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  1. Book: Iron: harmful biological effects of an essential nutrient

    Hider, Robert C.

    (European journal of clinical investigation ; 32, Suppl. 1)

    2002  

    Author's details guest ed.: R. C. Hider
    Series title European journal of clinical investigation ; 32, Suppl. 1
    Collection
    Language English
    Size 96 S. : Ill., graph. Darst.
    Publisher Blackwell
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT013317565
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 677 -32,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  2. Book ; Conference proceedings: Science proceedings / British Pharmaceutical Conference 1998

    Hider, Robert C.

    135st meeting, Eastbourne, September 8 - 11, 1998

    (Journal of pharmacy and pharmacology ; 50, Suppl.)

    1998  

    Event/congress British Pharmaceutical Conference (135, 1998, Eastbourne)
    Author's details science chairman R. C. Hider
    Series title Journal of pharmacy and pharmacology ; 50, Suppl.
    Collection
    Language English
    Size 262, XXXV S. : graph. Darst.
    Publisher Royal Pharmaceutical Soc. of Great Britain
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT009054156
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uf I Zs 149 -50,Suppl.- verfügbar in Königswinter Königswinter

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  3. Article ; Online: The Colorimetric Detection of the Hydroxyl Radical.

    Ran, Yandong / Moursy, Mohammed / Hider, Robert C / Cilibrizzi, Agostino

    International journal of molecular sciences

    2023  Volume 24, Issue 4

    Abstract: An aromatic substrate for hydroxylation by hydroxyl radicals ( ...

    Abstract An aromatic substrate for hydroxylation by hydroxyl radicals (
    MeSH term(s) Hydroxyl Radical/chemistry ; Colorimetry ; Ferric Compounds ; Iron/chemistry ; Iron Chelating Agents ; Hydroxylation ; Hydrogen Peroxide/chemistry
    Chemical Substances Hydroxyl Radical (3352-57-6) ; Ferric Compounds ; Iron (E1UOL152H7) ; Iron Chelating Agents ; Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2023-02-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24044162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Polypeptide and protein drugs

    Hider, Robert C.

    production, characterization and formulation

    (Ellis Horwood series in pharmaceutical technology)

    1991  

    Author's details editors R. C. Hider
    Series title Ellis Horwood series in pharmaceutical technology
    Keywords Peptides ; Proteins ; Chemistry, Pharmaceutical ; Proteine ; Pharmazeutische Chemie ; Polypeptide
    Subject Arzneimittelchemie ; Pharmakochemie ; Medizinische Chemie ; Eiweiss ; Protein
    Language English
    Size 281 S. : Ill., graph. Darst.
    Publisher Horwood
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT003746052
    ISBN 0-13-677253-6 ; 978-0-13-677253-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1992 A 129 order for loan Magazin

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  5. Article ; Online: The Role of Deferiprone in Iron Chelation. Reply.

    Hider, Robert C / Hoffbrand, A Victor

    The New England journal of medicine

    2019  Volume 380, Issue 9, Page(s) 892–893

    MeSH term(s) Chelation Therapy ; Deferiprone ; Iron ; Iron Chelating Agents
    Chemical Substances Iron Chelating Agents ; Deferiprone (2BTY8KH53L) ; Iron (E1UOL152H7)
    Language English
    Publishing date 2019-02-19
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1817335
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.34: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: The Role of Deferiprone in Iron Chelation.

    Hider, Robert C / Hoffbrand, A Victor

    The New England journal of medicine

    2018  Volume 379, Issue 22, Page(s) 2140–2150

    MeSH term(s) Anemia, Sickle Cell/therapy ; Chelation Therapy ; Deferiprone/adverse effects ; Deferiprone/pharmacokinetics ; Deferiprone/therapeutic use ; Deferoxamine/therapeutic use ; Drug Therapy, Combination ; Erythrocyte Transfusion/adverse effects ; Humans ; Iron Chelating Agents/adverse effects ; Iron Chelating Agents/pharmacokinetics ; Iron Chelating Agents/therapeutic use ; Iron Overload/drug therapy ; Iron Overload/etiology ; Thalassemia/therapy
    Chemical Substances Iron Chelating Agents ; Deferiprone (2BTY8KH53L) ; Deferoxamine (J06Y7MXW4D)
    Language English
    Publishing date 2018-11-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMra1800219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.34: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: A Novel Stilbene Analogue: Antioxidant Activity and Application in Controlling the Quality and Bacterial Growth of Shrimp Refrigerated at 4ºC

    Xia, Wei / Chakka, Vara Prasad / Chen, Kai / Wang, Fan / Xie, Yuan-Yuan / Hider, Robert C. / Zhou, Tao

    Journal of aquatic food product technology. 2022 Feb. 07, v. 31, no. 2

    2022  

    Abstract: The antioxidant potential of a novel stilbene analogue (5-hydroxy-2-[2-(3,5-dihydroxy-phenyl)-vinyl]-1-hexyl-pyridin-4-one) (named SA) along with its application in shrimp refrigeration was investigated. The antioxidant activity of SA was evaluated by ... ...

    Abstract The antioxidant potential of a novel stilbene analogue (5-hydroxy-2-[2-(3,5-dihydroxy-phenyl)-vinyl]-1-hexyl-pyridin-4-one) (named SA) along with its application in shrimp refrigeration was investigated. The antioxidant activity of SA was evaluated by determining the radical scavenging ability. Further, the shrimp preservative efficacy of SA was investigated on Penaeus vannamei stored at 4°C by determining the quality indicators. The shelf life of shrimp treated with SA was extended to 10 days, while the shelf life of shrimp treated with 4-hexylresorcinol (4-HR), kojic acid, and sterile saline was 9, 6, and 4 days, respectively. The shelf life of shrimp was further extended to 12 days when treated with SA in combination with 0.1% citric acid. The residue of SA in shrimp was found to be extremely low even after 12 days of storage. Furthermore, MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay indicated that SA was nontoxic to two cell lines. SA could find application in shrimp refrigeration.
    Keywords Litopenaeus vannamei ; antioxidant activity ; bacterial growth ; citric acid ; foods ; kojic acid ; refrigeration ; shelf life ; shrimp ; stilbenes
    Language English
    Dates of publication 2022-0207
    Size p. 214-225.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 1150134-0
    ISSN 1547-0636 ; 1049-8850
    ISSN (online) 1547-0636
    ISSN 1049-8850
    DOI 10.1080/10498850.2021.2024636
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 5698: Show issues

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  8. Article ; Online: Design and synthesis of novel stilbene-hydroxypyridinone hybrids as tyrosinase inhibitors and their application in the anti-browning of freshly-cut apples

    Zhu, Yu-Zhu / Chen, Kai / Chen, Yu-Lin / Zhang, Changjun / Xie, Yuan-Yuan / Hider, Robert C. / Zhou, Tao

    Food Chemistry. 2022 Aug., v. 385 p.132730-

    2022  

    Abstract: In order to develop the tyrosinase inhibitors with potential application in food industry, a series of stilbene-hydroxypyridinone hybrids were prepared. Among these compounds, 1h was found to possess the most potent tyrosinase inhibitory effect on both ... ...

    Abstract In order to develop the tyrosinase inhibitors with potential application in food industry, a series of stilbene-hydroxypyridinone hybrids were prepared. Among these compounds, 1h was found to possess the most potent tyrosinase inhibitory effect on both monophenolase and diphenolase activities, with IC₅₀ values of 2.72 μM and 15.86 μM, respectively. The inhibitory effect of 1h on monophenolase activity was 4.6 times that of kojic acid. An inhibition kinetic assay indicated that 1h was a mixed-type and reversible inhibitor. The copper-binding and reducing ability assays, molecular docking study, intrinsic and ANS–binding fluorescence assays indicated that copper coordination and reduction is likely to be the causative mechanism for 1h-induced inhibition on tyrosinase. The results of color measurement and browning index determination indicated that treatment with 1h retarded effectively the browning of freshly-cut apples during their storage. Meanwhile, PPO and POD activities in apple slices were found to be effectively inhibited.
    Keywords apples ; catechol oxidase ; color ; fluorescence ; food chemistry ; food industry ; kojic acid ; Stilbene ; Hydroxypyridinone ; Anti-browning ; Tyrosinase ; Inhibitor
    Language English
    Dates of publication 2022-08
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2022.132730
    Database NAL-Catalogue (AGRICOLA)

    Full text online

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    In stock of ZB MED Bonn / Germany

    Z 3634: Show issues

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  9. Article ; Online: Synthesis and iron chelating properties of hydroxypyridinone and hydroxypyranone hexadentate ligands.

    Zhou, Tao / Kong, Xiao-Le / Hider, Robert C

    Dalton transactions (Cambridge, England : 2003)

    2019  Volume 48, Issue 10, Page(s) 3459–3466

    Abstract: Chelation therapy has become an important therapeutic approach for some diseases. In attempt to identify clinically useful chelators, four hexadentate ligands were synthesized by conjugating the corresponding bidentate ligands (3-hydroxypyridin-4-one (3, ... ...

    Abstract Chelation therapy has become an important therapeutic approach for some diseases. In attempt to identify clinically useful chelators, four hexadentate ligands were synthesized by conjugating the corresponding bidentate ligands (3-hydroxypyridin-4-one (3,4-HOPO), 3-hydroxypyridin-2-one (3,2-HOPO), 1-hydroxypyridin-2-one (1,2-HOPO), and 3-hydroxypyran-4-one) each with a free amino group to a tripodal acid. Their pKa values and affinities for iron(iii) were investigated. The pFe3+ values of the hexadentate pyridinones 1 (3,4-HOPO), 3 (3,2-HOPO) and 4 (1,2-HOPO), and the pyranone 2 was found to follow the sequence 1 > 4 ≫ 3 > 2, which is different to the pFe3+ value sequence of the corresponding bidentate forms (3,4-HOPO ≫ 3,2-HOPO > 1,2-HOPO > 3-hydroxypyranone). Hexadentate 3,4-HOPOs and 1,2-HOPOs have the greatest potential as iron scavenging agents.
    Language English
    Publishing date 2019-02-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/c8dt05014g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The Efficacy of Iron Chelators for Removing Iron from Specific Brain Regions and the Pituitary-Ironing out the Brain.

    Crichton, Robert R / Ward, Roberta J / Hider, Robert C

    Pharmaceuticals (Basel, Switzerland)

    2019  Volume 12, Issue 3

    Abstract: Iron chelation therapy, either subcutaneous or orally administered, has been used successfully in various clinical conditions. The removal of excess iron from various tissues, e.g., the liver spleen, heart, and the pituitary, in beta thalassemia patients, ...

    Abstract Iron chelation therapy, either subcutaneous or orally administered, has been used successfully in various clinical conditions. The removal of excess iron from various tissues, e.g., the liver spleen, heart, and the pituitary, in beta thalassemia patients, has become an essential therapy to prolong life. More recently, the use of deferiprone to chelate iron from various brain regions in Parkinson's Disease and Friederich's Ataxia has yielded encouraging results, although the side effects, in <2% of Parkinson's Disease(PD) patients, have limited its long-term use. A new class of hydroxpyridinones has recently been synthesised, which showed no adverse effects in preliminary trials. A vital question remaining is whether inflammation may influence chelation efficacy, with a recent study suggesting that high levels of inflammation may diminish the ability of the chelator to bind the excess iron.
    Language English
    Publishing date 2019-09-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph12030138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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