acute inflammation, and maintaining physiological functions. The resolution of inflammation is a highly orchestrated biochemical process, partially modulated by a novel class of endogenous lipid mediators known as specialized pro-resolving mediators (SPMs). SPMs mediate their potent bioactions via activating specific cell-surface G protein-coupled receptors (GPCR).
    Recent findings: This review focuses on recent advances in understanding the multifaceted functions of SPMs, detailing their roles in expediting neutrophil apoptosis, promoting clearance by macrophages, regulating their excessive infiltration at inflammation sites, orchestrating bone marrow deployment, also enhances neutrophil phagocytosis and tissue repair mechanisms under both physiological and pathological conditions. We also focus on the novel role of SPMs in regulating bone marrow neutrophil functions, differentiation, and highlight open questions about SPMs' functions in neutrophil heterogeneity.
    Summary: SPMs play a pivotal role in mitigating excessive neutrophil infiltration and hyperactivity within pathological milieus, notably in conditions such as sepsis, cardiovascular disease, ischemic events, and cancer. This significant function highlights SPMs as promising therapeutic agents in the management of both acute and chronic inflammatory disorders.
    Language English
    Publishing date 2024-05-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1153887-9
    ISSN 1531-7048 ; 1065-6251
    ISSN (online) 1531-7048
    ISSN 1065-6251
    DOI 10.1097/MOH.0000000000000822
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A hypoxic ride for neutrophils in PDAC.

    Cerezo-Wallis, Daniela / Hidalgo, Andrés

    Gut

    2022  Volume 72, Issue 5, Page(s) 817–818

    MeSH term(s) Humans ; Neutrophils ; Carcinoma, Pancreatic Ductal ; Pancreatic Neoplasms ; Hypoxia ; Tumor Microenvironment
    Language English
    Publishing date 2022-07-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2022-327953
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: NETs in sickle cell disease, quo vadis?

    Torres, Lidiane S / Hidalgo, Andrés

    Blood

    2022  Volume 140, Issue 9, Page(s) 938–939

    MeSH term(s) Anemia, Sickle Cell/therapy ; Humans ; Liver ; Lung ; Lung Injury ; Receptor Protein-Tyrosine Kinases
    Chemical Substances Receptor Protein-Tyrosine Kinases (EC 2.7.10.1)
    Language English
    Publishing date 2022-09-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2022017346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Neutrophils as drivers of vascular injury in sickle cell disease.

    Torres, Lidiane S / Hidalgo, Andrés

    Immunological reviews

    2022  Volume 314, Issue 1, Page(s) 302–312

    Abstract: While neutrophils are the main effectors of protective innate immune responses, they are also key players in inflammatory pathologies. Sickle cell disease (SCD) is a genetic blood disorder in which red blood cells (RBCs) are constantly destroyed in the ... ...

    Abstract While neutrophils are the main effectors of protective innate immune responses, they are also key players in inflammatory pathologies. Sickle cell disease (SCD) is a genetic blood disorder in which red blood cells (RBCs) are constantly destroyed in the circulation which generates a highly inflammatory environment that culminates in vascular occlusions. Vaso-occlusion is the hallmark of SCD and a predictor of disease severity. Neutrophils initiate and propagate SCD-related vaso-occlusion through adhesive interactions with the activated and dysfunctional endothelium, sickle RBCs, and platelets, leading to acute and chronic complications that progress to irreversible organ damage and ultimately death. The use of SCD humanized mouse models, in combination with in vivo imaging techniques, has emerged as a fundamental tool to understand the dynamics of neutrophils under complex inflammatory contexts and their contribution to vascular injury in SCD. In this review, we discuss the various mechanisms by which circulating neutrophils sense and respond to the wide range of stimuli present in the blood of SCD patients and mice. We argue that the central role of neutrophils in SCD can be rationalized to develop targets for the management of clinical complications in SCD patients.
    MeSH term(s) Humans ; Mice ; Animals ; Neutrophils ; Vascular System Injuries/complications ; Vascular System Injuries/metabolism ; Anemia, Sickle Cell/complications ; Vascular Diseases/complications ; Vascular Diseases/pathology ; Erythrocytes/metabolism
    Language English
    Publishing date 2022-10-17
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.13146
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  9. Article ; Online: Neutrophils in Physiology and Pathology.

    Aroca-Crevillén, Alejandra / Vicanolo, Tommaso / Ovadia, Samuel / Hidalgo, Andrés

    Annual review of pathology

    2024  Volume 19, Page(s) 227–259

    Abstract: Infections, cardiovascular disease, and cancer are major causes of disease and death worldwide. Neutrophils are inescapably associated with each of these health concerns, by either protecting from, instigating, or aggravating their impact on the host. ... ...

    Abstract Infections, cardiovascular disease, and cancer are major causes of disease and death worldwide. Neutrophils are inescapably associated with each of these health concerns, by either protecting from, instigating, or aggravating their impact on the host. However, each of these disorders has a very different etiology, and understanding how neutrophils contribute to each of them requires understanding the intricacies of this immune cell type, including their immune and nonimmune contributions to physiology and pathology. Here, we review some of these intricacies, from basic concepts in neutrophil biology, such as their production and acquisition of functional diversity, to the variety of mechanisms by which they contribute to preventing or aggravating infections, cardiovascular events, and cancer. We also review poorly explored aspects of how neutrophils promote health by favoring tissue repair and discuss how discoveries about their basic biology inform the development of new therapeutic strategies.
    MeSH term(s) Humans ; Neutrophils ; Health Promotion ; Cardiovascular Diseases ; Neoplasms ; Cardiovascular Infections
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2227429-7
    ISSN 1553-4014 ; 1553-4006
    ISSN (online) 1553-4014
    ISSN 1553-4006
    DOI 10.1146/annurev-pathmechdis-051222-015009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The circadian neutrophil, inside-out.

    Ovadia, Samuel / Özcan, Alaz / Hidalgo, Andrés

    Journal of leukocyte biology

    2023  Volume 113, Issue 6, Page(s) 555–566

    Abstract: The circadian clock has sway on a myriad of physiological targets, among which the immune and inflammatory systems are particularly prominent. In this review, we discuss how neutrophils, the wildcard of the immune system, are regulated by circadian ... ...

    Abstract The circadian clock has sway on a myriad of physiological targets, among which the immune and inflammatory systems are particularly prominent. In this review, we discuss how neutrophils, the wildcard of the immune system, are regulated by circadian oscillations. We describe cell-intrinsic and extrinsic diurnal mechanisms governing the general physiology and function of these cells, from purely immune to homeostatic. Repurposing the concepts discovered in other cell types, we then speculate on various uncharted avenues of neutrophil-circadian relationships, such as topology, metabolism, and the regulation of tissue clocks, with the hope of identifying exciting new avenues of work in the context of circadian immunity.
    MeSH term(s) Neutrophils ; Circadian Rhythm/physiology ; Circadian Clocks/physiology ; Homeostasis
    Language English
    Publishing date 2023-03-31
    Publishing country England
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1093/jleuko/qiad038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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